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| Number | Title | Issue Date |
| 7914984 | Conformationally flexible cationic conjugated polymers Methods, compositions and articles of manufacture involving cationic conjugated conformationally flexible polymers are provided. A method for the synthesis of cationic water-soluble polymers with linkages along the polymer main chain structure which disrupt the abil... | 03/29/2011 |
| 7897684 | Conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detecti... | 03/01/2011 |
| 7811755 | Methods and articles for strand-specific polynucleotide detection with cationic multichromophores The invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitati... | 10/12/2010 |
| 7780165 | Gaming system The present invention provides a gaming apparatus adapted for substantially continuous play, comprising a first set of elements divisible into two or more distinguishable subsets; a second set of destinations divisible into two or more distinguishable subsets; selec... | 08/24/2010 |
| 7674526 | Process for producing a nanoscale zero-valent metal This invention describes a process for producing a nanoscale zero-valent metal, including reduction of a metal ion solution with a dithionite compound, wherein the reduction is carried out under alkaline conditions under substantially an inert atmosphere. A nanoscal... | 03/09/2010 |
| 7666594 | Methods for assaying a sample for an aggregant This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be trans... | 02/23/2010 |
| 7629448 | Compositions for detection and analysis of polynucleotides using light harvesting multichromophores Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary t... | 12/08/2009 |
| 7629313 | Immunomodulatory polymeric antigens for treating inflammatory pathologies Provided are natural and synthetic immunomodulatory polymeric antigens (SPAs), compositions containing SPAs, and methods of using these natural and synthetic SPAs and compositions to prevent or treat inflammatory pathologies. ... | 12/08/2009 |
| 7270956 | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary t... | 09/18/2007 |
| 7214489 | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the targe... | 05/08/2007 |
| 7144950 | Conformationally flexible cationic conjugated polymers Methods, compositions and articles of manufacture involving cationic conjugated conformationally flexible polymers are provided. A method for the synthesis of cationic water-soluble polymers with linkages along the polymer main chain structure which disrupt the abil... | 12/05/2006 |
| 7091348 | Fluorescent dyes, energy transfer couples and methods Fluorescent dyes, fluorescence energy transfer dye couples, multi-color dye sets, can be employed in art-recognized assays and certain novel methods, such as in proximity assays. ... | 08/15/2006 |
| 6783709 | Self-healing organosiloxane materials containing reversible and energy-dispersive crosslinking domains Self-healing copolymeric materials comprising a plurality of intermediate strength crosslinks are provided. The copolymeric materials comprise a silicon component and a plurality of crosslinking components. The crosslinking components comprise a polymeric structure ... | 08/31/2004 |
| 6716581 | Manganese superoxide dismutase gene polymorphism for predicting cancer susceptibility The invention provides a method for determining the colorectal cancer susceptibility of a patient comprising determining a patient's genotype at the manganese superoxide dismutase (MnSOD) gene locus, wherein a patient with one or two alleles encoding alanine at posi... | 04/06/2004 |
| 6703216 | Methods, compositions and apparatuses for detection of gamma-hydroxybutyric acid (GHB) Methods, compositions and articles of manufacture for assaying a sample for a GHB source are provided. A sample suspected of containing a GHB source is contacted with a first oxidoreductase selective for GHB and an oxidized cofactor. In the presence of GH... | 03/09/2004 |
| 6693153 | Catalyst system for the polymerization of alkenes to polyolefins The invention provides metallocene catalyst systems for the controlled polymerization of alkenes to a wide variety of polyolefins and olefin coplymers. Catalyst systems are provided that specifically produce isotactic, syndiotactic and steroblock polyolef... | 02/17/2004 |
| 6664086 | cDNA, genomic, and predicted protein sequences of learning-induced kinases To elucidate molecular mechanisms in learning and memory, the expression of mRNAs in brains of rabbitsundergoing eyeblink conditioning was analyzed. Infusion of the transcription inhibitor actinomycin D (ActD) into the cerebellar nuclei reversibly blocked... | 12/16/2003 |
| 6613518 | Quantitative measurement of gene expression based on isolation of RNA from formalin-fixed paraffin-embedded tissue specimens Methods are disclosed for rapid, reliable and simple isolation of RNA from formalin-fixed paraffin-embedded tissue samples. RNA purified in this manner can be used for quantitative measurement gene expression levels. The tissue sample can be a tumor or ot... | 09/02/2003 |
