Magatti; Anita W. - US Patent Attorneys and Agents

Attorney: Magatti; Anita W.

Number of patents: 119
Last date: June 22, 2010

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Number	Title	Issue Date
7741318	Pyrazolo [1,5-A]pyrimidine adenosine Areceptor antagonists Compounds having the structural formula I are disclosed, wherein A is alkylene, or optionally substituted arylene, cycloalkylene or heteroaryldiyl; X is —C(O)— or —S...	06/22/2010
7709492	Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A receptor antagonists Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, furanyl, thienyl, pyridyl, pyridyl N-oxide, oxazolyl or...	05/04/2010
7511062	Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors The invention claims compounds of the formula wherein is a 5-membered heteroaryl; X is S or O; R1 is H, alkyl...	03/31/2009
7300941	Non-imidazole compounds Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such ...	11/27/2007
7220735	Benzimidazolone histamine Hantagonists Disclosed are novel compounds of the formula wherein R1 is benzimidazolone derivative, M1 and M2 are optionally substituted carbon or nitrogen, R2 includes optionally s...	05/22/2007
7098213	CCR5 antagonists useful for treating AIDS Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R4–R7 and R13...	08/29/2006
7094784	High affinity ligands for nociceptin receptor ORL-1 Novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: the dotted line represents an optional double bond; X1	08/22/2006
7078408	[1,2,4]-Triazole bicyclic adenosine A2a receptor antagonists Compounds having the structural formula I wherein: n is 0, 1, 2 or 3; A is C(R1) or N; R1 and R1a are H, (C1–C6)-alkyl, halo,...	07/18/2006
7067655	Adenosine A2a receptor antagonists Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, cycloalkenyl, or heteroaryl; X is alkylene or —C(O)CH2	06/27/2006
7060701	CCR5 antagonists useful for treating AIDS Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R4–R7 and R13...	06/13/2006
7049320	NKantagonists A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R...	05/23/2006
7041666	Adenosine A2a receptor antagonists Disclosed are compounds having the structural formula or pharmaceutically acceptable salts or solvates thereof, wherein R is optionally substituted heteroaryl, optionally substituted ...	05/09/2006
7008946	CCR5 antagonists useful for treating AIDS Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R4–R7 and R13 ...	03/07/2006
6951871	Indole derivatives useful as histamine H3 antagonists Disclosed are novel compounds of the formula wherein M1 is CH or N and M2 is C(R3) or N; R1 is optionally substituted indolyl or an aza derivative thereof; R2 is o...	10/04/2005
6916811	Adenosine A2a receptor antagonists Disclosed herein are compounds having the structural formula A including pharmaceutically acceptable salts or solvates of said compound, wherein X, Y, Q and R are as defined in the specification; pharmaceutical composi...	07/12/2005
6906081	Use of dual H3/M2 antagonists in the treatment of cognition deficit disorders This invention relates to a method of treating cognition deficit disorders comprising administering to a mammal in need of such treatment an effective amount of a dual histamine H3 receptor antagonist/m2 muscarinic antagonist, or a combination ...	06/14/2005
6903123	Azetidinyl diamines useful as ligands of the nociceptin receptor ORL-1 Disclosed are nociceptin ORL-1 receptor agonists of the formula wherein: (a) R1 is optionally substituted alkyl, fluorenyl, pyrimidinyl or optionally substituted piperidinyl;	06/07/2005
6900211	CCR5 antagonists useful for treating aids Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R4-R7 and R13 a...	05/31/2005
6897216	Adenosine A2a receptor antagonists Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, cycloalkenyl, or heteroaryl; X is...	05/24/2005
6897217	2-Alkynyl-and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is R1, R2	05/24/2005
6875772	[1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists Compounds having the structural formula I wherein: n is 0, 1, 2 or 3; A is C(R1) or N; R1 and R1a are H, (C1	04/05/2005
6849621	Piperidine compounds Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, fo...	02/01/2005
6727254	Heteroaryl tropane derivatives as superior ligands for nociceptin receptor ORL-1 Novel compounds of the formula wherein R is optionally substituted heteroaryl or R1 is H or C1-C6 alkyl; and R2 and ...	04/27/2004
6720325	CCR5 antagonists useful for treating aids Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R4—R7 and R13 are H or alkyl; R1 is...	04/13/2004
6720328	Non-imidazole compounds Disclosed are novel compounds of the formula In Formula I, M1 is carbon, M2, M3 and M4 are carbon or nitrogen and the remaining variables are as defined in the specification. A...	04/13/2004
6689765	Piperazine derivatives useful as CCR5 antagonists The use of CCR5 antagonists of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is hydrogen or alkyl; R2 is substituted phenyl, substituted hete...	02/10/2004
6653315	Adenosine A2a receptor antagonists Compounds having the structural formula I ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl or heteroaryl, cycloalkenyl, --C(.dbd.CH2)CH3, --C.ident.C--CH3, --CH.dbd.C(C...	11/25/2003
6645987	Nor-seco himbacine derivatives useful as thrombin receptor antagonists Heterocyclic-substituted compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof, are disclosed....	11/11/2003
6635630	Selective neurokinin antagonists Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein Ar1 and Ar2 are optionally substituted heteroaryl or optionally substituted phenyl; X1 is --O--, --S--, --SO--, ...	10/21/2003
6632828	Substituted imidazole neuropeptide Y Y5 receptor antagonists Compounds of the formula I ##STR1## or a pharmaceutically acceptable salt, solvate or N-oxide thereof, wherein X is .dbd.CH-- or .dbd.N--; Y is H, halogen, trihaloalkyl, alkyl, alkenyl, cycloalkyl, cycloalkyl, SH, --S-alkyl, or --CN. R is alkyl, --...	10/14/2003
6630475	Adenosine A2a receptor antagonists Compounds having the structural formula I ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, cycloalkenyl, or heteroaryl; X is alkylene or --C(O)CH2 --; Y is --N(R2)CH2 CH...	10/07/2003
6602885	Piperidine derivatives useful as CCR5 antagonists The use of CCR5 antagonists of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein ##STR2## R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is H, alkyl or alkenyl; R2 is optionally substitut...	08/05/2003
6534502	Substituted oximes and hydrazones as neurokinin antagonists Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: a is 0-3; b, d and e are 0-2; R is H, alkyl, F or --OR6 ; A is an optionally substituted oxime or hydrazone; d is not 0 and X is a bond, --C(O...	03/18/2003
6498168	Muscarinic antagonists Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R1, R2, R3, R4, R21, R...	12/24/2002
6472394	MCH antagonists and their use in the treatment of obesity Disclosed are compounds represented by structural formula I: ##STR1## or a pharmaceutically acceptable salt, ester or solvate thereof, wherein W is R1 --CR3 R12 NR4 C(O)-- or R11 C(O)NR4 --; the...	10/29/2002
6458812	Muscarinic antagonists Amide derivatives of 1,4 di-substituted piperidine compounds of the formula: ##STR1## or a pharmaceutically acceptable salt, ester or solvate thereof, wherein R1 is optionally substituted cycloalkyl, cycloalkylalkyl, aryl, arylalkyl or heteroar...	10/01/2002
6455527	High affinity ligands for nociceptin receptor ORL-1 Novel compounds of the formula ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: the dotted line represents an optional double bond; X1 is optionally substituted alkyl, cycloalkyl, aryl, heteroaryl or heterocycloalkyl; X	09/24/2002
6451797	Muscarinic antagonists Heterocyclic derivatives of di-N-substituted piperazine or 1,4 di-substituted piperidine compounds in accordance with formula I (including all isomers, salts and solvates) ##STR1## wherein wherein one of Y and Z is --N-- and the other is --N-- or --CH--; ...	09/17/2002
6444687	Substituted imidazole neuropeptide Y Y5 receptor antagonists Compounds of the formula I ##STR1## or a pharmaceutically acceptable salt, solvate or N-oxide thereof, wherein X is .dbd.CH-- or .dbd.N--; Y is H, halogen, trihaloalkyl, alkyl, alkenyl, cycloalkyl, cycloalkyl, SH, --S-alkyl, or --CN. R is alkyl, --CF3	09/03/2002
6436928	Selective neurokinin antagonists A compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein Ar1 and Ar2 are optionally substituted heteroaryl or optionally substituted phenyl; X1 is --O--, --SO0-2	08/20/2002

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Attorney: Magatti; Anita W.