MacMillan; Keith D. - US Patent Attorneys and Agents

Attorney: MacMillan; Keith D.

Number of patents: 45
Last date: May 22, 2012

Browse patents
Browse applications

Number	Title	Issue Date
8183252	Heterocyclic aspartyl protease inhibitors Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2	05/22/2012
8168641	Aspartyl protease inhibitors Disclosed are compounds of formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, U, W, X, R1, R2, R6, R7, R30 and R31	05/01/2012
8143405	Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzhei...	03/27/2012
8143246	1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives The invention relates to 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivative having the general Formula I wherein R1 is H, (C1-6)alkyl (optionally substituted with oxo, (C1-3)alkylo...	03/27/2012
8114887	Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease The present invention is directed to spiropiperidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved...	02/14/2012
8110682	Preparation and use of compounds as aspartyl protease inhibitors Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein A is a bond, —C(O)—, or —C(R3′	02/07/2012
8093254	Aspartyl protease inhibitors Disclosed are compounds of formula I (Chemical formula should be inserted here as it appears on abstract in paper form) Formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3...	01/10/2012
8012953	Macrocyclic beta-secretase inhibitors Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, n and X are as defined in the specification. Also disclosed are pha...	09/06/2011
8008315	Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceu...	08/30/2011
7989464	mGluR1 antagonists as therapeutic agents In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J4, X, and R1-R5 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as se...	08/02/2011
7973067	Heterocyclic aspartyl protease inhibitors Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2	07/05/2011
7968571	2,4,6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's Disease The present invention is directed to 2,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The in...	06/28/2011
7951949	Macrocyclic aminopyridyl beta-secretase inhibitors for the treatment of Alzheimer's disease The present invention is directed to macrocyclic aminopyridyl compounds represented by general formula (I), which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alz...	05/31/2011
7932275	2-aminopyridine compounds useful as β-secretase inhibitors for the treatment of alzheimer's disease The present invention is directed to 2-aminopyridine compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also direc...	04/26/2011
7910590	Cyclic amine bace-1 inhibitors having a heterocyclic substituent Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is	03/22/2011
7847100	1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The inv...	12/07/2010
7868000	Aspartyl protease inhibitors Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein j, k, U, W, R, R1, R2, R3, R4, R6,...	01/11/2011
7829597	Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzhei...	11/09/2010
7820674	Aminomethyl beta-secretase inhibitors for the treatment of alzheimer's disease The present invention is directed to aminomethyl compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed ...	10/26/2010
7816378	Cyclic ketal beta-secretase inhibitors for the treatment of alzheimer's disease The present invention is directed to cyclic ketal compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, s...	10/19/2010
7812013	Macrocyclic heterocyclic aspartyl protease inhibitors Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt, solvate or ester thereof, wherein U, W, X, L, Y, M, Z, c, d, e, f, g, h, s, t, R1, R2, R7...	10/12/2010
7803802	Substituted amide beta secretase inhibitors Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R4 and X are as defin...	09/28/2010
7767815	Fused tricyclic mGluR1 antagonists as therapeutic agents In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J3, X, Z, and R1-R4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as...	08/03/2010
7763609	Heterocyclic aspartyl protease inhibitors Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2	07/27/2010
7763606	Heterocyclic aspartyl protease inhibitors Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein Ar, R1, R2, R3, R4 and R5 are as d...	07/27/2010
7759354	Bicyclic guanidine derivatives as asparyl protease inhibitors, compositions, and uses thereof The present application provides compounds of the Formula: and stereoisomers, tautomers, or pharmaceutically acceptable salts and solvates thereof, wherein U, W, R, R1, R2, R3 and R4	07/20/2010
7759353	Substituted spiro iminopyrimidinones as aspartyl protease inhibitors, compositions, and methods of treatment Disclosed are certain substituted spiro iminopyrimidinones and other compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein U, W, A, R, R1, R2...	07/20/2010
7750158	Cannabinoid receptor ligands Compounds of Formula I: and/or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions containing such compounds exhibit anti-inflammatory and immunomodulatory activity, and can be ef...	07/06/2010
7718702	Cannabinoid receptor ligands There are disclosed compounds of the formula a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit anti-inflammatory and immunodulatory activity....	05/18/2010
7714021	Pyrrolidin-3-yl compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease The present invention is directed to pyrrolidin-3-yl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is...	05/11/2010
7700603	Heterocyclic aspartyl protease inhibitors Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2	04/20/2010
7700597	Substituted piperazines as CB1 antagonists Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinf...	04/20/2010
7687501	Pyridothienopyridazinone derivatives as mGluR1 antagonists In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J3, X, Z, and R1, R3, and R4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagoni...	03/30/2010
7662816	Cyclic amine BACE-1 inhibitors having a benzamide substituent Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is	02/16/2010
7652003	Macrocyclic β-secretase inhibitors Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, n and X are as defined in the sp...	01/26/2010
7645774	Cannabinoid receptor ligands There are disclosed compounds of the formula I: or a pharmaceutically acceptable salt of the compound, which exhibit anti-inflammatory and immunomodulatory activity. Also disclosed are pharmaceutical compositions containing...	01/12/2010
7642272	Cannabinoid receptor ligands There are disclosed compounds of the formula I a pharmaceutically acceptable salt or solvate of the compound, which exhibit anti-inflammatory and immunomodulatory activity. Also disclosed are pharmaceutical compositions con...	01/05/2010
7608643	Compounds for inhibiting KSP kinesin activity The present invention relates to compounds of Formula I or pharmaceutically acceptable salts or solvates thereof: The present invention provides compositions comprising these compounds that are useful for treating cellular ...	10/27/2009
7598259	mGluR1 antagonists as therapeutic agents In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J4, X, and R1-R5 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as se...	10/06/2009
7598250	Cyclic amine BACE-1 inhibitors having a heterocyclic substituent Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is	10/06/2009

«First «Previous1 2 Next»Last»

PatentStorm

Bizarre Patents

PatentStorm News

Attorney: MacMillan; Keith D.