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| Number | Title | Issue Date |
| 8182532 | Composite bone graft, method of making and using same The invention is directed to a composite bone graft for implantation in a patient, and methods of making and using the composite bone graft, along with methods for treating patients by implanting the composite bone graft at a site in a patient. The composite bone gr... | 05/22/2012 |
| 8173089 | Method for the separation of sour gas Method for separating a gaseous mixture that comprises as main ingredients H2S and CO2, wherein the gaseous mixture is contacted in a first device with a solvent comprising a weak Lewis-acid, wherein H2S is absorbed in the solvent an... | 05/08/2012 |
| 8172785 | Bone-regeneration material The invention relates to a process for producing a bone-regeneration material. According to the method, a bio-compatible, open-pored body is exposed to a vacuum and osteoinductive and/or osteogenic substances are absorbed into the pores of the body, for example by m... | 05/08/2012 |
| 8168445 | Use of metal complexes A method of immobilizing a target molecule on a substrate, which comprises exposing the target molecule to the substrate in the presence of a metal complex, wherein the target molecule is an unmodified target molecule, and wherein the metal complex is selected to pr... | 05/01/2012 |
| 8161869 | Device and method for cleaning a french or coffee press A press cleaning device and method are described for removing coffee grinds from a French or coffee press. The device includes a stem having a handle and a circular disk-shaped declining plane ramp disposed at different ends. The circumference of the ramp is substan... | 04/24/2012 |
| 8158391 | Production of an α-carboxyl-ω-hydroxy fatty acid using a genetically modified strain A substantially pure Candida host cell for the production of a α-carboxyl-ω-hydroxy fatty acid having a carbon chain length in the range from C6 to C22, a α,ω-dicarboxylic fatty acid having a carbon chain length in the range from C6 to C22, or mixtures th... | 04/17/2012 |
| 8153835 | Fullerene derivatives The present invention provides a fullerene derivative represented by the following formula (1): wherein in formula (1), R1 is a substituted or unsubstituted organic group or a hydrogen atom, and wherein in formulae (2) and (3): W is a single bond, ... | 04/10/2012 |
| 8148083 | Methods of screening for TRPM4 modulators of insulin secretion The invention relates to methods useful in identifying candidate agents that modulate insulin secretion from an insulin secreting cell, where such molecules modulate TRPM4 activity and expression in the insulin secreting cell. ... | 04/03/2012 |
| 8143263 | Therapeutic agents A compound of Formula (I): is useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK or GK), leading to a decreased glucose threshold for insulin secretion. ... | 03/27/2012 |
| 8139092 | Thermal transfer dyesheet and printer A thermal transfer dyesheet comprising a substrate bearing a region of a thermally transferable dye, the region including a first printable portion within the region having a first optical density, a second printable portion within the region having a second optical... | 03/20/2012 |
| 8138172 | 8-oxoadenine derivatives acting as modulators of TLR7 The present invention provides 8-oxoadenine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The 8-oxoadenine derivatives act as modulators of Toll-like Receptor (TLR) 7 and thus may be used in the t... | 03/20/2012 |
| 8137512 | Process for analyzing sample by capillary electrophoresis method A process for analyzing a sample by a capillary electrophoresis method is provided that allows the apparatus to be reduced in size, allows a high analytical precision to be obtained, and can be carried out easily. The analytical process of the present invention is a... | 03/20/2012 |
| 8129380 | Phthalazinone derivatives A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; X and Y are selected from CH and CH, CF and CH, CH and CF and N and CH respectively; RC | 03/06/2012 |
| 8124731 | Optimized Fc variants and methods for their generation The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 02/28/2012 |
| 8114427 | Biologically active implants This invention relates to an implant for treating pathological changes in the spinal column and/or locomotor system. According to one embodiment of the invention, the implant has a surface, a body, and an enamel-like or varnish-like coating that is up to 100 μm thi... | 02/14/2012 |
| 8112335 | Systems and methods for processing pricing data Processing pricing data can be provided by receiving first data associating a first price source, a first market condition, and an instrument; receiving second data from at least one of a plurality of price sources, the second data comprising a first price quote for... | 02/07/2012 |
| 8110566 | Therapeutic agents 713 Disclosed herein are compounds of formula I in which R1, R2, R3, R4, R5, A, X, Y are as described in the specification, their use in pharmaceutical compositions and in ... | 02/07/2012 |
| 8109004 | Constant force mechanical scribers and methods for using same in semiconductor processing applications A scribing system comprising a mounting mechanism, stylus, and force generating mechanism is provided. The mounting mechanism is configured to rotate an elongated object in such a manner that the object is subjected to a bow effect wherein a middle portion of the ob... | 02/07/2012 |
| 8106032 | Lipid analogs for combating tumors The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the ... | 01/31/2012 |
| 8101720 | Immunoglobulin insertions, deletions and substitutions An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more FcγRs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide. ... | 01/24/2012 |
| 8097623 | Indoles useful in the treatment of inflammation There is provided compounds of formula (I), wherein X1, Q, T, Y, R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts t... | 01/17/2012 |
| 8095441 | Method and system for administering money laundering prevention program A money laundering prevention program administered by a financial institution. A plurality of risk factors associated with a potential for conducting illicit activities in connection with an account held at the financial institution are identified. The risk factors ... | 01/10/2012 |
| 8093359 | Optimized Fc variants and methods for their generation The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 01/10/2012 |
| 8093252 | Crystalline polymorphic form of glucokinase activator A new polymorphic form of 3-{[5-(azetidin-1-ylcarbonyl)pyrazin-2-yl]oxy}-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide, processes for making it and its use as an activator of glucokinase are described. ... | 01/10/2012 |
| 8090638 | Systems and methods for extendable swap A system and method for providing an extendable swap is provided. In a preferred embodiment, two parties enter into an ISDA Master Agreement and then negotiate one or more OTC derivative transaction agreements, including interest rate swaps, cross-currency swaps, co... | 01/03/2012 |
| 8088968 | Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located ... | 01/03/2012 |
| 8088206 | Inkjet printing using solvent-based ink compositions There is provided a transparent, single-phase, radiation-curable ink composition for inkjet printing white, opaque features on porous and non-porous substrates, which are excellent in color reproducibility, hiding power, and adhesiveness to the substrate, for partic... | 01/03/2012 |
| 8087696 | Vehicle occupant restraint and method A component of a vehicle occupant restraint system, the vehicle occupant restraint system having a webbing with a lap belt portion and a shoulder belt portion contiguous with the lap belt portion, the component including a web engaging device adapted to toggle betwe... | 01/03/2012 |
| 8084478 | Substituted 5- phenylamino- 1, 3, 4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme A diacylglycerol acyltransferase Compounds of formula (I), or salts thereof, which inhibit acetyl CoA (acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided, wherein R1, R2 and R3 are each independ... | 12/27/2011 |
| 8083051 | Bulk material pump feeder with reduced disk jamming A bulk materials pump feeder having a housing and a rotating drive rotor for transferring material from an inlet to an outlet of the housing. The drive rotor has a hub. Drive disks extend away from the hub toward a housing inner wall. Three structural features of th... | 12/27/2011 |
| 8076481 | Chemical process 632 A process for preparing pharmaceutically active compounds of formula (I) or a salt thereof wherein R1, n, m, R3, R6, X1, X2, X3 and X4 are as defi... | 12/13/2011 |
| 8074561 | Device and method for cleaning a french or coffee press A press cleaning device and method are described for removing coffee grinds from a French or coffee press. The device includes a stem having a handle and a circular disk-shaped declining plane ramp disposed at different ends. The circumference of the ramp is substan... | 12/13/2011 |
| RE43024 | Fork lift apparatus adapted to be coupled to a truck or trailer A fork lift with retractably extendable loading prongs for lifting loads from either side of a vehicle. The fork lift includes a mechanism for displacing the prongs over and across the vehicle, which mechanism has front and rear transverse girders which can be rigid... | 12/13/2011 |
| 8071665 | Inkjet printing A single phase aqueous composition suitable for thermal inkjet printing comprises a mixture of curable materials including at least two curable oligomers; and one or more co-solvents for the curable materials. ... | 12/06/2011 |
| 8071585 | Therapeutic agents A compound (2S)-2-[1-(2,6-dichlorophenyl)pyrazolo[4,5-e]pyrimidin-4-yl]oxy-3-(3-hydroxyazetidin-1-yl)-N-(5-methylpyrazin-2-yl)propanamide is useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK or GK), leading to ... | 12/06/2011 |
| 8071375 | Use of IL-6-type cytokines for maturation of oocytes The use of certain IL-6-type cytokines for the in vitro maturation of mammalian oocytes is described. The in vitro matured oocytes may be used in in vitro fertilization protocols. ... | 12/06/2011 |
| 8066968 | X-ray-induced dissociation of HO and formation of an O-Halloy at high pressure A novel molecular alloy of O2 and H2 and a method of producing such a molecular alloy are provided. When subjected to high pressure and extensive x-radiation, H2O molecules cleaved, forming O—O and H—H bonds. In the method of the... | 11/29/2011 |
| 8063213 | Production of rosuvastatin calcium salt An improved process for the manufacture of (E)-7-[4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfony)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium salt, Formula (1), which is useful for the production of a pharmaceutical useful in the treatm... | 11/22/2011 |
| 8063052 | Wound healing The present invention relates to the use of p38 MAP kinase inhibitors and p38 MAP kinase inhibition to promote wound healing. ... | 11/22/2011 |
| 8060189 | System and method for detection of hematoma A system and method for determining brain hematoma including a handheld device for emitting and detecting radiation with a removable light guide assembly. A method for determining a brain hematoma condition that includes determining optical density of various region... | 11/15/2011 |
