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| Number | Title | Issue Date |
| 4870084 | Bicyclic benzo fused pyran compounds used for nausea treatment and prevention Bicyclic fused benzenoid compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH2 or NR6 ; R6 is hydrogen, formyl, carbobenzyloxy or certain carboal... | 09/26/1989 |
| 4870170 | Process for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics Process and intermediates for the conversion of 3R,4R-4-acetoxy-3-[1R-1-(silyloxy)ethyl]-2-acetidinones to antibacterial 5R,6S-6-(1R-1-hydroxyethyl)-2-(1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids, and the pharmaceutically-acceptable salts and pivalo... | 09/26/1989 |
| 4868296 | 6-(1-carbamoyl-1-hydroxymethyl) penicillanic acid derivatives 6-(1-Carbamoyl-1-hydroxymethyl)penicillanic acid derivatives are useful as antibacterials and/or beta-lactamase inhibitors.... | 09/19/1989 |
| 4868297 | Process for preparing sultamicillin and analogs 6-Halo- and 6,6-dihalo-1,1-dioxopenicillanoyloxymethyl 6-[D-2-(2-alkoxycarbonyl-1-methylvinylamino- and 1-methyl-3-oxo-1-butenylamino)-2-phenylacetamido]penicillanates and analogs; process for their conversion to sultamicillin and analogs; and proces... | 09/19/1989 |
| 4864046 | Process for optically active 3-thiolanyl sulfonate esters Intermediates and a stepwise process for the conversion of ethyl 4-chloro-3R-hydroxybutyrate to optically active compounds of the formula ##STR1## wherein R is (C1 -C3)alkyl, phenyl or tolyl. The later compounds are in turn usef... | 09/05/1989 |
| 4863934 | Bicyclic benzo fused pyran compounds used for producing analgesia Bicyclic fused benzenoid compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH2 or NR6 ; R6 is hydrogen, formyl, carbobenzyloxy or certain carboal... | 09/05/1989 |
| 4861596 | Rolled matrix device having enhanced ability to unroll and method for its production A method for enhancing the unrolling of a rolled active agent-containing laminate device in an aqueous use environment which comprises coating one side of the device with an elastomer prior to constraining it in a rolled configuration; and the devices so ... | 08/29/1989 |
| 4861880 | 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents Certain substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones are highly potent gabaergic agents, valuable in the treatment of individuals suffering from schizophrenia or reversing the side effects of a previously or concurrently administered neurol... | 08/29/1989 |
| 4861891 | Antidepressant N-substituted nicotinamide compounds Certain N-substituted nicotinamide compounds having formula (I) below ##STR1## and pharmaceutically acceptable acid addition salts thereof wherein R1 is 1-piperidyl, 1-(3-indolyl)ethyl, C1-4 alkyl, phenyl, 1-(1-phenylethyl), ben... | 08/29/1989 |
| 4861794 | 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis This invention relates to the use of certain 3-substituted-2-oxindole-1-carboxamides of the formula ##STR1## and the pharmaceutically-acceptable base salts thereof wherein X is H, Cl or F; Y is H or Cl; and R is benzyl or thienyl to inhibit interleuk... | 08/29/1989 |
| 4859686 | Dihydropyridine anti-allergic and anti-inflammatory agents 4-Aryl-3-alkoxycarbonyl-6-methyl-5-carbamyl-2-triazolylalkoxymethyl-1,4-dih yd ropyridines as anti-allergic and anti-inflammatory agents.... | 08/22/1989 |
| 4859679 | Antiulcer (alkyldithio) quinoline derivatives Quaternary 8-(alkyldithio)-1-(2-pyrimidyl)-quinolinium salts, inhibitors of the H30 /K+ ATPase enzyme, are useful in the treatment of ulcers.... | 08/22/1989 |
| 4859654 | Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents Polypeptides and derivatives thereof containing homocyclostatine and cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.... | 08/22/1989 |
| 4857641 | C.12 modified erythromycin A derivatives Antibacterial 12,12'-anhydro-9R-hydroxy-9-deoxoerythromycin A derivatives, intermediate therefor and process of 12,12'-dehydration.... | 08/15/1989 |
| 4855303 | Fluorine containing renin inhibitors Polypeptides containing fluorinated cyclostatine derivatives as antihypertensive agents.... | 08/08/1989 |
| 4853410 | Hydroxyacetic acid derivatives for the treatment of diabetic complications Racemic and chiral (2R,4R)-4-c-hydroxy-2-4-(substituted)chroman(and thiochroman)-4-acetic acids and their pharmaceutically acceptable salts, their use in the treatment of diabetic complications and intermediates therefor.... | 08/01/1989 |
| 4853409 | 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function This invention relates to the use of certain 3-substituted-2-oxindole-1-carboxamides of the formula ##STR1## and the pharmaceutically-acceptable base salts thereof wherein X is H, Cl or F; Y is H or Cl; and R is benzyl or thienyl to suppress T-cell f... | 08/01/1989 |
| 4853392 | Fused 1,4-dihydropyridines as antiallergy and antiinflammatory agents Compounds of the formula ##STR1## where R1 is lower alkyl, R2 is chlorophenyl, Y is alkylene, X is heterocyclic and Z is a fused ring are useful as antiinflammatory and antiallergy agents.... | 08/01/1989 |
| 4851548 | Superior catalysts for preparation of 3-amino-2,2,4,4-tetramethylthietane via the Leuckart reaction Boric acid or aluminum salts, especially aluminum chloride, aluminum sulfate and aluminum nitrate and hydrates of said salts, are superior catalysts for preparation of 3-amino-2,2,4,4-tetramethylthietane via the Leuckart reaction.... | 07/25/1989 |
| 4851412 | Dihydropyridine antiallergic and antiinflammatory agents Compounds of the formula: ##STR1## where R is substituted phenyl, R1 is alkyl or pyridyl, R2 is hydrogen, R3 is alkoxy, alkylamino, hydroxy or benzyloxy, Y is alkylene and X is heterocyclic as antiallergic and antiinf... | 07/25/1989 |
| 4849518 | Quinazolin-4(3H)-one derivatives as anticoccidial agents Variously substituted trans-3-[3-(3-hydroxypiperid-2-yl)-2-oxopropyl]quinazoline-4(3H)-ones, a method of controlling or preventing coccidiosis in poultry therewith, intermediates therefor, and a process for the preparation of certain intermediates th... | 07/18/1989 |
| 4847245 | N-demethylefrotomycin N-Demethylefrotomycin, a valuable new antibiotic substance, is produced by the microbial conversion of mocimycin using a novel, efrotomycin-producing, microbial species ATCC 53758.... | 07/11/1989 |
| 4841078 | Benzopyrans Bicyclic fused benzenoid compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH2 or NR6 ; R6 is hydrogen, formyl, carbobenzyloxy or certain carboal... | 06/20/1989 |
| 4837334 | Precursors to quinolone inotropic agents A series of novel heterocyclic-substituted 2-(1H)-quinolone compounds have been prepared, including the 3,4-dihydro derivatives thereof, wherein the heterocyclic ring moiety is a pyrrolyl, imidazolyl, pyrazolyl, triazolyl or tetrazolyl group attached by a... | 06/06/1989 |
| 4835166 | Antiallergy and antiinflammatory agents Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R2 is hydrogen, al... | 05/30/1989 |
| 4835141 | Neutral macrolide antibiotics from Streptomyces An antibiotic complex, containing three major components, has been isolated from fermentations of a new strain of the microorganism Streptomyces hirsutus. The major components are new, neutral, macrolide antibiotic compounds, which are useful as antibacte... | 05/30/1989 |
| 4826833 | 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof Beta-lactamase inhibiting compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition or carboxylate salt thereof; where n is zero, 1 or 2; X3 is H or Br, R1 is H, the residue of certain carboxy-protecting g... | 05/02/1989 |
| 4814342 | Nor-statine and nor-cyclostatine polypeptides Polypeptides and derivatives thereof containing nor-statine and nor-cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.... | 03/21/1989 |
| 4812455 | Antiinflammatory compositions and methods An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesic acetaminophen, antidepressant doxepin, bronchodilator pir... | 03/14/1989 |
| 4812471 | Hypoglycemic 5-(isoxazolyl or isothiazolyl)-oxazolidine-2,4-diones Hypoglycemic 5-chromanyl, 2,3-dihydro-5-benzo[b]-furanyl, 5-pyridyl, 5-quinolyl, 5-pyrrolyl, 5-indolyl, 5-thiazolyl, 5-oxazolyl, 5-isothiazolyl and 5-isoxazolyl oxazolidine-2.4-diones and the pharmacetically-acceptable salts thereof; certain 3-acylated de... | 03/14/1989 |
| 4808601 | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds Certain novel 2-oxindole compounds, having an acyl substituent at both the 1-position and the 3-position, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic agents and antiinflammatory agents in mammalian ... | 02/28/1989 |
| 4808597 | Method for inhibiting the degradation of cartilage Certain carboxylic acids of the formula ##STR1## and the pharmaceutically-acceptable salts thereof, and certain esters and amides thereof, are useful for inhibiting the degradation of articular cartilage when administered to a mammalian subject affli... | 02/28/1989 |
| 4808591 | Antiulcer 8-(2-pyrimidylsulfinyl)quinolines 8-(2-Pyrimidylsulfinyl)quinolines, inhibitors of the H+ /K30 ATPase enzyme, are useful in the treatment of ulcers.... | 02/28/1989 |
| 4806557 | Dihydropyridines and use thereof in treating hypertension and ischaemia A compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R1 is amino, hydroxy, alkoxy, phenoxy or benzyloxy, useful in the treatment of hypertension, angina, renal impairment or acute renal failure.... | 02/21/1989 |
| 4804680 | Polycyclic ether antibiotic A new acidic polycyclic antibiotic UK-61,689 has the formula: ##STR1## or a pharmaceutically acceptable cationic salt thereof. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling cocci... | 02/14/1989 |
| 4803076 | Controlled release device for an active substance A device for the controlled release of a substance having useful activity into a fluid medium at a substantially constant rate, said substance contained in a shape which is substantially that of a truncated cone by means of an impermeable wall or coating ... | 02/07/1989 |
| 4801598 | Dihydropyridine anti-allergic and anti-inflammatory agents Compounds of the formula: ##STR1## where R is 2-substituted phenyl said substituent being chloro, bromo, cyano, methyl, methylthio, methylsulfonyl, trifluoromethyl, hydroxy, methoxy or benzyloxy; R1 is hydrogen, lower alkyl, pyridyl, ... | 01/31/1989 |
| 4798835 | dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)m ethyl]thiazolidine-2,4-dione as an anti-atherosclerosis agent This invention relates of the use of a certain thiazolidine-2,4-dione, namely, dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)methyl]thiazolidine-2,4-dio ne, or a pharmaceutically acceptable cationic salt thereof, for retarding the development of arte... | 01/17/1989 |
| 4797394 | 6-(1-carbamoyl-1-hydroxymethyl)penicillanic acid derivatives 6-(1-Carbamoyl-1-hydroxymethyl)penicillanic acid derivatives are useful as antibacterials and/or beta-lactamase inhibitors.... | 01/10/1989 |
| 4797486 | Heterocyclic ring fused pyrimidine-4(3H)-ones as anticoccidial agents Certain trans-3-[3-(3-hydroxy-2-piperidyl)-2-oxopropyl]thieno[3,2-d]pyrimidin-4(3H )-one and furo[3,2-d]pyrimidin-4(3H)-one derivatives, a method of using same as anticoccidial agents, intermediates therefor, and a process for certain intermediates th... | 01/10/1989 |
