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| Number | Title | Issue Date |
| 7972625 | Coated diclofenac tablets The invention relates to coated tablets comprising the pharmaceutically active substance diclofenac. Said tablets further comprise a single film coating. ... | 07/05/2011 |
| 7297789 | Process of preparation of olanzapine form I A process for the preparation of polymorph Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine, or olanzapine. ... | 11/20/2007 |
| 7071191 | Non-imidazole aryloxypiperidines Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions. ... | 07/04/2006 |
| 7049324 | Triazoles as farnesyl transferase inhibitors a prodrug, N-oxide, addition salt, quaternary amine or stereochemically isomeric form thereof, wherein L1 and L2 are R1—Y— wherein each (R1—Y)— substituent is defined... | 05/23/2006 |
| 6987110 | Substituted pyrrolines as kinase inhibitors The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. ... | 01/17/2006 |
| 6960597 | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists The invention is directed to aza-bridged-bicyclic compounds having Formula (I): and pharmaceutically acceptable salts thereof. The compounds are useful (α4 integrin receptor antagonists and, in particular, α4β1 and ... | 11/01/2005 |
| 6951857 | 6-Azauracil derivatives as IL-5 inhibitors The present invention is concerned with the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p represents 0, 1, 2 or 3; q... | 10/04/2005 |
| 6943149 | Benzimidazolone peptidomimetics as thrombin receptor antagonists The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke,... | 09/13/2005 |
| 6936604 | Bridged bicyclic amino acid-derived [1,4]benzodiazepine vasopressin receptor antagonists The invention is directed to bridged bicyclic amino acid-derived [1,4]benzodiazepine compounds, intermediates and pharmaceutical compositions thereof useful as vasopressin receptor antagonists and methods for treating vasopressin mediated disorders. ... | 08/30/2005 |
| 6911444 | Non-steroidal IL-5 inhibitors, processes and intermediates for their preparation and pharmaceutical compositions comprising said inhibitors The present invention relates to IL-5 inhibiting 6-azauracil derivatives useful for treating eosinophil-dependent inflammatory diseases, to processes and intermediates for their preparation as well as to pharmaceutical compositions comprising the said derivatives. I... | 06/28/2005 |
| 6894046 | IL-5 inhibiting 6-azauracil derivatives The present invention is concerned with the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 4; X is O, S, NR5 | 05/17/2005 |
| 6894162 | Intermediates in cephalosporin production Cefuroxime in the form of a salt with n-butylamine; and its use for the production of cefuroxime axetil or for the production of the sodium salt of cefuroxime. ... | 05/17/2005 |
| 6867207 | IL-5 inhibiting 6-azauracil derivatives The present invention is concerned with the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, p and q are 0, 1, 2, 3 or 4 and q is also 5... | 03/15/2005 |
| 6849643 | Indazolyl-substituted pyrroline compounds as kinase inhibitors The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliora... | 02/01/2005 |
| 6844459 | Pharmaceutical Composition Pharmaceutical compositions comprising a cyclosporin in a novel galenic formulations for oral administration. The compositions typically comprise a cyclosporin, 1,2-propylene glycol, a mixed mono-, di- and tri-glyceride and a hydrophilic surfactant. Further a refine... | 01/18/2005 |
| 6838467 | Dosing regimen This invention relates to a method of treatment and dosing regimen for treating mammalian tumors by the discontinuous administration of a farnesyl transferase inhibitor over an abbreviated one to five day dosing schedule. ... | 01/04/2005 |
| 6803364 | Il-5 inhibiting 6-azauracil derivatives The present invention is concerned with the compounds of formula (I), a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein p is 0 to 4; q is 0 to 5; X is O, S, NR3 or a direct bond... | 10/12/2004 |
| 6740753 | Olanzapine crystal modification A novel crystal form the pharmaceutical compound olanzapine, processes for its preparation and its pharmaceutical use are disclosed. ... | 05/25/2004 |
| 6723831 | Neoglycoproteins Polyamide conjugates comprising either (a) a xenoantigenic group; or (b) a biologically active group and a macromolecular, macro- or microscopic entity; bound to a polyamide backbone, processes for their preparation and the use of these conjugates in therapeutic com... | 04/20/2004 |
| 6723339 | Oil-free pharmaceutical compositions containing cyclosporin A The present invention provides a hard gelatine capsule containing a pharmaceutical composition comprising cyclosporin A in a mixture with a surfactant of HLB value at least 10, substantially free of any oil and when a hydrophilic phase is present, the hydrophilic ph... | 04/20/2004 |
| 6713305 | Metastasis-associated antigen and antibodies thereto There are provided membrane-associated polypeptides having the sequence shown in SEQ ID Nos. 1 and 9. Also provided are immunogenic determinants derived from said polypeptides and antibodies raised thereto. The polypeptides, their derived antigenic determinants and ... | 03/30/2004 |
| 6623753 | Allylamine-containing liposomes The invention concerns liposomal preparations comprising as the active agent a compound of formula I ##STR1## in free base form or in acid addition salt form. It also concerns a method of preparation of such liposomal preparations by encapsulating a compo... | 09/23/2003 |
| 6620325 | Purification process for cyclosporin This invention provides a process for purifying a cyclosporin, e.g. cyclosporin A, or a macrolide, to a high degree of purity on a large scale. In another aspect this invention provides a bulk quantity of cyclosporin A with an impurity level of less than ... | 09/16/2003 |
| 6586598 | , -dibromo--chloro-acetophenones as synthons This disclosure relates to the use of ,-dibromo--chloroacetophenone compounds as intermediates for the preparation of aromatic carbonyl compounds, especially aromatic amides. The compound 2,5-bis(2,2,2-trifluoroethoxy)-,&#... | 07/01/2003 |
| 6582718 | Cyclosporin compositions An ophthalmic composition particularly in the form of eye-drops suitable for the treatment of diseases of the eye and surrounding areas. The composition contains a cyclosporin and a surfactant selected from polyoxyethylene fatty acid esters, polyoxyethyle... | 06/24/2003 |
| 6565859 | Galenical formulations A pharmaceutical composition containing macrolide, e.g. a rapamycin compound in an emulsion preconcentrate or microemulsion preconcentrate for oral administration. The carrier medium for the rapamycin compound includes a hydrophilic phase, a lipophilic ph... | 05/20/2003 |
| 6531465 | Antibacterial cephalosporins A compound of formula ##STR1## wherein Ac, R1 and R2 have various meanings, a process for a preparation thereof and its use as a pharmaceutical, i.e. as antibacterial agent.... | 03/11/2003 |
| 6486124 | Cyclosporin compositions and process therefor The invention relates to formulations of cyclosporin with high bioavailability for oral administration, which contain about 1 part by weight of one or more cyclosporin(s), preferably cyclosporin A and/or cyclosporin G, 7.5 to 7.8 parts by weight of one or... | 11/26/2002 |
| 6455518 | Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-O-(2-hydroxyethyl)-rapamycin A synergistic combination of an IL-2 transcription inhibitor (e.g., cyclosporin A or FK506) and 40-O-(2-hydroxyethyl)-rapamycin is provided, which is useful in the treatment and prevention of transplant rejection and also certain autoimmune and inflammato... | 09/24/2002 |
| 6447806 | Pharmaceutical compositions comprised of stabilized peptide particles Particles of a substantially water insoluble biologically active substance, such as Cyclosporin, are loaded with a charged glyceryl ester as an electrostatic stabilizer which imparts to the particles a zeta potential and having an active substance:stabili... | 09/10/2002 |
| 6420355 | Pharmaceutical compositions containing cyclosporins A pharmaceutical composition in the form of an emulsion preconcentrate for oral administration and containing a cyclosporin. The pharmaceutical composition has a carrier medium for the cyclosporin that contains a hydrophilic organic solvent; a mixed mono-... | 07/16/2002 |
| 6365619 | Treatment of arteriosclerosis A method is disclosed of treating transplant-associated arteriosclerosis in a mammal which comprises administering to a mammal, preferably man, in need of such treatment an effective amount of a VLA-4 antagonist of formula I and a VCAM-1 inhibitor of form... | 04/02/2002 |
| 6365750 | Methods for the preparation of taxanes using oxazolidine intermediates Novel oxazolidines finding utility as intermediates in the preparation of C-13 acyloxy sidechain-bearing taxanes such as paclitaxel and analogs thereof. The present invention also relates to novel methods of coupling the oxazolidines to form the aforement... | 04/02/2002 |
| 6353120 | Process for the preparation of a paclitaxel C-4 methyl carbonate analog A process for the synthesis of a C-4 methyl carbonate paclitaxel analog from 10-deacetylbaccatin III by the selective reduction of the acetate at the C-4 position of 10-deacetylbaccatin using Red-Al.... | 03/05/2002 |
| 6348337 | Process for the preparation of C-4 deacetyltaxanes A process useful for the preparation of intermediates in synthesis or semi-synthesis of paclitaxel analogs wherein a starting taxane such as 10-deacetylbaccatin III is deacetylated at the C-4 position using a microorganism or an enzyme derived therefrom t... | 02/19/2002 |
| 6262127 | Polymeric matrices and their uses in pharmaceutical compositions This invention provides pharmaceutical compositions comprising polymeric matrices, especially those comprising IL-6 as an active ingredient. Specific novel poly(ethylene carbomate) polymers are also provided for more general use as matrix materials in sus... | 07/17/2001 |
| 6255100 | Cyclosporin fermentation process It has been found that nonimmunosuppressive, cyclophilin-binding cyclosporins are useful in the treatment and prevention of AIDS and AIDS-related disorders. Such cyclosporins include novel Ciclosporin derivatives modified at the 4- and/or 5-positions.... | 07/03/2001 |
| 6215000 | Crystalline complexes of baccatin III with imidazole, 2-methylimidazole or isopropanol Disclosed are crystalline complexes of baccatin III with imidazole, 2-methylimidazole or isopropanol, which are useful for isolating baccatin III from plant tissue cell culture and plant extracts containing baccatin Ill.... | 04/10/2001 |
| 6207831 | Fluorescent dyes (AIDA) for solid phase and solution phase screening The invention relates to new fluorescent dyes of formula (I) ##STR1## which can be used in high throughput screening both, on the solid phase as well as in homogeneous solution.... | 03/27/2001 |
| 6204244 | Amino acid compositions and use thereof in immunosuppression The present invention provides for the use glycine in the preparation of a medicament or nutritional formulation for the prophylaxis and/or therapy of renal dysfunction induced by cyclosporins or ascomycins.... | 03/20/2001 |
