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"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 6455592 | Use of hydrophilic penetration agents in dermatological compositions for the treatment of onychomycoses, and corresponding compositions The hydrophilic penetration agents customarily used for the transcutaneous penetration of active ingredients are, surprisingly, found to improve the penetration of antifungal agents through the nails. A corresponding dermatological composition contains at... | 09/24/2002 |
| 6423722 | Crystalline macrolides and process for their preparation 33-Epichloro-33-desoxyascomycin of formula I ##STR1## and various tautomeric or forms thereof, in crystalline form, such as Form A and Form B. Their preparation involves appropriately converting amorphous compound of formula I, or compound of formula I in... | 07/23/2002 |
| 6410547 | Phenylpyridine derivatives useful as phosphodiesterase inhibitors (4-oxy-3-(aryl)phenyl)pyridine compounds, in free or acid addition salt form, are useful as pharmaceuticals for treatment and prophylaxis of inflammation, particularly inflammatory or obstructive diseases of the airways, e.g. for asthma therapy. Preferred... | 06/25/2002 |
| 6410580 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases Compounds of formula (I) wherein W is --OH or --NHOH; X is an optionally substituted heterocycle, NR1 SO2 R2, heterocyclylalkythio, CONR2 R3 or NR1 COR2 ; Y, Z, R1 -R3... | 06/25/2002 |
| 6384042 | Systemic use of 5-HT3 receptor antagonists against rheumatic inflammatory processes The present invention relates to a new use for compounds having 5-HT3 (serotonin M) receptor antagonist activity, especially tropisetron, for the manufacture of a pharmaceutical composition for the systemic treatment of an inflammatory rheumati... | 05/07/2002 |
| 6380259 | Use of substituted amidino compounds in the treatment of chronic obstructive pulmonary disease Use in medicaments for the treatment of chronic obstructive pulmonary disease of compounds of formula ##STR1## wherein the C(.dbd.NH)--NHR3 group may be in tautomeric or isomeric form, or a pharmaceutically acceptable salt thereof, in which: R | 04/30/2002 |
| 6352998 | Pharmaceutical compositions This invention provides a topical composition, in the form of an emulsion, that comprises a compound of the FK506 class; a physiologically acceptable alkanediol, ether diol or diether alcohol containing up to 8 carbon atoms as solvent for the compound of ... | 03/05/2002 |
| 6346626 | Chromanone and thiochromanone compounds The invention concerns the compounds of formula I ##STR1## wherein R1 and R2 independently are hydrogen, acyl, alkoxycarbonyl or alkyl; either the sulfamoyloxy side chain is bound to the 6 position; R3 is alkyl; alkenyl; alkiny... | 02/12/2002 |
| 6319917 | Acylaminoalkenylene-amide derivatives as NK1 and NK2 antagonists Compounds of formula I ##STR1## wherein R1, R1 -R3, R4 ', R4 " and R5 are as defined in the description, have valuable pharmaceutical properties and are effective especially as NK1 and NK2 ... | 11/20/2001 |
| 6319509 | Pharmaceutical composition The invention concerns topical formulations such as nail varnishes comprising as the active agent the compound of formula I ##STR1## in free base form or in acid addition salt form, together with a polymeric film former and further excipients as appropria... | 11/20/2001 |
| 6288092 | Triaryl compounds (4-oxy-3-(aryl)phenyl)pyridine compounds, in free or acid addition salt form, are useful as pharmaceuticals for treatment and prophylaxis of inflammation, particularly inflammatory or obstructive diseases of the airways, e.g. for asthma therapy. Preferred... | 09/11/2001 |
| 6258843 | 4-oxy-3-(aryl)phenyl-arylcarbonyloxy compounds useful as phosphodiesterase inhibitors (4-oxy-3-(aryl)phenyl)pyridine compounds, in free or acid addition salt form, are useful as pharmaceuticals for treatment and prophylaxis of inflammation, particularly inflammatory or obstructive diseases of the airways, e.g. for asthma therapy. Preferred... | 07/10/2001 |
| 6214360 | Pharmaceutical composition The invention concerns topical formulations such as nail varnishes comprising as the active agent the compound of formula I ##STR1## in free base form or in acid addition salt form, together with a polymeric film former and further excipients as appropria... | 04/10/2001 |
| 6143793 | Use of hydrophilic penetration agents in dermatological compositions for the treatment of onychomycoses, and corresponding compositions The hydrophilic penetration agents customarily used for the transcutaneous penetration of active ingredients are, surprisingly, found to improve the penetration of antifungal agents through the nails. A corresponding dermatological composition contains at... | 11/07/2000 |
| 6136821 | Naphthyridine derivatives Novel 8-aryl-1,7-naphthyridines, in free or salt form, are PDE IV inhibitors and are thus useful as pharmaceuticals, e.g. for asthma therapy. Preferred compounds include compounds of formulae (I and II) wherein the R groups are as defined. Pharmaceutical ... | 10/24/2000 |
| 6124453 | Macrolides A novel class of macrolides in which i) positions 2 to 6 inclusive of the macrocyclic ring are provided by a piperidazinyl carboxylic acid residue; and/or ii) positions 7 to 9 inclusive of the macrocyclic ring are provided by an aromatic -amino acid res... | 09/26/2000 |
| 6107293 | Tachykinin antagonists Compounds of formula (I) wherein X is --CH2 --, --CO-- or direct linkage, Y is --O--, --S-- or --NH--, R1 is phenyl, R2 .dbd.H or phenyl and R3 is H or --CH3 -- and their pharmaceutically acceptable s... | 08/22/2000 |
| 6090817 | Phenylpyridine derivatives useful as phosphodiesterase inhibitors (4-oxy-3-(aryl)phenyl)pyridine compounds, in free or acid addition salt form, are useful as pharmaceuticals for treatment and prophylaxis of inflammation, particularly inflammatory or obstructive diseases of the airways, e.g. for asthma therapy. Preferred... | 07/18/2000 |
| 6051577 | N-7-heterocyclyl pyrrolo[2,3-D]pyrimidines and the use thereof There are described pyrrolo[2,3]pyrimidines of formula I ##STR1## wherein R1 -R5, m and n are as defined in the description. The compounds have valuable pharmaceutical properties and are effective especially as tyrosine protein ... | 04/18/2000 |
| 6013627 | Organic compounds Cyclopeptolides of formula I ##STR1## wherein A, B, R, Leu, Leu, C, X and Y are as defined, are inhibitors of adhesion molecule expression and are thus useful for treatment of inflammatory and other diseases which involve increased levels of adhesion... | 01/11/2000 |
| 5990116 | Trisubstituted phenyl derivatives The invention concerns compounds of formula I ##STR1## wherein the substituents have various meanings, and their use in the prevention or treatment of inflammatory and proliferative skin diseases and cancer.... | 11/23/1999 |
| 5985906 | Antifungal composition Use of a combination of the squalene epoxidase inhibitor terbinafine and an azole 14-alpha-methyldemethylase inhibitor (fluconazole or itraconazole) in mycotic infections caused by azole-resistant fungal strains, and corresponding pharmaceutical compositi... | 11/16/1999 |
| 5935998 | Use of all allylamine derivatives such as terbinafine, in the manufacture of a medicament for the treatment of helicobacter pylori infection or associated diseases Use of compounds of formula (I), wherein R has various significances, in free base form or in pharmaceutically acceptable salt form, as agents against H. pylori infection and associated diseases.... | 08/10/1999 |
| 5929067 | 1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists 1-Aryl-2-acylaminoethane compounds of formula I ##STR1## wherein R1 -R4, X and Am are as defined in the description, have valuable pharmaceutical properties and are especially effective as NK-1 antagonists.... | 07/27/1999 |
| 5925649 | Ascomycins The invention provides novel ascomycins bearing one or more physiologically hydrolyzable and acceptable oxycarbonyl moieties or carboxy moieties, such compounds being found useful as pharmaceuticals, especially in the treatment of asthma an dermatitis. Me... | 07/20/1999 |
| 5912238 | Heteroatoms-containing tricyclic compounds The invention concerns the compounds of formula I ##STR1## wherein the substituents have various significances. They are prepared by several processes including epimerizing replacement, treatment with cyanogen bromide or thiophosgene, treatment with ... | 06/15/1999 |
| 5905156 | Benzopyrans and pharmaceutical compositions containing them The invention provides novel 2,2-di(C1-5 alkyl)- or trans-2,2-di(C1-5 alkyl)-3,4-dihydro-3-hydroxy- -4-carboxamido-6-(N-arylsulfonamido)-2H-1-benzopyrans; and N-oxides, esters and salts thereof; processes for their production; and th... | 05/18/1999 |
| 5866105 | Pharmaceutical composition The invention concerns topical formulations such as nail varnishes comprising as the active agent the compound of formula I ##STR1## in free base form or in acid addition salt form, together with a polymeric film former and further excipients as appr... | 02/02/1999 |
| 5852005 | Tetracyclic triterpenes The present invention relates to 17 -dammara compounds having immunosuppressant and antiinflammatory activity and which are useful as pharmaceuticals, particularly for use as immunosuppressant and antiinflammatory agents. Specific 17 -dammar... | 12/22/1998 |
| 5814305 | Use of hydrophilic penetration agents in dermatological compositions for the treatment of onychomycoses, and corresponding compositions The hydrophilic penetration agents customarily used for the transcutaneous penetration of active ingredients are, surprisingly, found to improve the penetration of antifungal agents through the nails. A corresponding dermatological composition contains at... | 09/29/1998 |
| 5759565 | Galenic compositions comprising calcitonin and their use Pharmaceutical compositions for nasal administration comprising i) a calcitonin, and ii) benzalkonium chloride, and/or iv) a surfactant, suitable for application to the nasal mucosa, in iii) a liquid diluent or carrier, suitable for application to the nas... | 06/02/1998 |
| 5350870 | Thermal imaging methods and materials Leuco dyes are provided which comprise the coupling product of a N-acyl substituted aromatic amino color developer and a dye-forming coupler moiety substituted at the coupling carbon with a thermally removable leaving group. Thermal imaging systems employ... | 09/27/1994 |
| 5320929 | Image-recording materials There are disclosed compounds comprising at least one cyclic 1,3-sulfur-nitrogen substituted color-providing material and at least one ballast group which are linked to each other through a triazine group. The compounds are capable of releasing the color-... | 06/14/1994 |
| 5319143 | Bis(aminoethanethiols) There are disclosed certain bis(aminoethanethiols) and the salts thereof which find utility as intermediates in the preparation of certain dye-providing compounds useful in photographic imaging systems.... | 06/07/1994 |
| 5316887 | Thermally developable photosensitive material There are disclosed color-providing compounds comprising two or more cyclic 1,3 sulfur-nitrogen groups and two or more color-providing moieties, i.e., complete dyes or dye intermediates, capable of releasing the color-forming moieties upon cleavage in the... | 05/31/1994 |
| 5294375 | Thermochromic materials Disclosed is a class of bridged phthalides and sulfinate esters which exhibit reversible thermochromism. At room temperature and in the presence of base, these compounds are substantially colorless but upon the application of heat they become colored, rev... | 03/15/1994 |
| 5278127 | Transparent thermographic recording films This invention relates to the use of a compound containing at least two epoxide moieties in the protective topcoat layer and/or in a layer on top of the protective topcoat layer of certain thermographic recording films to reduce gouging and streaking of t... | 01/11/1994 |
| 5258279 | Reversible redox-controlled imaging methods A novel class of N-substituted triarylmethane sulfonamides is provided which undergo reversible oxidation into colored form and reversible reduction of the oxidized form into colorless form. Preferred embodiments comprise xanthene sulfonamides having N-ar... | 11/02/1993 |
| 5244771 | Photographic products and processes A novel class of bridged indicator dyes is disclosed which possess absorption in the infrared region of the electromagnetic spectrum. These bridged indicator dyes are useful as light-absorbing, pH-sensitive optical filter agents in diffusion transfer phot... | 09/14/1993 |
| 5198406 | Transparent thermographic recording films This invention provides transparent thermographic recording films which exhibit good anti-stick properties, are scratch resistant and substantailly craze-free. The thermographic recording films comprise a transparent support carrying (a) a dye image-formi... | 03/30/1993 |
