Ling; Lorraine B. - US Patent Attorneys and Agents

Attorney: Ling; Lorraine B.

Number of patents: 47
Last date: June 08, 2010

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Number	Title	Issue Date
7732600	Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors Disclosed are methods for the preparation of compounds of formula (I): wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the descrip...	06/08/2010
7718693	Receptor antagonists and their methods of use The present invention relates to novel oxo-prolinamide derivatives of formula (I) which modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor and the use of such compounds o...	05/18/2010
7704994	Benzazepine derivatives for the treatment of neurological disorders The present invention relates to benzazepine derivatives of formula (I) wherein: R1 represents —C3-7 cycloalkyl optionally substituted by C1-3 alkyl; having pharmacological activity, processes for their preparation, to compositions...	04/27/2010
7696193	Benzazepine derivatives for the treatment of neurological disorders The present invention relates to benzazepine derivatives of formula (I) wherein: R1 represents —C3-7 cycloalkyl optionally substituted by C1-3 alkyl; having pharmacological activity, processes for their preparation, to compositions...	04/13/2010
7544362	N protein mutants of porcine reproductive and respiratory syndrome virus The present invention provides a genetically modified PRRS virus, methods to make it and related polypeptides, polynucleotides and various components. Vaccines comprising the genetically modified virus and polynucleotides are also provided. ...	06/09/2009
7534441	Immunogenic LHRH compositions and methods relating thereto The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino acids. The present invention is useful, inter alia, as a prophylactic and...	05/19/2009
7468185	Vaccine for periodontal disease The present invention relates to novel bacterial isolates identified by their 16S rRNA DNA, that cause periodontal disease in companion animals, polynucleotide sequences contained therein, polypeptides encoded by such polynucleotide sequences and vaccines comprising...	12/23/2008
7132106	Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encode...	11/07/2006
7122534	Aryl fused azapolycyclic compounds The present invention relates to compounds of formula (I) and their pharmaceutically acceptable salts, wherein R1, R2, R3 and Z are as defined herein, intermediates in the synthesis of ...	10/17/2006
7084165	Monoamine reuptake inhibitors for treatment of CNS disorders The present invention relates to compounds that are useful exhibit activity as serotonin, norepinephrine and dopamine reuptake inhibitors, and their pharmaceutically acceptable salts, and their use in the treatment of central nervous system and other disorders. ...	08/01/2006
7022684	Treatment of rumen acidosis with α-amylase inhibitors The invention described herein relates to: the use of an effective inhibitor of a bacterial α-amylase and/or α-glucosidase in the manufacture of a composition for the treatment of rumen acidosis; a method of treatment of rumen acidosis which comprises administrati...	04/04/2006
7019016	NMDA NR2B antagonists for treatment The invention provides new methods for treating certain disorders resulting from neurodegeneration and for treating depression which comprise administration of NR2B subunit selective NMDA antagonists. The disorders that can be treating by the invention include heari...	03/28/2006
6992087	Substituted aryl 1,4-pyrazine derivatives Substituted aryl 1,4-pyrazine derivatives of formula I as defined herein and their use in treating anxiety disorders, depression and stress related disorders are disclosed. ...	01/31/2006
6972287	Method of inhibiting amyloid protein aggregation and imaging amyloid deposits The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of the Formula (I) and a method of imaging amyloid deposits, as well...	12/06/2005
6958351	NMDA NR2B antagonists for treatment The invention provides new methods for treating certain disorders resulting from neurodegeneration and for treating depression which comprise administration of NR2B subunit selective NMDA antagonists. The disorders that can be treating by the invention include heari...	10/25/2005
6951873	Methods for treating age-related behavioral disorders in companion animals Methods for the treatment of age-related behavioral disorders in companion animals are disclosed. These comprise administering to a companion animal in need of such treatment a therapeutically effective amount of an acetylcholinesterase inhibitor. A preferred acetyl...	10/04/2005
6951868	Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is any of: These compounds may be in the form of pharmaceutical salts or compositions, and racemic mixtu...	10/04/2005
6921760	Aralkyl and aralkylidene heterocyclic lactams and imides The present invention relates to compounds of the formula Orosco wherein R1, R2, R3, X, Y and the dashed line are defined as in the specification, to intermedia...	07/26/2005
6921764	Thieno-pyrimidin-4-one AMPA antagonists The present invention relates to novel quinazolin-4-one derivatives of the formula I, as defined in the specification, pharmaceutical compositions containing such compounds the use of such compounds to treat neurodegenerative, psychotropic, and drug and alcohol indu...	07/26/2005
6919359	Azabicyclic-substituted-heteroaryl compounds for the treatment of disease The invention provides compounds of Formula I: Azabicyclo-N(R1)—C(═X)—W Formula I These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Fo...	07/19/2005
6911477	Muscarinic receptor agonists This invention relates to a novel class of partial or full muscarinic receptor agonists intermediates for their preparation, and pharmaceutical compositions and methods of use for the treatment or prevention of diseases the treatment or prevention of which is mediat...	06/28/2005
6911543	Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is These compounds may be in the form of pharmaceutical salts or co...	06/28/2005
6899896	Hydrogel-driven layered drug dosage form A controlled release dosage form for sertraline has a core comprising a sertraline-containing composition and a water-swellable composition wherein the water-swellable composition is in a separate region within the core. A coating around the core is water-permeable,...	05/31/2005
6900217	Substituted 6,5-hetero-bicyclic derivatives This invention relates to compounds of the formula wherein A, B, D, E, K, T, G, R3 and R5 are defined as in the specification, and to the pharmaceutically acceptable salts of such compounds. ...	05/31/2005
6897310	Aryl fused azapolycyclic compounds Pharmaceutical compositions comprising compounds of the formula and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are defined as in the specification, in combination w...	05/24/2005
6894062	Quinoline derivatives The present invention relates to compounds of Formula I, wherein R1, R2, R3, R4, and n are as defined, and to pharmaceutically acceptable salts of said compounds. Compounds o...	05/17/2005
6890927	Tartrate salts of 5,8, 14-triazateracyclo[10.3.1.02,11 04.9]-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof The present invention is directed to the tartrate salts of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene: and pharmaceutical compositions thereof. The present inventio...	05/10/2005
6887472	Anti-IgE vaccines The present invention provides compositions and methods for the use of antigenic peptides derived from the Fc portion of the epsilon heavy chain of an IgE molecule as vaccines for the treatment and prevention of IgE-mediated allergic disorders. In particular, the in...	05/03/2005
6887884	Aryl fused azapolycyclic compounds Compounds of the formula and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are defined as in the specification, intermediates in the synthesis of such compounds, pharm...	05/03/2005
6887905	Treatment of depression or generalized anxiety disorder A pharmaceutical composition for treating a disorder that is treated by modulation of serotonergic neurotransmission comprising administering (7S,9aS)-cis-2-Benzo[d]isoxazol-3-yl-7-(3-pyrrolidin-1-ylmethyl-phenoxymethyl)-octahydro-pyrido-[1,2-a]pyrazine and sertrali...	05/03/2005
6881734	Pharmaceutical composition for the treatment of CNS and other disorders The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharmaceutical c...	04/19/2005
6869946	Substituted azabicyclic moieties for the treatment of disease The invention provides compounds of Formula I: wherein m1 is 0 or 1; m2 is 1 or 2; R1 is —H, alkyl, halogenated alkyl, subst...	03/22/2005
6852716	Substituted-aryl compounds for treatment of disease The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmac...	02/08/2005
6849620	N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is W0 is a bicyclic moiety and is	02/01/2005
6846487	Therapeutic compositions for treating infection by Lawsonia spp. The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganism. In ...	01/25/2005
6825344	Process for the preparation of cephalosporin compounds and synthetic intermediates There is provided a process for the preparation of a compound according to Formula (II): which includes the step of cyclising a compound of Formula (III): wherein R1...	11/30/2004
6825193	Citric acid salt of a therapeutic compound and pharmaceutical compositions thereof The present invention is directed to a polymorph of the citrate salt of 4-(3,4-dichlorophenyl)-2-[2-(4-methylpiperazin-1-yl)-benzylidene]-thiomorpholin-3-one: and pharmaceutical compositions thereof. ...	11/30/2004
6814971	Adjuvants for use in vaccines The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal. ...	11/09/2004
6803211	Methods and compositions for diagnosing and treating disorders involving angiogenesis The present invention relates to polynucleotides associated with angiogenesis-related disorders. The present invention also relates to canine endostatin genes, novel genes associated with angiogenesis-related disorders, such as cancer. The invention encompasses endo...	10/12/2004
6800734	Leptospira vaccine antigens for the prevention of Leptospirosis Four antigenic preparations are provided, each of which contains a different protein from Leptospira which can be used immunologically in vaccines for leptospirosis caused by this organism. Also provided in the invention are polynucleotides encoding these four prote...	10/05/2004

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Attorney: Ling; Lorraine B.