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| Number | Title | Issue Date |
| 8163562 | Photon reducing agents for fluorescence assays The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides a method fo... | 04/24/2012 |
| 8158194 | Method for preparing surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media Water-dispersible nanoparticles are prepared by applying a coating of a amphipathic dispersant to the surface of a hydrophobic nanoparticle comprised of a semiconductive or metallic material. The amphipathic dispersant is typically polymeric. Preferred polymeric dis... | 04/17/2012 |
| 8153828 | Optical molecular sensors for cytochrome P450 activity The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe of the inv... | 04/10/2012 |
| 8039642 | Pyrenyloxysulfonic acid fluorescent agents The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on th... | 10/18/2011 |
| 8003767 | Sulfonated [8,9]benzophenoxazine dyes and the use of their labelled conjugates Fluorescent, sulfonated 3,7-diamino-[8,9]benzophenoxazine dyes are provided that are especially useful for labelling biopolymers and other substrates. The dye-labelled conjugates can be used in a variety of contexts, including cell surface assays employing intact, l... | 08/23/2011 |
| 7989617 | Crown ether derivatives The invention describes crown ether chelators, including crown ethers having the formula: ... | 08/02/2011 |
| 7985340 | Magnetic separator A magnetic separator unit for the selective separation of at least one component from a fluid mixture is described. The unit can include at least one mandrel-shaped magnet unit and tubing wrapped around it. Fluid containing magnetisable particles can be passed throu... | 07/26/2011 |
| 7977057 | Detection of immobilized nucleic acid The present invention provides methods for determining the presence of immobilized nucleic acid employing unsymmetrical cyanine dyes that are derivatives of thiazole orange, a staining solution and select fluorogenic compounds that are characterized as being essenti... | 07/12/2011 |
| D638953 | Laboratory apparatus | 05/31/2011 |
| 7948015 | Methods and apparatus for measuring analytes using large scale FET arrays Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity a... | 05/24/2011 |
| 7943777 | Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluor... | 05/17/2011 |
| 7943752 | Modified oligonucleotides and applications thereof Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof. ... | 05/17/2011 |
| D637709 | Magnetic separation apparatus | 05/10/2011 |
| 7927830 | Modified carbocyanine dyes and their conjugates Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that a... | 04/19/2011 |
| 7888136 | Unsymmetrical cyanine dimer compounds and their application Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two unsymmetrical cyanine monomer moieties, which may be the same or different, that ... | 02/15/2011 |
| 7875261 | Fluorinated resorufin compounds and their application The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one o... | 01/25/2011 |
| 7871773 | Aza-benzazolium containing cyanine dyes Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject d... | 01/18/2011 |
| 7842811 | Cyanine dye compounds Cyanine dye compounds having a negatively charged substituent that are nucleic acid stains, particularly for fluorescent staining of DNA, including compounds having the formula wherein W forms one or two fused 5- or 6-membe... | 11/30/2010 |
| 7820824 | Modified carbocyanine dyes and their conjugates Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that a... | 10/26/2010 |
| 7816519 | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic r... | 10/19/2010 |
| 7790893 | Modified carbocyanine dyes and their conjugates Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that a... | 09/07/2010 |
| 7776529 | Methine-substituted cyanine dye compounds Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 | 08/17/2010 |
| 7763689 | Process for the preparation of functionalised polymer particles A process for the preparation of amine-functionalized vinyl polymer particles which process comprises suspension polymerizing minostyrene together with at least one other vinylic monomer and optionally a crosslinking agent. ... | 07/27/2010 |
| 7727716 | Detection of immobilized nucleic acid The present invention provides methods for determining the presence of immobilized nucleic acid employing unsymmetrical cyanine dyes that are derivatives of thiazole orange, a staining solution and select fluorogenic compounds that are characterized as being essenti... | 06/01/2010 |
| 7709808 | Systems, methods and apparatus for single molecule sequencing An embodiment generally relates to a system for analysis of an analyte. The system can include a transparent substrate. The system also includes an excitation light source configured to induce an evanescent wave excitation of a fluorescently labeled molecule near th... | 05/04/2010 |
| 7671214 | Modified carbocyanine dyes and their conjugates Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that a... | 03/02/2010 |
| 7655409 | Cyanine dye compounds Cyanine dye compounds having a negatively charged substituent that are nucleic acid stains, particularly for fluorescent staining of DNA, including compounds having the formula wherein W forms one or two fused 5- or 6-membe... | 02/02/2010 |
| 7598390 | Fluorescent chemical compounds having high selectivity for double stranded DNA, and methods for their use Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluor... | 10/06/2009 |
| 7579463 | Crown ether derivatives The invention describes crown ether chelators, including crown ethers having the formula: ... | 08/25/2009 |
| 7566790 | Intermediates and the synthesis of modified carbocyanine dyes and their conjugates Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that a... | 07/28/2009 |
| 7537886 | Primers and methods for the detection and discrimination of nucleic acids The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular biology applications and are particularly useful in allele specific PCR.... | 05/26/2009 |
| 7528241 | Methods and reagents for molecular cloning The present invention provides compositions, methods, and kits for covalently linking nucleic acid molecules. The methods include a strand invasion step, and the compositions and kits are useful for performing such methods. For example, a method of covalently linkin... | 05/05/2009 |
| 7521577 | Heavy metal binding compounds and their method of use The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of heavy metal ions in a sample. This metal chelating moiety is a —N,N,O-triacetic acid analog of BAPTA and has the following formula | 04/21/2009 |
| 7501252 | Use of predetermined nucleotides having altered base pairing characteristics in the amplification of nucleic acid molecules The present invention provides improved methods for amplifying a nucleic acid molecule. More specifically, the invention provides methods for nucleic acid amplification which use primers having equivalent priming efficiency. ... | 03/10/2009 |
