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| Number | Title | Issue Date |
| 7385103 | Animal model, cells, and treatment for malignant melanoma The present invention provides transgenic non-human animal models and cell lines which express a metabotropic glutamate receptor 1 in a melanocyte-specific manner and, as a result, exhibit a predisposition to the development of melanoma. The invention further teache... | 06/10/2008 |
| 7445781 | Anti-CD40CR MR1 antibody The present invention relates to a counter-receptor, termed CD40CR, for the CD40 B-cell antigen, and to soluble ligands for this receptor, including fusion molecules comprising at least a portion of CD40 protein. It is based, at least in part, on the discovery that ... | 11/04/2008 |
| 7402663 | Modified peptide The invention provides a peptide based on biologically active CCK-8 having improved characteristics for the treatment of obesity and/or type 2 diabetes wherein the primary structure of CCK-8 is: Asp1Tyr2(SO3H)-Met3Gly... | 07/22/2008 |
| 7402308 | Method of delivering genes to the central nervous system of a mammal The invention provides a method of delivering a selected DNA sequence to the central nervous system of a mammal by administering to said mammal a neurotropic virus, said virus containing a selected DNA sequence under the control of a promoter which permits expressio... | 07/22/2008 |
| 7399746 | Agents for wound healing The present invention relates to pharmaceutical compositions containing fragments of alpha-1 proteinase inhibitor (API) or chimeric proteins of API and insulin-like growth factor for use in stimulating wound healing. ... | 07/15/2008 |
| 7384751 | Methods of diagnosing muscle damage A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage, and evaluating the sample for the presence or absence of a myofilamen... | 06/10/2008 |
| 7378388 | Method of utilizing neurotrophins to manipulate reproductive capacity Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins, particularly BDNF, NT-4/5, and NGF, increase the reproductive capacity of a... | 05/27/2008 |
| 7364900 | Multi-lineage directed induction of bone marrow stromal cell differentiation Methods of inducing differentiation of mammalian bone marrow stromal cells into cells of multiple embryonic lineages by contacting marrow stromal cells with precursor differentiation-inducing compounds followed by contacting the partially differentiated precursor ce... | 04/29/2008 |
| 7364921 | Method and apparatus for separating biological materials and other substances A method for separating biological materials and other substances is disclosed, wherein a mixture containing desired and undesired components are exposed to magnetic particles having ligands capable of binding to the desired and/or the undesired components to form a... | 04/29/2008 |
| 7361482 | Method for detecting intracellular cholesterol The present invention relates to a method of detecting intracellular cholesterol. The method provides contacting a permeabilized cell with labeled cθ complex. Methods of using this detection method to identify agents which modulate cholesterol accumulation in a cel... | 04/22/2008 |
| 7361475 | Compositions and methods relating to colon specific genes and proteins The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to th... | 04/22/2008 |
| 7354589 | Multiple antigenic agents and methods for using the same The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections. The multiple antigenic agents of the invention contain at least one of a B cell determinant, a T cell determinant, or a targeting molecule... | 04/08/2008 |
| 7345021 | Method for PR-39 peptide regulated stimulation of angiogenesis The present invention provides both a method and means for regulating angiogenesis within living cells, tissues, and organs in-situ. The regulation is performed using native PR-39 peptide or one of its shorter-length homolog, for interaction with such proteasomes as... | 03/18/2008 |
| 7341867 | Human preprotachykinin gene promoter Compositions and methods are provided for identifying novel therapeutic agents for the treatment of breast cancer, bone marrow metastasis, pain, arthritis, aggressive behavior, depression, and certain hematopoietic disorders. Disclosed are promoters and 3′ regulat... | 03/11/2008 |
| 7329506 | Apparatuses and methods for determining protease activity The present invention relates to compositions and an apparatuses for determining protease activity. The compositions of the invention contain a reporter protein fused to at least one protease cleavage sequence, and a linker for attaching the protease cleavage sequen... | 02/12/2008 |
| 7208267 | Compositions and methods relating to breast specific genes and proteins The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to t... | 04/24/2007 |
| 6902890 | Method of diagnosing monitoring, staging, imaging and treating cancer The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating cancer. ... | 06/07/2005 |
