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| Number | Title | Issue Date |
| 4816564 | Method for producing hepatitis B virus proteins in yeast The entire hepatitis B Virus pre-S antigen gene linked in one contiguous reading frame to the hepatitis B virus surface antigen gene has been expressed in Saccharomyces cerevisiae. The expressed protein aggregates into a particulate form which displays th... | 03/28/1989 |
| 4816443 | Piptides having ANF activity Novel peptides having potent natriuretic activity are disclosed with the following amino acid sequence: ##STR1## wherein Z is H, acetyl, Boc or Ser-Leu, E is Phe, NMP, OMT, ChA, F is Gly or DAl, G is Ala or Gly, H is Arg or DAr, Pro, Lys or Dly, I is... | 03/28/1989 |
| 4812590 | Carbamates of 4-hydroxyanisole as prodrugs for chemotherapy of melanoma Derivatives of 4-hydroxyanisole carbamate are suitable as prodrugs for the delivery and concentration of 4-hydroxyanisole in melanomas.... | 03/14/1989 |
| 4812559 | Vaccine against varicella-zoster virus A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified by DNA sequence analysis. This gene can hybrid select messenger RNA which encodes and expresses a protein which reacts with human convalescen... | 03/14/1989 |
| 4739113 | Bis(cyclopropanecarboxamido)alkadienedioic acids as renal dipeptidase inhibitors Novel chemical compounds are provided which selectively inhibit the metabolism of renal dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are (Z,Z)-,'-bis(2,2-disubstitu... | 04/19/1988 |
| 4734497 | Intermediates for process for chiral synthesis of 1-ଲ-methyl-carbapenem intermediates A process is described for selectively obtaining 1-ଲ-methylcarbapenem intermediates. The desired chirality is obtained through the hydrogenation of certain bicyclic ଲ-lactam ring structures containing an exocyclic methylene double bond alpha t... | 03/29/1988 |
| 4727062 | 3-Halovinylglycine antibacterial agents Described are 3-halovinylglycines and their amino acid dipeptide and oligopeptide conjugates, a new class of efficient antibacterial agents, pharmaceutical compositions containing them as active ingredients, and methods of synthesis. The compounds are tho... | 02/23/1988 |
| 4715994 | Novel antibacterial agents and potentiators of carbapenem antibiotics New 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids are described which display antibacterial activity and potentiate carbapenem antibiotics.... | 12/29/1987 |
| 4695624 | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency Covalently modified bacterial polysaccharides and proteins; covalent conjugates of such polysaccharides linked by a bigeneric spacer, which permits proof of covalency and facilitates purification of conjugated materials, with immunogenic bacterial membran... | 09/22/1987 |
| 4656036 | Antibiotics Tejeramycin and production thereof The antibiotics Tejeramycin are active against gram negative and gram positive infections, especially against Pseudomonas aeruginosa. The antibiotics Tejeramycin are produced by the aerobic fermentation of Streptomyces griseus ATCC No. 39208 or 39209 in a... | 04/07/1987 |
| 4653668 | Medicament dispensing container A container for storing and dispensing small objects, such as capsules or pills containing medicament, one at a time, consists of a receptacle containing, within itself, a delivery mechanism including a funnel-shaped exit port for capsules and a capsule o... | 03/31/1987 |
| 4654359 | Allylsulfoxide enzyme inhibitors Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or Kcat type.... | 03/31/1987 |
| 4639458 | Tablet and formulation A direct compression tablet formulation containing a non-hydrated quinoline carboxylic acid type antibacterial agent.... | 01/27/1987 |
| 4610820 | Process for the preparation of thienamycin and intermediates In a process for the total synthesis of thienamycin from L-aspartic acid via intermediate III: ##STR1## R=H, blocking group or salt cation there is disclosed a process for preparing III via ##STR2## wherein R is a protecting group.... | 09/09/1986 |
| 4609641 | Renin-inhibitory peptide analogs Peptides having the formula ##STR1## and their use as pharmaceuticals are disclosed.... | 09/02/1986 |
| 4595750 | Process for chiral synthesis of 1-ଲ-methylcarbapenem intermediates A process is described for selectively obtaining 1-ଲ-methylcarbapenem intermediates. The desired chirality is obtained through the hydrogenation of certain bicyclic ଲ-lactam ring structures containing an exocyclic methylene double bond alpha t... | 06/17/1986 |
| 4594191 | Process for preparing a benzodiazepinedione derivative A non-fermentation process for preparing a benzodiazepinedione of the formula: ##STR1## and intermediates is disclosed.... | 06/10/1986 |
| 4587357 | Preparation of enantiomers of a substituted fluorenyloxyacetic acid A process for direct preparation of enantiomers of a substituted fluorenyloxyacetic acid is disclosed. The acetic acid derivative is useful for treating brain edema.... | 05/06/1986 |
| 4582931 | Preparation of 2-Deutero-D-serine A process for the preparation of 2-Deutero-D-serine and its fluorination is disclosed.... | 04/15/1986 |
| 4579849 | N-alkylguanine acyclonucleosides as antiviral agents Disclosed are compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof wherein R1 and R2 are independently alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, each having 1 to 19 carbon at... | 04/01/1986 |
| 4576750 | Tryptophan derivative A non-fermentation process for preparing a benzodiazepinedione of the formula: ##STR1## and intermediates are disclosed.... | 03/18/1986 |
| 4535167 | Chiral, N-protected, N-substituted -amino acids Chiral N-protected, N-substituted -amino acids are described. These compounds are prepared by condensation of an N-protected -amino acid with an aldehyde followed by the selective reductive cleavage of an oxazolidinone intermediate.... | 08/13/1985 |
| 4535171 | Dibenzo[b,f]thiepin-3-carboxaldehydes as prostaglandin antagonists Novel dibenzo[b,f]thiepin-3-carboxaldehydes and derivatives are prepared and employed in the treatment and control of allergic conditions such as allergic asthma.... | 08/13/1985 |
| 4505915 | 6-N-Heterocyclyl penicillins This invention relates to a new class of penicillins (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics: ##STR1## wherein the stylized radical (hereafter referred to as R'): ##STR2## attached to the 6... | 03/19/1985 |
| 4499278 | Trans-3-carboxymethylene-4-carboxy-5-methyl-delta2-isoxazoline as intermediate Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: ##STR1## wherein R5 and R6 are removable protecting groups.... | 02/12/1985 |
| 4467107 | 1-Hydroxyethyl-2-amino pentanedioic acid derivatives Disclosed is a process for the stereocontrolled total synthesis of thienamycin via intermediates II and IIa: ##STR1## wherein R is a readily removable carboxyl protecting group.... | 08/21/1984 |
| 4324554 | Use of TKP as an antimigrant TKP is used for the control of migration during pad dyeing of fabrics.... | 04/13/1982 |
| 4302578 | Cephalosporin antibiotics Disclosed are 7ଲ-(D-5-amino-5-carboxyvaleramido)-7-methoxy-3-cephem-4-carboxylic acids which are substituted in the three position of the "cephem" nucleus by a variety of alkyl, haloalkyl or oxygen, sulfur and nitrogen containing substituents; ... | 11/24/1981 |
| 4298741 | 6-Amido-3-substituted-1-azabicyclo[3.2.0]-hept-2-en-7-one-2-carboxylic acid Disclosed are 6-amido-3-substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acids (I): ##STR1## wherein R1 is hydrogen or acyl; and X is halo, oxygen (the 2-3 bond is saturated and the species I exists as a carboxylate salt or... | 11/03/1981 |
| 4297488 | 7--Methoxy cephalosporins Process and intermediate products useful in the preparation of cephalosporin compounds having a substituent at the 7-position in place of hydrogen are provided. The new cephalosporin compounds are active against various gram-negative and gram-positive org... | 10/27/1981 |
| 4293555 | 6- and 6,6-Disubstituted-2-substituted-oxapen-2-em-3-carboxylic acids Disclosed are 6- and 6,6-disubstituted-2-substituted-oxapen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein: R1 and R2 are independently selected from hydrogen, alkyl, alkoxyl, aralkyl, aryl, heterocycl... | 10/06/1981 |
| 4270916 | Dyeing composition and method Cationic or certain anionic dyes are rendered compatible with normally incompatible anionic and nonanionic polymers by the addition of certain surface active agents.... | 06/02/1981 |
| 4269939 | Preparation of heteropolysaccharide S-119 A process for producing heteropolysaccharide S-119 by bacterial fermentation of an organism deposited with the American Type Culture Collection under Accession No. ATCC 31643.... | 05/26/1981 |
| 4269974 | Clabber-free xanthan gum A novel form of xanthan gum and preparation therefor are disclosed. This gum is characterized in that when homogenized with oil and water, the resulting emulsion is smooth flowing (clabber-free).... | 05/26/1981 |
| 4267188 | 5-Substituted-1-carba-pen-2-em-3-carboxylic acid Disclosed are 1-carba-pen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein R1, R2, R3 and R4 are, inter alia, independently selected from the group consisting of hydrogen (R4 ... | 05/12/1981 |
| 4264621 | 5-Substituted-3 -(2-aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-en e-2-carboxylic acid Antibiotic 5-substituted-3-(2-aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3 .2.0]hept-2-ene-2-carboxylic acids (I) are disclosed: ##STR1## wherein R is alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or heteroaryl.... | 04/28/1981 |
| 4264734 | Process for producing antibiotic desacetyl 890A10 This invention relates to the new antibiotic, desacetyl 890A10, active against both gram-positive and gram-negative bacteria, which is produced by treating 890A10 with an N-acetyl-890A10 amidohydrolase produced by a soil m... | 04/28/1981 |
| 4264735 | Method of producing antibiotic 890A9 The antibiotic MSD 890A9 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotic 890A9) is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing species of St... | 04/28/1981 |
| 4264736 | Antibiotic 890A10 The antibiotic MSD 890A10 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotic 890A10) is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing species of ... | 04/28/1981 |
| 4264764 | Meningitis vaccine A high molecular weight capsular polysaccharide from H. influenza type b is an effective immunogenic agent against infection caused by the H. influenza type b bacterium.... | 04/28/1981 |
