Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 8168615 | Prodrugs of piperazine and substituted piperidine antiviral agents This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R | 05/01/2012 |
| 8124615 | Diketo substituted pyrrolo[2,3-C]pyridines Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, diketo fused azolopiperidine and azolopiperazine derivatives of Formula I: that possess ... | 02/28/2012 |
| 8119389 | strain The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4... | 02/21/2012 |
| 8067420 | Substituted pyrazinone melanin concentrating hormone receptor-1 antagonists and methods The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I wherein R1 | 11/29/2011 |
| 8039486 | Indole, azaindole and related heterocyclic N-substituted piperazine derivatives This invention provides compounds of Formula I, including pharmaceutically acceptable salts thereof, having drug and bio-affecting properties, their pharmaceutical compositions and method of use. These compounds possess unique antiviral activity, whether used alone ... | 10/18/2011 |
| 7981913 | Isophthalates as beta-secretase inhibitors There is provided a series of substituted isophthalates of formula (I) or a stereoisomer thereof; or a pharmaceutically acceptable salt thereof, wherein W, R3, R5 and R6 as defined herein, t... | 07/19/2011 |
| 7977362 | Alpha-(N-benzenesulfonamido)cycloalkyl derivatives Disclosed are compounds, pharmaceutical compositions containing the compounds, methods for using the compounds and processes for making the compounds. More specifically, the disclosure relates to alpha-(N-benzenesulfonamido)cycloalkyl compounds that may inhibit one ... | 07/12/2011 |
| 7968718 | Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and proce... | 06/28/2011 |
| 7960406 | Diketo substituted pyrrolo[2,3-c] pyridines Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, diketo fused azolopiperidine and azolopiperazine derivatives of Formula I: that possess ... | 06/14/2011 |
| 7915283 | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particul... | 03/29/2011 |
| 7902218 | Substituted tetrahydroisoquinolines as β-secretase inhibitors There is provided a series of tetrahydroisoquinoline diaminopropane compounds of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R, R8 and R9 are as defined herein... | 03/08/2011 |
| 7902204 | Diazaindole-dicarbonyl-piperazinyl antiviral agents The invention comprises substituted diazaindole-dicarbonyl-piperazinyl derivatives of general Formula I wherein: Q is selected from the group consisting of | 03/08/2011 |
| 7851476 | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1-pyrrolo[2,3-]pyridin-3-YL]-1,2-dioxoethyl]-piperazine Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine its salts and solvates thereof are herein set forth, as ar... | 12/14/2010 |
| 7829711 | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-C]pyridine-3-yl]-ethane-1,2-dione The instant invention provides crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione; processes for the production of such crystalline materials; pharmaceutical composition... | 11/09/2010 |
| 7820820 | Method of preparation of azaindole derivatives A method of preparing azaindole compounds for antiviral use having the formula ... | 10/26/2010 |
| 7807676 | Diketo-Piperazine and Piperidine derivatives as antiviral agents This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with diketo piperazine and piperadine derivatives that possess unique antiviral activity. Mor... | 10/05/2010 |
| 7807671 | Diketo-piperazine and piperidine derivatives as antiviral agents This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with diketo piperazine and piperadine derivatives that possess unique antiviral activity usef... | 10/05/2010 |
| 7776863 | Methods of treating HIV infection The invention encompasses pharmaceutical compositions and methods for using Compound 1 in combination with other agents for treating patients with AIDS or HIV infection. ... | 08/17/2010 |
| 7772221 | Diaminopropane derived macrocycles as inhibitors of β amyloid production There is provided a series of macrocyclic diaminopropanes of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, m, n, W, X, Y, Z and L as defin... | 08/10/2010 |
| 7745625 | Prodrugs of piperazine and substituted piperidine antiviral agents This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exis... | 06/29/2010 |
| 7745470 | Isophthalates as beta-secretase inhibitors There is provided a series of substituted isophthalates of formula (I) or a stereoisomer thereof; or a pharmaceutically acceptable salt thereof, wherein W, R3, R5 and R6 as defined herein, t... | 06/29/2010 |
| 7745463 | Alkene piperidine derivatives as antiviral agents This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with alkene piperidine derivatives that possess unique antiviral activity. More particularly,... | 06/29/2010 |
| 7732434 | Macrocyclic acyl guanidines as beta-secretase inhibitors There is provided a series of heterocyclic-containing macrocyclic acyl guanidines of Formula (I) or a stereoisomer; or a nontoxic pharmaceutically acceptable salt thereof, wherein R1, R2, R3... | 06/08/2010 |
| 7723338 | Crystalline forms of 1-benzoyl-4-[2-[4,7-dimethoxy-1-[(phosphonooxy)methyl]-1-pyrrolo[2,3-C]pyridin-3-yl]-1,2-dioxoethyl]-piperazine The instant disclosure provides crystalline forms of 1-benzoyl-4-[2-[4,7-dimethoxy-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine, salts and solvates thereof. The present disclosure also generally relates to pharmaceutical composi... | 05/25/2010 |
| 7714019 | Indole, azaindole and related heterocyclic pyrrolidine derivatives This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether u... | 05/11/2010 |
| 7678793 | Azolo triazines and pyrimidines Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or hear... | 03/16/2010 |
| 7678784 | Oxime-containing macrocyclic acyl guanidines as β-secretase inhibitors There is provided a series of oxime-containing macrocyclic acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, R4, ... | 03/16/2010 |
| 7662823 | Pharmaceutical formulations of substituted azaindoleoxoacetic piperazine derivatives This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activi... | 02/16/2010 |
| 7612069 | Acyl guanidines as beta-secretase inhibitors There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 | 11/03/2009 |
| 7601751 | Indole acetic acid acyl guanidines as β-secretase inhibitors There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R... | 10/13/2009 |
| 7601715 | Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoloxoacetic piperazine derivatives and proce... | 10/13/2009 |
| 7598380 | Method of preparation of azaindole derivatives A method of preparing azaindole compounds for antiviral use having the formula ... | 10/06/2009 |
| 7582468 | Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4... | 09/01/2009 |
| 7572810 | Alkene piperidine derivatives as antiviral agents This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with alkene piperidine derivatives that possess unique antiviral activity. More particularly,... | 08/11/2009 |
| 7557137 | Gamma-lactams as beta-secretase inhibitors There is provided a series of novel substituted gamma-lactams of Formula (I) wherein R1, R2, R3, R4 and R5 are defined herein, their pharmaceutical compositions and met... | 07/07/2009 |
| 7550445 | Aripiprazole complex formulation and method An aripiprazole formulation is provided which includes the antipsychotic agent aripiprazole in the form of an inclusion complex in a β-cyclodextrin, preferably, sulfobutyl ether β-cyclodextrin (SBECD), which in the form of an injectable produces reversible general... | 06/23/2009 |
| 7531552 | Indole, azaindole and related heterocyclic pyrrolidine derivatives This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether u... | 05/12/2009 |
| 7504399 | Piperazine enamines as antiviral agents This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with indole and azaindole piperazine enamine derivatives that possess unique antiviral activi... | 03/17/2009 |
| 7501420 | Composition and antiviral of substituted azaindoleoxoacetic piperazine derivatives This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activi... | 03/10/2009 |
| 7501419 | 4-Squarylpiperazine derivatives as antiviral agents This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with 4-squarylpiperazine derivatives that possess unique antiviral activity. More particularl... | 03/10/2009 |
