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| Number | Title | Issue Date |
| 6063814 | Phorbol esters as anti-neoplastic and white blood cell elevating agents Phorbol esters and particularly phorbol-12-myristate-13-acetate (TPA) are described as effective in treating patients with neoplastic diseases such as leukemia as well as in increasing the white blood cell count.... | 05/16/2000 |
| 4871755 | Method for treating diabetes obesity and conditions characterized by increased protein breakdown with novel oxazolidines The oxazolidines of the formula ##STR1## wherein n signifies the number 1 or 2. T signifies lower carbalkoxy. X signifies phenoxymethyl optionally mono-fluorinated or mono-chlorinated in the ortho-position or phenyl optionally monosubstituted by fluorine,... | 10/03/1989 |
| 4869895 | Radiolabeled benzazepine A compound of the formula: ##STR1## wherein T is tritium; is described as well as intermediates for its preparation. The compound of formula I is useful in vivo for detecting the presence of benzodiazepine receptor occupiers in a warmblooded animal.... | 09/26/1989 |
| 4867860 | Method of manufacturing ion-selective electrodes for analyzing selected ions in solution There is disclosed a process for producing a laminar electrode. The method comprises successive superposition of an insulating support, a conductive layer, a stable-potential internal reference element and an ion-selective diaphragm, all of which are prot... | 09/19/1989 |
| 4866205 | Prostaglandin intermediates New optically active intermediates and processes thereto are provided for use in synthesizing therapeutically active prostaglandins of the formula: ##STR1## wherein R1 is hydrogen or lower alkyl; from a compound of the formula: ##STR2... | 09/12/1989 |
| 4863920 | Imidazodiazepine derivatives for treatment of disorders of the central nervous system A compound for treating disorders of the central nervous system, which is of the formula wherein A taken together with the two carbon atoms denoted by and ଲ is one of the following groups: ##STR1## R1 is one of the following ... | 09/05/1989 |
| 4864058 | Process for making optically active naphtho[1,2-b][1,4]thiazepin-4(5H)-ones A process for preparing optically active naphtho[1,2-b][1,4]thiazepin-4(5H)-ones comprising resolution of rac-ଲ-[(2-amino-1-naphthalenyl)thio]--hydroxy-4-methoxybenzene propanoic acid and converting the optically active acids so obtained into ... | 09/05/1989 |
| 4863941 | Glycerol derivatives Glycerol derivatives of the formula ##STR1## wherein one of the residues R1, R2 and R3 is a group U of the formula OY1 or --X1 --CO--(A1)n --Z1, another residue i... | 09/05/1989 |
| 4864023 | Pyrido(3,2,1-IJ)-1,3,4-benzoxadiazine derivatives The invention is concerned with tricyclic compounds of the formula ##STR1## wherein R1 is a hydrogen atom or a carboxy-protecting radical; R2 is a hydrogen atom or a lower alkyl radical which may be substituted with a halogen at... | 09/05/1989 |
| 4861772 | Method and composition to treat panic syndrome The known compound, t-butyl (S)-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][ 1,4]benzodiazepine-1-carboxylate of the formula ##STR1## is effective in the prevention or interruption in a human being of panic states, accom... | 08/29/1989 |
| 4859229 | 3-Aryluracils having an ether (thio) carbomyloxy or sulphomyloxy substituent on the aromatic moiety The invention is concerned with 3-aryluracils of the formula ##STR1## wherein R1, R2, R3, R4, R5 and R6 are as described herein, as well as salts thereof and their manufacture, weed co... | 08/22/1989 |
| 4859665 | Antihypertensive combination products containing a dihydropyridine and a pyridazodiazepine Compositions for treating hypertension comprising an effective amount of a dihydropyridine of the formula ##STR1## in which X is 1 or 2 identical or different substituents from the group consisting of nitro, chlorine and trifluoromethyl, or together ... | 08/22/1989 |
| 4859306 | Selectively ion-permeable dry electrodes for analyzing selected ions in aqueous solution The electrode comprises an internal reference half-cell at stable potential comprising a conductive sheet, e.g. of metal of carbon, covered by a redox system. The redox system comprises a thin dehydrated layer of Prussian blue deposited by contact between... | 08/22/1989 |
| 4855297 | Tricyclic pyridone derivatives The compounds of the formula ##STR1## wherein Ra,Rb,Rc Rd are defined in the specification and pharmaceutically acceptable addition salts are disclosed. The compounds of formula I have valuable pharmacological properties a... | 08/08/1989 |
| 4855538 | Measuring table for co-ordinate measuring system A digitizer comprising a measuring table having a substrate on which a grid is mounted, and a movable coil inductively coupled to the grid. When a time variable current is applied, a variable magnetic flux produces a measuring signal in the form of an ind... | 08/08/1989 |
| 4853156 | Process for the manufacture of quinone derivatives A novel process for the manufacture of quinone derivatives is described. In this process a compound of the formula ##STR1## is reacted with a compound of the formula ##STR2## and the resulting compound of the formula ##STR3## is subjected t... | 08/01/1989 |
| 4851519 | Pyrimidine derivatives Compounds of the formula ##STR1## wherein R1 is halogen, C1-4 -alkyl, halo-(C1-4 -alkyl) or C2-4 -alkanoyl, R2 is hydrogen, hydroxy, C1-4 alkoxy, C1-4 -alkylthio or phenyl-(... | 07/25/1989 |
| 4849347 | Colorimetric biological assay Lactic acid produced by cells in culture is detected and used in a bioassay to determine cell growth and vitality. Lactic acid is detected by coupling the lactate dehydrogenase conversion of lactic acid to pyruvic acid to a reaction using micotinamide ade... | 07/18/1989 |
| 4847273 | Dihydropyridine derivatives Dihydropyridine derivatives of the formula ##STR1## wherein the symbols R and R1 to R6 have the significance given in claim 1, have a pronounced calcium-antagonist activity and can accordingly be used as medicaments, especially ... | 07/11/1989 |
| 4844085 | Pulmonary pressure and volume measurement A method and a device for measuring mechanical property parameters of the pulmonary system of a patient which comprises; inflating and deflating the lung with a predetermined gas volume with a pump; measuring the pressure changes generated in the lung during i... | 07/04/1989 |
| 4834534 | Flow cell A flow cell for high performance chromatography, in which the measuring chamber is formed by a bore (12) in a plate (11) and the supply and discharge ducts are formed by bores (13, 14) in the plate (11) communicating with grooves (16, 18) in the plate sur... | 05/30/1989 |
| 4833774 | Method of making a cursor for an inductive sensor A transparent disk with a round periphery is produced, for example, by a grinding operation, and a mark is placed at the geometric center of the disk. A coil is then wound about the periphery of the disk. As a consequence, the mark at the geometric center... | 05/30/1989 |
| 4831130 | ଲ-lactam antibacterial agents Compounds of the formula ##STR1## wherein A is one of the following: ##STR2## in which R1, is acyl, R2 is hydrogen, lower alkyl, lower alkoxycarbonyl or aminocarbonyl, R3 is hydrogen or lower alkyl and R | 05/16/1989 |
| 4830470 | Liquid crystalline esters Compounds of the formula ##STR1## wherein m represents is the number 0 or 1; A is a single covalent bond, --CH2 --CH2 --, --OCH2 --, --COO-- or --OOC--; rings B, C and D are 1,4-phenylene optionally substituted with c... | 05/16/1989 |
| 4826773 | Method and reagent for the quantitative determination of phosphorous in serum and urine A reagent for determining quantitatively the amount of phosphorous in bodily fluids which comprises a surface active agent, a strong acid, ammonium molybdate, a heavy metal chelating compound, and anti-oxidant, and deionized water is described. A method o... | 05/02/1989 |
| 4826980 | Pyridazine intermediates Compounds of the formula ##STR1## wherein R1 is hydrogen, alkanoyl or aroyl; R2 is hydrogen or alkyl; R3 is hydrogen or aryl; R4 and R5 each are hydrogen or R4 and R5 taken ... | 05/02/1989 |
| 4820835 | Radiolabeled benzazepine A compound of the formula: ##STR1## wherein T is tritium; is described as well as intermediates for its preparation. The compound of formula I is useful in an assay for detecting the presence of benzodiazepine receptor occupiers in a warmblooded anim... | 04/11/1989 |
| 4820734 | Phenethylamine derivatives The novel phenethylamine derivatives of the general formula ##STR1## wherein R1 and R2 each signify hydrogen, halogen, trifluoromethyl, lower alkoxy, lower alkyl, hydroxy or nitro, with the proviso that at least one of R1 | 04/11/1989 |
| 4816582 | Antimicrobial 2-oxo-1-azetidinesulphonic acids Antimicrobial 2-oxo-1-azetidinesulphonic acids of the formula ##STR1## in which H2 N ##STR2## represents an amino-substituted thiazolyl group, R1 is lower alkyl which is substituted by carbamoyl, lower alkylsuphonyl, azido,... | 03/28/1989 |
| 4816581 | 4-(phenylthio or phenylsulfonyl) azetidinones and process of manufacture The novel compounds of the formula ##STR1## wherein R11 signifies hydrogen, acyl or tri(lower alkyl)silyl, R2 signifies a phenyl group which is substituted in the o- and/or the p-position by halogen, lower alkyl, lower alkylthio... | 03/28/1989 |
| 4816476 | Heterocyclic rodenticidal compounds, compositions containing the compounds, and methods of use Heterocyclic compounds of the formula ##STR1## wherein X is --CH.dbd.CH--, --O-- or --S--; R1 is a group Ar--R2 or --CH.dbd.CH--C(CH3).dbd.CH--R21 ; Ar is phenyl, pyridyl, furyl or thienyl; R2 is... | 03/28/1989 |
| 4814332 | Antimicrobial 1,3-disubstituted/imidazolium salts The imidazolium compounds of the formula ##STR1## wherein the various substituents are defined hereinbelow and their pharmaceutically acceptable acid addition salts, which possess valuable pharmacological properties are described. In particular, they... | 03/21/1989 |
| 4808736 | Process for the preparation of hydroquinone derivatives and d--tocopherol In this process of the invention a compound of the formula ##STR1## wherein R is a leaving group, is reacted with a compound of the formula ##STR2## wherein R1 is an ether protecting group, and, if desired a thus-obtained compound of ... | 02/28/1989 |
| 4808727 | Imidazolium hydrogen carbonates The pharmaceutically acceptable salts corresponding to the imidazolium hydrogen carbonates of the formula ##STR1## wherein the symbol Q is arylene or heteroarylene, the group --NR1 R2 is a basic amino group, R3 is hyd... | 02/28/1989 |
| 4808713 | Anthypertensive pyridazo [1,2-a][1,2]diazepines Novel compounds of the formula ##STR1## wherein B represents a methylene, ethylene or vinylene group, R1 represents a hydrogen atom or an alkyl, aralkyl, amino-alkyl, mono-alkylamino-alkyl, dialkylamino-alkyl, acylamino-alkyl, phthali... | 02/28/1989 |
| 4808631 | Aromatic acid derivatives Use of compounds of the formula ##STR1## wherein R1, R2, R3, R4 and R5, independently are hydrogen, alkyl, or C3-7 -cycloalkyl or two adjacent residues R1 to R5 t... | 02/28/1989 |
| 4808605 | Tetrahydronaphthalene derivatives as calcium antagonists Compounds of the formula ##STR1## wherein R is lower-alkyl, R1 is halogen, R2 is C1 -C12 -alkyl, R3 is hydroxy, lower-alkoxy, lower-alkyl-carbonyloxy, lower-alkoxy-lower-alkylcarbonoyloxy, lower-... | 02/28/1989 |
| 4808580 | Naphtho[1,2-b][1,4]thiazepin-4(5H)-ones and use thereof in treatment of ischemia and blood pressure lowering Compounds of the formula: ##STR1## wherein R1 is phenyl substituted with 1 to 3 substituents selected from the group consisting of lower alkoxy and halogen; R2 is hydroxy, lower alkoxy, lower alkanoyloxy, lower cycloalkylcarbony... | 02/28/1989 |
| 4808630 | Method of treating psychotic illnesses This invention is directed towards methods for treating patients having a psychotic illness such as schizophrenia and/or inhibiting the occurrence of movement disorders in patients receiving or having received a neuroleptic medication by administering to ... | 02/28/1989 |
| 4805821 | Automatic ampule opener An ampule opener is provided for automatically opening ampules. The ampule opener is especially suitable for use in a robotic sterility test system and is provided with a pneumatic actuator means releasably connected to an ampule opener arm. The head of a... | 02/21/1989 |
