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| Number | Title | Issue Date |
| 7138406 | Modulators of the glucocorticoid receptor The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R1–R25 are as described in the speci... | 11/21/2006 |
| 7045653 | Pharmaceuticals The invention relates to NEP inhibitors for treating cardiovascular disorders. Preferred NEP inhibitors are compounds of formula (I) wherein R1 is C1–C6alkyl, C1–C6alkoxyC1–C3alkyl or... | 05/16/2006 |
| 6916805 | Quinoxalinones as serine protease inhibitors This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically acceptable co... | 07/12/2005 |
| 6875780 | Compounds that modulate PPAR activity and methods for their preparation This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic... | 04/05/2005 |
| 6861555 | Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith Alcohol and water solvates of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt are crystalline and have the formula (I), wherein R1 is H or lower alkyl, and x is a number from 0 to 10, and are useful for treating dyslipidemia. | 03/01/2005 |
| 6855726 | Quinolones as serine protease inhibitors The invention discloses quinolinones which display inhibitory effects on serine proteases such as factor Xa, thrombin and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically acceptable compos... | 02/15/2005 |
| 6800680 | Hot-melt adhesive composition comprising acidic polymer and basic polymer blends A hot-melt adhesive composition comprises a blend of at least one acidic polymer and at least one basic polymer. At least one of the polymers is a hot-melt adhesive. Thermally reversible crosslinks are formed between each of the two polymers. These crosslinks impart... | 10/05/2004 |
| 6773896 | Method for direct measurement of coagulation factor VIIa activity in plasma The present invention generally provides a method of measuring the biological activity of Coagulation Factor VIIa (Factor VIIa). Specifically, the present invention provides a method for directly measuring the activity of Factor VIIa in a plasma sample. More specifi... | 08/10/2004 |
| 6740648 | Treatment of pulmonary hypertension Disclosed is a method for treating pulmonary hypertension using a vasopressin antagonist. ... | 05/25/2004 |
| 6620835 | Method of inhibiting matrix metalloproteinases The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I ##STR1## More particularly, the present invention relates to a method of treating dis... | 09/16/2003 |
| 6545150 | Certain benzothiazine dioxide endothelin antagonists and processes for their preparation The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 ##STR1## The compounds are... | 04/08/2003 |
| 6528528 | Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis The present invention provides compounds of Formula I shown below. ##STR1## The present invention also provides methods of treating or preventing 3 inflammation or atherosclerosis, and a pharmaceutical composition that contains a compound of Formula I.... | 03/04/2003 |
