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| Number | Title | Issue Date |
| 8173805 | sEH inhibitors and their use The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R4, R5, R... | 05/08/2012 |
| 8101775 | Indole derivatives as S1P1 Receptor The invention relates to compounds of formula (I) wherein one of R5 and R6 is hydrogen or R2 and the other is (a) pharmace... | 01/24/2012 |
| 7994317 | sEH inhibitors and their use The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. ... | 08/09/2011 |
| 7935832 | Pyrrole and isoindole carboxamide derivatives as P2X7 modulators The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein: R2 represents hydrogen, halogen, C1-6 alkyl, C6-10 arylmethyl-, C2-6 | 05/03/2011 |
| 7592352 | Substituted thieno and furo-pyridines This invention relates to newly identified compounds for treating and preventing tumors and cancers, and methods for treating proliferative diseases associated with the imbalance or inappropriate activity of tyrosine kinases implicated in proliferative diseases.... | 09/22/2009 |
| 7582630 | Pyradazine compounds as GSK-3 inhibitors The present invention relates to pyrazaolpyradazine derivatives that inhibit GSK3 (glycogen synthase kinase), pharmaceutical compositions containing these derivatives, and methods for their use in the treatment of disorder characterized by misregulation of GSK3.... | 09/01/2009 |
| 7560467 | Indazolo-tetrahydropyrimidine-carboxamide derivative kinase inhibitors The present invention relates to indazolo-tetrahydropyrimidine-carboxamide derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such indazolo-tetrahydropyrimi... | 07/14/2009 |
| 7507834 | Substituted anilinopyrazoles The present invention relates to anilinopyrazole derivatives, methods for the preparation of such anilinopyrazoles, and use of such anilinopyrazoles in the treatment of certain diseases or conditions. In particular, the present invention relates to a nilinopyrazole ... | 03/24/2009 |
| 7501512 | Chemical compounds This invention relates to newly identified inhibitors of kinases for treating various disorders. ... | 03/10/2009 |
| 7482455 | Chemical compounds 3-carboxy quinoline derivatives, which are useful as YAK3 inhibitors are described herein. The described invention also includes methods of making such 3-carboxy quinoline derivatives as well as methods of using the same in the treatment of diseases mediated by inap... | 01/27/2009 |
| 7459454 | Aminopyrazine derivatives and compositions The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medcicaments. Such aminopyrazine derivatives are useful in the treatmen... | 12/02/2008 |
| 7459455 | Pyrimidine compounds Pyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases... | 12/02/2008 |
| 7449484 | Compounds The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred. ... | 11/11/2008 |
| 7427623 | 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatmen... | 09/23/2008 |
| 7402606 | Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle ... | 07/22/2008 |
| 7338966 | Substituted oxindole derivatives as tyrosine kinase inhibitors The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alt... | 03/04/2008 |
| 7338959 | Diamino-pyrimidines and their use as angiogenesis inhibitors Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative di... | 03/04/2008 |
| 7329678 | Chemical compounds Benzimidazolyl-pyridine derivatives, which are useful as SGK-1 inhibitors are described herein. The described invention also includes methods of making such benzimidazolyl-pyridine derivatives as well as methods of using the same in the treatment of diseases mediate... | 02/12/2008 |
| 7307097 | Chemical compounds Pyrazole derivatives are described herein. The described invention also includes methods of making such pyrazole derivatives as well as methods of using the same in the treatment of diseases. ... | 12/11/2007 |
| 7300952 | NF-κb inhibitors The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-κB in ... | 11/27/2007 |
| 7288541 | Propylcarbamate derivatives as inhibitors of serine and cysteine proteases The present invention includes ketone derivatives (I) and (II), which are useful as cathepsin K inhibitors. The described invention also includes methods of making such ketone derivatives as well as methods of using the same in the treatment of disorders, including ... | 10/30/2007 |
| 7282512 | Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, inclu... | 10/16/2007 |
| 7279473 | Pyrazolopyridazine derivatives Fused pyradazine derivatives which are usefule as CDK inhibitors are described herein. The described invention alos includes methods of making such fused pyradazine derivatives as wells as methods of using the same in the treatment of hyperproliferative diseases. | 10/09/2007 |
| 7276523 | Aminopyridine derivatives as estrogen receptor modulators Aminopyridine derivatives of the following formula I which exhibit pharmacological activity at estrogen receptors alpha (ERα) and beta (ERβ) are described herein. The described invention also includes compositions and medicaments containing the aminopyridine deriv... | 10/02/2007 |
| 7265123 | Heterocyclic compounds Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein... | 09/04/2007 |
| 7238813 | Chemical compounds Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative dis... | 07/03/2007 |
| 7217710 | Substituted pyrazolopyrimidines Pyrazolo-pyrimidine derivatives are described herein. The described invention also includes methods of making such derivatives as well as methods of using the same in the treatment of diseases. ... | 05/15/2007 |
| 7189712 | 1,3-Oxazole compounds for the treatment of cancer Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases. | 03/13/2007 |
| 7189734 | Anilinoquinazaolines as protein tyrosine kianse inhibitors Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein... | 03/13/2007 |
| 7179836 | Chemical compounds Thiophene derivatives are described herein. The described invention also includes methods of making such thiophene derivatives as well as methods of using the same in the treatment of diseases. ... | 02/20/2007 |
| 7166639 | NF-κB inhibitors The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-κB in ... | 01/23/2007 |
| 7157466 | Quinazoline ditosylate salt compounds Ditosylate salts of 4-quinazolineamines are described as well as methods of using the same in the treatment of disorde4rs characterized by aberrant erbB family PTK activity. ... | 01/02/2007 |
| 7141576 | Cancer treatment method A method of treating cancer is described including administration of a 4-quinazolineamine and at least one other anti-neoplastic agent as well as pharmaceutical combinations and compositions containing the same. ... | 11/28/2006 |
| 7119096 | Uracil reductase inactivators Uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro-5-substituted uracil, potentiate 5-flourouracil and find use particularly in the treatment of cancer. The 5-substituent is selected from bromo, ido, cyano, halo-substituted C1-4 ... | 10/10/2006 |
| 7109333 | Heterocyclic compounds A process for the preparation of a compound of formula (I) comprising the steps: (a) reacting a compound of formula (II) ... | 09/19/2006 |
| 7084147 | Anilinoquinazaolines as protein tyrosine kinase inhibitors Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein... | 08/01/2006 |
| 7071217 | Substituted oxindole derivatives as tyrosine kinase inhibitors The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alt... | 07/04/2006 |
| 7015231 | Chemical compounds The present invention is related to aza-oxindole derivatives, compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mi... | 03/21/2006 |
| 6964977 | Oxindole derivatives The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alt... | 11/15/2005 |
| 6943162 | Piperazinyltriazines as estrogen receptor modulators Triazine derivatives of formula (I), which exhibit pharmacological activity at estrogen receptors alpha (ER alpha) and beta (ER beta) are described herein. The described invention also includes compositions and medicaments containing the triazine derivatives as well... | 09/13/2005 |
