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| Number | Title | Issue Date |
| 8173657 | Imidazoquinoxaline compounds as immunomodulators The invention provides novel compositions comprising imidazoquinoxaline compounds of formula (I) and analogs thereof. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are... | 05/08/2012 |
| 8173137 | Polycistronic HIV vector constructs The present disclosure relates to vectors comprising polynucleotide sequences that encode HIV polypeptides. In particular, the disclosure relates polycistronic vector constructs comprising sequences that encode HIV polypeptides as a single polyprotein. Compositions ... | 05/08/2012 |
| 8168418 | Expression of HIV polypeptides and production of virus-like particles The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as... | 05/01/2012 |
| 8168194 | Fusion proteins comprising CD4 minimal modules and human immunodeficiency virus (HIV) Tat scaffold polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of these hybrid molecules with Env as well as methods of diagnosis, treatme... | 05/01/2012 |
| 8165823 | Pamps, pathogen associated molecular patterns A method for identifying a polypeptide which acts as an adjuvant in a host organism. The invention further provides adjuvant compositions comprising said polypeptides and optionally further comprising an antigen. ... | 04/24/2012 |
| 8163296 | Dimensional analysis of saccharide conjugates with GPC and SEC-MALS GPC (gel permeation chromatography) and size exclusion chromatography with detection by multi-angle light scattering photometry (SEC-MALS) can be used to accurately measure molecular size and molar mass, respectively, of saccharide conjugates. The invention provides... | 04/24/2012 |
| 8158418 | Chimeric alphavirus replicon particles Chimeric alphaviruses and alphavirus replicon particles are provided, including methods of making and using same. Specifically, alphavirus particles are provided having nucleic acid molecules derived from one or more alphaviruses and structural proteins (capsid and/... | 04/17/2012 |
| 8142793 | Norovirus and Sapovirus antigens Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strain... | 03/27/2012 |
| 8137680 | Analysis of saccharide vaccines without interference The invention is based on methods that allow analysis of mixed meningococcal saccharides from multiple serogroups even though they share monosaccharide units. With a combination of saccharides from serogroups C, W135 and Y, the invention analyses sialic acid, glucos... | 03/20/2012 |
| 8133494 | Expression cassettes endcoding HIV-1 south african subtype C modified ENV proteins with deletions in V1 and V2 The invention relates to polynucleotides encoding modified immunogenic HIV-1 South African subtype C Env polypeptides. The modifications to the Env polypeptides include deletions of V1, V2 and the stem region. The expression cassettes may be used, for example, to ex... | 03/13/2012 |
| 8124104 | Norovirus and sapovirus antigens Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strain... | 02/28/2012 |
| 8119145 | Methods for producing norovirus VLPS Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strain... | 02/21/2012 |
| 8097243 | Microparticle-based transfection and activation of dendritic cells The present invention provides an effective method for the transfection of dendritic cells by non-viral methods. The present invention provides this benefit by incubating dendritic cells and a specified transfection agent. The transfection agent comprises a polynucl... | 01/17/2012 |
| 8063063 | Immunopotentiating compounds The invention provides novel compositions comprising Imidazopyridine compounds. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of adm... | 11/22/2011 |
| 8034378 | Immunogenic compositions containing phospholipid Immunogenic compositions containing phospholipid adjuvants, including microparticle and emulsion compositions. According to one aspect of the invention, an immunogenic microparticle composition is provided that comprises: water; a polymer microparticle comprising a ... | 10/11/2011 |
| 8021834 | Use of microparticles combined with submicron oil-in-water emulsions Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submi... | 09/20/2011 |
| 8007807 | Multiple vaccination including serogroup C meningococcus Various improvements to vaccines that include a serogroup C meningococcal conjugate antigen, including: (a) co-administration with acellular B. pertussis antigen; (b) co-administration with an inactivated poliovirus antigen; (c) supply in a kit together with ... | 08/30/2011 |
| 7994283 | Dimeric proteins for immunization A dimeric protein comprising a first fusion protein and a second fusion protein, wherein the first fusion protein comprises a targeting domain, a leucine zipper domain, and an antigen; and wherein the second fusion protein comprises a targeting domain, a leucine zip... | 08/09/2011 |
| 7977091 | Eukaryotic layered vector initiation systems The present disclosure provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems. ... | 07/12/2011 |
| 7943375 | Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof The present invention relates to polynucleotides encoding immunogenic HIV type C Gag- and/or Env-containing polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of Gag- and/or Env-co... | 05/17/2011 |
| 7935805 | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof The present invention relates to polynucleotides encoding immunogenic HIV type C Pol, Gag- and/or Env-containing polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of Pol, Gag- and... | 05/03/2011 |
| 7915218 | Polypeptides for oligomeric assembly of antigens A system for expressing antigenic polypeptides in oligomeric form fuses the antigenic polypeptide to an oligomerisation polypeptide such that the oligomerisation polypeptide can interact with other oligomerisation polypeptides and bring multiple copies of the antige... | 03/29/2011 |
| 7893096 | Use of small molecule compounds for immunopotentiation The invention provides immunostimulatory compositions comprising a small molecule immuno-poteniator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune respons... | 02/22/2011 |
| 7883709 | Stabilised compositions This invention relates to the stabilization of a bacterial ADP-ribosylating exotoxin class protein (bARE), a method for analysing a bARE class protein, a method for the stabilization of the bARE class bacterial protein, compositions comprising a stabilized bARE prot... | 02/08/2011 |
| 7846687 | Cytomegalovirus Intron A fragments Cytomegalovirus (CMV) Intron A fragments for expressing gene products are disclosed. Also described are expression vectors including the fragments, as well as methods of using the same. ... | 12/07/2010 |
| 7846479 | Microparticle compositions and methods for the manufacture thereof Microparticles with adsorbed complexes of macromolecule and detergent, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a p... | 12/07/2010 |
| 7872114 | Immunogenic detoxified mutants of cholera toxin An immunogenic detoxified protein comprising the amino acid sequence of subunit A of a cholera toxin (CT-A) or a fragment thereof or the amino acid sequence of subunit A of an Escherichia coli heat labile toxin (LT-A) or a fragment thereof wherein the amino a... | 01/18/2011 |
| 7867498 | Polypeptide carrier protein The invention relates to polypeptide carrier proteins that comprise at least five CD4+ T cell epitopes, for conjugation to capsular polysaccharides. The carrier proteins are useful as components of vaccines that can elicit a T-cell dependent immune response. These v... | 01/11/2011 |
| 7833803 | Analysis of liquid chromatography eluates When analysing saccharides by HPAEC, the eluate from the column is typically analysed using a amperometric detector. According to the invention, amperometric detection is coupled with ultraviolet detection, with both methods being applied to the eluate. Thus the inv... | 11/16/2010 |
| 7811812 | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of v... | 10/12/2010 |
| 7811580 | Chimeric HIV Env proteins comprising CD4 mini-proteins or CD4 mimetics that are capable of inducing neutralizing antibody responses against cryptic Env epitopes Env-CD4 complexes and hybrids are disclosed that expose cryptic epitopes that are important in virus neutralization. Methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided. ... | 10/12/2010 |
| 7803583 | Measuring degree of polymerisation for meningococcal capsular saccharides that contain sialic acid The degree of polymerisation (DP) is an important parameter for analysis of saccharide antigens, particularly in glycoconjugates. The invention provides methods that can be used to measure DP for capsular saccharides, particularly for meningococcal saccharides e.g. ... | 09/28/2010 |
| 7803387 | Heterologous expression of Neisserial proteins Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/... | 09/28/2010 |
| 7771979 | Compositions and methods for generating an immune response utilizing alphavirus-based vector systems Methods are provided for generating immune responses utilizing alphavirus-based vector systems. ... | 08/10/2010 |
| 7763589 | Compositions and methods for treating intracellular diseases The present invention provides methods of treating intracellular infections comprising the step of administering a vector construct which directs the expression of at least one immunogenic portion of an antigen derived from an intracellular pathogen, and also admini... | 07/27/2010 |
| 7754218 | Vaccines comprising aluminum adjuvants and histidine To improve the stability of vaccines comprising aluminum salt(s), the invention uses the amino acid histidine. This can improve pH stability and adjuvant adsorption and can reduce antigen hydrolysis. Histidine is preferably present during adsorption to the aluminum ... | 07/13/2010 |
| 7744900 | Enhancement of the immune response for vaccine and gene therapy applications Expression cassettes are provided comprising a promoter operably linked to a nucleic acid molecule which, when transcribed in vivo, forms double-stranded RNA that induces the production of interferon. Expression cassettes also are provided comprising a promoter oper... | 06/29/2010 |
| 7731967 | Compositions for inducing immune responses The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an i... | 06/08/2010 |
| 7718401 | Expression of HIV polypeptides and production of virus-like particles The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as... | 05/18/2010 |
| 7714121 | Meningococcal antigens The invention provides proteins from Neisseria meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions... | 05/11/2010 |
