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| Number | Title | Issue Date |
| 6303374 | Antisense modulation of caspase 3 expression Antisense compounds, compositions and methods are provided for modulating the expression of caspase 3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding caspase 3. Methods of using t... | 10/16/2001 |
| 6238921 | Antisense oligonucleotide modulation of human mdm2 expression Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expr... | 05/29/2001 |
| 6235527 | Lineage restricted glial precursors from the central nervous system A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM- glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bear... | 05/22/2001 |
| 6235723 | Antisense oligonucleotide modulation of human protein kinase C-δ expression Compositions and methods are provided for modulating the expression of PKC-δ and for the treatment and diagnosis of diseases associated with protein kinase C-δ. Methods of treating animals suffering from disease amenable to therapeutic intervention by m... | 05/22/2001 |
| 6221850 | Antisense oligonucleotide compositions and methods for the modulation of JNK proteins Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are s... | 04/24/2001 |
| 6214986 | Antisense modulation of bcl-x expression Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x ex... | 04/10/2001 |
| 6210892 | Alteration of cellular behavior by antisense modulation of mRNA processing The present invention provides compositions and methods for controlling the behavior of a cell, tissue or organism through antisense modulation of mRNA processing, using antisense compounds which does not support cleavage of the mRNA target.... | 04/03/2001 |
| 6204055 | Antisense inhibition of Fas mediated signaling Compounds, compositions and methods are provided for inhibiting Fas mediated signaling. The compositions comprise antisense compounds targeted to nucleic acids encoding Fas, FasL and Fap-1. Methods of using these antisense compounds for inhibition of Fas,... | 03/20/2001 |
| 6204028 | Methods for identifying antiviral agents against human herpesviruses A method of screening compounds for antiviral activity against a selected human herpesvirus by measuring inhibition of DNA synthesis by DNA polymerase and processivity factor of the selected human herpesvirus in the presence of the compound is provided.... | 03/20/2001 |
| 6200807 | Antisense inhibition of SHP-2 expression Antisense compounds, compositions and methods are provided for modulating the expression of SHP-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding SHP-2. Methods of using these com... | 03/13/2001 |
| 6197584 | Antisense modulation of CD40 expression Antisense compounds, compositions and methods are provided for modulating the expression of CD40. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD40. Methods of using these compo... | 03/06/2001 |
| 6198017 | Medical pressure-sensitive adhesives with high permeability to water vapor and high adhesive force, and plasters provided therewith Medicinal pressure-sensitive adhesives, adhering to both dry and wet skin, characterized by a mixture of a) 20-50 wt-% of a hydrophilic (meth)acrylate copolymerizate containing tertiary amino groups, b) 20-50 wt-% of a hydrophobic (meth)acrylate copolymerizate... | 03/06/2001 |
| 6190872 | Method for identifying and monitoring patients at risk for systemic inflammatory conditions and apparatus for use in this method A method of identifying and monitoring patients at risk for developing a systemic inflammatory condition prior to development of signs and symptoms using a systemic mediator-associated physiologic test profile is provided.... | 02/20/2001 |
| 6190869 | Antisense inhibition of protein kinase C-theta expression Antisense compounds, compositions and methods are provided for modulating the expression of Protein kinase C-theta. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Protein kinase C... | 02/20/2001 |
| 6187587 | Antisense inhibition of e2f transcription factor 1 expression Antisense compounds, compositions and methods are provided for modulating the expression of E2F transcription factor 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding E2F transcri... | 02/13/2001 |
| 6187586 | Antisense modulation of AKT-3 expression Antisense compounds, compositions and methods are provided for modulating the expression of Akt-3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Akt-3. Methods of using these com... | 02/13/2001 |
| 6187545 | Antisense modulation of pepck-cytosolic expression Antisense compounds, compositions and methods are provided for modulating the expression of PEPCK-cytosolic. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PEPCK-cytosolic. Method... | 02/13/2001 |
| 6187787 | Bis(9-aminoacridine) DNA intercalating agents having antitumor activity A series of bis-acridinyl DNA intercalating agents with anticancer cell activity represented by formula (I), where Z is a linear arrangement of multiple aromatic rings, containing at least three aromatic rings, or at least two alicyclic rings, said rings ... | 02/13/2001 |
| 6187542 | Methods for the identification of patients at risk for heart failure A method of predicting the clinical outcome of patients suffering from congestive heart failure by identifying patients with a mutant allele of the AMPD1 gene is provided. Methods for increasing survival time in patients suffering from congestive heart fa... | 02/13/2001 |
| 6184034 | Deoxyribonuclease II proteins and cDNAS The present invention provides cDNAs encoding deoxyribonuclease II and isolated, purified deoxyribonuclease II proteins. Antibodies against this protein and antisense agents targeted to a cDNA or corresponding mRNA encoding deoxyribonuclease II are provid... | 02/06/2001 |
| 6183969 | Intron-based assay for detecting and characterizing chromosomal rearrangement An assay is provided for detecting and characterizing chromosomal rearrangements in eukaryotic cells by genetically engineering a eukaryotic cell to contain a selectable/counter-selectable marker gene with a site for generating a double strand break withi... | 02/06/2001 |
| 6184212 | Antisense modulation of human mdm2 expression Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions include antisense compounds targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression a... | 02/06/2001 |
| 6180353 | Antisense modulation of daxx expression Antisense compounds, compositions and methods are provided for modulating the expression of daxx. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding daxx. Methods of using these compo... | 01/30/2001 |
| 6180403 | Antisense inhibition of tumor necrosis factor alpha converting enzyme (TACE) expression Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor--converting enzyme (TACE). Antisense oligonucleotides targeted to nucleic acids encoding TACE are preferred. Methods of using these oligonucleotides ... | 01/30/2001 |
| 6177273 | Antisense modulation of integrin-linked kinase expression Antisense compounds, compositions and methods are provided for modulating the expression of Integrin-linked kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Integrin-linked ... | 01/23/2001 |
| 6177257 | Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibi... | 01/23/2001 |
| 6174868 | Compositions and methods for treatment of hepatitis C virus-associated diseases Antisense oligonucleotides are provided which are complementary to and hybridizable with at least a portion of HCV RNA and which are capable of inhibiting the function of the HCV RNA. These oligonucleotides can be administered to inhibit the activity of H... | 01/16/2001 |
| 6174870 | Antisense oligonucleotide inhibition of papillomavirus Oligonucleotides and oligonucleotide analogs are provided which are capable of antisense interaction with messenger RNA of papillomavirus. Such oligonucleotides or oligonucleotide analogs can be used for diagnostics and therapeutics as well as for researc... | 01/16/2001 |
| 6174684 | CYP3A4 NFSE variant and methods of use therefore A nucleic acid sequence encoding a variant CYP3A4 gene is provided. Also provided are methods and kits for identifying individuals carrying a variant CYP3A4 gene with a heightened risk of developing or having prostate cancer or a decreased risk for develo... | 01/16/2001 |
| 6172216 | Antisense modulation of BCL-X expression Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x ex... | 01/09/2001 |
| 6171860 | Antisense inhibition of rank expression Antisense compounds, compositions and methods are provided for inhibiting the expression of RANK. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding RANK. Methods of using these compo... | 01/09/2001 |
| 6169079 | Oligonucleotide inhibition of cell adhesion Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are p... | 01/02/2001 |
| 6168950 | Antisense modulation of MEKK1 expression Antisense compounds, compositions and methods are provided for modulating the expression of MEKK1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK1. Methods of using these com... | 01/02/2001 |
| 6165791 | Antisense inhibition of E2F transcription factor 3 expression Antisense compounds, compositions and methods are provided for modulating the expression of E2F transcription factor 3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding E2F transcri... | 12/26/2000 |
| 6165790 | Antisense modulation of PI3 kinase p55 gamma expression Antisense compounds, compositions and methods are provided for inhibiting the expression of PI3 kinase p55 gamma. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PI3 kinase p55 gam... | 12/26/2000 |
| 6165789 | Antisense modulation of hnRNP A1 expression Antisense compounds, compositions and methods are provided for modulating the expression of hnRNP A1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding hnRNP A1. Methods of using the... | 12/26/2000 |
| 6165788 | Antisense modulation of Survivin expression Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using the... | 12/26/2000 |
| 6165786 | Antisense modulation of nucleolin expression Antisense compounds, compositions and methods are provided for inhibiting the expression of Nucleolin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Nucleolin. Methods of using t... | 12/26/2000 |
| 6165728 | Antisense modulation of NCK-2 expression Antisense compounds, compositions and methods are provided for modulating the expression of nck-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding nck-2. Methods of using these com... | 12/26/2000 |
| 6159734 | Antisense modulation of peroxisome proliferator-activated receptor gamma expression Antisense compounds, compositions and methods are provided for modulating the expression of Peroxisome proliferator-activated receptor gamma. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids... | 12/12/2000 |
