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| Number | Title | Issue Date |
| 6653072 | Methods and compositions for polypeptide engineering Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.... | 11/25/2003 |
| 6440722 | Microfluidic devices and methods for optimizing reactions Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, sys... | 08/27/2002 |
| 6406910 | Recombination of insertion modified nucleic acids Methods of modulating, tuning and improving hybridization properties and recombination properties of molecules for use in nucleic acid shuffling procedures, relates recombination mixtures and methods of modulating, tuning, improving and evolving splicing ... | 06/18/2002 |
| 6376246 | Oligonucleotide mediated nucleic acid recombination Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provide... | 04/23/2002 |
| 6373501 | Portable device comprising keypad and screen Portable electronic devices including housings in which input keypads are disposed above display screens and in which input keypads and/or display screens are optionally directly oriented for one-handed operation are provided. Devices including input keyp... | 04/16/2002 |
| 6368861 | Oligonucleotide mediated nucleic acid recombination Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provide... | 04/09/2002 |
| 6362008 | Generic signalling mechanism for detection of analytes A generic signaling assay method comprising an affinity matrix for the detection of low molecular weight compositions is provided. A test sample is mixed with a pre-determined amount of a substance conjugated to at least two molecules of the target analyt... | 03/26/2002 |
| 6358740 | Recombination of insertion modified nucleic acids Methods of modulating, tuning and improving hybridization properties and recombination properties of molecules for use in nucleic acid shuffling procedures, relates recombination mixtures and methods of modulating, tuning, improving and evolving splicing ... | 03/19/2002 |
| 6355484 | Methods and compositions for polypeptides engineering Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.... | 03/12/2002 |
| 6352859 | Evolution of whole cells and organisms by recursive sequence recombination The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome ... | 03/05/2002 |
| 6337186 | Method for producing polynucleotides with desired properties The invention provides methods for the production of polynucleotides with a desired property (e.g., conferring a desired phenotype and/or encoding polypeptide with a desired property) which is selectable or can be screened for. The method includes making ... | 01/08/2002 |
| 6335167 | Comparative genomic hybridization (CGH) Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substant... | 01/01/2002 |
| 6335160 | Methods and compositions for polypeptide engineering Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.... | 01/01/2002 |
| 6326204 | Evolution of whole cells and organisms by recursive sequence recombination The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome ... | 12/04/2001 |
| 6326083 | Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety Hydrophilic protein adsorption resistant coatings for microfluidic devices are provided. Additionally, microfluidic devices and methods of manufacturing microfluidic devices that include the coatings are provided.... | 12/04/2001 |
| 6319714 | Oligonucleotide mediated nucleic acid recombination Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provide... | 11/20/2001 |
| 6309883 | Methods and compositions for cellular and metabolic engineering The present invention is generally directed to the evolution of new metabolic pathways and the enhancement of bioprocessing through a process herein termed recursive sequence recombination. Recursive sequence recombination entails performing iterative cyc... | 10/30/2001 |
| 6306659 | High throughput screening assay systems in microscale fluidic devices An apparatus for analyzing a plurality of compounds is used in conjunction with microfluidic devices for performing high throughput screening assays. A conveyor system delivers libraries of compounds to a microfluidic device which accesses the compounds i... | 10/23/2001 |
| 6303343 | Inefficient fast PCR Methods of performing fast polymerase mediated reactions are provided. These reactions can be used in an inefficient fashion in the cycles of the polymerase mediated reactions to produce product at a much faster rate than conventional polymerase mediated ... | 10/16/2001 |
| 6274337 | High throughput screening assay systems in microscale fluidic devices The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for... | 08/14/2001 |
| 6267858 | High throughput screening assay systems in microscale fluidic devices The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for... | 07/31/2001 |
| 6265716 | Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry A sample preparation method is disclosed for volatilization and mass spectrometric analysis of nonvolatile high molecular weight molecules. Photoabsorbing molecules having significant sublimation rates at room temperature under vacuum, and preferably cont... | 07/24/2001 |
| 6238538 | Controlled fluid transport in microfabricated polymeric substrates Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low co... | 05/29/2001 |
| 6235471 | Closed-loop biochemical analyzers Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, sys... | 05/22/2001 |
| 6162967 | Positional cloning of soybean cyst nematode resistance genes A method for introgressing soybean cyst nematode resistance into elite soybean germplasm is disclosed. The method involves using genetically mapped loci associated with soybean cyst nematode resistance for marker-assisted selection during introgression of... | 12/19/2000 |
| 6156181 | Controlled fluid transport microfabricated polymeric substrates Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low co... | 12/05/2000 |
| 6090558 | DNA typing by mass spectrometry with polymorphic DNA repeat markers The present invention is related to the fields of genetic mapping and genetic identity detection, including forensic identification and paternity testing. This invention is more specifically directed to the use of mass spectrometry to detect length variat... | 07/18/2000 |
