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| Number | Title | Issue Date |
| 8173616 | RNA-induced translational silencing and cellular apoptosis The invention is directed to RNA molecules that can be used to inhibit protein synthesis and to induce cells to undergo apoptosis. It also includes pharmaceutical compositions containing the RNAs that can be used in treating or preventing tumors; abnormal dermatolog... | 05/08/2012 |
| 8153576 | Coated sodium percarbonate particles Sodium percarbonate particles with a coating layer which comprises from 70 to 99.8% by weight of anhydrous sodium sulfate and from 0.2 to 20% by weight of a sodium borate, and whose proportion by weight is from 1 to 10% based on the mass of the sodium percarbonate p... | 04/10/2012 |
| 7994110 | Solid redispersible emulsion The invention relates to a solid redispersible emulsion, which is comprised of an oil-in-water emulsion consisting of a laundry care constituent, which is encapsulated in an enclosure. This enclosure is stabilized by polyvalent metal ions and, initially, is water-in... | 08/09/2011 |
| 7935831 | Process for the preparation of 2-azabicyclo[3.3.0]octane-3-carboxylic Acid Derivatives The present invention is aimed at a process for the preparation of compounds of the general formula (I). The objective process is in this case based on the Michael reaction of compounds of the general formula (III) | 05/03/2011 |
| 7700311 | Alcohol dehydrogenases The invention relates to novel polypeptides which have the biological activity of an NAD- or NADP-dependent alcohol dehydrogenase. The invention furthermore relates to nucleic acids encoding said polypeptides, to nonhuman hosts or host cells and to reaction systems ... | 04/20/2010 |
| 7655431 | Compositions and methods based upon the kinase haspin The present invention is directed to methods for increasing or decreasing the phosphorylation of histone H3 using factors that alter the activity of the kinase haspin. The invention includes assays for identifying inhibitors, peptides that can serve as inhibitors or... | 02/02/2010 |
| 7632665 | Coupled cofactor-dependent enzymatic reaction systems in aqueous media The present application relates to a reaction system in which chemically valuable compounds can be obtained in high enantiomer concentrations with the aid of a coupled enzymatically operating transformation process. The coupled enzymatic reaction system comprises a ... | 12/15/2009 |
| 7612237 | Process for preparing β-amino-α-hydroxycarboxamides The present invention is directed to a process for preparing β-amino-α-hydroxycarboxamides. The process works with epoxycarboxamides of the formula 2 which are reacted with ammonia or other amines. ... | 11/03/2009 |
| 7604788 | Process for the conversion of polysulfanes The invention provides a process for the removal of polysulfanes from gas streams formed during H2S synthesis. ... | 10/20/2009 |
| 7588697 | Coated sodium percarbonate granules with improved storage stability The invention concerns coated sodium percarbonate granules comprising a core produced by fluidized bed spray granulation, containing sodium percarbonate as its main component, an inner coating layer containing an organic, hydrate-forming salt as its main component, ... | 09/15/2009 |
| 7553645 | Process for preparing L-amino acids using improved strains of the Enterobacteriaceae family The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family in which the ytfQ-ORF is overexpressed. ... | 06/30/2009 |
| 7534442 | Immunogenic compositions comprising covalently bound polysaccharides, antigen, and bacterial toxoid The present invention is directed to immunogenic conjugates comprised of a polymer, preferably a polysaccharide, with a covalently attached antigen and an agent for boosting a patient's immune response. The conjugates may be used in vaccines for a wide range of dise... | 05/19/2009 |
| 7531652 | Process for preparation of solid tris (2,3-dibromopropyl) isocyanurate The present invention is directed to a process for the isolation of tris(2,3-dibromopropyl)isocyanurate. The process uses an adsorbent which promotes easy conversion into a solid form of TDPI. The invention also includes to the solid TDPI product prepared in this wa... | 05/12/2009 |
| 7524657 | Alleles of the sigA gene from coryneform bacteria The invention relates to alleles of the sigA gene from coryneform bacteria which code for sigma factors A and a process for the fermentative preparation of L-lysine using bacteria which contain these alleles. ... | 04/28/2009 |
| 7518009 | Process for preparing mercaptoorganyl (alkoxysilanes) The present invention relates to a process for preparing mercaptoorganyl(alkoxysilanes), by hydrogenating bis(alkoxy-silylorganyl) polysulphides with hydrogen in the presence of at least one alcohol and a doped metal catalyst. The doped metal catalyst comprises at l... | 04/14/2009 |
| 7504542 | Preparation of α-hydroxy ketones via carbene-catalyzed umpolung reaction of aldehydes The present invention relates to the preparation of α-hydroxy ketones of the general formula I. In particular, the invention relates to novel imidazolinium carboxylate adducts and to a novel process for using catalytic amounts of imidazolium and imidazolinium carbo... | 03/17/2009 |
| 7491521 | Rhodococcus nitrile hydratase The invention relates to a Rhodococcus polynucleotide cluster which contains nucleotide sequences which encode polypeptides having the activity of a nitrile hydratase, of an auxiliary protein P15K which activates this enzyme and of a cobalt transporter... | 02/17/2009 |
| 7488481 | Polypeptides derived from anti-HIV-1 gp120 antibodies that abrogate gp120 binding to CCR5 The present invention is directed to peptides that are capable of blocking the entry of HIV-1 into host cells by means of the CCR5 receptor. The affinity of the peptides for gp120 on the HIV viral surface may be increased by sulfating tyrosine residues. In addition,... | 02/10/2009 |
| 7462221 | Process and device for the extraction of substances from silane-modified fillers Process for the extraction of substances from at least one silane-modified oxidic or silicatic filler, wherein at least one gas compressed by means of pressure and/or temperature is employed as the extraction agent and the compressed gas is led in the radial directi... | 12/09/2008 |
| 7435714 | Liquid detergent and cleaning agent composition comprising a multi-coated bleach particle The invention relates to liquid detergent and cleaning agent compositions of high storage stability. They comprise a liquid medium with a water content of up to 15 wt. % and particulate coating bleaching agents suspended therein. The bleaching agent has a dissolving... | 10/14/2008 |
| 7429567 | Sustained delivery of PDGF using self-assembling peptide nanofibers The present invention is directed to a therapeutic composition in which human PDGF is bound directly to peptides that self assemble into a biologically compatible gel. When implanted in a patient's body, the composition provides for the slow, sustained release of PD... | 09/30/2008 |
| 7402432 | Process for producing T lymphocytes The present invention is directed to an in vitro method for producing T lymphocytes. The method involves culturing bone marrow cells on a matrix seeded with keratinocytes and fibroblasts. ... | 07/22/2008 |
| 7384997 | Rubber mixtures The invention is directed to rubber mixtures comprising rubber, fillers, optionally further rubber auxiliaries and at least one organosilane of the general formula I: R1R2R3SiR4—SH (I) wherein: | 06/10/2008 |
| 7386349 | Rapid analgesia for skin puncture The present invention is directed to a device for providing transcutaneous electrical stimulation (TENS) to the finger of a patient at the same time that the finger is being punctured for the purpose of obtaining a blood sample. The device should reduce the pain ass... | 06/10/2008 |
| 7368600 | Method for production of methionine from homoserine The invention relates to a method for production of D- and/or L-methionine via D- and/or L-homoserine with subsequent chemical transformation to give methionine. ... | 05/06/2008 |
| 7364718 | Process for the production of hydrogen peroxide Hydrogen peroxide is produced by reacting hydrogen and oxygen in the presence of a noble metal catalyst in a liquid reaction medium, the reaction being performed in the presence of a sulfuric acid alkyl ester. In the presence of sulfuric acid alkyl esters the noble ... | 04/29/2008 |
| 7332183 | Multilayer dosage forms containing NSAIDs and triptans The present invention is directed to multilayer pharmaceutical tablets in which an NSAID and a triptan are present in separate and distinct layers. The layers are in a side-by-side configuration, which allows the dissolution of triptan and NSAID to occur independent... | 02/19/2008 |
| 7326393 | Process for the conversion of polysulfanes The invention provides a process for the removal of polysulfanes from gas streams formed during H2S synthesis. ... | 02/05/2008 |
| 7319026 | Amino acid-producing bacteria and a process for preparing L-amino acids The invention relates to amino acid-producing bacteria from the family Enterobacteriaceae, in particular from the species Escherichia coli, which contain a stop codon chosen from the group amber, ochre and opal in the nucleotide sequence for the coding region... | 01/15/2008 |
| 7306932 | Coryneform bacteria with altered glucokinase activity in the production of L-lysine The invention relates to alleles of the glk gene from coryneform bacteria coding for glucokinases, and to processes for the production of L-lysine by fermentation using bacteria containing such alleles. ... | 12/11/2007 |
| 7288383 | Eosinophil-derived neurotoxin as a marker for ovarian cancer The present invention is directed to methods of identifying women at increased risk of having ovarian cancer. Identification is based upon the extent to which biological samples derived from the women exhibit elevated levels of eosinophil-derived neurotoxin (EDN). | 10/30/2007 |
| 7271313 | Presenilin-deficient mouse model of age-dependent neurodegeneration and cognitive loss The present invention is directed to recombinantly engineered mice that are deficient in the expression of both presenilin-1 and presenilin-2. The mice exhibit characteristics of age-dependent cognitive impairments and neurodegeneration similar to those seen in Alzh... | 09/18/2007 |
| 7256021 | Enterobacteriaceae strains with an attenuated aspA gene for the fermentative production of amino acids The invention relates to a process for the preparation of L-amino acids, especially L-lysine, L-valine, L-homoserine and L-threonine, by fermenting a microorganism of the genus Escherichia which has a mutation or deletion in the gene encoding aspartate ammoni... | 08/14/2007 |
| 7255735 | Surface-modified silicon dioxide-titanium dioxide mixed oxides Pyrogenically prepared surface-modified silicon dioxide-titanium dioxide mixed oxides are prepared by spraying pyrogenically prepared silicon dioxide-titanium dioxide mixed oxides with a surface-modifying agent. The surface-modified pyrogenically prepared silicon di... | 08/14/2007 |
| 7247465 | Screening process for hydantoin racemases The present invention relates to a screening process for hydantoin racemases and to novel hydantoin racemases, to the nucleic acid sequences coding therefor and to a proces for mutagenesis. Hydantoin racemases are of interest in connection with the production... | 07/24/2007 |
| 7238335 | Process for the preparation of hydrogen peroxide by the anthraquinone cyclic process The invention concerns a process for the preparation of hydrogen peroxide by the anthraquinone cyclic process. The process includes a regeneration stage in which working solution is regenerated by being brought into contact with an aqueous solution containing an alk... | 07/03/2007 |
| 7229614 | Interferon gamma in the detection and treatment of angiomyolipomas The present invention is directed to methods of treating or preventing angiomyolipomas by administering interferon gamma. It also encompasses methods for assessing the risk of a patient developing angiomyolipomas based upon interferon gamma expression. ... | 06/12/2007 |
| 7229958 | Fragrance alcohol-releasing polysiloxane Organopolysiloxanes which contain a fragrance alcohol Y—OH bonded via a betaine ester group having the structure —N+R1R2—CH2—C(O)OY, cleave off the fragrance alcohol under acid conditions and are resistant to hydro... | 06/12/2007 |
| 7217544 | Method for the preparation of L-amino acids from D-amino acids The invention relates to recombinant microorganisms which, in comparison to the starting organism, have a higher concentration or activity of a D-amino acid oxidase, of an L-amino acid dehydrogenase, of an NADH cosubstrate regenerating enzyme and, if necessary, of a... | 05/15/2007 |
| 7214501 | Methods of detecting cancer based on osteopontin The present invention is directed to diagnostic methods based upon the expression of the protein prostasin. In particular, it is concerned with assays performed on women to determine their risk of ovarian cancer. ... | 05/08/2007 |