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Patent No. 5076029

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Attorney: Law Office of Michael A. Sanzo, LLC


Number of patents: 44
Last date: May 08, 2012

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NumberTitleIssue Date
8173616RNA-induced translational silencing and cellular apoptosis
The invention is directed to RNA molecules that can be used to inhibit protein synthesis and to induce cells to undergo apoptosis. It also includes pharmaceutical compositions containing the RNAs that can be used in treating or preventing tumors; abnormal dermatolog...
05/08/2012
8153576Coated sodium percarbonate particles
Sodium percarbonate particles with a coating layer which comprises from 70 to 99.8% by weight of anhydrous sodium sulfate and from 0.2 to 20% by weight of a sodium borate, and whose proportion by weight is from 1 to 10% based on the mass of the sodium percarbonate p...
04/10/2012
7994110Solid redispersible emulsion
The invention relates to a solid redispersible emulsion, which is comprised of an oil-in-water emulsion consisting of a laundry care constituent, which is encapsulated in an enclosure. This enclosure is stabilized by polyvalent metal ions and, initially, is water-in...
08/09/2011
7935831Process for the preparation of 2-azabicyclo[3.3.0]octane-3-carboxylic Acid Derivatives
The present invention is aimed at a process for the preparation of compounds of the general formula (I). The objective process is in this case based on the Michael reaction of compounds of the general formula (III)
05/03/2011
7700311Alcohol dehydrogenases
The invention relates to novel polypeptides which have the biological activity of an NAD- or NADP-dependent alcohol dehydrogenase. The invention furthermore relates to nucleic acids encoding said polypeptides, to nonhuman hosts or host cells and to reaction systems ...
04/20/2010
7655431Compositions and methods based upon the kinase haspin
The present invention is directed to methods for increasing or decreasing the phosphorylation of histone H3 using factors that alter the activity of the kinase haspin. The invention includes assays for identifying inhibitors, peptides that can serve as inhibitors or...
02/02/2010
7632665Coupled cofactor-dependent enzymatic reaction systems in aqueous media
The present application relates to a reaction system in which chemically valuable compounds can be obtained in high enantiomer concentrations with the aid of a coupled enzymatically operating transformation process. The coupled enzymatic reaction system comprises a ...
12/15/2009
7612237Process for preparing β-amino-α-hydroxycarboxamides
The present invention is directed to a process for preparing β-amino-α-hydroxycarboxamides. The process works with epoxycarboxamides of the formula 2 which are reacted with ammonia or other amines. ...
11/03/2009
7604788Process for the conversion of polysulfanes
The invention provides a process for the removal of polysulfanes from gas streams formed during H2S synthesis. ...
10/20/2009
7588697Coated sodium percarbonate granules with improved storage stability
The invention concerns coated sodium percarbonate granules comprising a core produced by fluidized bed spray granulation, containing sodium percarbonate as its main component, an inner coating layer containing an organic, hydrate-forming salt as its main component, ...
09/15/2009
7553645Process for preparing L-amino acids using improved strains of the Enterobacteriaceae family
The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family in which the ytfQ-ORF is overexpressed. ...
06/30/2009
7534442Immunogenic compositions comprising covalently bound polysaccharides, antigen, and bacterial toxoid
The present invention is directed to immunogenic conjugates comprised of a polymer, preferably a polysaccharide, with a covalently attached antigen and an agent for boosting a patient's immune response. The conjugates may be used in vaccines for a wide range of dise...
05/19/2009
7531652Process for preparation of solid tris (2,3-dibromopropyl) isocyanurate
The present invention is directed to a process for the isolation of tris(2,3-dibromopropyl)isocyanurate. The process uses an adsorbent which promotes easy conversion into a solid form of TDPI. The invention also includes to the solid TDPI product prepared in this wa...
05/12/2009
7524657Alleles of the sigA gene from coryneform bacteria
The invention relates to alleles of the sigA gene from coryneform bacteria which code for sigma factors A and a process for the fermentative preparation of L-lysine using bacteria which contain these alleles. ...
04/28/2009
7518009Process for preparing mercaptoorganyl (alkoxysilanes)
The present invention relates to a process for preparing mercaptoorganyl(alkoxysilanes), by hydrogenating bis(alkoxy-silylorganyl) polysulphides with hydrogen in the presence of at least one alcohol and a doped metal catalyst. The doped metal catalyst comprises at l...
04/14/2009
7504542Preparation of α-hydroxy ketones via carbene-catalyzed umpolung reaction of aldehydes
The present invention relates to the preparation of α-hydroxy ketones of the general formula I. In particular, the invention relates to novel imidazolinium carboxylate adducts and to a novel process for using catalytic amounts of imidazolium and imidazolinium carbo...
03/17/2009
7491521Rhodococcus nitrile hydratase
The invention relates to a Rhodococcus polynucleotide cluster which contains nucleotide sequences which encode polypeptides having the activity of a nitrile hydratase, of an auxiliary protein P15K which activates this enzyme and of a cobalt transporter...
02/17/2009
7488481Polypeptides derived from anti-HIV-1 gp120 antibodies that abrogate gp120 binding to CCR5
The present invention is directed to peptides that are capable of blocking the entry of HIV-1 into host cells by means of the CCR5 receptor. The affinity of the peptides for gp120 on the HIV viral surface may be increased by sulfating tyrosine residues. In addition,...
02/10/2009
7462221Process and device for the extraction of substances from silane-modified fillers
Process for the extraction of substances from at least one silane-modified oxidic or silicatic filler, wherein at least one gas compressed by means of pressure and/or temperature is employed as the extraction agent and the compressed gas is led in the radial directi...
12/09/2008
7435714Liquid detergent and cleaning agent composition comprising a multi-coated bleach particle
The invention relates to liquid detergent and cleaning agent compositions of high storage stability. They comprise a liquid medium with a water content of up to 15 wt. % and particulate coating bleaching agents suspended therein. The bleaching agent has a dissolving...
10/14/2008
7429567Sustained delivery of PDGF using self-assembling peptide nanofibers
The present invention is directed to a therapeutic composition in which human PDGF is bound directly to peptides that self assemble into a biologically compatible gel. When implanted in a patient's body, the composition provides for the slow, sustained release of PD...
09/30/2008
7402432Process for producing T lymphocytes
The present invention is directed to an in vitro method for producing T lymphocytes. The method involves culturing bone marrow cells on a matrix seeded with keratinocytes and fibroblasts. ...
07/22/2008
7384997Rubber mixtures
The invention is directed to rubber mixtures comprising rubber, fillers, optionally further rubber auxiliaries and at least one organosilane of the general formula I: R1R2R3SiR4—SH  (I) wherein:
06/10/2008
7386349Rapid analgesia for skin puncture
The present invention is directed to a device for providing transcutaneous electrical stimulation (TENS) to the finger of a patient at the same time that the finger is being punctured for the purpose of obtaining a blood sample. The device should reduce the pain ass...
06/10/2008
7368600Method for production of methionine from homoserine
The invention relates to a method for production of D- and/or L-methionine via D- and/or L-homoserine with subsequent chemical transformation to give methionine. ...
05/06/2008
7364718Process for the production of hydrogen peroxide
Hydrogen peroxide is produced by reacting hydrogen and oxygen in the presence of a noble metal catalyst in a liquid reaction medium, the reaction being performed in the presence of a sulfuric acid alkyl ester. In the presence of sulfuric acid alkyl esters the noble ...
04/29/2008
7332183Multilayer dosage forms containing NSAIDs and triptans
The present invention is directed to multilayer pharmaceutical tablets in which an NSAID and a triptan are present in separate and distinct layers. The layers are in a side-by-side configuration, which allows the dissolution of triptan and NSAID to occur independent...
02/19/2008
7326393Process for the conversion of polysulfanes
The invention provides a process for the removal of polysulfanes from gas streams formed during H2S synthesis. ...
02/05/2008
7319026Amino acid-producing bacteria and a process for preparing L-amino acids
The invention relates to amino acid-producing bacteria from the family Enterobacteriaceae, in particular from the species Escherichia coli, which contain a stop codon chosen from the group amber, ochre and opal in the nucleotide sequence for the coding region...
01/15/2008
7306932Coryneform bacteria with altered glucokinase activity in the production of L-lysine
The invention relates to alleles of the glk gene from coryneform bacteria coding for glucokinases, and to processes for the production of L-lysine by fermentation using bacteria containing such alleles. ...
12/11/2007
7288383Eosinophil-derived neurotoxin as a marker for ovarian cancer
The present invention is directed to methods of identifying women at increased risk of having ovarian cancer. Identification is based upon the extent to which biological samples derived from the women exhibit elevated levels of eosinophil-derived neurotoxin (EDN).
10/30/2007
7271313Presenilin-deficient mouse model of age-dependent neurodegeneration and cognitive loss
The present invention is directed to recombinantly engineered mice that are deficient in the expression of both presenilin-1 and presenilin-2. The mice exhibit characteristics of age-dependent cognitive impairments and neurodegeneration similar to those seen in Alzh...
09/18/2007
7256021Enterobacteriaceae strains with an attenuated aspA gene for the fermentative production of amino acids
The invention relates to a process for the preparation of L-amino acids, especially L-lysine, L-valine, L-homoserine and L-threonine, by fermenting a microorganism of the genus Escherichia which has a mutation or deletion in the gene encoding aspartate ammoni...
08/14/2007
7255735Surface-modified silicon dioxide-titanium dioxide mixed oxides
Pyrogenically prepared surface-modified silicon dioxide-titanium dioxide mixed oxides are prepared by spraying pyrogenically prepared silicon dioxide-titanium dioxide mixed oxides with a surface-modifying agent. The surface-modified pyrogenically prepared silicon di...
08/14/2007
7247465Screening process for hydantoin racemases
The present invention relates to a screening process for hydantoin racemases and to novel hydantoin racemases, to the nucleic acid sequences coding therefor and to a proces for mutagenesis. Hydantoin racemases are of interest in connection with the production...
07/24/2007
7238335Process for the preparation of hydrogen peroxide by the anthraquinone cyclic process
The invention concerns a process for the preparation of hydrogen peroxide by the anthraquinone cyclic process. The process includes a regeneration stage in which working solution is regenerated by being brought into contact with an aqueous solution containing an alk...
07/03/2007
7229614Interferon gamma in the detection and treatment of angiomyolipomas
The present invention is directed to methods of treating or preventing angiomyolipomas by administering interferon gamma. It also encompasses methods for assessing the risk of a patient developing angiomyolipomas based upon interferon gamma expression. ...
06/12/2007
7229958Fragrance alcohol-releasing polysiloxane
Organopolysiloxanes which contain a fragrance alcohol Y—OH bonded via a betaine ester group having the structure —N+R1R2—CH2—C(O)OY, cleave off the fragrance alcohol under acid conditions and are resistant to hydro...
06/12/2007
7217544Method for the preparation of L-amino acids from D-amino acids
The invention relates to recombinant microorganisms which, in comparison to the starting organism, have a higher concentration or activity of a D-amino acid oxidase, of an L-amino acid dehydrogenase, of an NADH cosubstrate regenerating enzyme and, if necessary, of a...
05/15/2007
7214501Methods of detecting cancer based on osteopontin
The present invention is directed to diagnostic methods based upon the expression of the protein prostasin. In particular, it is concerned with assays performed on women to determine their risk of ovarian cancer. ...
05/08/2007
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