Quotables
"The production of too many useful things results in too many useless people."
Karl Marx
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7683091 | Substituted indoles and methods of their use The present invention relates generally to substituted indoles and methods of using them. ... | 03/23/2010 |
| 7674818 | Aryl, aryloxy, alkyloxy substituted 1-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) Compounds of formula I are provided: wherein: R1, R2, and R3, are as defined herein, as well as pharmaceutical composition and methods using the compounds as inhibitors of plasminogen activator inhibitor (PAI-1) and... | 03/09/2010 |
| 7645752 | Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors The present invention is directed to compounds of Formula I: which are modulators of the 5-hydroxtryptamine-6 and 5-hydroxytryptamine-2A receptors and which are inhibitors of norepinephrine reuptake. The compounds of the in... | 01/12/2010 |
| 7629377 | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8,... | 12/08/2009 |
| 7605172 | Thiazolo-naphthyl acids The present invention relates to thiazolo-naphthyl acids of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders. ... | 10/20/2009 |
| 7582773 | Substituted phenyl indoles The present invention relates generally to substituted phenyl indoles and methods of using them, for example as PAI-1 inhibitors. ... | 09/01/2009 |
| 7576087 | Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 08/18/2009 |
| 7566791 | Substituted 3-carbonyl--indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives of formula I are provided: wherein: R1, R2, R3, R4 and R5 are as defined herein wh... | 07/28/2009 |
| 7560470 | Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor. ... | 07/14/2009 |
| 7557098 | 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor. ... | 07/07/2009 |
| 7544701 | Sulfonyldihydrobenzimidazolone compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 06/09/2009 |
| 7534894 | Biphenyloxy-acids The present invention relates generally to substituted biphenyloxy acids (such as 4′-aryl-amido-biphenyl-4(3)-yloxy-acids and 4′-aryl-amidomethyl-biphenyl-4(3)-yloxy-acids) and methods of using them, for example, as PAI-1 inhibitors. ... | 05/19/2009 |
| 7534801 | Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a CNS disorder relating to or affected by the 5-HT6 receptor. ... | 05/19/2009 |
| 7501421 | Benzoxazole and benzothiazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 03/10/2009 |
| 7498327 | Indolylalkylamine metabolites as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 03/03/2009 |
| 7488832 | Azolylacylguanidines as β-secretase inhibitors The present invention provides an azolylacylquanidine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tang... | 02/10/2009 |
| 7482461 | Sulfonyl-3-heterocyclylindazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 01/27/2009 |
| 7459478 | Substituted dihydropyrano indole-3,4-dione derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) Compounds of formula (I) and II) are provided wherein: X is an alkali metal or a basic amine moiety; R1 is alkyl, cycloalkyl, —CH2-cycloalkyl, pyridinyl, —CH2-pyridinyl, phenyl or benzyl... | 12/02/2008 |
| 7456186 | Diphenylimidazopyrimidines as inhibitors of β-secretase The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated β-amyloid deposits or β-amyloid levels in a patient. | 11/25/2008 |
| 7429582 | Dihydro[1,4]oxazino[2,3,4-hi]indazole derivatives as 5-hydroxytryptamine-6 ligands and use thereof in the treatment of attention deficit disorders The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor ... | 09/30/2008 |
| 7423158 | Amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compounds for the inhibition of β-secretase The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyl... | 09/09/2008 |
| 7417047 | Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and ... | 08/26/2008 |
| 7414051 | Substituted-dihydro[1,4]oxazino[2,3,4-hi]indazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 08/19/2008 |
