Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 5200453 | Preservative for ophthalmic solutions An ophthalmic formulation comprising a salt of sepazonium or a similar imidazolium compound as a preservative is provided.... | 04/06/1993 |
| 5182270 | Stabilizing preparation for thymoxamine Experiments have been performed which test the stability of thymoxamine in aqueous solution at room temperature and above. It was determined that dimethyl-beta-cyclodextrin slows the hydrolysis degradation of thymoxamine while other beta-cyclodextrin anal... | 01/26/1993 |
| 5116837 | 2,9-dihydro-(6 or 7)-(3-oxo-2,3,4,5-tetrahydropyridazinyl)-pyrazolo [4,3-B]-1,4-benzoxazines The invention relates to novel compounds, 2,9-dihydro(6 or 7)-3-oxo-2,3,4,5-tetrahydropyridazinyl)pyrazolo[4,3-b]benzoxazines. The claimed compounds are inhibitors of phosphodiesterase fraction III and have potent positive inotropic activity. These compou... | 05/26/1992 |
| 5112866 | Ethanesulfonamide derivatives The synthesis of novel ethanesulfonamide compounds is described. The novel ethanesulfonamide compounds have antisecretory activity and are used in the treatment of peptic ulcer disease. The intermediates used to prepare the ethanesulfonamides are useful i... | 05/12/1992 |
| 5106863 | Substituted imidazole and pyridine derivatives Novel substituted imidazole and pyridine derivatives and their synthesis are disclosed. The derivatives inhibit the enzyme, H+ /K+ ATPase, and are therefore useful for the treatment of gastrointestinal diseases.... | 04/21/1992 |
| 5081242 | 6-benzoxazinyl- and 6-benzothiazinyl 2,3,4,5-tetrahydropyridazin-3-ones The synthesis of benzoxazinyl- and benzothiazinylpyridazinone compounds is described. The novel compounds are cardiotonic agents and inhibitors of phosphodiesterase. In addition, the compounds are useful as smooth muscle relaxants and bronchodilators.... | 01/14/1992 |
| 5066658 | Substituted hydroxyureas The present invention relates to substituted hydroxyureas. These compounds inhibit the enzyme 5-lipoxygenase. In addition, certain of the compounds also inhibit the enzyme-cyclooxygenase. The compounds are useful for treating asthma, allergies, arthritis,... | 11/19/1991 |
| 5039750 | Natural rubber latex film products with improved tear resistance Natural rubber latex compounds are modified by the addition of a high styrene content styrene-butadiene copolymer. The films prepared from these modified NR latex compositions exhibit improved tear strength and a good balance of other properties.... | 08/13/1991 |
| 5030635 | 6-7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides Novel 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides and their synthesis are described. These novel compounds are cardiotonic agents and bronchodilating agents, and as such are useful for the treatment of heart failure and asthma.... | 07/09/1991 |
| 5030736 | Substituted thienopyrans Substituted thienopyrans and processes for preparing the thienopyrans are disclosed. The thienopyrans are useful as antihypertensive agents; antianginals are peripheral antivasoconstrictive agents.... | 07/09/1991 |
| 5021574 | 6-substituted purinyl piperazine derivatives 6-Substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.... | 06/04/1991 |
| 5019569 | Reversal of glucocorticoid-induced skin atrophy The present invention is directed to the topical administration of a retinoid-containing pharmaceutical composition for reversing the effects of glucocorticoid-induced skin atrophy.... | 05/28/1991 |
| 5011843 | Treatment of glaucoma using phosphodiesterase inhibitors Lowering of intraocular pressure, e.g. in the treatment of glaucoma is carried out by administering a phosphodiesterase inhibitor to a patient. Particular ophthalmic pharmaceutical compositions are disclosed for topical application to the eye.... | 04/30/1991 |
| 5001127 | 4-substituted pyrazolo[3,4-d]pyrimidine derivatives 4-Substituted pyrazolo[3,4-d]pyrimidine derivatives and a method of synthesis for the derivatives are described. The 4-substituted pyrazolopyrimidine derivatives are useful as cardiotonic agents and antiarrhythmic agents.... | 03/19/1991 |
| 4992435 | Substituted thienopyrans as antihypertensive agents Substituted thienopyrans and processes for preparing the thienopyrans are disclosed. The thienopyrans are useful as antihypertensive agents; antianginals are peripheral antivasoconstrictive agents.... | 02/12/1991 |
| 4975428 | Treatment of glaucoma using phosphodiesterase inhibitors Lowering of intraocular pressure, e.g. in the treatment of glaucoma is carried out by administering a phosphodiesterase inhibitor to a patient. Particular ophthalmic pharmaceutical compositions are disclosed for topical application to the eye.... | 12/04/1990 |
| 4963554 | 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides Novel 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides and their synthesis are described. These novel compounds are cardiotonic agents and bronchodilating agents, and as such are useful for the treatment of heart failure and asthma.... | 10/16/1990 |
| 4939137 | Ring-fused thienopyrimidinedione derivatives The synthesis of ring-fused thienopyrimidinedione derivatives is described. The novel ring-fused thienopyrimidinedione derivatives are generally vasodilating agents and antihypertensive agents and as such are useful as cardiovascular agents.... | 07/03/1990 |
| 4915256 | Dispenser A dispenser for dispensing a series of different pills over a prescribed period. The dispenser is provided with an indicator that is adjustable to preset the start of the pill regimen on whatever day desired. The pill package and dispenser are constructed... | 04/10/1990 |
| 4910198 | 1,5-epoxy-2,3,4,5-tetrahydro-1H-3-benzazepins The synthesis of epoxybenzazepin compounds is described. The novel compounds have anti-ulcer activity.... | 03/20/1990 |
| 4902692 | Method and composition for ophthalmic anesthesia using rodocaine Rodocaine or a pharmaceutically-acceptable salt thereof has been found to be an effective anesthetic in ophthalmology. Topical and injectable formulations are disclosed.... | 02/20/1990 |
| 4885300 | 4-Substituted pyrazolo[3,4-D]pyrimidine derivatives 4-Substituted pyrazolo[3,4-d]pyrimidine derivatives and a method of synthesis for the derivatives are described. The 4-substituted pyrazolopyrimidine derivatives are useful as cardiotonic agents and antiarryhythmic agents.... | 12/05/1989 |
| 4883787 | Process for preparing 2-acyl-3, 4-dialkoxyanilines A process for preparing 2-acyl-3,4-dialkoxyanilines is described. The 2-acyl-3,4-dialkoxyanilines are useful intermediates in the preparation of 5,6-dialkoxy-4-alkyl-2(1H)-quinazolinones. The substituted quinazolinones are active as cardiotonic agents.... | 11/28/1989 |
| 4880817 | O-functionalized derivatives of substituted isoquinolin-3-ols having cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties O-functional derivatives of substituted isoquinolin-3-ol compounds of the general formula ##STR1## that exhibit cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating are pharmacologically active in the ... | 11/14/1989 |
| 4879384 | Preparation of thiocycloalkno [3,2-b] pyridines Novel substituted thiacycloalkeno [3,2-b] pyridines are described. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstrictor activity.... | 11/07/1989 |
| 4876257 | 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents 6-Substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.... | 10/24/1989 |
| 4874771 | Ethanesulfonamide derivatives The synthesis of novel ethanesulfonamide compounds is described. The novel ethanesulfonamide compounds have antisecretory activity and are used in the treatment of peptic ulcer disease.... | 10/17/1989 |
| 4871745 | 2- or 3-aryl substituted imidazo(1,2-A)pyridines and their use as antisecretory agents Novel 2- or 3- aryl substituted imidazo[1,2-a]pyridines and their synthesis are described. The compounds have local anesthetic properties and are useful as local anesthetic agents, calcium channel blocking agents and antisecretory agents.... | 10/03/1989 |
| 4861897 | 2-Aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles The present invention relates to novel 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles. The novel compounds are useful as antisecretory agents.... | 08/29/1989 |
| 4855426 | Process of preparing 1,5-epoxy-2,3,4,5-tetrahydro-1H-3-benzazepins The synthesis of epoxybenzazepin compounds is described. The novel compounds have anti-ulcer activity.... | 08/08/1989 |
| 4845225 | Substituted thiacycloalkeno [3,2-b] pyridines Novel substituted thiacycloalkeno [3,2-b] pyridines are described. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstrictor activity.... | 07/04/1989 |
| 4843077 | Isoquinoline derivatives having renal vasodilating properties and/or cardiotonic properties and/or phosphodiesterase inhibiting properties Isoquinoline derivatives of compounds of the general formula ##STR1## that exhibit cardiotonic and/or phosphodiesterase fraction III inhibiting properties and/or renal vasodilating are pharmacologically active in the treatment of cardiac conditions. ... | 06/27/1989 |
| 4835157 | Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents Novel thienopyrimidine-2,4-dione piperidine derivatives and novel furo[3,4-d]pyrimidine-2,4-dione piperidine derivatives are described. The novel piperidine derivatives are selective serotonin antagonists and alpha adrenergic blocking agents with cardiova... | 05/30/1989 |
| 4833149 | 2- or 3-aryl substituted imidazo[1,2-a]pyridines Novel 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their synthesis are described. The compounds have local anesthetic properties and are useful as local anesthetic agents, calcium channel blocking agents and antisecretory agents.... | 05/23/1989 |
| 4826868 | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use 1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and cardiovascular disorders in mammals.... | 05/02/1989 |
| 4822800 | Isoquinolinol compounds having cardiotonic and phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties Substituted 3-isoquinolinol compounds of the general formula ##STR1## that exhibit cardiotonic, renal vasodilating and phosphodiesterase fraction III properties are pharmacologically active in the treatment of cardiac conditions. Methods for synthesi... | 04/18/1989 |
| 4820828 | Cinnamohydroxamic acids The present invention relates to cinnamohydroxamic acids. These compounds inhibit 5-lipoxygenase and are useful as bronchodilators.... | 04/11/1989 |
| 4814487 | Amido substituted naphthalenes and intermediates thereof The synthesis of amido substituted naphthalenes and their intermediates is described. The intermediates and amido substituted naphthalenes are useful as anti-inflammatory agents.... | 03/21/1989 |
| 4804756 | Process for preparing 5,6-dialkoxy-4-alkyl-2(1H)-quinazolinones A method for preparing 5,6-dialkoxy-4-alkyl-quinazolinones is described. The 5,6-dialkoxy-4-alkyl-quinazolinones are active cardiotonic agents.... | 02/14/1989 |
| 4791200 | 2-substituted-4-aryl-substituted thiazoles The present invention relates to novel 2-substituted-4-aryloxyalkylamine thiazoles as described herein. The thiazoles are useful as antisecretory agents.... | 12/13/1988 |
