Did You Know...
...In 1790, the cost to obtain a patent was between $4 and $5.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7763434 | Antagonists of interleukin-15 Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are incapable of transducing a signal through either the β- or γ-subunit... | 07/27/2010 |
| 7745494 | Vitamin K for prevention and treatment of skin rash secondary to anti-EGFR therapy The invention provides methods and compositions for treating and preventing a skin rash secondary to anti-epidermal growth factor receptor (EGFR) therapy, where the method comprises applying a vitamin K analog or a phosphatase inhibitor to the skin. ... | 06/29/2010 |
| 7672820 | Analyzing linearization of models in modeling environments A device provides an interface for permitting a user to define a block diagram model that represents a system, linearizing at least a portion of the block diagram model, analyzing a linearization result of at least one block of the block diagram model to determine c... | 03/02/2010 |
| 7597892 | Method for treating psoriasis by administering human antibodies specific for Interleukin 15 (IL-15) Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a trans... | 10/06/2009 |
| 7581458 | Method and apparatus for segregation testing of particulate solids A bed of particulate solids is fluidized in a test chamber to yield multiple test samples for subsequent evaluation of segregation effects. A controlled stream of gas enters the chamber in a series of flow rate cycles each progressively increasing to a maximum rate ... | 09/01/2009 |
| 7543822 | Composite rotary seal assembly A composite seal assembly for providing a seal between a rotating shaft and a static surface. The composite seal assembly includes first and second axially adjacent annular seal elements. The first and second seal elements each include a sealing edge contacting the ... | 06/09/2009 |
| 7527112 | Electric system for fuel cell, fuel cell vehicle, and method of supplying electric power An electric system has a fuel cell and an electric storage device which are connected in parallel to each other with respect to a propulsive motor, and a DC-to-DC converter connected closer to the electric storage device than a junction where the fuel cell and the e... | 05/05/2009 |
| 7485698 | Pharmaceutical composition for preventing or treating malignant glioma An object of the present invention is to provide a novel malignant glioma antitumor agent and malignant glioma antitumor agent for animals, and in order to achieve this object, in the present invention a polypeptide indicated by the following (a) or (b), or a mixtur... | 02/03/2009 |
| 7452999 | Chemical process for the preparation of intermediates to obtain -formyl hydroxy-lamine compounds Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl}-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or more of the following features: (1) m... | 11/18/2008 |
| 7449544 | p21 peptides The present invention relates to p21 derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides are derived from a C-terminal region of p21 and display selectivity f... | 11/11/2008 |
| 7439050 | genes encoding diaminopimelate epimerase Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nuc... | 10/21/2008 |
| 7425435 | genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS ... | 09/16/2008 |
| 7417092 | End-capped polymer chains and products thereof Methods are described herein for converting carbocationically terminated polymers to anionically terminated polymers. These methods comprise: (a) providing a carbocationically terminated polymeric moiety; (b) reacting the carbocationically terminated polymeric moiet... | 08/26/2008 |
| 7414076 | Methods and compositions for treating amyloid-related diseases Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease. ... | 08/19/2008 |
| 7410766 | genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS ... | 08/12/2008 |
| 7405235 | Transcription factor modulating compounds and methods of use thereof Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reduci... | 07/29/2008 |
| 7393944 | T-bet compositions and methods of use thereof Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the ... | 07/01/2008 |
| 7381407 | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In p... | 06/03/2008 |
| 7368528 | Antineoplastic peptides The present invention provides antineoplastic peptides of formula I, R1R2N—CHX—CO-A-B-D-E-(G)s-K I wherein R1, R2, X, A, B, D, E, G, K, and s have the meanings stated in the description. ... | 05/06/2008 |
| 7359805 | Methods and systems for classifying mass spectra Methods and systems are disclosed for classifying mass spectra to discriminate the absence or existence of a condition. The mass spectra may include raw mass spectrum intensity signals or may include intensity signals that have been preprocessed. The method and syst... | 04/15/2008 |
| 7355699 | Optical detector for a particle sorting system An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from ... | 04/08/2008 |
| 7350172 | Reporting of aspects and partitioning of automatically generated code according to a partitioning scheme A method and system are described for generating a performance prediction report to assist finalizing a partitioning scheme of a block diagram model. Providing a user-defined partitioning scheme and information describing a target hardware platform used in that part... | 03/25/2008 |
| 7340441 | Search directions in pattern search via rotation In performing a pattern search algorithm to find an optimal solution for an optimization, using a set of positive basis vectors that is non-maximal like a set of minimal positive basis vectors as search directions can sometimes causes the algorithm to converge at a ... | 03/04/2008 |
| 7337538 | Methods and apparatuses for joining a pumping cartridge to a pump drive Apparatus and methods of their use are described for engaging a pumping cartridge with a pump drive. In certain embodiments, the cartridge, comprising a cylinder and a movable piston assembly, is initially assembled or subsequently positioned so that the distance be... | 03/04/2008 |
| 7337102 | Hierarchical references or links in modeling environments Methods and systems for making a reference to a resource in modeling environments are disclosed. The resource to which the reference is made includes the data of the system designed and/or executed in the modeling environments. The system includes subsystems and hie... | 02/26/2008 |
| RE40093 | Compressor test kit | 02/26/2008 |
| 7329489 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 02/12/2008 |
| 7326681 | Methods for producing modified glycoproteins Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield g... | 02/05/2008 |
| 7326526 | Films with photoresponsive wettability In various aspects, the present invention provides substantially monolayer thick molecular films with photoresponsive wettability, the molecules of said films comprising a photochromic molecule coordinated to a metal atom, which is coordinated to an organic tetherin... | 02/05/2008 |
| 7326696 | Amino-methyl substituted tetracycline compounds Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed. ... | 02/05/2008 |
| 7324842 | Atlas and methods for segmentation and alignment of anatomical data The present invention provides an atlas comprising values representative of magnetic resonance properties of a magnetic resonance (MR) scan and optionally, prior probability data relating to tissue type. Further embodiments of the invention involve a system includin... | 01/29/2008 |
| 7316923 | Compositions and methods for non-targeted activation of endogenous genes The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also is directed generally to methods for expressing an endogenous gene in a cell at levels higher than tho... | 01/08/2008 |
| 7311476 | Multilayer hydrodynamic sheath flow structure A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for foc... | 12/25/2007 |
| 7306446 | Co-injection nozzle with improved interior layer termination Disclosed herein are a method and apparatus for combining two or more streams of a polymeric material to form a plastic object. The method and apparatus are capable of ending an interior layer of the plastic object at a desired length to avoid the need to clean sele... | 12/11/2007 |
| 7298478 | Optical detector for a particle sorting system An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from ... | 11/20/2007 |
| 7293581 | Latching micro-regulator A latching microregulator for regulating liquid flow on micro-scale levels comprises a substrate having an inlet port and an outlet port, a valve element defining a valve chamber for opening and closing the inlet port, and an actuator assembly for actuating the valv... | 11/13/2007 |
| 7292964 | Translating of geometric models into block diagram models Methods and systems for translating models generated in one modeling environment into models that can be used in other modeling environments are disclosed. Models are created using different data formats in different modeling environments. These data formats are gen... | 11/06/2007 |
| 7279162 | Isolated broadly reactive opsonic immunoglobulin for treating a pathogenic coagulase-negative staphylococcus infection The invention describes the identification, making, and isolation of immunoglobulin and antigen useful for preventing, diagnosing, and treating staphylococcal infections. The invention further describes an in vivo animal model useful for testing the efficacy of phar... | 10/09/2007 |
| 7258839 | Temperature controlled microfabricated two-pin liquid sample dispensing system A cooled liquid sample dispensing system comprises a pair of pins for holding a droplet of liquid therebetween and a cooling element. Each pin includes a tip spaced predetermined distance from the other pin to define a sample acquisition region. The pins acquire and... | 08/21/2007 |
| 7253306 | Pharmaceutical drug candidates and methods for preparation thereof The present invention is directed to methods of preparation of sulfonate derivatized compounds, e.g., 3-amino-1-propanesulfonic acid and 1,3-propanedisulfonic acid disodium salt with increased purity, with reduced potential for toxic by-products, and that are pharma... | 08/07/2007 |
