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"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| 7060667 | Treatment of follicular lymphomas using inhibitors of the LT pathway Therapeutic uses of inhibitors of the Lymphotoxin Pathway to treat tumors, specifically to treat follicular lymphomas. ... | 06/13/2006 |
| 7049395 | Anti-inflammatory compounds and uses thereof The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inh... | 05/23/2006 |
| 7030080 | Lymphotoxin-β, lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof This invention relates to lymphotoxin-β, a lymphocyte membrane type protein. This protein is found on the surface of a number of cells, including phorbol ester (PMA) stimulated T cell hybridoma II-23.D7 cells. This invention also relates to complexes formed between... | 04/18/2006 |
| 7026136 | Methods of reducing microbial resistance to drugs The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of sc... | 04/11/2006 |
| 6802022 | Maintenance of consistent, redundant mass storage images Methods and apparatus for providing improved maintenance of consistent, redundant mass storage images. In one embodiment, one feature of the invention is the presence of non-volatile storage and persistent volatile memory, where the persistent volatile memory is use... | 10/05/2004 |
| 6580428 | Method and system for identifying peripheral elements of a complex model The present invention relates to a method and system for determining peripheral elements, e.g., outer surfaces, of a geometrical representation of an object. The method of the invention can be implemented in any computer platform having a facility for cre... | 06/17/2003 |
| 6235466 | Method for the early detection of HIV infection Methods for the early detection of HIV infection by detecting a change in signal transduction mediator activity, particularly, an enzyme mediator, more particularly a member of the src protein tyrosine kinase family. The methods are applicable to HIV dete... | 05/22/2001 |
| 6136602 | Oligonucleotides specific for the marORAB operon Disclosed are synthetic oligonucleotides complementary to a transcript of the marORAB operon which inhibit expression of a gene in the operon. Also disclosed are methods of reducing bacterial resistance to antibiotics, and pharmaceutical formulations cont... | 10/24/2000 |
| 6004936 | Method of use of serum amyloid a protein A method is provided for potentiating the release and collection of cholesterol from inflammatory or atherosclerotic sites in vivo, the method including the steps of increasing the affinity of high-density lipoprotein for macrophages by administering to a... | 12/21/1999 |
| 5972328 | Method for treating amyloidosis Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic compound comprising ... | 10/26/1999 |
| 5958543 | Micro-texturing for sputtered, thin film magnetic media disks utilizing titanium sputtered in the presence of hydrogen to form micro-texturing Hydrogen-treated, sputter deposited, titanium nodules providing enhanced micro-texturing for thin film, magnetic, disk media.... | 09/28/1999 |
| 5872094 | Method for attaching cartilaginous tissue, cartilage matrix protein or link protein to a surface Link protein and cartilage matrix protein, which are two major components of the extracellular cartilage matrix, have been found to bind to each other. Cartilaginous tissue is attached to a surface by anchoring on the surface a fragment of cartilage matri... | 02/16/1999 |
| 5863744 | Neural cell protein marker RR/B and DNA encoding same The invention contemplates the novel neural cell protein marker RR/B, cDNA encoding RR/B, nucleic acid probes for detection of mRNA encoding RR/B, synthetic polypeptides whose sequences correspond to a portion of RR/B and have a molecular weight equal to ... | 01/26/1999 |
| 5840316 | Ryegrass pollen allergen The present invention provides nucleic acid sequences coding for two ryegrass pollen allergen Lol p Ib family members, purified Lol p Ib.1 and Lol p Ib.2 proteins and fragments thereof, methods of producing recombinant Lol p Ib.1 or Lol p Ib.2 or at least... | 11/24/1998 |
| 5821051 | E6 binding proteins An assay for screening test compounds to indentify agents which modulate the binding of an E6-BP polypeptide with a papilloma virus E6 protein. The assay includes combining, as a cell-free system, an E6-binding protein or fragment thereof which binds to t... | 10/13/1998 |
| 5807358 | Dry suction regulator blood collection device A blood collection device has a modular suction regulator assembly in the form of an adjustable negative pressure relief valve which controls the level of suction in a collection chamber by admitting air to a short bleed-in passage proximate to a suction ... | 09/15/1998 |
| 5804176 | Compositions comprising leukocyte-derived growth factors and methods of administering same to facilitate wound healing A gene encoding a leukocyte-derived growth factor (LDGF) has been isolated, cloned and sequenced. LDGF is believed to correspond to a PDGF-like monocyte-derived growth factor with chemotactic activity which is found in human wound fluid. Protease-resistan... | 09/08/1998 |
| 5776685 | Protein kinase C assay A method evaluating the tumor promoter agonist or antagonist activity or the PKC activator or inhibitor activity of a compound. The method includes supplying a yeast cell expressing a PKC , contacting the yeast cell with a compound to be evaluated; and de... | 07/07/1998 |
| 5741670 | Cartilage matrix protein and methods for use DNA constructs coding for a chimeric polypeptides containing fragments of cartilage matrix proteins that can bind collagen and their protein products are described. Also, the invention relates to purified chimeric polypeptides, and methods of their produc... | 04/21/1998 |
| 5714325 | Prenatal diagnosis by isolation of fetal granulocytes from maternal blood A method for detecting presence or absence of a nucleic acid of interest in fetal nucleic acid derived from a sample of peripheral blood obtained from a pregnant woman is described. The method involves obtaining a sample of peripheral blood from a pregnan... | 02/03/1998 |
| 5687462 | Packaged strain actuator A modular actuator assembly includes one or more plates or elements of electro-active material bonded to an electroded sheet, preferably by a structural polymer to form a card. The card is sealed, and may itself constitute a practical device, such as a va... | 11/18/1997 |
| 5686059 | Cartilage matrix protein and methods for use DNA constructs coding for a chimeric polypeptides containing fragments of cartilage matrix proteins that can bind collagen and their protein products are described. Also, the invention relates to purified chimeric polypeptides, and methods of their produc... | 11/11/1997 |
| 5660695 | Methods for evaluating the effectiveness of protective overcoats for thin film, magnetic disk media A method for manufacturing thin film magnetic media disks entailing the improvement arising from causing spaced electrical probes to engage spaced portions of an exposed outer surface of a disk overcoat layer; creating a voltage across the spaced electrod... | 08/26/1997 |
| 5658564 | Xenograft thymus The invention features methods of replacing thymus function and inducing immunological tolerance.... | 08/19/1997 |
| 5656438 | CAIP-like gene family CAIP polypeptide, nucleic acids, antibodies thereto and uses thereof.... | 08/12/1997 |
| 5656609 | Method of enhancing and/or prolonging expression of gene introduced into a cell using colchicine The expression of polynucleotide introduced into a cell by means of a targeted complex of the polynucleotide linked to a cell-specific binding agent can be enhanced and prolonged by inhibiting translocation or fusion of endosomes to lysosomes using colchi... | 08/12/1997 |
| 5653255 | Sewage treatment system A sewage treatment system includes a pair of substantially identical unitary fluid treatment modules, each module having a central sedimentation tank surrounded by a peripheral wetland. The sedimentation tanks are coupled through a dosing device to an inp... | 08/05/1997 |
| 5651980 | Methods of use of uncoated gel particles The invention covers a method of implanting a living donor cell into a host animal without inflammatory response or rejection of the donor cell by the host animal, by obtaining an uncoated particle of a biocompatible, temperature-independent gel that enca... | 07/29/1997 |
| 5651784 | Rotatable aperture apparatus and methods for selective photoablation of surfaces Apparatus and methods to modify the intensity distribution of a beam of radiation, such as a laser, and for eroding surfaces with predetermined shapes. A rotatable mask is formed with one or more apertures that have a geometric spiral shape originating su... | 07/29/1997 |
| 5650856 | Fiber laser intra-cavity spectroscope The present invention is directed to methods and apparatus for detecting species in a laser cavity. According to one preferred embodiment, a device according to the invention includes: a source of excitation energy at a first wavelength; a first optic fib... | 07/22/1997 |
| 5642575 | Midsole construction A composite midsole for shoes comprising an energy absorbing cellular foam cushion having recesses extending inwardly from its undersurface, thermally bonded to a sheet of resilient material extending over the undersurface and into the recesses to form do... | 07/01/1997 |
| 5643562 | Method for treating amyloidosis Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic compound comprising ... | 07/01/1997 |
| 5643253 | Phototherapy apparatus with integral stopper device Phototherapeutic instruments are disclosed having integral stopper devices which limit the penetration of an optical fiber during tissue penetrating phototherapy. In one preferred embodiment, a fluted outer sheath is disposed about an internal optical fib... | 07/01/1997 |
| 5641748 | Caip-like gene family A substantially pure preparation of a polypeptide, the sequence of which comprises the sequence of a CAIP polypeptide.... | 06/24/1997 |
| 5639304 | Device for applying a coating to a solid medicament A device and method for applying a coating material to a solid medicament. The device comprises a reservoir which contains the coating material, and a platform mounted with an actuator above the reservoir for holding the medicament. The medicament is plac... | 06/17/1997 |
| 5637877 | Ultraviolet sterilization of instrument lumens Methods and devices are disclosed for sterilization of endoscopic instrument lumens. Diffuse ultraviolet radiation is employed to sterilize the inner surfaces of the instrument lumen. The ultraviolet radiation can be delivered via one or more optical fibe... | 06/10/1997 |
| 5631296 | Drugs containing S(+)-ibuprofen Rapid-release S(+)-ibuprofen pellets are proposed whose bioavailability is comparable to that of commercially available racemate formulations. The rapid release of the active substance is promoted by using small amounts of basic inorganic salts, preferabl... | 05/20/1997 |
| 5630811 | Method and apparatus for hair removal A laser treatment method for removing unwanted human hair includes irradiating a treatment site with post-coherent light of selected wavelength and peak power level and post duration, and repeating the post-coherent laser irradiation on one or more subseq... | 05/20/1997 |
| 5629021 | Micellar nanoparticles The present invention relates to micellar nanoparticles and methods of their production. Micellar nanoparticles are made by hydrating a mixture of an oil, a stabilizer/surfactant, and an alcoholic initiator with an aqueous solution. These micellar nanopar... | 05/13/1997 |
| 5629194 | Isolated porcine pancreatic cells for use in treatment of diseases characterized by insufficient insulin activity Isolated porcine pancreatic cells, isolated populations of such cells and methods for isolating and using the cells to treat subjects with diseases characterized by insufficient insulin activity are described. The porcine pancreatic cells are preferably n... | 05/13/1997 |
