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...that the first rickshaw was invented in 1869 by an American Baptist minister, the Rev. E. Jonathan Scobie, to transport his invalid wife around the streets of Yokohama?
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| Number | Title | Issue Date |
| 4867915 | 16-Substituted polyunsaturated hexadecanoic fatty acids Sixteen carbon atom carboxylic acids having 16-phenoxy or 16-phenylthio substituents, and 0, 1, or 4 triple bonds, methods of preparing them, and pharmaceutical preparations containing them. These compounds are useful as lipoxygenase inhibitors.... | 09/19/1989 |
| 4859765 | Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture The present invention relates to novel synthetic antigens, conjugates and antibodies based upon specific peptide sequences and the production thereof. More particularly, the invention relates to a polypeptide which is a determinant site of a protein, the ... | 08/22/1989 |
| 4810706 | Piperazine derivatives of theophylline and theobromine New compounds of formulas I and II ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein M is selected from the group consisting of hydrogen, morpholino, benzylamino, di-n-lower alkylamino, n-lower alkylamino and ##ST... | 03/07/1989 |
| 4803079 | Controlled release naproxen and naproxen sodium tablets A controlled release tablet for once-daily oral administration of about 500-1200 mg of naproxen or naproxen sodium, said tablet comprising a homogeneous matrix comprising about 4-9 weight percent of hydroxypropyl methylcellulose having a number average mo... | 02/07/1989 |
| 4801577 | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists Synthetic nona- and decapeptide LHRH antagonist analogs are disclosed, having a sterically hindered guanidino-substituted arginyl or homoarginyl residue at position 8, with no arginyl substituent at position 6.... | 01/31/1989 |
| 4792570 | 3- and 4-biphenyloxyaminoalkanes and related compounds as anti-inflammatory and analgetic agents Compounds useful for treating inflammation, swelling and associated pain, represented by the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: a is an integer of 0-3; b is an integer of 0-2; n is an integer o... | 12/20/1988 |
| 4792561 | Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors The invention concerns a method of inhibiting both thromboxane synthetase and cyclic-AMP phosphodiesterase in a mammal having a disease characterized by elevated thromboxane levels or an imbalance of prostacyclin/thromboxane levels with a compound of the ... | 12/20/1988 |
| 4792551 | 9-anthryloxyaminoalkanes and related compounds as anti-inflammatory and analgetic agents Compounds useful for treating inflammation, pain and swelling, represented by the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: Y and Z are each independently halo, alkyl or alkoxy; l and m are each indep... | 12/20/1988 |
| 4761416 | N-N-disubstituted-ω-[2-amino-3-(carbonylmethyl)-3, 4-dihydroquinazolinyl]oxyalkylamides and related compounds Pharmaceutical compositions comprising, or compositions consisting essentially of, compounds according to the formula ##STR1## or an optical isomer thereof are disclosed, wherein the substituents A, Z and R1 are defined herein. The inventi... | 08/02/1988 |
| 4698442 | ω-Guanidino-substituted--amino acids -amino acids having a substituted ω-guanidino group are disclosed herein.... | 10/06/1987 |
| 4686234 | Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis Compounds useful for treating inflammatory diseases, in particular rheumatoid arthritis, represented by the formula: ##STR1## and the pharmaceutically acceptable salts thereof, wherein: R1 is H or lower alkyl having 1 to 6 carbon atoms; R2... | 08/11/1987 |
| 4684625 | Method for enhancing the anti-infective activity of muramyldipeptide derivatives Co-administration of a muramyldipeptide derivative with liposomes enhances the anti-infective activity of the muramyldipeptide derivative.... | 08/04/1987 |
| 4681889 | Method for treating cardiovascular disease with calcium channel antagonists Compounds of the formula ##STR1## wherein R1 and R2 are each independently --H or lower alkoxy; R3 and R4 are each independently lower alkyl; and R5 and R6 are each --OCH3, or togethe... | 07/21/1987 |
| 4678805 | Novel 8-(lower alkyl)bicyclo[4.2.0]octane derivatives with valuable therapeutic properties Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension, and atherosclerosis are compounds depicted in formulas (1), (2), and (3): ##STR1## wherein: Y is exo-(lower alkyl) or endo-(lower alkyl); n is 2 or 3; R1 | 07/07/1987 |
| 4672071 | Antihypertensive dihydropyridine compositions, optical isomers and intermediates Compositions containing dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, or angina have the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein n is an integer f... | 06/09/1987 |
| 4667038 | Tetrahydroisoquinoline derivatives Compounds of the formula ##STR1## wherein R1 and R2 and each independently --H or lower alkoxy; R3 and R4 are each independently lower alkyl; and R5 and R6 are each --OCH3, ... | 05/19/1987 |
| 4647580 | Treatment of Alzheimer's disease A treatment for senile dementia of the Alzheimer's type comprising administering to the patient a tertiary amine of the formula ##STR1## wherein R1 is alkyl, alkoxy, alkylthio or dialkylamino hydroxyl, hydrogen, chlorine or fluorine; R | 03/03/1987 |
| 4642378 | Arylalkyl amines useful for lowering intraocular pressure Intraocular hypertensive diseases such as glaucoma are treated with compounds represented by formula I ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R1 is alkyl of two to four carbon atoms; R2 is ... | 02/10/1987 |
| 4629730 | Method for treating intraocular hypertension Elevated intraocular pressure diseases such as glaucoma are treated with compounds represented by formula I ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R1 is alkyl of two to four carbon atoms; and R2 | 12/16/1986 |
| 4629782 | Crystalline form of N-acetylmuramyl-L--aminobutyryl-D-isoglutamine Crystalline N-acetylmuramyl-L--aminobutyryl-D-isoglutamine monohydrate useful as an adjuvant for vaccines and as an immunostimulant.... | 12/16/1986 |
| 4618696 | 9-oxo-15-hydroxy-16-phenoxy and 16-substituted phenoxy 17,18,19,20-tetranorprosta-4,5,13,(E)-trienoates This invention covers a compound of the formula ##STR1## wherein R is hydrogen, lower alkyl or a pharmaceutically acceptable, non-toxic salt of a compound wherein R is hydrogen; and X is hydrogen, halo, trifluoromethyl, lower alkyl or lower alkoxy; a... | 10/21/1986 |
| 4613606 | Tetrahydroisoquinoline derivatives Compounds of the formula ##STR1## wherein R1 and R2 are each independently --H or lower alkoxy; R3 and R4 are each independently lower alkyl; and R5 and R6 are each --OCH3, or togethe... | 09/23/1986 |
| 4612325 | 5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories Novel 5-aroyl-6-methylthio-, 6-methylsulfinyl-, or 6-methylsulfonyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids represented by the formulas ##STR1## and the pharmaceutically acceptable, non-toxic esters and salts thereof, wherein R | 09/16/1986 |
| 4608388 | Novel [4,2,0]bicyclooctane derivatives with valuable therapeutic properties Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension, and atherosclerosis are compounds depicted in formulas (1), (2), and (3): ##STR1## wherein: n is 2 or 3; R1 is CH2 OH, CHO, CO2 R... | 08/26/1986 |
| 4606917 | Synergistic antiviral composition Combinations of 9-(1,3-dihydroxy-2-propoxymethyl) guanine or a pharmaceutically acceptable salt thereof, with ଲ-interferon show a surprisingly high degree of synergism in their activity against viral infections.... | 08/19/1986 |
| 4606918 | Polyoxypropylene-polyoxyethylene block polymer based adjuvants A method for enhancing the immunogenicity of an antigen is emulsifying it with a polyoxypropylene-polyoxyethylene block polymer, a glycol ether-based surfactant, a metabolizable non-toxic oil, isoosmotic saline, and an immunopotentiating amount of an immu... | 08/19/1986 |
| 4602005 | Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis This invention discloses novel glycosides which are potent inhibitors of cholesterol absorption and therefore useful in treating hypercholesterolemia and atherosclerosis. Particularly useful in this respect is glycoside tigogenin cellobioside. The method ... | 07/22/1986 |
| 4600785 | Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives This invention relates to a process for making an enantiomer or racemic mixture of a compound of the formula ##STR1## wherein R is hydrogen, lower alkyl or a pharmaceutically acceptable, non-toxic salt of a compound wherein R is hydrogen; X is hydrog... | 07/15/1986 |
| 4599331 | Etianic acids as antiangiogenics This invention provides a method for inhibiting angiogenesis in mammals. A pharmaceutically acceptable formulation containing a compound of the formula ##STR1## where X1 X2 and X3 are H, C1, or F and X3 mus... | 07/08/1986 |
| 4595690 | Antihypertensive dihydropyridine derivatives Novel dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, and angina have the formula 1: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein: n is an integer from 0 to 8; Y is --... | 06/17/1986 |
| 4593029 | Novel ω-(N-imidazolyl)alkyl ethers of 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones Novel compound of the formula ##STR1## wherein n is an integer of 1 to 8; R1 is hydrogen or alkyl of 1-6 carbons; R2 is hydrogen; R3 is hydrogen, alkyl of 1-6 carbons, phenyl, benzyl, hydroxy lower alkyl, carbamoyl alkyl, ... | 06/03/1986 |
| 4591592 | Acid stabilized compositions of thieno-pyridine derived compounds A novel pharmaceutical composition which comprises an acid salt of a thieno-pyridine derived compound, a pharmaceutically acceptable, non-volatile organic acid (particularly citric acid) and optionally other suitable pharmaceutical excipients.... | 05/27/1986 |
| 4581169 | Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists Synthetic nona-peptide and deca-peptide LHRH antagonist analogs have a novel guanido-substituted, amidine, tertiary or quaternary aminoacyl residue at position 6.... | 04/08/1986 |
| 4571333 | Controlled release naproxen and naproxen sodium tablets A controlled release tablet for once-daily oral administration of about 500-1200 mg of naproxen or naproxen sodium, said tablet being a homogeneous matrix comprising about 4-9 weight percent of hydroxypropylmethylcellulose having a number average molecula... | 02/18/1986 |
| 4567264 | Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry Novel compounds of the general formula ##STR1## and the pharmaceutically acceptable esters and acid addition salts thereof, wherein: R1, R2, R3, R4 and R5 are each independently hydrogen, lower a... | 01/28/1986 |
| 4560699 | 5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories Novel 5-(4-vinyl- or 4-ethynylbenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids represented by the formula ##STR1## and the pharmaceutically acceptable, non-toxic alkyl esters and salts thereof, wherein R is vinyl or ethynyl, and ... | 12/24/1985 |
| 4558066 | Treatment and prevention of ocular hypertension This invention relates to a method of treatment of ocular hypertension and to a topical ophthalmic pharmaceutical composition useful for management of ocular hypertension. When administered topically to an eye with increased intraocular pressure, &#b1;2-[... | 12/10/1985 |
| 4558129 | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and ଲ-blockade Novel compounds of the general formula: ##STR1## and the pharmaceutically acceptable esters and acid addition salts thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8 an... | 12/10/1985 |
| 4552898 | [3.2.0]Bicycloheptanone oxime ethers with valuable therapeutic properties Compounds useful in treating cardiovascular disorders are the carboxylic acids depicted in formulas (1) and (2) ##STR1## as well as their pharmaceutically acceptable, non-toxic salts and esters, wherein: n is an integer from one to four; R1 | 11/12/1985 |
| 4548949 | +2-[(3,4-Methylenedioxy)phenethyl]-5-[(3-carboxamido-4-hy droxy)--hydroxybenzyl]pyrrolidines A compound of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof are potent antihypertensive agents and are therefore useful as cardiovascular system regulators. These compounds are also useful as bronchodilators.... | 10/22/1985 |
