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| Number | Title | Issue Date |
| 7678783 | Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease The present invention is directed to macrocyclic tertiary amine compounds represented by general formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the be... | 03/16/2010 |
| 7638629 | Piperidines and related compounds for treatment of alzheimer's disease Compounds of formula I: selectively inhibit production of Aβ(1-42) and hence are useful in treatment or prevention of disease associated with deposition of β-amyloid in the brain. ... | 12/29/2009 |
| 7598386 | Sulphones which modulate the action of gamma-secretase Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of γ-secretase and are therefore useful in the treatment or... | 10/06/2009 |
| 7408067 | Aza-cyclic compounds as modulators of acetylcholine receptors Compounds comprising an aza-cyclic portion and an aromatic portion linked via a sulphur atom are disclosed. The compounds disclosed are selective modulators of beta 4 subtype nicotinic acetylcholine receptors and are useful for the treatment of dysfunctions of the c... | 08/05/2008 |
