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| Number | Title | Issue Date |
| 8168056 | Electrocomposite coatings for hard chrome replacement The invention provides a method and system for electrolytically coating an article. The method includes providing an article to be coated and disposing the article in an electrolytic cell. The cell includes an anode, a cathode in operable communication with the arti... | 05/01/2012 |
| 8143393 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with o... | 03/27/2012 |
| 8138336 | Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders,... | 03/20/2012 |
| 8133995 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angio... | 03/13/2012 |
| 8129379 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with o... | 03/06/2012 |
| 8126818 | Knowledge-management systems for law firms The present inventors devised unique systems, methods, interfaces, and software for managing and leveraging knowledge in law firms and potentially other enterprises. For example, one system provides a single user interface for researching case law for online legal r... | 02/28/2012 |
| 8013166 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases. ... | 09/06/2011 |
| 7984053 | System, method, and software for identifying historically related legal cases The American legal system, judges and lawyers are continually researching an ever-expanding body of past judicial opinions, or case law, for the ones most relevant to resolution of new disputes. To facilitate these searches, some companies collect and publish the ju... | 07/19/2011 |
| 7943045 | Reactor with a thermal gradient controlled for the production of pure hydrogen A device for the thermal separation of water into hydrogen and oxygen, including a closed reaction chamber (1) containing water and, in said reaction chamber: —a heating system including one or several heat source elements (4,11), —one or several m... | 05/17/2011 |
| 7935254 | Reactor for simultaneous separation of hydrogen and oxygen from water We disclose a device for the production of hydrogen from water using heat. The device employs thermal water splitting and works essentially without electricity. It is based on the concept of a membrane reactor with two kinds of membranes allowing the separation of h... | 05/03/2011 |
| 7837782 | Yellow inorganic pigments and process for preparing same The present invention provides yellow inorganic pigments comprising praseodymium, oxides of transition metals selected from molybdenum, titanium, zirconium and combinations thereof, essentially molybdenum, optionally with alkaline earth metal (A) and the said yellow... | 11/23/2010 |
| 7809738 | System for determining changes in the relative interest of subjects A system for determining changes in the interest of a subject over a time period. The system measures the volume of news articles for a subject over a time period and makes a comparison to a previous volume of news articles for the same subject over a previous time ... | 10/05/2010 |
| 7759376 | Preparation and use of biphenyl-4-yl-carbonylamino acid derivatives for the treatment of obesity This invention relates to certain biphenyl-4-yl carbonylamino acid compounds, compositions, and methods for treating or preventing obesity and related diseases. ... | 07/20/2010 |
| 7750017 | Heterocycles This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly hyperproliferative diseases such as cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the t... | 07/06/2010 |
| 7737153 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive... | 06/15/2010 |
| 7709491 | Substituted quinazolines as antiviral agents, especially against cytomegaloviruses The invention relates to substituted quinazolines and to methods for the production thereof, in addition to the use thereof in the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, especially against ... | 05/04/2010 |
| 7705043 | Substituted aminodicarboxylic acid derivatives having pharmaceutical properties The invention relates to compounds of formula (I) and their salts and stereoisomers in which the variables are as defined in the description and claims, for producing medicaments used in the treatment of cardiovascular and ... | 04/27/2010 |
| 7700653 | Halogen-substituted aminodicarboxylic acid derivatives This invention relates to methods for treating cardiovascular disorders selected from heart failure, thromboembolic disorders, venous diseases, and fibriotic disorders other than fibrosis of the liver, comprising administering an effective amount of a compound of fo... | 04/20/2010 |
| 7695900 | Method and device for detecting biologically active substances This application claims a method for detecting biologically active substances, comprising the following steps a) providing a support carrying substances to be tested b) providing a suspension containing luminescent... | 04/13/2010 |
| 7687510 | Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases. ... | 03/30/2010 |
| 7678804 | Pyrimidine derivatives for treatment of hyperproliferative disorders Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a lin... | 03/16/2010 |
| 7662956 | Tetrahydrobenzo[d]azepin-2-one derivatives and the use thereof for treating cardiovascular diseases The present application relates to novel tetrahydrobenzo[d]azepin-2-one derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases... | 02/16/2010 |
| 7659412 | Benzofuran derivatives useful for treating hyper-proliferative disorders The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders. ... | 02/09/2010 |
| 7598378 | Method for the production of 4-(4-aminophenyl)-3-morpholinone The present invention relates to a process for preparing 4-(4-aminophenyl)-3-morpholinone by reacting 4-(4-nitrophenyl)-3-morpholinone with hydrogen in the presence of a hydrogenation catalyst, characterized in that the reaction is effected in an aliphatic alcohol. | 10/06/2009 |
| 7589195 | Tetrahydrobenzo[d]azepin-2-one derivatives and the use thereof for treating cardiovascular diseases The present application relates to novel tetrahydrobenzo[d]azepin-2-one derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases... | 09/15/2009 |
| 7582666 | Substituted 2-oxo-3-phenyl-5-carbonylaminomethyl-1,3-oxazolines and their use as anticoagulant and antithrombotics The invention relates to the field of blood coagulation, more particularly, to novel compounds of general formula (I), to a method for producing the compounds and to their use as active ingredients in medicaments for the pr... | 09/01/2009 |
| 7582646 | Pyrimidine derivatives for treatment of hyperproliferative disorders Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a lin... | 09/01/2009 |
| 7582645 | Pyrimidine derivatives for treatment of hyperproliferative disorders Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharm... | 09/01/2009 |
| 7566723 | 1-phenyl1-3,4-dihydropyrimidin-2(1H)-one derivatives and their use The invention relates to novel 1-Phenyl-3,4-dihydropyrimidin-2(1H)-one derivatives having the formula processes for their preparation, and their use in medicaments, especially for the treatment of c... | 07/28/2009 |
| 7563791 | Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angio... | 07/21/2009 |
| 7553851 | Amides of acetic and propionic acids The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory. | 06/30/2009 |
| 7544709 | Derivatives of andrimide and moiramide B having antibacterial properties The invention relates to compounds of general formula (I), to a method for the production thereof, to pharmaceutical compositions containing them, and to their use in the treatment and/or prophlaxis of diseases in humans or animals, particularly bacterial infections... | 06/09/2009 |
| 7517896 | Aminodicarboxylic acid derivatives having pharmaceutical properties The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for u... | 04/14/2009 |
| 7517878 | Heteroarylaminopyrazole derivatives useful for the treatment of diabetes The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders. ... | 04/14/2009 |
| 7514565 | 3,5-Difluoropyridines The invention relates to compounds of the formule ... | 04/07/2009 |
| 7511048 | Pyrimidothienoindazoles The invention relates to novel pyrimidothienoindazoles of formula (I) processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative d... | 03/31/2009 |
| 7511041 | Fused azole-pyrimidine derivatives The present invention relates to hovel fused azolepyrimidine derivatives, processes for preparing them and pharmaceutical preparations containing them. The fused azolepyrimidine derivatives of the present invention exhibit enhanced potency for phosphotidylinositol-3... | 03/31/2009 |
| 7507714 | Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use This invention provides novel peptides that function in vivo to stimulate insulin release from pancreatic beta cells in a glucose-dependent fashion. These insulin secretagogue peptides are shown to stimulate insulin release in rat islet cells in vitro, and in vivo. ... | 03/24/2009 |
| 7498460 | Isophthalic acid derivatives The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular of cardiovascular disorders. ... | 03/03/2009 |
| 7494978 | Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders. ... | 02/24/2009 |