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| Number | Title | Issue Date |
| 8182816 | Methods of treating cancer Disclosed are methods of treating subjects having cancers including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods... | 05/22/2012 |
| 8173372 | Methods of donor specific crossmatching The detection of endothelial cell antibodies has been proven clinically important for successful organ transplantation. Disclosed are methods of isolating Tie-2+ and CD34− precursor endothelial cells for use in donor-specific crossmatching. | 05/08/2012 |
| 8158122 | Mixed cell populations for tissue repair and separation technique for cell processing The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the inv... | 04/17/2012 |
| 8148080 | Gene and protein relating to hepatocellular carcinoma and methods of use thereof The present invention provides a novel human gene ZNFN3A1 whose expression is markedly elevated in a great majority of HCCs compared to corresponding non-cancerous liver tissues. The gene encodes a protein having a zinc finger domain as well as a SET domain and has ... | 04/03/2012 |
| 8119405 | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues Disclosed are methods and pharmaceutical compositions for inducing pancreatic hormone production. ... | 02/21/2012 |
| 8105775 | IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes The invention provides methods and compositions relating to identification and use of genetic information from the IL-I gene cluster—including the structure and organization of novel IL-I-like genes found within the IL-I locus as well as polymorphisms and associat... | 01/31/2012 |
| 8101360 | IL-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associat... | 01/24/2012 |
| 8093012 | Multiplex in situ immunohistochemical analysis A method of in situ immunohistochemical analysis of a biological sample is provided. The method allows for the multiplex and simultaneous detection of multiple antigens, including multiple nuclear antigens, in a tissue sample. ... | 01/10/2012 |
| 8062897 | Diagnostic histopathology using multiplex gene expression FISH The present invention relates to a method for detecting one or more nascent RNAs in a tissue sample using FISH. In the method, a plurality of probes (8 to 82) may be used to detect a single species of nascent RNA. Further, a plurality of nascent RNA species may be d... | 11/22/2011 |
| 8057796 | Compositions and methods for the therapy and diagnosis of influenza The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection. ... | 11/15/2011 |
| 8034782 | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in com... | 10/11/2011 |
| 8034635 | Methods of donor specific crossmatching The detection of endothelial cell antibodies has been proven clinically important for successful organ transplantation. Disclosed are methods of isolating endothelial cell antibodies and methods for donor-specific crossmatching. ... | 10/11/2011 |
| 8034351 | Mucin fusion polypeptide vaccines, compositions and methods of use thereof The present invention provides compositions and methods for augmenting vaccine immunogenicity using mucin-immunoglobulin fusion proteins. ... | 10/11/2011 |
| 8030470 | Isolated nucleic acids encoding farnesyltransferase polypeptides The present invention provides isolated polynucleotides encoding farnesyltransferase polypeptides, vectors, and cells transformed with farnesyltransferase polynucleotides. ... | 10/04/2011 |
| 7957909 | Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles Gene expression data, in particular gene expression profiles, are created and used in the identification, monitoring and treatment of disease and characterization of biological conditions. Profile data sets are derived from subject samples and include quantitative s... | 06/07/2011 |
| 7935482 | Gene expression profiling for identification monitoring and treatment of rheumatoid arthritis A method is provided in various embodiments for determining a profile data set for a subject with rheumatoid arthritis or inflammatory conditions related to rheumatoid arthritis based on a sample from the subject, wherein the sample provides a source of RNAs. The me... | 05/03/2011 |
| 7919274 | Light-emitting fusion proteins and diagnostic and therapeutic methods therefor Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bio... | 04/05/2011 |
| 7897328 | Blood group antigens of different types for diagnostic and therapeutic applications The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing. ... | 03/01/2011 |
| 7871763 | Hepatocellular carcinoma-related genes and polypeptides, and method for detecting hepatocellular carcinomas Genes up-regulated in hepatocellular carcinomas and polypeptides encoded by these genes are provided. Vectors, transformants and methods for producing the recombinant polypeptides are also provided. Probes and primers of these genes and antibodies against the polype... | 01/18/2011 |
| 7871605 | Mixed cell populations for tissue repair and separation technique for cell processing The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the inv... | 01/18/2011 |
| 7868133 | BH3 peptides and method of use thereof The invention provides peptides and the nucleic acid sequences that encode them. The invention further provides therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of apoptosis associated disorders. ... | 01/11/2011 |
| 7867475 | Immune regulation based on the depletion of CD69+ cells Disclosed are methods of treating subjects having disorders or conditions characterized by an unwanted immune response including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antib... | 01/11/2011 |
| 7858331 | Compositions and methods for the treatment of cancer Disclosed herein are methods and compositions for the treatment of cancer. In particular, the present invention discloses inhibitors of the Fanconi anemia pathway and methods using same. Such inhibitors are useful in inhibiting DNA damage repair and can be useful, f... | 12/28/2010 |
| 7851591 | Cancer immunotherapy and diagnosis using universal tumor associated antigens, including hTERT The invention provides methods for conducting cancer immunotherapy and diagnosis using universal tumor associated antigens, such as the telomerase catalytic subunit (hTERT), and methods for identifying and characterizing universal tumor associated antigens. ... | 12/14/2010 |
| 7829662 | Method of treating apoptosis and compositions thereof Disclosed herein are novel polypeptides and the nucleic acid sequences that encode them. Also disclosed are antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, ... | 11/09/2010 |
| 7816500 | Antibody SACK-1 that binds CD44 glycoforms Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein. ... | 10/19/2010 |
| 7807415 | Methods of producing stable B-lymphocytes The invention provides a method of producing a stable lymphocyte culture and methods of producing monoclonal antibodies. ... | 10/05/2010 |
| 7807136 | Method and composition for the treatment of cancer by the enzymatic conversion of soluble radioactive toxic precipitates in the cancer The invention features compositions and methods for treating or alleviating a symptom of cancer. The compositions and methods of the invention direct supra-lethal doses of radiation, called Hot-Spots, to virtually all cancer cell types. ... | 10/05/2010 |
| 7799897 | Guanylate cyclase receptor agonists for the treatment of tissue inflammation and carcinogenesis A method of treatment of inflamed, pre-cancerous or cancerous tissue or polyps in a mammalian subject is disclosed. The treatment involves administration of a composition of at least one peptide agonist of a guanylate cyclase receptor and/or other small molecules th... | 09/21/2010 |
| 7786354 | Compositions and methods of increasing stress tolerance in plants The present invention provides novel isolated FT polynucleotides and polypeptides encoded by the FT polynucleotides. Also provided are the antibodies that immunospecifically bind to a FT polypeptide or any derivative, variant, mutant or fragment of the FT polypeptid... | 08/31/2010 |
| 7781393 | Methods for inhibiting tumor cell growth The invention methods using a insulin-like growth factor receptor inhibitor to inhibit tumor cell growth in a subject in need thereof. ... | 08/24/2010 |
| 7767392 | Gene and protein relating to hepatocellular carcinoma and methods of use thereof The present invention provides a novel human gene ZNFN3A1 whose expression is markedly elevated in a great majority of HCCs compared to corresponding non-cancerous liver tissues. The gene encodes a protein having a zinc finger domain as well as a SET domain and has ... | 08/03/2010 |
| 7750123 | Antibodies against SARS-CoV and methods of use thereof The invention provides scFv antibodies and monoclonal antibodies that neutralize SARS-CoV. Also provided are methods of treating and/or preventing a coronavirus-related disease or disorder such as SARS. The invention also provides methods of vaccinating a patient ag... | 07/06/2010 |
| 7700105 | Methods of inducing IL-10 production The invention provides a method of inducing IL-10 production. ... | 04/20/2010 |
| 7658925 | Human anthrax toxin neutralizing monoclonal antibodies and methods of use thereof The invention fully humanized monoclonal antibodies that neutralize Bacillus anthracis. Also provided are methods of treating or preventing a Bacillus anthracis infection. The invention also provides methods of passive vaccination of a subject against ... | 02/09/2010 |
| 7658919 | Compositions and methods for inhibiting adhesion and infection The present invention provides compositions and methods for treating or preventing bacterial infections. Also provide by the invention are genetically modified cell expressing Lewisb carbohydrate epitope. ... | 02/09/2010 |
| 7638323 | Fusion proteins and methods of producing same The present invention provides compositions and methods for treating or preventing hyperacute rejection. ... | 12/29/2009 |
| 7029906 | Carbonyl stress-ameliorating agents Carbonyl stress-ameliorating agents have been provided, which contain an enzyme having a glyoxalase I activity and a carbonyl compound-reducing agent as the active ingredients. The carbonyl stress-ameliorating agents of the present invention rapidly eliminate carbon... | 04/18/2006 |
| 7396678 | Method for detection of alterations in the DNA mismatch repair pathway We have now discovered that eukaryotes, including mammals, have a DNA mismatch repair pathway analogous to the pathway that exists in bacteria. Defects or alterations in this mismatch repair pathway in a mammal, such as a human, will result in the accumulation of un... | 07/08/2008 |
| 7355017 | Blood group antigen fusion polypeptides and methods of use thereof The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection. ... | 04/08/2008 |
