Knowles; Sherry M. - US Patent Attorneys and Agents

Attorney: Knowles; Sherry M.

Number of patents: 29
Last date: November 24, 2009

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Number	Title	Issue Date
7622302	Process for improving the manufacture of clavams e.g. clavulanic acid New processes for improving the manufacture of clavams e.g. clavulanic acid. Novel DNA sequences and new microorganisms capable of producing increased amounts of clavulanic acid are also disclosed. ...	11/24/2009
7531316	High throughput assay of Lp-PLA2 activity This invention relates to a method for determining the activity of Lp-PLA2 in a plurality of samples from animals. The invention also relates to a kit for determining Lp-PLA2 activity in a plurality of samples. ...	05/12/2009
7504102	Anti-αβhumanized monoclonal antibodies This invention relates to novel humanized and other recombinant or engineered antibodies or monoclonal antibodies to the vitronectin αvβ3 receptor and to the genes encoding same. Such antibodies are useful for the therapeutic and/or prophylac...	03/17/2009
7442526	Method for preparing a physiologically active IL-18 polypeptide The present invention provides a method for producing physiologically active human Interleukin-18 (“IL-18”). ...	10/28/2008
7399593	Member of the TNF ligand family The invention provides an isolated protein which is a member of the TNF ligand superfamily and comprising: i) a polypeptide having the amino acid sequence of FIG. (1) or ii) a variant of the polypeptide of i). ...	07/15/2008
7311902	Conjugates comprising human IL-18 and substitution mutants thereof Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjuga...	12/25/2007
7022734	Treatment of septic shock The use of transition metal complexes in the treatment of septic shock, in particular the hypotension associated therewith and pharmaceutical formulations comprising such complexes are disclosed. The use of such transition metal complexes in the treatment of other c...	04/04/2006
6946450	β-L-2′-deoxy-nucleosides for the treatment of hepatitis B This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2′-deoxy-β-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereo...	09/20/2005
6881860	Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholest...	04/19/2005
6878364	Animal model for flaviviridae infection The present invention is a woodchuck or an isolated woodchuck cell infected with bovine viral diarrhea virus. The invention can be used to identify new compounds for the treatment of flavivirus, pestivirus or hepatitis C infection using these models. ...	04/12/2005
6878199	Biodegradable or compostable containers The present invention provides an improved method and materials for forming biodegradable containers that can hold food products in dry, damp or wet conditions and provides the biodegradable containers prepared according to the disclosed process. The containers are ...	04/12/2005
6806363	Cobalamin conjugates useful as antitumor agents The invention provides cobalamin compounds linked to a neutron capture therapy target (e.g. Boron-10 or Gadolinium-157), and optionally linked to a detectable moiety, as well as pharmaceutical compositions comprising the compounds, and methods for using the compound...	10/19/2004
6743899	Process for inactivating prions in lipoproteins A process for treatment of a purified lipoprotein material to inactivate prions in a manner that does not substantially adversely affect the biological activity of the lipoprotein is provided that includes treating the lipoprotein prion composition with a solution o...	06/01/2004
6710068	Phenylindoles for the treatment of HIV The invention as disclosed herein is a method and composition for the treatment of HIV in humans and other host animals, that includes the administration of an effective HIV treatment amount of a phenylindole as described herein or a pharmaceutically acceptable salt...	03/23/2004
6670342	Method of treating hepatitis delta virus infection A method for the treatment for hepatitis delta infection in a host, that includes administering an effective amount of a nucleoside or a nucleoside analog that suppresses the expression of the hepatitis B surface or preS1 antigen in the host 100-fold or m...	12/30/2003
6613305	Radionuclide labeling of vitamin B12 and coenzymes thereof A compound useful for in vivo imaging of organs and tumors is provided of formula: ##STR1## wherein ##STR2## is a cobalamin, ##STR3## is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is a chelating gro...	09/02/2003
6610835	Sphingolipid derivatives and their methods of use Derivatives of sphingolipids of the formula: ##STR1## are provided wherein the substituents are as defined in the specification and wherein there is at least one R2 substituent in the sphingolipid derivative. The compounds are useful in the tre...	08/26/2003
6608101	1, 3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory dis...	08/19/2003
6596700	Methods of treating hepatitis delta virus infection with ଲ-L-2'-deoxy-nucleosides A method and composition for treating a host infected with hepatitis D comprising administering an effective hepatitis D treatment amount of a described 2'-deoxy-ଲ-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug ther...	07/22/2003
6525033	Nucleosides with anti-hepatitis B virus activity A method for treating HBV infections via administration of 2', 3' dideoxynucleoside compounds....	02/25/2003
6215004	Method of manufacture of 1,3-oxathiolane nucleosides Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the process...	04/10/2001
6194391	3'-azido-2',3'-dideoxyuridine administration to treat HIV and related test protocol It has been discovered that 3'-azido-2',3'-dideoxyuridine (CS-87) induces a transient mutation in HIV-1 at the 70th codon (K to R, i.e., lysine to arginine) of the reverse transcriptase region of the virus. Based on this discovery, a method and...	02/27/2001
5773231	Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat...	06/30/1998
5773209	Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat...	06/30/1998
5762963	Method and compositions for controlling oral and pharyngeal pain using capsaicinoids Methods and compositions are provided for the oral delivery of temporally increasing concentrations of capsaicin, its derivatives, and analogs (collectively, "capsaicinoids"), to provide oral or pharyngeal analgesia while minimizing sensations of nausea a...	06/09/1998
5681966	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders Enantiomerically enriched disubstituted tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocy...	10/28/1997
5648489	Syntheses of acyclic guanine nucleosides A method is provided for the synthesis of synthesis of acyclic purine nucleosides, particularly 9-(2-hydroxy-ethoxymethyl)-guanine (acyclovir) and 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine ("DHPG") where the N2,N9 -diprotected guani...	07/15/1997
5639782	Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both PAF and 5-lipoxygenase antagonist activity....	06/17/1997
5630978	Preparation of biologically active molecules by molecular imprinting A method for preparing mimics of a wide variety of drugs and other biologically active molecules using molecular imprinting techniques, and the mimics produced thereby, is disclosed. Specifically, the mimic is designed by: (i) polymerization of functional...	05/20/1997

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Attorney: Knowles; Sherry M.