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| Number | Title | Issue Date |
| 8138183 | Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example in the treatment of proliferative disease such as cancer and particularly in d... | 03/20/2012 |
| 8101623 | Substituted pyrrolo[2,3-d]pyrimidine as a protein kinase B inhibitor The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which ma... | 01/24/2012 |
| 8101602 | Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors There is provided a compound of formula I: or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicam... | 01/24/2012 |
| 7943800 | Migrastatin analogs and uses thereof The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving... | 05/17/2011 |
| 7902189 | Compounds There is provided a compound of formula I: or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicam... | 03/08/2011 |
| 7759374 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprisi... | 07/20/2010 |
| 7649006 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprisi... | 01/19/2010 |
| 7575889 | Compound combinations for inhibiting cell division and methods for their identification and use The present invention provides in vitro assays, e.g., FtsZ GTPase assays, and/or in vivo assays and methods of use thereof to identify particular compounds and combinations of compounds that affect microbial cell division. The invention further provides such compoun... | 08/18/2009 |
| 7470799 | Dihydrobenzofuran derivatives and uses thereof Compounds of formula I are provided: wherein each of R1, R2, y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of melatoninergic rec... | 12/30/2008 |
| 7435854 | Methods for preparing O-desmethylvenlafaxine The present invention provides an efficient method of making O-desmethyl-venlafaxine. ... | 10/14/2008 |
| 7435837 | Dihydrobenzofuranyl alkanamine derivatives and methods for using same Compounds of Formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compoun... | 10/14/2008 |
| 7402687 | Dihydrobenzofuran derivatives and uses thereof Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. or pharmaceutically acceptable salts thereof, wherein each of R1, R2, ... | 07/22/2008 |
| 7368477 | Benzofuranyl alkanamine derivatives and uses thereof Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R1′, R2, R3, R4, n, and Ar are as defined, and described in clas... | 05/06/2008 |
| 7358268 | Imidazole derivatives as factor Xa inhibitors This invention is directed to the compound of formula (I) which is useful for inhibiting the activity of Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their use, such as in inhibiting th... | 04/15/2008 |
| 7342029 | Substituted indoles Compounds of the formula I are suitable for preparing pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFκB is involved. ... | 03/11/2008 |
| 7326723 | Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; n is an ... | 02/05/2008 |
| 7285560 | Indole derivatives or benzimidazole derivatives for modulating IκB kinase The present invention relates to indole derivatives or benzimidazole derivatives, to processes for preparing such compounds, to pharmaceutical compositions comprising such compounds, and methods for the prophylaxis and therapy of a disease associated with an increas... | 10/23/2007 |
| 7276552 | Compositions and methods for inhibiting protein on surfaces The use of NIPAM polymers to prevent or reduce the formation of protein deposits on the surfaces of medical devices is described. The invention is particularly directed to reduction of the adsorption of proteins on surfaces of contact lenses and other medical prosth... | 10/02/2007 |
| 7223780 | Triazole-derivatives as blood clotting enzyme factor Xa inhibitors The present invention is directed to the compound of formula I which is useful for inhibiting the activity of blood clotting enzyme Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their us... | 05/29/2007 |
| 7211578 | Nitrogenous tetrahydropyridyl-alkyl-heterocycles with TNF activity This invention relates to nitrogenous (tetrahydropyridyl)(alkyl)heterocycles, to pharmaceutical compositions comprising them, to processes for preparing them and to the method of use thereof in the treatment of pain and diseases related to immune and inflammatory di... | 05/01/2007 |
| 7196103 | Indole derivatives as factor Xa inhibitors The present invention is directed to the compound of formula I which is useful for inhibiting the activity of Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their use, such as for inhibit... | 03/27/2007 |
| 7186735 | Acylated arylcycloalkylamines and their use as pharmaceuticals The present invention relates to acylated arylcycloalkylamines, to pharmaceutical compositions comprising such compounds, to methods for the stimulation of the expression of endothelial NO synthase, and methods of treatment comprising administering such compounds. | 03/06/2007 |
| 7186720 | Tetrahydropyridyl-alkyl-heterocycles, method for preparing the same and pharmaceutical compositions containing the same The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independent... | 03/06/2007 |
| 7126026 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines A process for preparing 4-pentafluorosulfanylbenzoylguanidines of formula I wherein R1 to R4 have the meanings indicated in the specification. The compounds of formula I are NHE1 inhibitors and can be employed, f... | 10/24/2006 |
| 7081467 | C2-disubstituted indan-1-ones and their derivatives, processes for their preparation and their use as pharmaceuticals The present invention is directed C2-disubstituted indan-1-ones of the Formula I, physiologically acceptable salts, and physiologically functional derivatives thereof, and pharmaceutical compositions comprising s... | 07/25/2006 |
| 6982353 | C2-disubstituted indan-1-ol compounds, their derivatives, processes for their preparation, and their use as pharmaceuticals The present invention is directed to C2-disubstituted indan-1-ol systems of the Formula I, physiologically acceptable salts and physiologically functional derivatives thereof, and pharmaceutical compositions comprising... | 01/03/2006 |
| 6977263 | Chemical compounds Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration ... | 12/20/2005 |
| 6951940 | Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them The invention relates to the compounds of formula: as well as to the salts thereof with inorganic or organic acids, to solvates thereof and/or to hydrates thereof, which have strong affinity and high selectivity for th... | 10/04/2005 |
| 6949556 | Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents The present invention relates to compounds of general formula (I), wherein R1-R4 have the meanings given in the specification, A is CH2, CHOH or CH—(C1-C3-alkyl), B and C a... | 09/27/2005 |
| 6770640 | 1-Carboxylmethyl-2-oxo-azepan derivatives useful as selective inhibitors of MMP-12 The present invention relates to certain novel 1-carboxymethyl-2-oxo-azepan derivatives of the formula useful as inhibitors of matrix metalloproteinases (MMPs). The compounds of formula (1) are especially useful as selec... | 08/03/2004 |
| 6716853 | Cyclic N-substituted alpha-imino carboxylic acids for selective inhibition of collogenase The invention is related to compounds of formula I to pharmaceutical compositions comprising such compounds, to processes for the preparation of such compounds, and to methods of prevention and treatment of disorders, th... | 04/06/2004 |
| 6486193 | 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases The present invention provides novel 3-substituted pyrrolidines of the formula ##STR1## useful in as inhibitors of matrix metallo-proteinases (MMPs). Pharmaceutical compositions containing said compounds as well as methods of treating disease states ... | 11/26/2002 |
| 6417350 | Preparation of (11ଲ,16ଲ)-21-(3-carboxy-1-oxopropoxy)-11-hydroxy-2'-methyl-5'H-p regna-1,4-dieno [17,16-D]oxazole-3,20-dione A process for preparing the compound (11ଲ,16ଲ)-21-(3-CARBOXY-1-OXOPROPOXY)-11-HYDROXY-2'-METHYL-5'H-P REGNA-1,4-DIENO(17,16-D) OXAZOLE-3,20-DIONE which comprises reacting the compound (11ଲ,16ଲ)-11,21-DIHYDROXY-2'-METHYL-5'H-PREGNA-1... | 07/09/2002 |
| 6352976 | Selective inhibitors of MMP-12 The present invention provides novel mercaptoacetylamido dipeptide carboxylic acids of the formula ##STR1## which are MMP inhibitors useful for the treatment of smoking-induced emphysema.... | 03/05/2002 |
