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| Number | Title | Issue Date |
| 8168866 | Generation of plants with altered oil content The present invention is directed to plants that display an altered oil content phenotype due to altered expression of a HIO32.2 nucleic acid. The invention is further directed to methods of generating plants with an altered oil content phenotype. ... | 05/01/2012 |
| 8168160 | Anti-inflammatory fusion protein The present invention relates to a fusion protein comprising therapeutic and diagnostic potential against chronic vascular diseases, such as atherosclerosis, a nucleic acid molecule encoding said fusion protein, a pharmaceutical and diagnostic composition which comp... | 05/01/2012 |
| 8163803 | Compounds derived from lidocaine, pharmaceutical compositions, use and method of treatment, prevention or inhibition of disease The present invention relates to lidocaine derived compounds, which present less anesthetic activity than lidocaine itself, but with more anti-inflammatory and spasmolytic activity than said lidocaine as well as pharmaceutical compositions with at least one of these... | 04/24/2012 |
| 8163545 | Vaccine against pandemic strains of influenza viruses The present disclosure provides compositions and methods for eliciting an immune response against avian or pandemic influenza. The compositions include adenovirus vectors comprising avian influenza antigens, recombinant adenovirus and immunogenic compositions compri... | 04/24/2012 |
| 8158603 | Fragments of secreted frizzled related protein The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt prot... | 04/17/2012 |
| 8129432 | Method of correcting imbalance between bone resorption and bone formation and kits and compositions therefor Compounds, methods, uses, compositions, kits and packages for the treatment of imbalance between bone resorption and bone formation, based on uses of 4-phenyl-2 propionamidotetralin (4-P-PDOT) and analogs, derivatives, prodrugs, precursors thereof, and salts thereof... | 03/06/2012 |
| 8124838 | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids The amino acid and nucleic acid sequences of a Δ5-desaturase enzyme and a Δ8-desaturase enzyme are disclosed. The nucleic acid sequences can be used to design recombinant DNA constructs and vectors. These vectors can then be used to transform... | 02/28/2012 |
| 8124110 | Proteins with repetitive bacterial-Ig-like (Big) domains present in species The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Acc... | 02/28/2012 |
| 8114653 | Thermostable Y-family polymerases and chimeras The present disclosure is related to thermostable Y-family polymerases, in particular several novel Y-family polymerases and chimeras made therefrom, as well as methods of identifying other Y-family polymerases, methods of generating other chimeric Y-family polymera... | 02/14/2012 |
| 8106006 | Modified defensins and their use This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. Compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods ... | 01/31/2012 |
| 8071777 | Compounds derived from artesunate, preparation process, pharmaceutical composition and use of the respective medicine The present invention refers to new compounds derived from artesunate salts with quinolines represented by the general formula (I) where X is represented by the general formula (II) and Y is represented by the general formula (III) depending on the radicals substitu... | 12/06/2011 |
| 8048630 | Methods and agents for detecting The present disclosure provides methods that permit detection of all known species of Parechovirus, including Human parechovirus and Ljungan virus (LV). In particular examples the method includes amplifying at least a portion of the 5′NTR of parechovirus nucleic a... | 11/01/2011 |
| 8044262 | Generation of plants with improved drought tolerance The present invention is directed to plants that display a pathogen resistance and increased drought tolerance phenotype due to altered expression of a PRDT1 nucleic acid. The invention is further directed to methods of generating plants with a pathogen resistance a... | 10/25/2011 |
| 8030473 | Method to trigger RNA interference A method to generate siRNAs in vivo is described, as are constructs and compositions useful in the method. The method does not depend on the use of DNA or synthetic constructs that contain inverted duplications or dual promoters so as to form perfect or largely doub... | 10/04/2011 |
| 8021673 | Proteins with repetitive Bacterial-Ig-like (Big) domains present in species The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Acc... | 09/20/2011 |
| 8017830 | Generation of plants with altered oil, protein or fiber content The present invention is directed to plants that display an improved oil quantity phenotype or an improved meal quality phenotype due to altered expression of an HIO nucleic acid. The invention is further directed to methods of generating plants with an improved oil... | 09/13/2011 |
| 8008463 | Compositions and methods for diagnostics and therapeutics for hydrocephalus The present disclosure relates to RFX4_v3 protein and nucleic acids encoding the RFX4_v3 protein. The present disclosure provides non-human transgenic animals with altered RFX4_v3 genes, and provides assays for the detection of RFX4_v3 and RFX4_v3 polymorphisms asso... | 08/30/2011 |
| 8003764 | Folliculin-specific antibodies and methods of detection The present disclosure relates to Birt-Hogg-Dubé syndrome, nucleic acids encoding the BHD gene, and antibodies that specifically bind to the BHD protein (folliculin). In addition, the present disclosure relates to methods of diagnosing BHD disease and related condi... | 08/23/2011 |
| 7993857 | Determination of AM-binding proteins and the association of adrenomedullin (AM) therewith The present invention provides methods for the isolation, identification, and purification of adrenomedullin (AM)-binding proteins. Also, provided are methods for utilizing the purified AM-binding proteins, or functional portions thereof, to diagnose, treat, and mon... | 08/09/2011 |
| 7964576 | Anti-arthropod vector vaccines, methods of selecting and uses thereof The present invention provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present invention also provides compositions for vaccines to prevent Leishmaniasis. ... | 06/21/2011 |
| 7947651 | Secreted frizzled related protein, sFRP, fragments and methods of use thereof The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt prot... | 05/24/2011 |
| 7939639 | Functional role of adrenomedullin (AM) and the gene related product (PAMP) in human pathology and physiology The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides ... | 05/10/2011 |
| 7939492 | Factor C for treating gram-negative bacterial infection Recombinant fragments of Factor C are disclosed. These proteins and peptides show great potency in recognizing, binding to, neutralizing and removing endotoxin. These molecules can thus be used for anti-microbial, anti-endotoxin, and anti-sepsis therapy. SSCrFCES is... | 05/10/2011 |
| 7935357 | Proteins with repetitive Bacterial-Ig-like (Big) domains present in species The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Acc... | 05/03/2011 |
| 7923535 | Tryptophan as a functional replacement for ADP-ribose-arginine in recombinant proteins A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, s... | 04/12/2011 |
| 7897837 | Generation of plants with improved pathogen resistance The present invention is directed to plants that display a pathogen resistance phenotype due to altered expression of a PPR2 nucleic acid. The invention is further directed to methods of generating plants with a pathogen resistance phenotype. ... | 03/01/2011 |
| 7862815 | Methods for inhibiting angiogenesis with inhibitors of proadrenomedullin N-terminal 20 peptide (PAMP) The present disclosure concerns the use of peptides and compositions, such as pharmaceutical compositions, to influence angiogenesis. Particular methods are useful for promoting angiogenesis, while others are particularly useful for inhibiting angiogenesis. ... | 01/04/2011 |
| 7855076 | Use of discoidin domain receptor 1 (DDR1) and agents that affect the DDR1/collagen pathway The disclosure provides methods of modulating the activity of DDR1. Methods for screening for agents that activate DDR1 are disclosed. Methods for inducing the maturation of immature macrophages and immature dendritic cells are also disclosed. In addition, methods f... | 12/21/2010 |
| 7851677 | Generation of plants with altered oil content The present invention is directed to plants that display an altered oil content phenotype due to altered expression of a HIO nucleic acid. The invention is further directed to methods of generating plants with an altered oil content phenotype. ... | 12/14/2010 |
| 7851674 | Generation of plants with altered oil, protein, or fiber content The present invention is directed to plants that display an improved oil quantity phenotype or an improved meal quality phenotype due to altered expression of an HIO nucleic acid. The invention is further directed to methods of generating plants with an improved oil... | 12/14/2010 |
| 7851673 | Generation of plants with altered oil, protein, or fiber content The present invention is directed to plants that display an improved oil quantity phenotype or an improved meal quality phenotype due to altered expression of an HIO nucleic acid. The invention is further directed to methods of generating plants with an improved oil... | 12/14/2010 |
| 7851672 | Generation of plants with altered oil, protein, or fiber content The present invention is directed to plants that display an improved oil quantity phenotype or an improved meal quality phenotype due to altered expression of an HIO nucleic acid. The invention is further directed to methods of generating plants with an improved oil... | 12/14/2010 |
| 7842479 | Methods for altering acetic acid production and enhancing cell death in bacteria Methods of increasing cultured cell growth yields and/or protein production from bacterial cell cultures are provided. More particularly, mutant bacterial cells having an alteration in the expression or activity of the cidABC operon, a gene therein, or a homolog or ... | 11/30/2010 |
| 7838531 | Farnesyltransferase inhibitors for treatment of laminopathies, cellular aging and atherosclerosis Although it can be farnesylated, the mutant lamin A protein expressed in Hutchison Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effect... | 11/23/2010 |
| 7834241 | Generation of plants with improved pathogen resistance The present invention is directed to plants that display a pathogen resistance phenotype due to altered expression of a PPR2 nucleic acid. The invention is further directed to methods of generating plants with a pathogen resistance phenotype. ... | 11/16/2010 |
| 7820385 | Method for retaining methylation pattern in globally amplified DNA A method for preserving information about cytosine methylation status in amplified nucleic acid molecules is disclosed. The method includes contacting a sample that contains nucleic acid molecules, such as nucleic acid molecules having or suspected of having methyla... | 10/26/2010 |
| 7786346 | Generation of plants with improved drought tolerance The present invention is directed to plants that display a pathogen resistance and increased drought tolerance phenotype due to altered expression of a PRDT1 nucleic acid. The invention is further directed to methods of generating plants with a pathogen resistance a... | 08/31/2010 |
| 7763719 | Variants of humanized anti-carcinoma MAb CC49 The invention is directed towards mouse-human chimeric variants of CC49 monoclonal antibodies with minimal murine content. A first aspect of the invention provides CDR variants of humanized monoclonal antibody (HuCC49) in which less than all six (three heavy chain a... | 07/27/2010 |
| 7745695 | Generation of plants with altered oil content The present invention is directed to plants that display an altered oil content phenotype due to altered expression of a HIO1005 nucleic acid. The invention is further directed to methods of generating plants with an altered oil content phenotype. ... | 06/29/2010 |
| 7741437 | polypeptides, polypeptides and methods of use Substantially purified salivary P. ariasi and P. perniciosus polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the P. ariasi and P. perniciosus polynucleotides are also disclosed... | 06/22/2010 |
