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| Number | Title | Issue Date |
| 8049038 | Carnitine conjugates of adamantanamines derivatives as dual prodrugs for various uses This invention concerns compounds of adamantanamines and neramexane, including their pharmaceutically-acceptable salts, diesterioisomers, and formulations for treating Alzheimer's related dementias, depression, AIDS related dementias, as antivirals, inflammatory dis... | 11/01/2011 |
| 7985424 | Dendritic polymers with enhanced amplification and interior functionality Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to ... | 07/26/2011 |
| 7981444 | Dendritic polymers with enhanced amplification and interior functionality Poly(ester-acrylate) and poly(ester/epoxide) dendrimers. These materials can be synthesized by utilizing the so-called “sterically induced stoichiometric” principles. The preparation of the dendrimers is carried out by reacting precursor amino/polyamino-function... | 07/19/2011 |
| 7977511 | Carnitine conjugates of adamantanamines and neramexane derivatives as dual prodrugs for various uses This invention concerns compounds of adamantanamines and neramexane, including their pharmaceutically-acceptable salts, diesterioisomers, and formulations for treating Alzheimer's related dementias, depression, AIDS related dementias, as antivirals, inflammatory dis... | 07/12/2011 |
| 7977452 | Janus dendrimers and dendrons This invention provides a cost effective process and new Janus dendrimers where at least two dendrons are attached at the core (with or without a connector group) and where at least two of the dendrons have different functionality. Preferred are those Janus dendrime... | 07/12/2011 |
| 7972629 | Product comprising a combination of milk serum apoproteins and free fatty acids The present invention relates to use of a milk apoprotein or a mixture thereof to prevent or treat microbial or viral infection of the human or animal body. It is believed that this is achieved by inhibiting adhesion of potential pathogens. More preferably, at least... | 07/05/2011 |
| 7893289 | Adamantanamines and neramexane salts of thiomolybdic and thiotungstic acids This invention concerns adamantanamines (e.g. memantine, amantadine, and rimantadine) and neramexane salts of thiomolybdic and thiotungstic acids, including their preparation and pharmaceutical compositions, as dual acting drugs. These salts are used to treat or pot... | 02/22/2011 |
| 7777071 | Production of carnitine conjugate intermediates The present invention discloses novel dual prodrug compounds of formula (1), methods for their preparation and intermediates in their syntheses, formula (1): wherein A is a single bond, —O—, or —CH2—; m and n vary independently and are an integer ... | 08/17/2010 |
| 7718696 | Methods of treating diabetes using carnitine conjugates as dual prodrugs Compounds of Formula 1 are dual prodrug compounds of the formula The various terms in Formula 1 are selected to optimize the physiochemical and biological properties such as, lipophilicity, bioavailability, and pharmacokineti... | 05/18/2010 |
| 7687074 | Use of milk serum apoproteins in the treatment of microbial or viral infection The present invention relates to use of a milk apoprotein or a mixture thereof to prevent or treat microbial or viral infection of the human or animal body. It is believed that this is achieved by inhibiting adhesion of potential pathogens. More preferably, at least... | 03/30/2010 |
| 7345190 | Carnitine conjugates as dual prodrugs and uses thereof The present invention discloses novel dual prodrug compositions of Formula 1, wherein A is a single bond, —O—, or —CH2—; m and n vary from 0 to 15; p and q vary from 0 to 4; B is a single bond or —CR | 03/18/2008 |
| 7005124 | Dendritic-antineoplastic drug delivery system Antineoplastic dendritic polymer conjugates which are useful drug delivery systems for carrying antineoplastic agents to malignant tumors are prepared by obtaining a dendritic polymer having functional groups which are accessible to an antineoplastic agent capable o... | 02/28/2006 |
| 6790437 | Method of treating cancerous tumors with a dendritic-platinate drug delivery system Dendritic polymer conjugates which are useful drug delivery systems for carrying platinum containing anti-tumor agents to malignant tumors are prepared by obtaining a dendritic polymer having functional groups which are accessible to a platinum containing compound c... | 09/14/2004 |
| 6664315 | Nanocomposites of dendritic polymers In the present invention, an inorganic reactant is, or reactants are, localized with respect to a dendritic polymer by physical constraint within or by a non-covalent conjugation to the dendritic polymer. The localized inorganic reactant or reactants is/a... | 12/16/2003 |
| 6635720 | Core-shell tectodendrimers Core-shell tecto(dendrimers) useful in biomedicine, pharmaceuticals, personal care products, and in other ways analogous to the known uses for dendrimers, hypercomb branched polymers, and other dendritic polymers are the reaction product of a core dendrit... | 10/21/2003 |
| 6585956 | Dendritic-platinate drug delivery system Dendritic polymer conjugates which are useful drug delivery systems for carrying platinum containing anti-tumor agents to malignant tumors are prepared by obtaining a dendritic polymer having functional groups which are accessible to a platinum containing... | 07/01/2003 |
| 6475994 | Method and articles for transfection of genetic material A gene transfection particle includes a polymer, a support particle conjugated with the dendritic polymer, and genetic material conjugated with the dendritic polymer. The gene transfection particles are highly efficient and are capable of delivering highe... | 11/05/2002 |
| 6315979 | Radioiodinated sulfonated phenols for brachytherapy The present invention concerns the use of a radioiodinated phenolic compound of the formula ##STR1## wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged at physiological pH, R, R1, R2 | 11/13/2001 |
| 6312679 | Dense star polymer conjugates as dyes Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the ... | 11/06/2001 |
| 6177414 | Starburst conjugates Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the ... | 01/23/2001 |
| 5928627 | Fluorescent chelates as visual tissue specific imaging agents Fluorescent chelates of terbium and europium with tri- and tetra-cyclopolyazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These chelates are tissue specific imaging agents.... | 07/27/1999 |
| 5834456 | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents Polyazamacrocyclofluoromonoalkylphosphonic acid compounds are disclosed which form inert complexes with Gd, Mn, Fe or La ions. The complexes are useful as contrast agents for diagnostic purposes.... | 11/10/1998 |
| 5808033 | Family of anti-carcinoembryonic antigen chimeric antibodies The present invention discloses novel chimeric monoclonal antibodies directed against human carcinoembryonic antigen, having antigen-specific variable regions. DNA constructs for the light and heavy chain variable regions comprising the novel antibodies o... | 09/15/1998 |
| 5766638 | Hydroxypropyl methocellulose ether compositions for reduction of serum lipid levels The present invention concerns cool-water dispersible powder formulations of high molecular weight hydroxypropyl methylcellulose which has been milled to a specified particle size, with or without encrustation or other surface treatment, for dispersion in... | 06/16/1998 |
| 5762907 | Frozen radiopharmaceutical formulations Radiopharmaceutical formulations for complexes comprising at least one radionuclide complexed with a ligand, or its physiologically-acceptable salts thereof, especially 153 samarium-ethylenediaminetetramethylenephosphonic acid, which optionally... | 06/09/1998 |
| 5756065 | Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents A group conjugates having a functionalized polyaminocarboxylate chelant that form complexes with rare earth-type metal ions, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.... | 05/26/1998 |
| 5750660 | Bicyclopolyazamacrocyclophosphonic acid half esters Bicyclopolyazamacrocyclophosphonic acid compounds are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization. Such complexes can be covalently attached to an an... | 05/12/1998 |
| 5739294 | Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents Bicyclopolyazamacrocyclophosphonic acid compounds are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization. Such complexes can be covalently attached to an an... | 04/14/1998 |
| 5714631 | Conjugates possessing ortho ligating functionality A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or di... | 02/03/1998 |
| 5714604 | Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives A novel process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives is disclosed. The process concerns the reaction of an appropriate azamacrocyclic or acyclic primary or secondary amine with trialkyl phosphite and paraform... | 02/03/1998 |
| 5714166 | Bioactive and/or targeted dendrimer conjugates Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response modifier, have been prepared. The conjugate can also have a targ... | 02/03/1998 |
| 5696239 | Conjugates possessing ortho ligating functionality and complexes thereof A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or di... | 12/09/1997 |
| 5652361 | Macrocyclic ligands and complexes A group of functionalized polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.... | 07/29/1997 |
| 5587451 | Process for preparing polyazamacrocycles A process for preparing polyazamacrocyclic compounds using a nucleophilic imidazoline with (A) an ethylene oxide or an ethylene carbonate, in an aprotic solvent, followed by intramolecular amination, and then either basic or acidic hydrolysis; or (B) an e... | 12/24/1996 |
| 5560929 | Structured copolymers and their use as absorbents, gels and carriers of metal ions Dense star polymers or dendrimers having a highly branched interior structure capable of associating or chelating with metal ions are modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell. The modified dendrimers are ... | 10/01/1996 |
| 5527524 | Dense star polymer conjugates Dense star polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties du... | 06/18/1996 |
| 5489425 | Functionalized polyamine chelants A group of functionalized polyamine chelants that form complexes with rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes.... | 02/06/1996 |
| 5480990 | Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents Complexes of bicyclopolyazamacrocyclocarboxylic acid with Gd, Mn or Fe ions are disclosed. The complexes can be covalently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complexes and conjugates ... | 01/02/1996 |
| 5472633 | Process for the preparation of a stable salt-free iron chelate for use in hydrogen sulfide abatement A stable, salt-free iron chelate for use in aqueous alkaline systems is prepared by contacting iron oxide with an aqueous mixture of from 30 to 45 mole percent trisodium HEDTA and from 55 to 70 mole percent EDTA, heating the mixture to dissolve the iron, ... | 12/05/1995 |
| 5462725 | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents 2-Pyridylmethylenepolyazamacrocyclophosphonic acid compounds and their derivatives are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization. The complexes are... | 10/31/1995 |
