Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 8178541 | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts ther... | 05/15/2012 |
| 8119648 | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts ther... | 02/21/2012 |
| 8096971 | Dual chamber container for lyophilization, process for the filling up and use thereof Double chamber container for holding and combining, e.g., a lyophilizate and a liquid reconstitution medium, comprising an integral cylindrical body (15) with a closure (20, 60) at each of the two ends (5, 70), an upper... | 01/17/2012 |
| 8087286 | Method for checking the permeability rate of a closed container In a method for checking the permeability rate of a closed container (3) with respect to a medium, in particular for checking the permeability rate of a film-type container for accommodating a film container for accommodating a pharmaceutical active constitue... | 01/03/2012 |
| 8002734 | Dual chamber container and process for its filling up A double chamber container for holding and combining a solid lyophilizate and a liquid reconstituting medium, comprising a cylindrical body with a closure at each of the two ends, an upper displaceable closure at the reconstituting medium end, and a lower closure at... | 08/23/2011 |
| 7984713 | Powder inhaler having a nozzle with a plurality of channels The invention relates to a powder inhaler (1) with mouthpiece (2) for dispersing pharmaceutical medicament formulations, which comprises an auxiliary energy source in the form of a pressure medium system (3), having a device for supplying (6 | 07/26/2011 |
| 7942146 | Impaction nozzle for propellant driven metered dose aerosols Propellant gas inhaler fitted with a valve or valve system through which at least two clouds of aerosols or at least two jet streams are produced that travel towards one another at an angle from 0° to 180°, so that the individual aerosol particles at least partial... | 05/17/2011 |
| 7896264 | Microstructured high pressure nozzle with built-in filter function A microstructured nozzle consists of a number of channels produced by microstructuring a plate-shaped member. In the nozzle the channels are located between projections which are arranged side by side in rows and project from a base plate. This microstructured base ... | 03/01/2011 |
| 7870856 | Inhaler An inhaler for administering a medicament in the form of inhalable substances, formulations or mixtures of substances comprises a housing (1) having an inner cavity for holding the medicament, which is coupled to a mouthpiece (2). The housing (1... | 01/18/2011 |
| 7837235 | Device for clamping a fluidic component A fluidic component is arranged in an elastomeric shaped part, the contour of which is matched to the outer contour of the component and to the inner contour of a holder. The elastomeric shaped part is chamfered towards the fluidic component on its pressure side. Wh... | 11/23/2010 |
| 7820815 | Process for the preparation of chiral 8-(-3-aminopiperidin-1-yl) xanthines The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines. The process involves reacting a compound of the formula (III) with 3-(phthalimido)piperidine or an enantiomer thereof | 10/26/2010 |
| 7819342 | Atomizer for dispensing liquids for medical purposes Atomizers (1) comprising a cartridge holder (4) which is arranged in the housing (3), a mouthpiece (5) which is provided on the housing (3) and in which an atomization device (6) is arranged, and a connecting tube system ( | 10/26/2010 |
| 7802568 | Cartridge for a liquid For meteredly dispensing a liquid over a period of several months from a container which can be stored over a long period of time, the need is for a container which is practically diffusion-tight and in which the liquid does not come into contact with the ambient at... | 09/28/2010 |
| 7758936 | Pharmaceutical blister The present invention relates to a new pharmaceutical blister with reduced permeability to water vapor and gas. It is proposed according to the invention to coat conventional blisters with a silicon oxide-containing functional layer to protect against gases, water v... | 07/20/2010 |
| 7726588 | Locking-tensioning mechanism for a miniaturised high pressuriser A locking tensioning mechanism for a miniaturised high pressure generator is disclosed, which mechanism will allow delivery of a set volume of a liquid, and the volume to be delivered by a high pressure generator can be altered subsequently by adjusting one of the s... | 06/01/2010 |
| 7714010 | Pyrrolobenzimidazolones and their use as anti-proliferative agents The invention relates to pyrrolobenzimidazolone compounds of formula (I), wherein A, T and R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessiv... | 05/11/2010 |
| 7708011 | Dry powder inhaler A dry powder inhaler (1) is to be made available, with which a particle size and particle size distribution preferred for inhalation are to be achieved and by means of which as high a line particle fraction as possible is to be realized. This is achieved by m... | 05/04/2010 |
| 7696212 | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions Disclosed are substituted xanthines of general formula wherein R1 to R4 are defined hereinbelow, the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, whic... | 04/13/2010 |
| 7694676 | Dry powder inhaler An inhaler for inhaling powdered pharmaceutical compositions from capsules includes: a lower part; a plate which can be latched to the lower part and with which the lower part can be closed off; a capsule holder for receiving the capsules, this holder being adapted ... | 04/13/2010 |
| 7678911 | 1,6 naphthyridines useful as inhibitors of SYK kinase Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting... | 03/16/2010 |
| 7674488 | External composition comprising an aqueous extract of red vine leaves and an anti-inflammatory agent This invention relates to a new composition containing the effective concentration of an aqueous extract of red vine leaves (1) and an anti-inflammatory agent (2) for preventing or alleviating the discomfort associated with mild-to-moderate chronic venous insufficie... | 03/09/2010 |
| 7667035 | Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides The invention relates to new substituted imidazoles of general formula wherein R1 to R3 and X are defined as in the claims, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and t... | 02/23/2010 |
| 7645763 | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical composition The present invention relates to substituted xanthines of general formula wherein R1 and R2 are defined as in the claims, the tautomers, the stereoisomers, the mixtures thereof, and the salts thereof, ... | 01/12/2010 |
| 7645383 | Microstructured filter A microstructured filter is presented having an inlet for unfiltered fluid; an outlet for filtered fluid; a plurality of projections, which form at least one row in a mutually juxtaposed relationship across the filter, that project out of a base plate and are an int... | 01/12/2010 |
| 7616310 | Process for determining the particle size distribution of an aerosol and apparatus for carrying out such a process The present invention provides, for the first time, a process that meets the needs of the drug industry for measuring the particle size of nebulized aerosols simultaneously or one after another by the laser diffraction method and the cascade impactor method which is... | 11/10/2009 |
| 7604006 | Control unit for flow regulation The invention relates to a control unit for flow regulation for use in an apparatus for testing the delivery of a dose of powder from a powder inhaler, a collecting tube for use in conjunction with the control unit and an apparatus containing the control unit and th... | 10/20/2009 |
| 7569574 | Purine derivatives, the preparation thereof and their use as pharmaceutical compositions The invention relates to new purine derivatives of general formula wherein R1 to R4 are defined as in the claims, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts ther... | 08/04/2009 |
| 7569339 | Use of flow-cytrometric analysis to optimize cell banking strategies for CHO cells Production of biopharmaceuticals from CHO cells requires generation of master-, working- and post-production cell banks of high quality, partly under GMP conditions. An optimal cryopreservation strategy is needed for each new production cell line, particularly with ... | 08/04/2009 |
| 7566707 | Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula wherein Y and R1 to R4 are defined as in claim 1, the tautomers, enantiomers, diaste... | 07/28/2009 |
| 7560450 | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions The present invention relates to substituted xanthines of general formula the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, which have valuable pharmacological properties, p... | 07/14/2009 |
| 7550455 | 8-(piperazin-1yl)- and 8-([1,4]diazepan-1yl)-xanthines, the preparation thereof and their use as pharmaceutical composition The present invention relates to substituted xanthines of the general formula in which R1 to R3 and n are as defined in claims 1 to 8, their tautomers, their enantiomers, their diastereom... | 06/23/2009 |
| 7534787 | Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) is... | 05/19/2009 |
| 7501426 | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions Disclosed are substituted xanthines of the formula wherein R is defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, par... | 03/10/2009 |
| 7495005 | Xanthine derivatives, their preparation and their use in pharmaceutical compositions Compounds of formula (I) wherein R1 is a phenylcarbonylmethyl group wherein the phenyl moiety is substituted, and R2 to R4 are defined as in the claims, or the prodrugs or salts thereof, par... | 02/24/2009 |
| 7495003 | 8-(3-amino-piperidin-1-yl)-7-(but-2-ynyl)-xanthines, the preparation thereof and their use as pharmaceutical compositions The application relates to new substituted xanthines of general formula wherein R1 and R2 are defined as in claims 1 to 11, the tautomers, the enantiomers, the diastereomers, the mixtures... | 02/24/2009 |
| 7495002 | 3-methyl-7-butinyl-xanthines, the preparation thereof and their use as pharmaceutical compositions The present invention relates to new substituted xanthines of general formula wherein R1, R2 and X are defined as in the claims, the tautomers, the enantiomers, the diastereomers, the mixtures thereof ... | 02/24/2009 |
| 7491851 | Method for generating secondary phosphines This invention provides a method for generating secondary phosphines from secondary phosphine oxides in the presence of a reducing agent, such as diisobutylaluminum hydride (DIBAL-H), triisobutyldialuminoxane, triisobutylaluminum, tetraisobutyldialuminoxane, or anot... | 02/17/2009 |
| 7482337 | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions Disclosed are substituted xanthines of general formula wherein R1 to R4 are defined hereinbelow, the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, whic... | 01/27/2009 |
| 7476671 | 2-amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions The present invention relates to 2-amino-imidazo[4,5-d]pyridazin-4-ones and 2-amino-imidazo[4,5-c]pyridin-4-ones of general formula wherein R1 to R4 and X are defined as in claims 1 to 6,... | 01/13/2009 |
| 7470716 | Imidazoles and triazoles, their preparation, and their use as pharmaceutical compositions The present invention relates to imidazoles and triazoles of general formula wherein R1 to R4 and X are defined as in claims 1 to 8, the tautomers, the enantiomers, the diastereomers, the mixtures ther... | 12/30/2008 |
