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| Number | Title | Issue Date |
| 8039028 | Use of an extract of the orchid as a skin hydrating agent The present invention relates to the use, in a cosmetic composition, of an extract of at least one part of an orchid of the species Vanda coerulea, as an agent for maintaining or restoring the hydration state of the skin, said composition also containing a co... | 10/18/2011 |
| 8030462 | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compou... | 10/04/2011 |
| 7932367 | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compou... | 04/26/2011 |
| 7884197 | Synthetic agonists of TLR9 The invention provides novel oligonucleotide-based compounds that individually provide distinct immune response profiles through their interactions as agonists with TLR9. The TLR9 agonists according to the invention are characterized by specific and unique chemical ... | 02/08/2011 |
| 7875594 | Synergistic treatment of cancer using immunomers in conjunction with chemotherapeutic agents The invention relates to the therapeutic use of immunostimulatory oligonucleotides and/or immunomers in combination with chemotherapeutic agents to provide a synergistic therapeutic effect. ... | 01/25/2011 |
| 7824696 | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compou... | 11/02/2010 |
| 7790168 | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compou... | 09/07/2010 |
| 7786089 | Immunostimulatory activity of immune modulatory oligonucleotides (IMO™) containing different lengths of palindromic segments The invention provides a palindromic immune modulatory nucleic acid. The invention also provides methods for generating, enhancing and modifying the immune response caused by palindromic immune modulatory compounds used for immunotherapy applications. ... | 08/31/2010 |
| 7785352 | Modular spinal fixation system A spinal fixation system having a modular construction to allow universal application to varying spine anatomy and load requirements of individual vertebral attachment members, while reducing requirements for large inventories to optimize spinal fixation. Modularity... | 08/31/2010 |
| 7776834 | Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides an immunostimulatory oligonucleotides for use in methods for generating an immune response or for tr... | 08/17/2010 |
| 7709617 | Synergistic stimulation of the immune system using immunostimulatory oligonucleotides and/or immunomer compounds in conjunction with cytokines and/or chemotherapeutic agents or radiation therapy The invention provides optimized methods and compositions for enhancing the immune response caused by immunostimulatory compounds used for the treatment of disease such as, but not limited to, treatment of cancer, autoimmune disorders, asthma, respiratory allergies,... | 05/04/2010 |
| 7700570 | Oligonucleotide mediated specific cytokine induction and prophylaxis and treatment of viral infection in a mammal The invention provides new methods for modulating specific CMI-inducing cytokines in vivo. Such new methods result in stimulation of the cytokines IL-6, IL-12 MIP-1β and MCP without substantially inducing undesired cytokines. The methods according to the invention ... | 04/20/2010 |
| 7671035 | Epidermal growth factor receptor antisense oligonucleotides Disclosed are synthetic oligonucleotides complementary to nucleic acids encoding epidermal growth factor and methods of their use. ... | 03/02/2010 |
| 7595305 | Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers and an immunostimulatory oligonucleotides for use in methods for generating an immune res... | 09/29/2009 |
| 7569554 | Synergistic treatment of cancer using immunomers in conjunction with therapeutic agents The invention relates to the therapeutic use of immunostimulatory oligonucleotides and/or immunomers in combination with chemotherapeutic agents to provide a synergistic therapeutic effect. ... | 08/04/2009 |
| 7566702 | Immunostimulatory oligonucleotide multimers The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is at least partially self-complementary. ... | 07/28/2009 |
| 7517862 | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of... | 04/14/2009 |
| 7498426 | Immunostimulatory oligonucleotide multimers The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is at least partially self-complementary. ... | 03/03/2009 |
| 7498425 | Immunostimulatory oligonucleotide multimers The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is at least partially self-complementary. ... | 03/03/2009 |
| 7470674 | Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides an immunostimulatory oligonucleotides for use in methods for generating an immune response or for tr... | 12/30/2008 |
| 7427405 | Immunostimulatory oligonucleotide multimers The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is at least partially self-complementary. ... | 09/23/2008 |
| 7407944 | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of... | 08/05/2008 |
| 7405285 | Immunostimulatory oligonucleotide multimers The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is at least partially self-complementary. ... | 07/29/2008 |
| 7329648 | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides The invention provides methods for modulating the immune response caused by CpG-containing oligonucleotides. The methods according to the invention enable both decreasing the immunostimulatory effect for antisense applications, as well as increasing the immunostimul... | 02/12/2008 |
| 7288567 | Inhibitors of histone deacetylase The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and cond... | 10/30/2007 |
| 7276489 | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of... | 10/02/2007 |
| 7262286 | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compou... | 08/28/2007 |
| 7241456 | Formulations for topical delivery of bioactive substances and methods for their use The invention relates to topical delivery of bioactive agents. More particularly, the invention relates to anhydrous formulations for percutaneous absorption. The invention provides formulations that allow efficient topical delivery of high concentrations of bioacti... | 07/10/2007 |
| 7030103 | Sulfonamidomethyl phosphonate inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/18/2006 |
| 6984500 | Method for detecting microorganisms and detection kit A method for detecting a microorganism by coloration is provided that includes adding and reacting, in a liquid culture medium, an alkaline sensitizing solution and a coloring reagent containing a redox dye, the liquid culture medium having been inoculated with a te... | 01/10/2006 |