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Attorney: Kempler; Gail M.


Number of patents: 19
Last date: April 10, 2012

NumberTitleIssue Date
8153430Methods related to surgery
The invention is directed to methods related to surgery, for example gastrointestinal surgery. In particular, the invention is methods of treating fistulae, promoting accelerated healing of anastomoses and preventing failure of anastomoses. Such methods utilize nove...
04/10/2012
8153423Pluripotent cells from the mammalian late epiblast layer
This invention relates to the isolation and propagation of pluripotent cells isolated from the mammalian late epiblast layer, termed Epiblast Stem Cells' (EpiSCs). These cells are useful in a range of applications, including the generation of transgenic animal speci...
04/10/2012
8088732Compositions comprising physiologic concentrations of cytokines
The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), ...
01/03/2012
8058066Cellular factor-containing solution compositions
The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), ...
11/15/2011
5955290Assay systems using the CNTF signal transduction pathway
The present invention provides for a stable, biologically active CNTF/receptor complex, and hybrids or mutants thereof. The invention is also based in part on the discovery that the CNTF/receptor complex promotes differentiation through a signal transduct...
09/21/1999
5892003Ciliary neurotrophic factor receptor antibodies
The present invention relates to the ciliary neurotropic factor (CNTF) receptor, and provides for CNTF receptor antibodies. It also relates to diagnostic techniques for identifying CNTF-related neurologic conditions....
04/06/1999
5889173DNA encoding multifunctional neurothrophic factors
Neurotrophins having activities of multiple parental neurotrophins are described, as well as DNA for their production and pharmaceutical preparations thereof....
03/30/1999
5849897Nucleic acid molecule encoding ciliary neurotrophic factor receptor
The present invention relates to the ciliary neurotrophic factor (CNTF) receptor, and provides for CNTF receptor nucleic acid and amino acid sequences. It also relates to (i) assay systems for detecting CNTF activity; (ii) experimental model systems for s...
12/15/1998
5843749Ehk and Ror tyrosine kinases
The present invention provides for novel receptor tyrosine kinases known as Ror-1, Ror-2, Ehk-1 and Ehk-2. The invention also provides for assay systems that may be used to detect and/or measure neurotrophin activity or to identify agents that exhibit neu...
12/01/1998
5705617Neurotrophic factors having altered receptor binding specificities
A method of altering the receptor binding properties and the stability of neurotrophic factors is set forth. Mutant neurotrophic factors having altered receptor binding specificities are described. Specific embodiments include neurotrophic factors that bi...
01/06/1998
5688911Trk neurotrophin binding motifs
Trk neurotrophin binding motifs consisting of 24 amino acid, leucine rich domains are described as well as nucleic acid sequences encoding such peptides. The leucine rich motifs are useful in screens for novel agonists and antagonists of the neurotrophins...
11/18/1997
5667968Prevention of retinal injury and degeneration by specific factors
Photoreceptor injury or cell death (retinal degeneration) is prevented by the introduction into the living mammalian eye of specific, survival-promoting factors. These specific factors prevent damage and degeneration of photoreceptors when introduced into...
09/16/1997
5622862Assay systems for trkB neurotrophin activity
The present invention provides for assay systems that may be used to detect and/or measure neurotrophin activity or to identify agents that exhibit neurotrophin-like activity, and for methods of using such assay systems. It is based, at least in part, on ...
04/22/1997
5512661Multitrophic and multifunctional chimeric neurotrophic factors
The present invention relates to chimeric neurotrophic factors which comprise at least a portion of a naturally occurring cellular factor and a portion of at least one other molecule such that the resulting chimeric molecule has neurotrophic activity. It ...
04/30/1996
5488099Multifunctional chimeric neurotrophic factors
Neurotrophins having activities of multiple parental neurotrophins are described, as well as DNA for their production and pharmaceutical preparations thereof....
01/30/1996
5470952CNTF and IL-6 antagonists
Heterodimer proteins comprising a soluble ଱ specificity determining cytokine receptor component and the extracellular domain of a ଲ receptor component function as CNTF and IL-6 antagonsists....
11/28/1995
5360740Assay system for degenerative muscle disease
An assay system useful for detecting denervated or degenerating muscle by measuring the amount of soluble ciliary neurotrophic factor receptor in body fluids is described....
11/01/1994
5349055Nerve growth factor having altered receptor binding specificities
A method of altering the receptor binding properties and the stability of neurotrophic factors is set forth. Mutant neurotrophic factors having altered receptor binding specificities are described. Specific embodiments include neurotrophic factors that bi...
09/20/1994
5332672Prevention of ES cell differentiation by ciliary neurotrophic factor
The present invention provides for a stable, biologically active CNTF/receptor complex, and hybrids or routants thereof. The invention is also based in part on the discovery that the CNTF/receptor complex promotes differentiation through a signal transduc...
07/26/1994
 
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