...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| 8182985 | Anti-TSG101 antibodies and their uses for treatment of viral infections The present invention provides methods of using antibodies that bind a TSG101 protein to inhibit or reduce viral production. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV infection. The invent... | 05/22/2012 |
| 8021833 | Method for reducing HIV viral budding by administering a VPS28-specfic antibody that disrupts Gag-TSG101-VPS28 binding interactions The importance of interaction between TSG101 and Vps28 in the release of HIV-1 and other viruses is disclosed. Suppressing or interfering in this interaction may inhibit HIV-1 virion release from infected cells. Agents that modulate this interaction include antibodi... | 09/20/2011 |
| 8007842 | Composition for inhalation therapy and methods of use A composition for providing aromatherapy, and in particular, symptomatic relief of nasal and sinus congestion is provided in unit dosage format. The composition includes a penetrating aromatic vapor whose release from a preparation of warm water is augmented by an e... | 08/30/2011 |
| 7981410 | Therapeutic targeting of escort proteins The invention provides for inhibition of viral disease by the provision to a mammalian host of antibodies directed against an escort protein likeTsg 101. These proteins appear on the surface of a cell, and thus can be bound by circulating antibodies thereto. By bind... | 07/19/2011 |
| 7964708 | Anti-TSG101 antibodies and their uses for treatment of viral infections The present invention provides antibodies that bind to the C-terminal region of TSG101. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV and Ebola virus infection. ... | 06/21/2011 |
| 7903337 | High contrast grating light valve A grating light valve is provided with a plurality of spaced reflective ribbons, spatially arranged over a semiconductor substrate, the ribbons and substrate being provided with reflective surfaces. The grating light valve is configured to optimize the conditions fo... | 03/08/2011 |
| 7745148 | Random homozygous gene perturbation to enhance antibody production The invention reflects enhanced antibody expression of an antibody of interest by cell lines transformed by random homozygous gene perturbation methods to either increase or decrease the expression pattern of a gene of the cell line other than the antibody of intere... | 06/29/2010 |
| 7714108 | Mammalian tumor susceptibility gene products and their uses The present invention provides methods and compositions for regulating ubiquitination in a cell. In particular, the present invention provides purified polypeptides comprising an ubiquitination-regulating domain. The invention also provides methods of using such pol... | 05/11/2010 |
| 7452871 | Compositions and methods for treating mammals with modified alginates and modified pectins A modified alginate and/or modified pectin composition and method for preventing and/or treating diseases and/or conditions caused by circulating agents such as poisonous heavy metals, environmental toxins, calcium and cholesterol, is provided. The composition inclu... | 11/18/2008 |
| 7427468 | Anti-TSG101 antibodies and their uses for treatment of viral infections The present invention provides methods of using antibodies that bind a TSG101 protein to inhibit or reduce viral production. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV infection. The invent... | 09/23/2008 |
| 7205107 | Macrophage migration inhibitory factor (MIF) promoter polymorphism in inflammatory disease Describe herein is a CATT-tetranucleotide repeat polymorphism at position −817 of the human Mif gene that functionally affects the activity of the Macrophage Inhibitory Factor (MIF) promoter in gene reporter assays. Four genotypes are described which comprise 5, 6... | 04/17/2007 |
| 7144675 | Radiation-sensitive resin composition A radiation-sensitive resin composition comprising (A) a resin comprising at least two recurring units of the formulas (1)–(6) in the total amount of 5–70 mol %, but each in the amount of 1–49 mol %, the resin being insoluble or scarcely soluble in alkali, but... | 12/05/2006 |
| 7122377 | Acid-labile isotope-coded extractant (ALICE) and its use in quantitative mass spectrometric analysis of protein mixtures The method of the invention provides novel compounds, termed acid-labile isotope-coded extractants (ALICE), for quantitative mass spectrometric analysis of protein mixtures. The compounds contain a thiol-reactive group that is used to capture cysteine-containing pep... | 10/17/2006 |
| 7122514 | Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against staphylococci due to antibiotic activity mediated by c... | 10/17/2006 |
| 7119380 | Lateral trench field-effect transistors in wide bandgap semiconductor materials, methods of making, and integrated circuits incorporating the transistors A junction field effect transistor is described. The transistor is made from a wide bandgap semiconductor material. The device comprises source, channel, drift and drain semiconductor layers, as well as p-type implanted or Schottky gate regions. The source, channel,... | 10/10/2006 |
| 7112413 | Heteroaryl substituted benzothiazole dioxetanes Chemiluminescent heteroaryl substituted benzothiazole 1,2-dioxetane compounds capable of producing light energy when decomposed are provided. These chemiluminescent compounds are represented by the general formula: The... | 09/26/2006 |
| 7108955 | Polysiloxane, process for production thereof and radiation-sensitive resin composition A novel polysiloxane having high transparency to radiations with a wavelength of 193 nm or less, particularly 157 nm or less, and exhibiting superior dry etching resistance and a radiation-sensitive resin composition comprising the polysiloxane exhibiting superior s... | 09/19/2006 |
| 7105269 | Copolymer, polymer mixture, and radiation-sensitive resin composition 1. A copolymer having recurring units of the following formulas (1), (2), and (3), wherein R1, R4, R5, and R6 are a hydrogen atom or a methyl group, R2, R | 09/12/2006 |
| 7084066 | Method of uniformly etching refractory metals, refractory metal alloys and refractory metal silicides This invention is directed to a process for etching a semiconductor device using an etchant composition to form a predetermined etched pattern therein. The semiconductor device typically has a plurality of layers. At least one of the layers comprises a refractory me... | 08/01/2006 |
| 7078377 | Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against staphylococci due to antibiotic activity mediated by cell-wall activ... | 07/18/2006 |
| 7033796 | Nucleic acids encoding protein tyrosine kinases The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver carcinoma cell line (i.e., Hep 3B) using PCR amplification. Provided herein... | 04/25/2006 |
| 7026302 | Compositions and methods for treating mammals with modified alginates and modified pectins A modified alginate and/or modified pectin composition and method for preventing and/or treating diseases and/or conditions caused by circulating agents such as poisonous heavy metals, environmental toxins, calcium and cholesterol, is provided. The composition inclu... | 04/11/2006 |
| 7016853 | Method and system for resume storage and retrieval This a method and system for resume storage and retrieval from multiple resume warehouses. The method system allow recruiters to collect and organize job applicant information gathered from multiply resume warehouses and store them local to a service provider. ... | 03/21/2006 |
| 7005230 | Radiation-sensitive resin composition A radiation-sensitive resin composition comprising (A) a resin which comprises at least one recurring unit (I-1), (I-2), or (I-3), and a recurring unit (II), and is insoluble or scarcely soluble in alkali, but becomes alkali soluble by action of an acid, (B) a photo... | 02/28/2006 |
| 6998238 | Method for determining MIF content A diagnostic method for determining MIF protein content in a sample using a direct or an indirect detection technique and wherein MIF is a human MIF protein having a molecular weight of approximately 12.5 kDa. ... | 02/14/2006 |
| 6986739 | Architecture tool and methods of use The invention provides an apparatus and methods for depositing materials on a substrate, and for performing other selected functions, such as material destruction and removal, temperature control, imaging, detection, therapy and positional and locational control. In... | 01/17/2006 |
| 6974678 | Micro-fluidic device for measuring osmotic second virial coefficients A micro-fluidic device having a cavity containing a solid support (e.g., a plurality of particles) and a biomolecule immobilized on a surface of the solid support is provided. The micro-fluidic device can be used to monitor interactions between a biomolecule in a sa... | 12/13/2005 |
| 6964840 | Radiation-sensitive resin composition A radiation-sensitive resin composition comprising an acid-labile group-containing resin and a photoacid generator is disclosed. The resin has a structure of the formula (1), wherein R1 represents a hydrogen... | 11/15/2005 |
| 6956122 | Multiple fluorescent natural dye compound from a marine organism The present invention provides a novel compound multiple fluorescent natural dye from a marine organism Holothuria Scabra having a chemical structure of of Si—O—R type wherein silica matrix is an integral part of the compound, taking part in the metabolis... | 10/18/2005 |
| 6936243 | Adeno-associated viral vector-mediated delivery of DNA to cells of the liver The instant invention provides methods of expressing polynucleotides in the cells of the liver comprising administering viral particles comprising a recombinant AAV vector into a mammal, preferably a human. ... | 08/30/2005 |
| 6933094 | Radiation-sensitive resin composition A chemically amplified radiation-sensitive resin composition comprising a specific copolymer and a photoacid generator, wherein the copolymer contains the following recurring unit (1) and/or the recurring unit (2), and the recurring unit (3-1), | 08/23/2005 |
| 6933126 | Membrane transportable fluorescent substrates Intracellular enzyme-activated fluorescent substrates that can be transported into a cell are provided. The membrane transportable fluorescent substrates are complexes (e.g., ionic complexes) formed between an enzyme activated fluorescent substrate and a carrier mol... | 08/23/2005 |
| 6925305 | Information management system In a method and apparatus for managing information relating to a wireless service provider enterprise, sites having potential customers are classified based on an ability to obtain legal rights to install a wireless infrastructure at the site and an ability of a wir... | 08/02/2005 |
| 6916492 | Natural nontoxic multicolor fluorescent protein dye from a marine invertebrate, compositions containing the said dye and its uses The present invention discloses the process of extraction, purification and characterization of a natural eco-friendly nontoxic cell permeant multiple fluorescent protein dye from a non bioluminescent marine echinoderm Holothuria scabra, compositions containi... | 07/12/2005 |
| 6916918 | Human glandular kallikrein enhancer, vectors comprising the enhancer and methods of use thereof Enhancers which preferentially increase the transcription of cis-linked coding sequences in prostate cells are provided. Methods of using DNA constructs comprising the enhancers to control transcription of heterologous polynucleotides are also provided. Delivery veh... | 07/12/2005 |
| 6913897 | Kit for conducting an assay to detect a substance using enzymatically-induced decomposition of dioxetanes In an assay method in which a member of a specific binding pair is detected by means of an optically detectable reaction, the improvement wherein the optically detectable reaction includes the reaction, with an enzyme, of a dioxetane having the formula ... | 07/05/2005 |
| 6913197 | Method for inducing upgrading of an expandable product The security modules used in pay television and in other applications are intended to develop and thus to be replaced. In order to promote the replacement of a previous generation by a new one, the method according to the invention consists in sending by a control c... | 07/05/2005 |
| 6911200 | Methods of treating neoplasia with combination of target-cell specific adenovirus, chemotherapy and radiation The invention provides methods of treating neoplasia using combinations of target cell-specific replication competent adenoviral vectors and chemotherapy, radiation therapy or combinations thereof. The adenoviral vectors are target cell-specific for the particular t... | 06/28/2005 |
| 6908722 | Acid generator, sulfonic acid, sulfonic acid derivatives and radiation-sensitive resin composition A novel photoacid generator containing a structure of the following formula (I), wherein R is a monovalent organic group with a fluorine content of 50 wt % or less, a nitro group, a cyano group, or a hydrogen atom, and... | 06/21/2005 |
| 6908491 | System and method for color-revitalizing hair A method for color-revitalizing a color tone of hair that involves applying a color-revitalizing composition to hair previously dyed with an oxidative hair dye composition. The color-revitalizing composition, which has a color determined by the color of the oxidativ... | 06/21/2005 |