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| Number | Title | Issue Date |
| 8178655 | Method and composition for crystallizing G protein-coupled receptors Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a st... | 05/15/2012 |
| 8168385 | Methods and compositions for tagging and identifying polynucleotides The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the oligonucleotide tags of polynucleotides selected in such assays. Words, or subuni... | 05/01/2012 |
| 8148068 | Methods and compositions for tagging and identifying polynucleotides The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the oligonucleotide tags of polynucleotides selected in such assays. Words, or subuni... | 04/03/2012 |
| 8139715 | Method and composition for crystallizing G protein-coupled receptors Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a st... | 03/20/2012 |
| 8124336 | Methods and compositions for reducing the complexity of a nucleic acid sample Aspects of the present invention are drawn to methods and compositions for sorting nucleic acid molecules into physically separate compartments according to the identity of a nucleotide base or sequence of bases at a specific location, resulting in the production of... | 02/28/2012 |
| 8097425 | Multiplex protein fractionation The invention provides methods, compositions, and kits for multiplex fractionation of proteins in a sample. Protein-binding molecules, such as small epitope antibodies or small epitope aptamers, are used for multiplex fractionation of proteins in a protein containin... | 01/17/2012 |
| RE43096 | Tagged extendable primers and extension products This invention provides a duplex comprising an oligonucleotide primer and a template, wherein the primer is coupled chemically to a chromophore or fluorophore so as to allow chain extension by a polymerase. In one embodiment, the primer is extended by a polymerase t... | 01/10/2012 |
| 8088375 | Anti-VEGF antibody An antibody is provided. In certain cases, the antibody comprises: a) a heavy chain variable domain that comprises CDR regions that are substantially identical to the heavy chain CDR regions of a selected antibody and b) a light chain variable domain that comprises ... | 01/03/2012 |
| 8071742 | Method and composition for crystallizing G protein-coupled receptors Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a st... | 12/06/2011 |
| 8071322 | Method for identifying differentially expressed proteins The invention provides a method of identifying an antigen that is present in different amounts in two different samples. In general, the methods involve generating a first and second distinguishably labeled population of antibodies that reactive to the two samples, ... | 12/06/2011 |
| 8071286 | Gene expression profiling in biopsied tumor tissues The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and method... | 12/06/2011 |
| 8062867 | Fusion partner for production of monoclonal rabbit antibodies The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not detectably express endogenous immunoglobulin heavy chain and may contain, ... | 11/22/2011 |
| 8039795 | Ion sources for improved ionization Improved apparatuses and methods are provided for ionizing samples and analyzing the samples with mass spectrometry. ... | 10/18/2011 |
| 8036835 | Probe design methods and microarrays for comparative genomic hybridization and location analysis Methods and systems for identifying and selecting nucleic acid probes for detecting a target with a nucleic acid probe array or comparative genome hybridization microarray, comprising selecting a plurality of potential target sequences, generating a plurality of can... | 10/11/2011 |
| 8034917 | Primer-directed chromosome painting An oligonucleotide composition is provided. The subject composition comprises: a mixture of at least 10 of sets of oligonucleotides, wherein each of the sets of oligonucleotides comprises at least 100 different oligonucleotides of the following formula: X1 | 10/11/2011 |
| 8032346 | System and method for high-content oncology assay The present invention provides an apparatus, system, method and computer program and computer program product for analyzing cellular samples. One embodiment of the apparatus and method provides a multiparameter assay that provides information with respect to cell pr... | 10/04/2011 |
| 8030095 | Gel microdrop composition and method of using the same A gel microdrop composition is provided. In certain embodiments, the gel microdrop composition contains a polymer matrix, an effector particle that releases an effector molecule into the polymer matrix, a first reporter particle that emits a first optically detectab... | 10/04/2011 |
| 8027823 | Methods and system for viewing genomic data A computer-implemented method for viewing experimental data is provided. In certain embodiments the method comprises: a) inputting genomic array data and cytogenetic data into a computer memory; and b) producing a graphical user interface comprising: i) a chromosoma... | 09/27/2011 |
| 8021844 | Enzymatic labeling of RNA Methods are described in which a sample containing RNA is contacted with an enzyme having an RNA ligation activity in the presence of a labeled substrate to provide labeled RNA. Methods of performing an array analysis of a labeled RNA sample are also described. ... | 09/20/2011 |
| 8017328 | Genome partitioning using a nicking endonuclease A method for partitioning a genome is provided. In certain embodiments, the method comprises: a) nicking a region of the genome using a sequence-specific nicking endonuclease to produce a nicked double-stranded genomic region; b) hybridizing the nicked double-strand... | 09/13/2011 |
| 8017313 | Human G protein-coupled receptor and modulators thereof for the treatment of cardiovascular disorders The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In some embodiments, the GPCR is mammalian, preferably human. In some embodiments, the GPCR is expressed endogenously by cardi... | 09/13/2011 |
| 8012765 | Method for mixing a film of fluid A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and mov... | 09/06/2011 |
| 7998685 | Methods of identifying candidate compounds of the human G protein-coupled receptor, GPR50, as modulators of body mass or adiposity The present invention relates to methods of using a G protein-coupled receptor (GPCR) to screen one or more candidate compounds as a modulator of body mass or of adiposity or of percentage body fat in a subject or as a pharmaceutical agent for obesity and conditions... | 08/16/2011 |
| 7979215 | Methods and systems for evaluating CGH candidate probe nucleic acid sequences Methods of evaluating candidate CGH probe nucleic acid sequences are provided. Aspects of the methods include providing a candidate CGH probe nucleic acid sequence for a target sequence of a copy number variation (CNV) of a genome. A proximity score is then determin... | 07/12/2011 |
| 7970549 | System and method for high-content oncology assay The present invention provides an apparatus, system, method and computer program and computer program product for analyzing cellular samples. One embodiment of the apparatus and method provides a multiparameter assay that provides information with respect to cell pr... | 06/28/2011 |
| 7960517 | Methods for antibody engineering The invention provides a method for identifying positions of an antibody that can be modified without significantly reducing the binding activity of the antibody. In many embodiments, the method involves identifying a substitutable position in a parent antibody by c... | 06/14/2011 |
| 7959921 | TNFα-neutralizing antibodies The invention provides monoclonal antibodies that neutralize TNFα activity. The monoclonal antibodies may be rabbit monoclonal antibodies or monoclonal antibodies having CDR regions derived from those rabbit monoclonal antibodies. In certain embodiments, the monocl... | 06/14/2011 |
| 7947807 | Method for obtaining G protein-coupled receptor (GPCR) diffraction-quality crystals employing a monoclonal antibody that binds to the third intracellular loop (IL3) An antibody that specifically binds a three dimensional epitope on the IC3 loop of a GPCR is provided. The antibody may be employed in a method that comprises: contacting a GPCR with a monovalent version of the antibody binding conditions to form a complex; and crys... | 05/24/2011 |
| 7930104 | Predicting response to chemotherapy using gene expression markers The present invention provides gene expression information useful for predicting whether a cancer patient is likely to have a beneficial response to treatment with chemotherapy, comprising measuring, in a biological sample comprising a breast tumor sample obtained f... | 04/19/2011 |
| 7912654 | Crystal structure βadrenoreceptor A computer readable medium comprising atomic coordinates for the human β2 adrenoreceptor is provided. The computer readable medium programming for displaying a molecular model of the human β2 adrenoreceptor, programming for identifying a comp... | 03/22/2011 |
| 7872096 | Methods for cyclizing synthetic polymers The invention provides methods and compositions for production of a cyclic polymer in a cell free system. In general, the methods of the invention involve ligating first and second recombinant intein domains to a linear synthetic polymer to form a compound containin... | 01/18/2011 |
| 7871769 | Gene expression markers for predicting response to chemotherapy The present invention provides sets of genes the expression of which is important in the prognosis of cancer. In particular, the invention provides gene expression information useful for predicting whether cancer patients are likely to have a beneficial treatment re... | 01/18/2011 |
| 7863222 | shRNA library As noted above, certain aspects of this disclosure relate to a library of nucleic acid vectors, as well as a method for making the same. In certain embodiments, the library of nucleic acid vectors comprises: a plurality of nucleic acid molecules of the following for... | 01/04/2011 |
| 7858304 | Gene expression profiling in biopsied tumor tissues The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and method... | 12/28/2010 |
| 7838224 | Gene expression profiling in biopsied tumor tissues The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and method... | 11/23/2010 |
| 7803371 | Anti-VEGF antibody An antibody is provided. In certain cases, the antibody comprises: a) a heavy chain variable domain that comprises CDR regions that are substantially identical to the heavy chain CDR regions of a selected antibody and b) a light chain variable domain that comprises ... | 09/28/2010 |
| 7790850 | Method and composition for crystallizing G protein-coupled receptors Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a st... | 09/07/2010 |
| 7776558 | Human G protein-coupled receptor and modulators thereof for the treatment of cell death-related disorders The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In certain embodiments, the GPCR is human. In certain embodiments, the GPCR is expressed endogenously by neuronal cells or mus... | 08/17/2010 |
| 7767391 | Use of intronic RNA to measure gene expression The invention is based on the use of intronic RNA in monitoring gene expression. Accordingly, the present invention concerns methods of gene expression profiling using intronic RNA, the expression of which correlates with the expression of corresponding exonic RNA, ... | 08/03/2010 |
| 7745196 | Methods and compositions for identifying peptide modulators of cell surface receptors The invention provides methods and compositions for identifying modulators, particularly peptide modulators, of cell surface receptor activity. Specifically, the invention provides a cell containing a recombinant nucleic acid encoding a polypeptide modified for intr... | 06/29/2010 |
