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| Number | Title | Issue Date |
| 5283250 | Quinolinyl/quinolinylalkyl-N-terminal amino hydroxy Non-peptidyl compounds characterized generally as quinolinyl/quinolinylalkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula ##S... | 02/01/1994 |
| 5231111 | Imidazolyl/imidazolylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as imidazolyl/imidazolylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are ... | 07/27/1993 |
| 5229420 | Ethereal N-terminal aminodiol amino acid derivatives as anti-hypertensive agents Non-peptidyl compounds characterized generally as ethereal N-terminal aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are of the formula ##STR1## wherein X i... | 07/20/1993 |
| 5229406 | 1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders A class of 1,3,5-trisubstituted-1,2,4-triazole compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula ##STR1## wherein m is one; wherein R1 is se... | 07/20/1993 |
| 5229369 | Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents Non-peptidyl compounds characterized generally as aminoalkylaminocarbonyl aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are of the formula ##STR1## wherein... | 07/20/1993 |
| 5227401 | Ethynyl alanine amino diol compounds for treatment of hypertension Compounds characterized generally as ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO2 | 07/13/1993 |
| 5223534 | Benzofuuranyl/benofuranylaklyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as benzofuranyl/benzofuranylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest ... | 06/29/1993 |
| 5223532 | Chromonyl/chromonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino derivatives Non-peptidyl compounds characterized generally as chromonyl/chromonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of... | 06/29/1993 |
| 5223514 | Quinolinyl/quinolinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as quinolinyl/quinolinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are ... | 06/29/1993 |
| 5223512 | Quinolonyl/quinolonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as quinolonyl/quinolonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are ... | 06/29/1993 |
| 5223535 | Propargyl glycine amino propargyl diol compounds for treatment of hypertension Compounds characterized generally as propargyl glycine amino propargyl diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO a... | 06/29/1993 |
| 5217985 | Renal-selective biphenylalkyl 1H-substituted-1,2,4-triazole angiotensin II antagonists for treatment of hypertension Renal-selective compounds are described which, in one embodiment, are prodrugs preferentially converted in the kidney to compounds capable of blocking angiotensin II (AII) receptors. These prodrugs are conjugates formed from two components, namely, a firs... | 06/08/1993 |
| 5217989 | Benothiophenyl/benzothiophenylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as benzothiophenyl/benzothiophenylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular int... | 06/08/1993 |
| 5217991 | Cycloalkyl/cycloalkylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as cycloalkyl/cycloalkylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are ... | 06/08/1993 |
| 5217988 | Indolyl indolylakyl-N-terminal cycloalkoxy-C-terminal amino hydroxyଲ-amino acid derivatives Non-peptidyl compounds characterized generally as indolyl/indolylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the... | 06/08/1993 |
| 5216003 | Diacid-containing benzimidazole compounds for treatment of neurotoxic injury A class of diacid-containing benzimidazole compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a... | 06/01/1993 |
| 5216013 | Aralkyl-N-terminal cycloalkoxy-C terminal amino hydroxy ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as heterocyclic acyl aminodiol ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are compounds of the formula ##STR1## whe... | 06/01/1993 |
| 5215996 | Naphthyridinyl/naphthyridinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as heterocyclic acyl aminodiol ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are compounds of the formula ##STR1## whe... | 06/01/1993 |
| 5212175 | Benzothiophenyl benzothiophenylalkyl-N-terminal amino hydroxy ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as benzothiophenyl/benzothiophenylalkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formul... | 05/18/1993 |
| 5212185 | Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension Compounds characterized generally as piperidinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wher... | 05/18/1993 |
| 5210095 | Chromonyl/chromonylalkyl-N-terminal amino hydroxy Non-peptidyl compounds characterized generally as chromonyl/chromonylalkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula ##STR... | 05/11/1993 |
| 5196537 | 5-apylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders A class of 5-arylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds is described for use in treatment of circulatory disorders such as hypertension. Compounds of particular interest are antiotensin II antagonists of the formula ##STR1## ... | 03/23/1993 |
| 5187171 | Use of a Glycine B partial agonist as an antipsychotic A class of Glycine B partial agonists is described for use for treatment of psychosis. Preferred Glycine B partial agonists include amino-isoxazolidone compounds such as D-cycloserine and its prodrugs.... | 02/16/1993 |
| 5187271 | N-substituted (-imidazolyl-toluyl) pyrrole compounds for treatment of circulatory disorders A class of N-substituted (-imidazolyl-toluyl)pyrrole compounds described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula ##STR1## wherein m is one; wherein each of R... | 02/16/1993 |
| 5180744 | Aralkyl-N-terminal amino hydroxy Non-peptidyl compounds characterized generally as aralkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula ##STR1## wherein ... | 01/19/1993 |
| 5180725 | Quinoxalinyl/quinoxaliy; alkyl-N-terminal amino hydroxy Non-peptidyl compounds characterized generally as quinoxalinyl/qunioxalinylalkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula ... | 01/19/1993 |
| 5179102 | Naphthyridinyl/naphthyridinylalkyl-n-terminal anino hydroxy ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as naphthyridinyl/naphthyridinylalkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula ... | 01/12/1993 |
| 5175181 | Imidazolyl/imidazolylalkyl-N-terminal amino hydroxy Non-peptidyl compounds characterized generally as imidazolyl/imidazolylalkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula ##S... | 12/29/1992 |
| 5175170 | ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as cycloalkyl/cycloalkylkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest of the formula ##STR1## ... | 12/29/1992 |
| 5175180 | N-substituted N-(alpha-triazolyl-toluyl)pyrrole compounds and use for treatment of circulatory disorders A class of N-substituted N-(-triazolyltoluyl)pyrrole compounds described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula ##STR1## wherein m is one; wherein R1 | 12/29/1992 |
| 5171751 | Benzofuran/benzofuranalkyl-N-terminal amino hydroxy Non-peptidyl compounds characterized generally as benzofuran/benzofuranalkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula ##S... | 12/15/1992 |
| 5164403 | N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders A class of N-arylheteroarylalkyl imidazol-2-one compounds is described for use in treatment of circulatory disorders such as hypertension and congestive heart failure. Compounds of particular interest are angiotensin II antagonists of the formula ##S... | 11/17/1992 |
| 5162569 | Phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives A class of substituted phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds having immunosuppressive properties is described. Compounds of this class would be useful in reducing recipient rejection of transplanted organs and for treatment of... | 11/10/1992 |
| 5155117 | 1-arylheteroarylalkyl substituted-1H-1,2,4-triazole compounds for treatment of circulatory disorders A class of 1-arylheteroarylalkyl substituted-1H-1,2,4-triazole compounds is described for use in treatment of circulatory disorders such as hypertension. Compounds of particular interest are angiotensin II antagonists of the formula ##STR1## whe... | 10/13/1992 |
| 5147888 | N-terminal indolyy indolylalkylaminodiol ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as heterocyclic acyl aminodiol ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula ##STR1## wherein R | 09/15/1992 |
| 5140036 | 1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders A class of 1,3,5-trisubstituted-1,2,4-triazole compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula ##STR1## wherein m is one; wherein R1 is se... | 08/18/1992 |
| 5106834 | Linear free-sulfhydryl-containing oligopeptide derivatives as antihypertensive agents Synthesis and use of novel oligopeptides are described, many of which peptides contain one or several unnatural amino acids. These short linear peptide derivatives are characterized by the presence of a free sulfhydryl function. These compounds have a hig... | 04/21/1992 |
| 5104891 | Cycloheptimidazolone compounds as angiotensin II antagonists for control of hypertension A class of cycloheptimidazolone compounds is described as angiotensin II antagonists for use in control of hypertension. Compounds of particular interest are those of the formula ##STR1## wherein each of R1 and R2 is independent... | 04/14/1992 |
| 5098920 | 1H-substituted-1,2,4-triazole compounds and methods of use thereof for treatment of cardiovascular disorders A class of 1H-substituted-1,2,4-triazole compounds is described for use in treatment of cardiovascular disorders. Compounds of particular interest are angiotensin II antagonists of the formula ##STR1## wherein R1 is selected from hydroxy, ... | 03/24/1992 |
| 5098916 | Propanobicyclic amine derivatives for CNS disorders Certain propanobicyclic amine compounds are described for treatment of CNS disorders such as psychotic disorders, convulsions, dystonia and cerebral ischemia. Compounds of particular interest are of the formula ##STR1## wherein each R1, R | 03/24/1992 |
