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| Number | Title | Issue Date |
| 8163484 | Light emission modifiers and their uses in nucleic acid detection, amplification and analysis The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic acid sequences, e.g., using singly labeled probes. These methods and re... | 04/24/2012 |
| 8137937 | Method for bisulfite treatment The present application is directed to a method for performing a bisulfite reaction to determine methylation positions in a nucleic acid via treatment of the solid phase-bound nucleic acid with bisulfite, desulfonation and elution of the nucleic acid from the solid ... | 03/20/2012 |
| 8137616 | System for multi color real time PCR The invention is directed to a system for performing multi-color real time PCT, comprising a flexible real time PCT instrument and a specific composition or reaction mixture for performing multiplex PCR: In particular, the present invention is directed to a composit... | 03/20/2012 |
| 8119346 | Light emission modifiers and their uses in nucleic acid detection, amplification and analysis The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic acid sequences, e.g., using singly labeled probes. These methods and re... | 02/21/2012 |
| 8114595 | Light emission modifiers and their uses in nucleic acid detection, amplification and analysis The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic acid sequences, e.g., using singly labeled probes. These methods and re... | 02/14/2012 |
| 8097717 | Compositions comprising polidocanol and derivatives This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to t... | 01/17/2012 |
| 8058423 | High-risk human papillomavirus detection This invention provides compositions and methods for detecting HPV in a sample. This invention also provides related kits, systems, and computers. ... | 11/15/2011 |
| 8039215 | Multiplex quantitative nucleic acid amplification and melting assay The invention is a single-tube multiplex assay, capable of simultaneously amplifying, detecting and quantifying multiple nucleic acid targets, using multiple hybridization probes, labeled with the same fluorescent reporter label, but each having a distinct melting t... | 10/18/2011 |
| 8026068 | Use of silica material in an amplification reaction This invention relates to a method for the isolation of a target nucleic acid using a material with an unmodified silica surface and subsequent amplification of the target nucleic acid in the presence of the material with an unmodified silica surface. The method is ... | 09/27/2011 |
| 8017094 | Rack for analyzer and analyzer comprising such a rack A rack for holding containers containing liquids used in clinical chemistry analyzers. The rack comprises (a) a frame having two or more sections, each section being adapted for receiving a liquid containing component, ... | 09/13/2011 |
| 7981606 | Control for nucleic acid testing The present invention is related to a method for detecting a target biomolecule in test sample by adding an internal control biomolecule to the test sample; to a negative control sample, to a positive control sample and to a reagent control sample or adding an inter... | 07/19/2011 |
| 7977108 | Method for detecting a mutation in a repetitive nucleic acid sequence The present invention provides methods and probe nucleic acids for detecting mutant forms of target nucleic acids that comprise repetitive nucleotide sequences. In certain embodiments, for example, these approaches and reagents can be used to detect instability in r... | 07/12/2011 |
| 7947817 | Synthesis and compositions of 2'-terminator nucleotides The invention provides compositions that comprise nucleotides and/or nucleosides having blocking groups at 2′-positions of sugar moieties. Methods of synthesizing these nucleic acids are also provided. ... | 05/24/2011 |
| 7947237 | Rack system The invention provides a rack system containing an adapter for convenient application of small volumes of sample in a vessel to analysis. ... | 05/24/2011 |
| 7931879 | Containers and methods for the automated handling of a liquid The invention relates to a method for the automated handling of a fluid biological sample in an analytical instrument. Furthermore, the invention provides containers as well as instruments and systems suitable for the automated handling and processing of the fluid b... | 04/26/2011 |
| 7928207 | Synthesis and compositions of nucleic acids comprising 2′-terminator nucleotides The invention provides methods of producing blocked oligonucleotides that include 2′-terminator nucleotides. These blocked oligonucleotides are used primers and probes in a variety of nucleic acid technologies. Related kits are also provided. ... | 04/19/2011 |
| 7919249 | 2′-Terminator nucleotide-related methods and systems The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2′-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention als... | 04/05/2011 |
| 7919242 | Light emission modifiers and their uses in nucleic acid detection, amplification and analysis The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic acid sequences, e.g., using singly labeled probes. These methods and re... | 04/05/2011 |
| 7919063 | Device with a compressible matrix having homogeneous flow profile A fluidic device containing a flow through chamber comprising an inlet port, an outlet port, and a fluid permeable, compressible matrix located in the chamber between said inlet port and said outlet port, and said compressible matrix having a higher flow resistance ... | 04/05/2011 |
| 7897378 | Method and device for purifying nucleic acids The invention concerns a method for isolating and purifying nucleic acids from a sample and a device that is suitable therefore. ... | 03/01/2011 |
| 7890268 | De-novo sequencing of nucleic acids The present invention is directed to an improved analysis procedure for the comparative sequencing of nucleic acids using multistage mass spectrometry. More precisely, the invention is directed to a method enabling the de-novo sequencing of nucleic acid molecules us... | 02/15/2011 |
| 7847075 | 2-Azapurine compounds and their use Within oligonucleotides, 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaa... | 12/07/2010 |
| 7829800 | Device and method for the gravimetric determination of liquid volumes and analyzer system comprising such a device A device for the gravimetric volume determination of liquid volumes. The device comprises a housing (11) having the shape and dimensions of a standard rack used in a clinical diagnostic analyzer system for holding sample or reagent containers, and the followi... | 11/09/2010 |
| 7820110 | Drop catcher The invention relates to a device for catching drops from a pipette mechanically attached to a pipetting device in the field of nucleic acid purification and amplification. Furthermore, a method for pipetting a liquid with a decreased potentiality of contamination o... | 10/26/2010 |
| 7790371 | Associations of polymorphisms in the FRZB gene in obesity and osteoporosis The present invention relates to polymorphisms of the FRZB gene and the analysis of nucleic acids thereof. The invention further relates to methods of predicting risks of certain conditions in individual and kits for the determination of such risks. ... | 09/07/2010 |
| 7741467 | Non-fluorescent energy transfer The present invention relates generally to the transfer of non-fluorescent energy between donor and acceptor moieties. In certain embodiments, the invention provides biomolecules that include substantially non-fluorescent donor moieties. Processes involving these do... | 06/22/2010 |
| 7720613 | Method for sequencing nucleic acids Method for sequencing nucleic acids in which the values of the CID spectrum calculated for an assumed sequence are compared with the measured spectrum of the nucleic acid and the degree of correspondence is calculated, at least one position of the assumed sequence i... | 05/18/2010 |
| 7612187 | 2-azapurine compounds and their uses Within oligonucleotides 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaad... | 11/03/2009 |
| 7600438 | Device and method for the adjustment of a temperature of a liquid A device and a method for the adjustment of a temperature of a liquid which is contained in one or more sample vessels are specified, a control unit and a temperature adjustment unit being provided, which acts on the liquid contained in the sample vessels. Furthermo... | 10/13/2009 |
| 7572581 | 2′-terminator nucleotide-related methods and systems The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2′-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention als... | 08/11/2009 |
| 7566775 | N- and C-linked purine bases and structurally related heterocycles as universal nucleosides used for oligonucleotides hybridization The present invention is directed to a nucleic acid binding compound comprising N8- or C8-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this nucleic acid b... | 07/28/2009 |
| 7560231 | Mannitol and glucitol derivatives The present invention is related to compounds comprising mannitol or glucitol derivatives which may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods... | 07/14/2009 |
| 7537935 | System for providing biological materials A process and closure arrangement is provided for isolating purified biological material. The process includes placing biological materials in separate lysis vessels, adding lysis liquids to the biological materials in the lysis vessels, and transferring the liquids... | 05/26/2009 |
| 7501504 | Detectable labeled nucleoside analogs and methods of use thereof The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides, and nucleic acids incorporating such compounds, and methods utilizing s... | 03/10/2009 |
| 7501240 | Method for bisulfite treatment The invention is related to the detection of a methylated cytosine in a nucleic acid wherein guanidinium hydrogen sulfite is used for the preparation of a solution containing guanidinium ions and sulfite ions and subsequent modification of the nucleic acid. Thereby,... | 03/10/2009 |
| 7482142 | High-risk human papillomavirus detection This invention provides compositions and methods for detecting HPV in a sample. This invention also provides related kits, systems, and computers. ... | 01/27/2009 |
| 7465561 | Probes and methods for hepatitis C virus typing using single probe analysis This invention provides compositions and methods for HCV typing, e.g., genotyping and/or subtyping. The compositions and methods of the invention can be used to assign an HCV isolate to one of at least five HCV genotypes (for example, selected from genotypes 1, 2, 3... | 12/16/2008 |
| 7456266 | Detectable labeled nucleoside analogs and methods of use thereof The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides, and nucleic acids incorporating such compounds, and methods utilizing s... | 11/25/2008 |
| 7452674 | Detectable labeled nucleoside analogs and methods of use thereof The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides, and nucleic acids incorporating such compounds, and methods utilizing s... | 11/18/2008 |
| 7445900 | Homogeneous assay system A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for det... | 11/04/2008 |
