Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 4895570 | Locking port shroud for peritoneal dialysis tubing connector A tubing connector adapted for peritoneal dialysis connections between tubing sets and containers of dialysate. The connection prevents inadvertent disengagement of tubing sets.... | 01/23/1990 |
| 4859776 | (S)-7-(3-aminopyrrolidin-1-yl)-1-(ortho, para-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carb oxylic acid and method for its preparation A process for the preparation of enantiomerically homogeneous aminopyrrolidinyl naphthyridine carboxylic acids and quinolone carboxylic acids, and for the preparation of intermediates that are useful in the production of these carboxylic acids. The compou... | 08/22/1989 |
| 4857507 | Angiotensinogen analogs The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is hydrogen; loweralkyl; arylalkyl; OR10 or SR10 wherein R10 is hydrogen, loweralkyl or aminoalkyl; NR11 R12 ... | 08/15/1989 |
| 4851211 | LHRH analog formulations The invention relates to novel aerosol formulations comprising LHRH analogs, a lipophilic counterion, solvent and propellant and, optionally, surfactant, valve lubricant, an antioxidant and flavor and fragrance.... | 07/25/1989 |
| 4837204 | Functionalized peptidyl aminodiols and -triols The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is hydrogen; loweralkyl; aryalkyl; OR8 or SR8 wherein R8 is hydrogen, loweralkyl or aminoalkyl; NR9 R10 wherein ... | 06/06/1989 |
| 4836908 | Miniaturized reference electrodes A reference electrode is disclosed for use in potentiometric analysis of ion activity in a solution.... | 06/06/1989 |
| 4826958 | Renin inhibiting compounds The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is ##STR2## wherein B is thiomorpholino, morpholino, 4-sulfonylmorpholino, 3,4-dihydroxypyrrolidino, alkoxy or loweralkyl and C is NH or CH2 ; ... | 05/02/1989 |
| 4826985 | Intermediates for preparation of racemate and optically active ofloxacin and related derivatives A process for producing racemic or optically active compounds of the formula: ##STR1## wherein R1 is hydrogen, C1 to C6 alkyl or benzyl; and Z is amino or substituted amino. Also disclosed are intermediates useful in ... | 05/02/1989 |
| 4826815 | Renin inhibiting compounds The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is hydrogen; loweralkyl; arylalkyl; Or10 wherein R10 is hydrogen or loweralkyl; NR11 R12 wherein R11 and R | 05/02/1989 |
| 4822809 | Benzazole lipoxygenase inhibiting compounds Compounds of the formula: ##STR1## wherein R1 is (1) hydrogen, (2) C1 to C4 alkyl, (3) C2 to C4 alkenyl, or (4) NR2 R3, wherein R2 and R3 are independe... | 04/18/1989 |
| 4822811 | Carbazole lipoxygenase inhibiting compounds, compositions and use Compounds of the formula: ##STR1## wherein R1 is hydrogen, C1 to C4 alkyl, C2 to C4 alkenyl, or NR2R3, wherein R2 and R3 are independently selected from hydrogen, C1 to C4 alkyl and hydroxyl, but R2 and R3 are not simultaneously hydroxyl; X is oxygen... | 04/18/1989 |
| 4814282 | Centrifuge for two-dimensional centrifugation Method and apparatus for generating centrifugal forces, including a plate rotatable about an axis, and at least one holding means mounted on the plate for rotation therewith, the holding means being adapted to receive an article to be subjected to centrif... | 03/21/1989 |
| 4800167 | Reagent and process for the determination of hemoglobin in blood A reagent system for determing the hemoglobin content of whole blood comprising an aqueous solution of polyvinylpyrrolidone of molecular weight from about 10,000 to about 360,000 at a pH greater than about 8.0 to denature hemoglobin in whole blood. A meth... | 01/24/1989 |
| 4788136 | Diagnostic immunoassay by solid phase separation for digoxin A method for performing a diagnostic immunoassay by solid phase separation for digoxin. To a reaction mixture of a test sample and labeled anti-digoxin antibody, which forms a complex of any digoxin present in the test sample, is added a solid phase mater... | 11/29/1988 |
| 4786279 | Container for mixture of materials A container having two compartments for keeping two materials in separated relation. When it is desired that the two materials be intermixed, an actuator carrying a pair of piercing pins is inserted into ports of the compartments until membranes blocking ... | 11/22/1988 |
| 4784961 | Fluorescence polarization method for monitoring fetal lung maturity The present invention is directed to a fluorescence polarization method for monitoring fetal lung maturity, to various components needed for preparing and carrying out such monitoring, and to methods of making these components.... | 11/15/1988 |
| 4781679 | Container system with integral second substance storing and dispensing means The invention is an integral container system designed for separately storing a liquid, such as a diluent, and a second substance, such as a medicament, and subsequently adding the second substance to the liquid in a simple and sterile operation. In one e... | 11/01/1988 |
| 4782023 | Stabilized horseradish peroxidase conjugate composition An enzyme conjugate composition comprising an enzyme conjugate, a calcium salt and a polyethylene glycol is disclosed. The enzyme conjugate composition is effectively stabilized by the presence of the calcium salt and the polyethylene glycol.... | 11/01/1988 |
| 4777253 | Process for preparation of racemate and optically active ofloxacin and related derivatives A process for producing racemic or optically active compounds of the formula: ##STR1## wherein R1 is hydrogen, C1 to C6 alkyl or benzyl; and Z is amino or substituted amino. Also disclosed are intermediates useful in ... | 10/11/1988 |
| 4776832 | Centrifuge having multiple induction motors for rotating objects about a second axis An improved centrifuge, including a main wheel for rotating objects to be subjected to centrifugal force about a main axis of rotation, is disclosed. Such objects are simultaneously rotated about a second axis of rotation from a first to a second position... | 10/11/1988 |
| 4774246 | Quinoline antibacterial compounds Quinoline compounds having the formula: ##STR1## wherein R is a phenyl or substituted phenyl group or an aromatic heterocyclic group, R1 is a hydrogen or a carboxy-protecting group and Z is an amine group or an aliphatic heterocyclic group... | 09/27/1988 |
| 4772377 | Membrane anchor for ion-selective electrodes A membrane anchor for an ion-selective electrode may be formed by intersolubilizing an ion-selective membrane lying above a sensing pad with a region of thermoplastic material laterally disposed around the membrane. A first layer of electrically insulatin... | 09/20/1988 |
| 4771429 | Circuit combining functions of cyclic redundancy check code and pseudo-random number generators A circuit is disclosed which combines the functions of a cyclic redundancy check code (CRCC) generator and a pseudo-random number generator in such a way that common elements are shared rather than duplicated. A 16-stage shift register and two linear feed... | 09/13/1988 |
| 4769387 | Dibenzofuran lipoxygenase inhibiting compounds, compositions and use Compounds of the formula: ##STR1## wherein R1 is (1) hydrogen, (2) C1 to C4 alkyl, (3) C2 to C4 alkenyl, or (4) NR2 R3, wherein R2 and R3 are independe... | 09/06/1988 |
| 4767762 | Tricyclic quinoline and naphthyride antibacterials This invention relates to novel isoxazolo-naphthyridine, isoxazolo-quinoline, isothiazolo-naphthyridine, and isothiazolo-quinoline, derivatives having antibacterial properties.... | 08/30/1988 |
| 4765843 | Process for preventing contamination of reagent systems A process for preventing contamination of a reagent system by a reagent delivery system. The process is suitable for performing an iron determination of a sample which prevents iron contamination of the sample from metal or iron-containing surfaces contai... | 08/23/1988 |
| 4762845 | 7-(3-Substituted imino-1-pyrrolidinyl)-quinolone-3-carboxylic acids New 7-substituted 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acids or esters having a substituted or unsubstituted phenyl radical, an aromatic heterocyclic radical, an alkyl or cycloalkyl radical in the 1-position are antibacterial agents.... | 08/09/1988 |
| 4761403 | Lipoxygenase inhibiting compounds Hydroxy quinol-1-one and quinol-2-one based compounds found to be potent inhibitors of 5-, 12-, and 15-lipoxygenase enzymes.... | 08/02/1988 |
| 4751190 | Fluorescence polarization immunoassay and reagents for use therein An method of carrying out a fluorescence polarization immunoassay is disclosed wherein the immunoassay is conducted in the presence of from about 0.001 to about 1.0 percent (weight/volume) of dioctyl sodium sulfosuccinate. Also disclosed are reagents usef... | 06/14/1988 |
| 4748115 | Substrate formulation in 2-amino-2-methyl-1-propanol buffer for alkaline phosphatase assays A stable substrate formulation for an alkaline phosphatase assay includes 5-bromo-4-chloro-3-indolyl phosphate, nitro blue tetrazolium and a 2-amino-2-methyl-1-propanol buffer. Addition of MgCl2 to this formulation promotes stability.... | 05/31/1988 |
| 4748110 | Immunoassay for HTLV-III antigens The invention is a diagnostic immunoassay which detects human T-cell lymphotropic virus-III (HTLV-III) antigen. The immunoassay utilizes a sandwich assay technique and the addition of a labeled second antibody to increase sensitivity. The second antibody ... | 05/31/1988 |
| 4743561 | Luminescent assay with a reagent to alter transmitive properties of assay solution An improved method and reagents are disclosed for determining a ligand in an assay solution containing the ligand, a reagent system and a luminescent compounds, wherein the intensity of the light emitted by the assay solution is related to the change in t... | 05/10/1988 |
| 4740080 | Analog to digital converter for fluid analyzing apparatus A device for producing a digital representation of an analog signal in apparatus for use in analyzing samples of biological material. The apparatus conducts such analysis by optical techniques, whereby an analog signal is generated which corresponds to th... | 04/26/1988 |
| 4734378 | Precipitation of interfering proteins in fluorescence polarization immunoassay for digoxin Interfering proteins are precipitated and digoxin extracted in a fluorescence polarization immunoassay for digoxin with a protein precipitating reagent. The reagent contains about 3 to 4% 5-sulfosalicyclic acid in an aqueous solution including about 40 to... | 03/29/1988 |
| 4730000 | Quinoline antibacterial compounds Quinoline compounds having the formula: ##STR1## wherein R is a phenyl group or an aromatic heterocyclic group, Z is an aliphatic heterocyclic group or an amine, and R1 is hydrogen or a carboxy-protecting group. The compounds here disclose... | 03/08/1988 |
| 4725584 | Peptidyl-1-amino-2,4-diols The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is an N-protecting group; R1, R2, R3 and R5 are independently selected from loweralkyl or lipophilic or aromatic amino a... | 02/16/1988 |
| 4725583 | Functionalized peptidylaminoalcohols The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is an N-protecting group; R1, R2 and R3 are independently selected from loweralkyl or lipophilic or aromatic amino acid side chains... | 02/16/1988 |
| 4721675 | Production of hepatitis A virus in vitro utilizing a persistently virus infected cell culture system The present invention relates to a method for producing human hepatitis A virus in vitro employing tissue culture techniques. In particular, the present invention relates to an in vitro tissue culture procedure utilizing a persistently infected cell line ... | 01/26/1988 |
| 4720636 | Drop detecting system which operates under different ambient light conditions A drop detecting system has light emitting diodes and phototransistors located on either side of a translucent drip chamber. The phototransistors respond to either the shadow or the reflection from a drop falling through a light beam produced by the light... | 01/19/1988 |
| 4708604 | Pressure surface for a peristaltic pump A pressure plate for a peristaltic pump utilizing flexible tubing has an arcuate surface and a pivot mount. The arcuate surface is retained in operative association with the flexible tubing by a spring bias.... | 11/24/1987 |
