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| Number | Title | Issue Date |
| 6383479 | Neutrophil-activating factor Biologically active, pure neutrophil-activating factor (NAF) isolated from human monocytes or after expression of a synthetic NAF gene in E.coli and having the following amino acid sequence Ser-Ala-Lys-Glu-Leu-Arg-Cys-Gln-Cys-Ile-Lys-Thr-Tyr-Ser-Lys-Pro-Phe-Hi... | 05/07/2002 |
| 6262244 | DNA and amino acid sequence specific for natural killer cells Proteins expressed in NK and some T cells and being transmembrane molecules with Type II membrane protein structure, the extracellular part of the receptor being characterized by a C-type animal lectin domain, DNA sequences encoding such proteins and anti... | 07/17/2001 |
| 5827706 | Cyclosporin synthetase The nucleotide sequence which codes for cyclosporin synthetase and similar enzymes and recombinant vectors containing the sequence. The vectors are used in methods for the production of cyclosporin and cyclosporin derivatives.... | 10/27/1998 |
| 5759533 | Neutrophil-activating peptide-2 Peptides having the amino acid sequence ##STR1## wherein X is H, Asp-Leu-Tyr-, Ser-Asp-Leu-Tyr- or Asp-Ser-Asp-Leu-Tyr-. The peptide wherein X is H is human neutrophil-activating peptide-2 (hNAP-2) and those wherein X is other than H are natural vari... | 06/02/1998 |
| 4870199 | Processes for the synthesis of diprotected R[R*,S*]-3,5-dihydroxy-6-oxohexanoate esters Process for the synthesis of compounds of the formula ##STR1## in R[R*,S*] enantiomeric form, wherein each P1 is independently an hydroxy group-protecting group, and R2z is C1-4 alkyl, benzyl or allyl, comprising, as a key... | 09/26/1989 |
| 4866163 | Disazo compounds having two 4,8 Disulfonaphthyl-2 diazo component radicals and two triazine 1,3,5 triazine rings linked by a piperazinylene radical Compounds of the formula ##STR1## wherein each R1 is independently hydrogen, halo, C1-4 alkyl, C1-4 alkoxy or --NHCOC1-4 alkyl, each R2 is H, halo, C1-4 alkyl or C1-4 alkoxy... | 09/12/1989 |
| 4851427 | Pyrrole analogs of mevalonolactone, derivatives thereof and pharmaceutical use Compounds of the formula ##STR1## wherein R1 is C1-6 alkyl not containing an asymmetric carbon atom, C3-7 cycloalkyl or ##STR2## wherein R5, R6 and R7 are as defined below, R... | 07/25/1989 |
| 4843152 | Copper complexes of disazo compounds having di- or tri- sulfonaphthol and 6-[2,4-di-(amino or substituted amino)-1,3,5-triazia-6-ylamino-]-1-hydroxy-3-sulfonaphthalene coupling component radicals Complexes of the formula ##STR1## and salts thereof, wherein each of X1 and X2 is independently --NR1 R2, wherein R1 is hydrogen, C1-4 alkyl or C2-4 alkyl monosubstituted by hyd... | 06/27/1989 |
| 4840642 | Monoazo compounds having a 6-(5'-chloro-2',4'-difluoropyrimid-6'-ylamino)-1-hydroxy-3-sulfonaphthal ene group and their use as dyes Compounds of the formula ##STR1## and salts thereof, useful for dyeing and printing hydroxy group - or nitrogen-containing organic substrates, for example, leather and fibrous materials containing or consisting of natural or synthetic polyamides or ... | 06/20/1989 |
| 4822799 | Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals Compounds of the formula ##STR1## and processes for and intermediates in the synthesis thereof, pharmaceutical compositions comprising such a compound and the use of such compounds for inhibiting cholesterol biosynthesis and lowering the blood c... | 04/18/1989 |
| 4820309 | 1:2-chromium complex dyes for tanned leather Complexes of the formula ##STR1## wherein each R1 is independently (a) the radical of a coupling component of the active methylene non-cyclic or homocyclic series, (b) the radical of a coupling component of the heterocyclic series or (c) t... | 04/11/1989 |
| 4820806 | Metal-free azo compounds containing a vinylsulfonyl group and at least one basic group and 1:1 and 1:2 metal complexes thereof Metal-free monoazo and disazo compounds of the formula 1:1 and 1:2 metal complexes of such metallizable metal-free compounds and acid addition salts of such metal-free compounds and 1:1 and 1:2 metal complexes, wherein D is the radical of a diazo component of ... | 04/11/1989 |
| 4820808 | Copper Complexes of disazo compounds having two substituted 2-hydroxyphenyl diazo component radicals and two 3-methylpyrazol-5-one coupling component radicals Complexes of the formula ##STR1## and salts thereof each cation of which is independently a non-chromophoric cation, wherein B is --CO--CH.dbd.CH--CO--, --CO--(CH2)a --CO--, ##STR2## and each of R1, R2... | 04/11/1989 |
| 4808607 | Imidazole analogs of mevalonolactone and derivatives thereof for use in inhibiting cholesterol biosynthesis and lowering blood cholesterol level Compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow and the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol... | 02/28/1989 |
| 4804679 | Erythro-(E)-7-(3'-C1-3alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl )-3,5-dihydroxyhept-6-enoic acids and derivatives thereof Compounds of the formula ##STR1## wherein R1 is C1-3 alkyl, and Z is ##STR2## wherein R7 is hydrogen, R8 or M, wherein R8 is a physiologically acceptable and hydrolyzable ester group, and M is a ... | 02/14/1989 |
| 4785083 | Mixtures of 1-N-C3-7 alkyl-5-(4'-chloro-2'nitrophenylozo)-3-cyano-6-hydroxy-4-methylpyrid-2-o ne compounds Mixtures comprising at least two dyes of formula I ##STR1## where R is unsubstituted linear C3-7 alkyl, with the proviso that at least two different dyes of formula I are each present to the extent of at least 10 mole %, based on the total... | 11/15/1988 |
| 4780106 | Use of metal-free azo _compounds having at least one _6-hydroxypyrid-2-one _coupling component radical and metal _complexes thereof for dyeing _substrates and substrates dyed therewith Metal-free compounds of the formula ##STR1## 1:1 and 1:2 metal complexes thereof, and acid addition salts of metal-free compounds of said formula and 1:1 and 1:2 metal complexes thereof, wherein B is hydrogen; C1-4 alkyl; C1-4 alkyl ... | 10/25/1988 |
| 4764175 | Metal-free monoazo and disazo compounds having a 1-hydroxy-5,6-, 7- or 8- substituted 1,3,5-triazinylamino-3- or 4 sulfonic acid coupling component radical and 1:1 copper complexes Metal-free compounds of the formula, ##STR1## and 1:1 copper complexes of metallizable metal-free compounds of said formula and internal and external salts of metal-free compounds of said formula and of 1:1 copper complexes of metallizable metal-free... | 08/16/1988 |
| 4755606 | Imidazolyl-3,5-di-(diphenyl-butylsilyloxy) carboxylic acid ester intermediates Compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined herein below, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol l... | 07/05/1988 |
| 4751235 | Anti-atherosclerotic indolizine derivatives 7-(indolizin-2-yl)hept-6-enoic acids of the formula I: ##STR1## wherein each of R1 and R2 is, independently, H, alkyl, cycloalkyl, aralkyl or aryl, ##STR2## in which R8 is H, an ester residue or cation; or the la... | 06/14/1988 |
| 4742160 | Sulfo group-containing basic azo compounds having a central 1,3,5-triazine ring and two terminal 1-hydroxynaphthyl-2 groups and 1:1 and 1:2 metal complexes therof Metal-free compounds of the formula ##STR1## and 1:1 and 1:2 metal complexes thereof, and salts of the metal-free compounds and 1:1 and 1:2 metal complexes, where R is hydrogen, --SO3 H or --NR5 R6 ; Ra is hydro... | 05/03/1988 |
| 4742161 | Disazo and trisazo compounds containing one 6-hydroxypyrid-2-one coupling component radical per azo radical Disazo and trisazo compounds of the formula ##STR1## and salts thereof, wherein in each B is independently hydrogen; C1-4 alkyl; (C1-4 alkoxy) C1-4 alkyl; C2-4 hydroxyalkyl; C5-6 cycloalkyl; C | 05/03/1988 |
| 4739073 | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof Compounds of the formula ##STR1## wherein one of R and Ro is ##STR2## and the other is primary or secondary C1-6 alkyl not containing an asymmetric carbon atom, C3-6 cycloalkyl or phenyl(CH2)m | 04/19/1988 |
| 4734515 | 1:2 metal complexes of 2-nitroso-acetoacetic acid and benzoylacetic acid arylamides Complexes of the formula ##STR1## wherein each R1 is independently a monocyclic or fused ring aromatic or heteroaromatic group free of water-solubilizing groups, each R2 is independently is phenyl or methyl, and Me is Ni, Cu, Co or Z... | 03/29/1988 |
| 4728338 | Mixtures of at least one monoazo compound having a 2-cyano 4,6-dinitrophenyl diazo component radical and at least one monoazo compound having a 2-cyano-6-halo-4-nitrophenyl diazo component radical and their use Compositions comprising (a) 30-70% by weight of one or more compounds of the formula ##STR1## wherein each R1 is independently C2-4 alkyl, and R3 is methyl or ethyl; and (b) 30-70% by weight of one or more compounds of th... | 03/01/1988 |
| 4699626 | Mixtures of copper complexes of disazo compounds: 4,4'-(3,3'-dihydroxybiphenylene) tetrazo component and disulfonaphthol and 3-sulfo-6-(2'-chloro-4'-chloro or hydroxy-1,3,5-triazin-6'-ylamino)-naphth-1-ol coupling component Complexes of the formula ##STR1## or a water-soluble salt thereof each cation of which is independently a non-chromophoric cation, wherein X is chloro or hydroxy, m is 1 or 2, and n is 0 or 1, with the proviso that m + n is 2, with the proviso that one of... | 10/13/1987 |
| 4687842 | Monoazo compounds having an imidazolium-2 group linked through an azo radical to a substituted phenyl group Compounds of the formula ##STR1## wherein each of R and R1 is independently hydrogen, C1-4 alkyl, phenyl or phenyl substituted by 1 to 3 C1-4 alkyl, C1-4 alkoxy or halo substitutents or R and R1 ... | 08/18/1987 |
| 4686237 | Erythro-(E)-7-[3'-C1-3 alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl]-3,5-dihydroxyhept-6-enoic acids and derivatives thereof Compounds of the formula ##STR1## wherein R1 is C1-3 alkyl, and Z is ##STR2## wherein R7 is hydrogen, R8 or M, wherein R8 is a physiologically acceptable and hydrolyzable ester group, and M is ... | 08/11/1987 |
| 4686285 | Basic azo and non-azo compounds having one or two disubstituted 1,3,5-triazine rings each of which is linked through a bridging radical to the 1-position of a pyrazole ring (i) Metal-free compounds of the formula ##STR1## (ii) tautomers thereof, (iii) 1:1 and 1:2 metal complexes of (i) and (ii), (iv) salts of (i), (ii), and (iii), and (v) mixtures of (i), (ii), (iii), and (iv), wherein the symbols are as defined in the Specificat... | 08/11/1987 |
| 4685934 | Mono- and di-sulfo group containing compound having a substituted pyrazolyl diazo component radical and their use Monoazo compounds of formula ##STR1## wherein R1 is a coupling component radical, R1 is C1-6 alkyl; C1-6 alkyl substituted by 1 or 2 substituents selected from chloro, cyano, hydroxy, C1-4 alkoxy, ... | 08/11/1987 |
| 4675388 | Polymeric azo compounds containing at least four cationic groups Polymers comprising two the more recurring units of formula ##STR1## wherein A1 is an aromatic bridging group each K1 is independently the radical of a coupling component, E is an aliphatic, aromatic or aromatic heterocyclic bridging radi... | 06/23/1987 |
| 4673735 | Azo compounds having at least one 6-hydroxypyrid-2-one coupling component radical metal complexes thereof and intermediates therefor A compound of formula I ##STR1## in metal-free; 1:1 or 1:2 metal complex form and, when an acid group is present, in free acid or acid addition salt form, in which R1 is hydrogen or --N.dbd.N--D where D is a diazo component and R, T and B ... | 06/16/1987 |
| 4670546 | Disazo and polyazo compounds containing at least two cationic groups in metal-free or 1:1 or 1:2 metal complex form Compounds of the formula ##STR1## in metal-free, 1:1 or 1:2 metal complex form, or in acid addition salt form, where the symbols are defined in the specification, useful as dyes for, for example, regenerated cellulose, cotton, synthetic polyamides an... | 06/02/1987 |
| 4670547 | Tetrakisazo compounds having two 1-hydroxy-3- or 4-sulfo-6- or 7-amino- or substituted amino-naphthalene coupling component radicals the amino or substituted amino groups of which are linked 1,3,5-triazine rings Tetrakisazo compounds of the formula ##STR1## and salts thereof, wherein B is ##STR2## wherein B1 is a bridging radical as defined in the specification, R7 is hydrogen or C1-4 alkyl, R8 is hydrogen or C | 06/02/1987 |
| 4668794 | Intermediate imidazole acrolein analogs Compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol ... | 05/26/1987 |
| 4668238 | The dyeing of leather with mixtures of trisazo and tetrakisazo compounds having 1-amino-8-hydroxynaphthalene-mono- or di-sulfonic acid biscoupling component radicals A process of dyeing a leather substrate comprising applying to the leather substrate a mixture of at least one compound of the formula ##STR1## and at least one compound of the formula ##STR2## wherein each R is independently ##STR3## ... | 05/26/1987 |
| 4667023 | 4-(2'-halo-4'-nitrophenylazo)-2-2[2'-(C1-2 alkoxy or 2"-methoxyethoxy)ethoxycarbonylamino --N,N-di-C2-3 alkylanilines Monoazo compounds of the formula ##STR1## wherein R1 is chloro, bromo nitro, C1-4 alkylsulfonyl, phenylsulfonyl, (C1-4 alkyl)carbonyl or benzoyl, each of R2 and R3, independently, is hydrogen, chloro ... | 05/19/1987 |
| 4665162 | 1:1 and 1:2 metal complexes of sulfo group-free azo compound having on average at least 1.3 basic water-solubilizing groups Metal-free azo compounds of the formula ##STR1## wherein Ra is an aromatic group or an active methylene coupling component radical as defined in the specification, Rt is an arylazo group or a group of the formula --Y--Z, wherein Y is a direct b... | 05/12/1987 |
| 4649194 | 1:2 metal complexes of a disazo compound having a 5-hydroxy-1-(aminophenyl)pyrazole coupling/diazo component radical and disazo compound having a 1-amino-8-hydroxynaphthalene coupling/diazo component 1:2 Metal complexes of the formula ##STR1## wherein X1 is --O-- or ##STR2## and X2 is --O-- or ##STR3## the starred atom being attached A1 or A2, respectively, A1 is a diazo comp... | 03/10/1987 |
| 4634764 | Non-azo and azo compounds containing at least one 4,6-diamino-1-substituted-5-substituted carbamoylpyrid-2-one group Compounds of the formula ##STR1## wherein each R is independently --N(R1)2, --N.sym. (R2)3 A.crclbar. or hydroxy, wherein each R1 is independently hydrogen, alkyl, substituted al... | 01/06/1987 |
