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| Number | Title | Issue Date |
| 7750312 | Method and apparatus for generating ions for mass analysis An apparatus and method is disclosed for reducing contamination in a mass spectrometer instrument system. The system includes an ion source at a first pressure for generating ions by laser desorption/ionization and an inlet aperture to a vacuum chamber at a second, ... | 07/06/2010 |
| 7518107 | Methods and apparatus for time-of-flight mass spectrometer Disclosed are methods and apparatus for compensating for mass error for a time-of-flight mass spectrometer. A reference flight distance for a pulse of ions corresponding to a reference temperature of one or more components of an ion flight path assembly is determine... | 04/14/2009 |
| 7518104 | Methods and apparatus for time-of-flight mass spectrometer Disclosed is a method of determining when to calibrate a time-of-flight mass spectrometer. In various embodiments, the method comprises storing within a controller a set of parameters for the mass spectrometer; providing an updated set of parameters while retaining ... | 04/14/2009 |
| 7259371 | Method and apparatus for improved sensitivity in a mass spectrometer In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined ... | 08/21/2007 |
| 7256395 | Method and apparatus for improved sensitivity in a mass spectrometer In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined ... | 08/14/2007 |
| 7166441 | Method and apparatus for the identification and quantification of biomolecules Polypeptides are electroblotted through a digestion membrane to a composite capture membrane that can be directly analyzed using mass spectrometry. The molecular weights of the fragments generated by the digestion membrane are then used to identify the polypeptide f... | 01/23/2007 |
| 7045296 | Process for analyzing protein samples Methods using gel electrophoresis and mass spectrometry for the rapid, quantitative analysis of proteins or protein function in mixtures of proteins derived from two or more samples in one unit operation are disclosed. In one embodiment the method includes (a) prepa... | 05/16/2006 |
| 7030373 | MALDI plate construction with grid A MALDI plate construction is provided to support a sample in a manner to effect mass spectrometry of the sample. The plate construction comprises a sample receiving surface, a plate holder for retaining the sample receiving surface and an electrically conductive gr... | 04/18/2006 |
| 6993958 | Capillary column chromatography process and system A microfluidic system is provided for separating components of many fluid samples in a parallel fashion through an array of capillary conduits. The system includes capillary conduits for receiving fluid samples, and for effecting separation of substituents of the sa... | 02/07/2006 |
| 6995363 | Reduction of matrix interference for MALDI mass spectrometry analysis A MALDI plate suitable for MS or MS-MS analysis provided with a composite coating that comprises a hydrophobic coating and a thin layer coating of a mixture of a MALDI matrix material and an intercalating agent such as a polymer is disclosed. A MALDI plate produced ... | 02/07/2006 |
| 6936224 | Apparatus and process for transporting sample plates A process and apparatus are provided for simultaneously moving a first sample plate into an analytical apparatus and a second sample plate from the analytical apparatus. The first sample plate is moved on an entry path which is vertically spaced apart from an exit p... | 08/30/2005 |
| 6900061 | MALDI plate and process for making a MALDI plate A sample plate for a MALDI process is provided which comprises an electrically conductive substrate having a hydrophobic coating whose thickness and hydrophobic character can be modified by changing the coating substrate and/or the concentration of the substrate. Di... | 05/31/2005 |
| 6844545 | MALDI plate with removable insert A sample plate structure is provided including a retainer plate having a central opening, a sample insert plate which fits into the opening, an optional pressure plate and a handle. The handle applies pressure to the sample insert plate to retain it within the retai... | 01/18/2005 |
| 6825478 | MALDI plate with removable magnetic insert A sample plate structure is provided including a retainer plate having a central recess with a trough along its periphery, a sample insert plate which fits into and rests on contact surface of the recess, and a magnet that is held below the contact surface. A portio... | 11/30/2004 |
| 6672344 | Robotic system having positionally adjustable multiple probes An array of probes is provided wherein the probes are maintained in place in bores extending through a housing by a friction force applied to the probes. The friction force can be overcome by another force applied to the probes, thereby allowing the probe... | 01/06/2004 |
| 6670606 | Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis The use of a segmented-ion trap with collisional damping is disclosed to improve performance (resolution and mass accuracy of single stage and tandem time-of-flight mass spectrometers. In the case of single stage spectrometers ions are directly injected f... | 12/30/2003 |
| 6662818 | Programmable tracking pressure regulator for control of higher pressures in microfluidic circuits Regulator for precision control of pressure based on a means of measuring pressure differentials. More specifically, the present invention provides a pressure control that tracks a relatively high background pressure, and applies a positive or negative of... | 12/16/2003 |
| 6621074 | Tandem time-of-flight mass spectrometer with improved performance for determining molecular structure A tandem time-of-flight mass spectrometer is described. The tandem time-of-flight mass spectrometer includes a pulsed ion source that generates a plurality of ions. A first time-of-flight mass separator accelerates the plurality of ions, fragments at leas... | 09/16/2003 |
| 6581441 | Capillary column chromatography process and system A microfluidic system is provided for separating components of many fluid samples in a parallel fashion through an array of capillary conduits. The system includes capillary conduits for receiving fluid samples, and for effecting separation of substituent... | 06/24/2003 |
| 6545268 | Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis The use of a segmented-ion trap with collisional damping is disclosed to improve performance (resolution and mass accuracy) of single stage and tandem time-of-flight mass spectrometers. In the case of single stage spectrometers ions are directly injected ... | 04/08/2003 |
| 6534764 | Tandem time-of-flight mass spectrometer with damping in collision cell and method for use A tandem mass spectrometer is disclosed having a collisional damping cell that slows down and adapts an ion beam, from a time-of-flight mass spectrometer (TOF MS) to a second mass spectrometer, preferably an orthogonal TOF MS. The cell provides a substant... | 03/18/2003 |
| 6512225 | Tandem time-of-flight mass spectrometer with improved mass resolution A tandem time-of-flight mass spectrometer is described. The spectrometer includes a pulsed source of ions that focuses a packet of ions substantially within a predetermined mass-to-charge ratio range onto a focal plane in a flight path of the ions. An ion... | 01/28/2003 |
| 6504150 | Method and apparatus for determining molecular weight of labile molecules A mass spectrometer instrument for determining the molecular weight of labile molecules of biological importance, in particular heavy molecules, such as proteins, peptides or DNA oligomers, is disclosed. The instrument includes a MALDI ion source that is ... | 01/07/2003 |
| 6483109 | Multiple stage mass spectrometer A highly sensitive multiple stage (MSn) mass spectrometer is disclosed, capable of eliminating losses of ions during the isolation stage. Ions of interest are isolated (by m/z value) without rejecting ions of other m/z values, permitting the se... | 11/19/2002 |
| 6441369 | Tandem time-of-flight mass spectrometer with improved mass resolution A tandem time-of-flight mass spectrometer is described. The spectrometer includes a pulsed source of ions that focuses a packet of ions substantially within a predetermined mass-to-charge ratio range onto a focal plane in a flight path of the ions. An ion... | 08/27/2002 |
| 6193471 | Pneumatic control of formation and transport of small volume liquid samples A process and system are provided for forming and transporting precise small volumes of liquid samples by means of controlled gas pressures. As the controlled gas pressures are changed at a multiplicity of control points in the fluid circuit, transitions ... | 02/27/2001 |
| 5695702 | Thermoplastic hollow fiber membrane module and method of manufacture A hollow fiber membrane module and its method of manufacture are disclosed wherein the module is fabricated utilizing superior hollow fiber materials, namely high molecular weight (i.e. molecular weight>500,000 Daltons) polymers. In a preferred embodiment... | 12/09/1997 |
| 5603900 | Vacuum filter device A vacuum filter device is disclosed which includes a filter body which is adapted to receive in fluid-fight, sealed relationship a pair of closed containers for solutions to be filtered by a membrane filter positioned within the filter body. A vacuum port... | 02/18/1997 |
| 5597486 | Membrane filtration with optimized addition of second liquid to maximize flux A membrane-based tangential flow filtration system is disclosed which includes optimized performance capabilities by taking into account the variety of flux and component passage behavior occurring during filtration processing. The system maximizes the re... | 01/28/1997 |
| 5581017 | Integrity test for porous structures using acoustic emission A rapid, highly sensitive determination, in-situ, of the integrity and/or pore size distribution of a porous membrane structure (e.g. a pleated membrane filter cartridge) is disclosed. The identification of the integrity and/or pore size characteristics i... | 12/03/1996 |
| 5556591 | Membrane sealing techniques using thermoplastic polymers A process for potting hollow fibers within a body is disclosed wherein a bundle of hollow fibers is formed within a hollowed portion of the body such that the fibers are substantially aligned and uniformly spaced. A molten thermoplastic composition is dis... | 09/17/1996 |
| 5554536 | Biological analysis device having improved contamination prevention A device for conducting biological analysis, such as cell culture, is disclosed having improved contamination prevention features. In a preferred embodiment, a microwell membrane plate for cell analysis is adapted to be inserted into a shallow rectangular... | 09/10/1996 |
| 5543054 | Method and apparatus for covalent immobilization of charge- conjugated carbohydrate molecules A method for covalent immobilization of a carbohydrate molecule with an oppositely charged surface, comprising the steps of adsorbing the carbohydrate molecule to the oppositely charged surface in proximity to reactive moieties bound to the charged surfac... | 08/06/1996 |
| 5487771 | High-efficiency metal membrane element, filter, and process for making A high-porosity metallic membrane element comprising a sintered element having at least about 55% porosity, the sintered element comprising a matrix of substantially interconnected pores, each of the pores being defined by a plurality of dendtritic metall... | 01/30/1996 |
| 5465748 | Sanitizable slider diaphragm valve A sanitary slider valve shown specifically as a rotary carousel diaphragm valve which has a thermoplastic elastomeric diaphragm integrally molded to form the multiple sealing ports of the rotor/stator interface is described. Ports or grooves molded into t... | 11/14/1995 |
| 5456125 | Membrane cutter and retriever A membrane cutter and retriever is disclosed which includes a hollow circular die securely fastened through a hollow connector to the luer opening of a syringe. The die/syringe assembly is inserted within a filter holder unit having a membrane secured to ... | 10/10/1995 |
| 5456740 | High-efficiency metal membrane getter element and process for making A getter-filter composite membrane element, comprising a sinterable getter material and a sinterable metal filter material, the composite element defining a matrix of substantially interconnected pores. Membrane elements may be comprised of at least three... | 10/10/1995 |
| 5417917 | Metallic porous membrane and method of manufacture A method for the preparation of an open cell porous metallic material is provided. The method includes first molding a metal oxide powder into a desired gas-permeable body, then firing the body to obtain a sintered body of metal oxide. Lastly, oxygen is r... | 05/23/1995 |
| 4792454 | Container for fermentation A device particularly suitable for refermentation of sugared wine in a bottle according to the champagne method consists of a cartridge comprising a tubular body formed with grooves and perforations which provide fluid communication between the exterior o... | 12/20/1988 |
| 4761230 | Small volume tangential flow filtration apparatus A filter system particularly useful with small sample volumes includes first and second housing sections with a flow channel extending therebetween. A membrane filter forms one boundary of the flow channel. A pair of reservoirs, one for feed and the other... | 08/02/1988 |
