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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 5552438 | Compounds useful for treating allergic and inflammatory diseases Novel compounds of Formula (I) ##STR1## where X4 is a substituted cyclohexane or cyclohexane group and the other radicals are defined herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment o... | 09/03/1996 |
| 5525733 | Process for preparing tetrazole-5-carboxylic acid derivatives A process for preparing a compound of structure (I) or a hydrate or solvate thereof in which R1 is C1-6 alkyl, optionally substituted phenyl or optionally substituted phenylC1-6 alkyl, which comprises reacting an azide of ... | 06/11/1996 |
| 5468859 | Process for asymmetric total synthesis of camptothecin analogues The present invention provides a process for the asymmetric synthesis of camptothecin analogs as well as novel chemical intermediates of Formula I, II, and III. In general, the present process comprises conversion of a cis dioxolanone, having the same des... | 11/21/1995 |
| 5449686 | Compounds useful for treating allergic or inflammatory diseases Novel cyclohexanes of Formulas (I) and (II) ##STR1## are described herein. They inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; these compounds are also usef... | 09/12/1995 |
| 5449687 | 4-phenyl-1,2-cyclohexyl derivatives and anti-inflammatory compositions and methods thereof Novel compounds of Formulas (I) and (II) ##STR1## are described herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; these compounds are a... | 09/12/1995 |
| 5393788 | Phenylalkyl oxamides Novel oxamide derivatives are described which inhibit the production of TNF and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful as inhibitors of PDE IV and are... | 02/28/1995 |
| 5373965 | Collapsible container for pasty products A collapsible container for extrudable viscous fluids comprising a tube, two opposing side walls of the tube being deformable under applied compressive pressure, the tube closed at one end and open at the other, the open end having a nozzle and openable c... | 12/20/1994 |
| 5362915 | Phenyl-substituted cycloalkenyl compounds useful as PDE IV inhibitors A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R1 is --CH3 or --CH2 CH3 unsubstituted or substituted by 1 to 3 fluorines; X is O or S(O)s where s=0 to 2; R | 11/08/1994 |
| 5230899 | Methods and compositions for making liposomes Liposome-forming materials containing a long chain aliphatic or aromatic-based acid or amine, hydrating agents and discrete amounts of water form gels which are useful drug delivery systems and spontaneously form highly stable liposomes in aqueous solutio... | 07/27/1993 |
| 5214201 | Crystallization of optical isomers of leukotriene antagonists This invention relates to certain salts of leukotriene antagonists and the use of a particular amine to form these salts as a means for selectively crystallizing optical isomers of the leukotriene antagonists disclosed herein.... | 05/25/1993 |
| 5189226 | Ortho-substituted benzaldehydes This invention relates to certain 2-substituted benzaldehydes which are useful intermediates for preparing certain diacids which are useful as leukotriene antagonists.... | 02/23/1993 |
| 5176901 | Dental composition Dentifrices containing cationic antibacterial agents are disclosed herein.... | 01/05/1993 |
| 5143931 | Leukotriene antagonists containing tetrazolyl groups This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating disea... | 09/01/1992 |
| 5135938 | Leukotriene antagonists Leukotriene antagonist thiadiazoles have been prepared.... | 08/04/1992 |
| 4996214 | Quinolinyl substituted phenyl/thioalkanoic acid substituted propionic acids and leucotriene antagonist use thereof This invention covers quinolinyl substituted phenyl/thioalkanoic acid substituted propionic acids leukotriene inhibitors having the following general formula ##STR1## where the substituents are defined herein.... | 02/26/1991 |
| 4963549 | Medicament The present invention relates to the use of 6-[4-(N3 -methyl-N2 -cyanoguanidino)phenyl]-5-methyl-4,5-dihydro-3-(2H)-pyridazinone in a method of treating or preventing cardiac arrhythmias.... | 10/16/1990 |
| 4954513 | Leukotriene antagonists This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists, pharmaceutical compositions containing such compounds, and methods of treating diseases in which leukotrienes are ... | 09/04/1990 |
| 4954632 | Process for preparing intermediates for azatidine 3-(2-Phenethyl)-1-carbamoyloxypyridinium halide is an intermediate for the preparation of the antihistamine azatadine.... | 09/04/1990 |
| 4939279 | Leukotriene antagonists This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating diseases in whi... | 07/03/1990 |
| 4937253 | Ester prodrugs This invention relates to ester prodrugs for alkanoic acid compounds useful as leukotriene antagonists, and pharmaceutical compositions containing such ester prodrug compounds. This invention also relates to methods of treating diseases in which leukotrie... | 06/26/1990 |
