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| Number | Title | Issue Date |
| 5948791 | Quinoline derivatives for treating malaria The invention relates to novel quinoline derivatives and their therapeutic use against malaria.... | 09/07/1999 |
| 5889026 | 4-hydroxy-piperodine derivatives The present invention relates to compounds of the formula ##STR1## wherein x is --O--, --NH--, --CH2 --, --CH.dbd., --CO2 --, --CONH--, --CON(lower alkyl)--, --S-- and --SO2 --; R1 -R4 are, independen... | 03/30/1999 |
| 5869500 | Pyridone compounds useful in treating Alzheimer's disease The invention is concerned with the use of bi- and tricyclic pyridone compounds of the formula ##STR1## where A, R1, R3, R4, and R7 are described herein and of their pharmaceutically acceptable salts for th... | 02/09/1999 |
| 5853721 | Antibody to interleukin-12 receptor The present invention relates to a novel antibody against the IL-12 receptor and a novel combination of anibodies anainst the IL-12 receptor. The novel anti-IL-12 receptor anbody, designated as 2B10, provided in accordance with the present invention binds... | 12/29/1998 |
| 5846936 | Growth hormone releasing factor analogs Novel growth hormone releasing factor analogs are presented having a sequence of from about twenty-nine (29) to about forty-four (44) amino acids (SEQ ID NO: 6) wherein Xaa at position 1 is His, 3-MeHis, desNH2 His, Tyr, or desNH2 Ty... | 12/08/1998 |
| 5824698 | Antibacterial dibenzimidazole derivatives Novel and known dibenzimidazoles of the formula ##STR1## wherein R1 and R2 can be the same or different and signify C6 H4 R3 --, C6 H3 (OH)R4 -- or heterocyclyl, ... | 10/20/1998 |
| 5811548 | Tri-and tetracyclic compounds There are described compounds of the formula ##STR1## Wherein the variables have been defined herein. The compounds are useful as research tools in the determination of biologically active peptides sequences and also potentially suitable as medicamen... | 09/22/1998 |
| 5811420 | Fungarrestins Compounds of formula (I), ##STR1## wherein R1 and R2 are independently hydrogen, unsubstituted lower alkyl or lower alkyl substituted by lower alkoxy or lower alkyl thio, or acyl which is unsubstituted or substituted by one or m... | 09/22/1998 |
| 5811419 | Isooxacephem-derivatives Compounds of formula I ##STR1## wherein R1 is hydrogen or an acyl group derived from a carboxylic acid; R2 is hydrogen, hydroxy, lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, cycloalkenyl, lower alkynyl, aryl-lower alkyl... | 09/22/1998 |
| 5811389 | Tri- and tetracyclic compounds There are described compounds of the formula ##STR1## Wherein the variables have been defined herein. The compounds are useful as research tools in the determination of biologically active peptides sequences and also potentially suitable as medicamen... | 09/22/1998 |
| 5804577 | Cephalosporin derivatives The present invention relates to compounds of formula I ##STR1## wherein R1 is a group selected from 2-, 3-, and 4-hydroxyphenyl, 3-nitrophenyl, and 3-fluoro-4-hydroxyphenyl; as well as readily hydroyzable esters thereof, pharmaceutically ... | 09/08/1998 |
| 5773446 | Diamino pyrimidines Compounds of formula I ##STR1## wherein either R1 signifies straight-chain C5-10 -alkyl, branched C3-5 -alkyl, C3-6 -cycloalkyl or C3-5 ω-carboxyalkyl and R2 and R3 signify... | 06/30/1998 |
| 5766894 | Production of vitamin B6 by fermentation A process for producting vitamin B6 comprises cultivating a microorganism belonging to the genus Rhizobium and being capable of producing vitamin B6 in a culture medium under aerobic conditions, and separating the resulting vitamin B... | 06/16/1998 |
| 5721242 | Antibiotic combination Pharmaceutical preparations containing an antibacterially-active synergistic combination of epiroprim and dapsone are useful in the treatment or control of infections caused by mycobacteria, Actinomycetes and toxoplasmosis pathogens.... | 02/24/1998 |
| 5712268 | Compositions of tricyclic ଲ-lactams and uses thereof There are described pharmaceutical compositions comprising (a) compounds of the formula ##STR1## in which R signifies lower alkoxycarbonyl, lower alkoxy-carbonylamino, the acyl residue of an - or ଲ-amino acid or a residue of the general... | 01/27/1998 |
| 5710322 | Optically active iminocarboxylic acid derivatives The compounds of the formula ##STR1## wherein R is OH, NH2, lower-alkyl-NH or phenyl-lower alkyl-NH are presented. These compounds can be catalytically hydrogenated to the corresponding -aminocarboxylic acid derivatives which are ... | 01/20/1998 |
| 5698577 | Compositions of bicyclic ଲ-lactams and uses thereof There are described pharmaceutical compositions comprising (a) compounds of the formula ##STR1## in which R signifies lower alkoxycarbonyl, lower alkoxy-carbonylamino, the acyl residue of an - or ଲ-amino acid or a residue of the general... | 12/16/1997 |
| 5696089 | Histidine substituted growth hormone releasing factor analogs Novel growth hormone releasing factor analogs are presented having the formula: ##STR1## wherein R1 is His, 3-MeHis, desNH2 His, Tyr, or desNH2 Tyr; R2 is Val, Leu, or Ile; R3 is Ala; R4 | 12/09/1997 |
| 5665746 | Mono- and bicyclic DNA gyrase inhibitors The present invention relates to a compound of the formula ##STR1## wherein X1, R1, R2, OP, R3, R4, R5, R6, and R0 are as described herein, and their pharmaceutically ... | 09/09/1997 |
| 5652369 | Amino acid derivatives Compounds of the formula ##STR1## wherein R1, R2, R3, R4, R5, R6, and --N(R7)--CH(R8)(R9) are as claimed herein or their pharmaceutically acceptable ac... | 07/29/1997 |
| 5650492 | P-40 homodimer of interleukin-12 Analysis of the culture media of p40-transfected COS cells indicated the presence of 40 kDa monomers and 80 kDa disulfide-linked homodimers. Examination of partially purified p40 recombinant proteins demonstrated that only the homodimer but not the monome... | 07/22/1997 |
| 5644053 | Penam derivatives The present invention discloses compounds having the formula ##STR1## wherein one of R1 and R2 is --COR4, --CN, --CH2 R5, halogen, --CH.dbd.CHR6 or Q and the other is hydrogen or lower... | 07/01/1997 |
| 5641806 | Growth promotion and feed utilization in swine with Frenolicin B Methods and compositions for enhancing the growth and increasing the feed utilization of swine by using frenolicin B as the active ingredient to promote growth and increase feed utilization in swine. Frenolicin B is used in sufficient amounts to achieve t... | 06/24/1997 |
| 5637579 | Penam derivatives The present invention discloses compounds having the formula ##STR1## wherein one of R1 and R2 is --COR4, --CN, --CH2 R5, halogen, --CH.dbd.CHR6 or Q and the other is hydrogen or lower... | 06/10/1997 |
| 5631366 | Process for making 3-formylcephem derivatives The present invention is concerned with a novel process for the making of a compound of formula I ##STR1## by oxidizing the corresponding 3-hydroxymethyl-cephem derivative with an inorganic hypohalite or inorganic halite in the presence of compounds ... | 05/20/1997 |
| 5620987 | Amino acid derivatives Compounds of the formula ##STR1## wherein R1, R2, R3, R4, R5, R6, and --N(R7)--CH(R8)(R9) are as claimed herein or their pharmaceutically acceptable ac... | 04/15/1997 |
| 5602661 | Optical component An optical component includes an anisotropic layer of cross-linked liquid crystal monomers with varying local orientation of the liquid crystal molecules. The liquid crystal layer is in contact with an orientation layer comprising a photo-orientable polym... | 02/11/1997 |
| 5594135 | Tricyclic DNA gyrase inhibitors The present invention relates to a compound of the formula ##STR1## wherein X1, R1, R2, OP, R3, R4, R5, R6, and R0 are as described herein, and their pharmaceutically ... | 01/14/1997 |
| 5594055 | Antioxidant system for polyolefins A phosph(on)ite free antioxidant system based on an -tocopherol formulation and a compound selected from tetrakis[methylene(3,5-di-tert.-4-hydroxyhydrocinnamate]methane or octadecyl 3,5-di-tert.-4-hydroxyhydrocinnamate is disclosed. This system ... | 01/14/1997 |
| 5554756 | Amino acid derivatives Compositions containing compounds ##STR1## and their pharmaceutically acceptable acid addition salts inhibit proteases of viral origin and can be used as medicaments for the treatment or prophylaxis of viral infections. They can be manufactured accor... | 09/10/1996 |
