Did You Know...
...that on Dec. 15, 1836, the Patent Office was completely destroyed by fire? Lost were some 7,000 models, 9,000 drawings, and 230 books plus all records of patent applications and grants.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 6538015 | Anti-HIV pyrazole derivatives The invention is concerned with novel pyrazole derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula I are inhibitors of the human immunodeficiency viru... | 03/25/2003 |
| 6528543 | Urea derivatives Glucokinase activating compounds of the formula ##STR1## wherein R1 and R2 are independently hydrogen, halo, amino, nitro, cyano, sulfonamido, lower alkyl, perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower al... | 03/04/2003 |
| 6518293 | Anti-HIV imidazolone derivatives The invention is concerned with novel imidazolone derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds are inhibitors of the human immunodeficiency virus reverse ... | 02/11/2003 |
| 6515124 | Dehydroamino acids Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and accordingly reduce or eliminate inflammatory skin disease psoriasi... | 02/04/2003 |
| 6503907 | Indole and dihydroindole derivatives The present invention relates to indole derivatives, dihydroindole derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are ass... | 01/07/2003 |
| 6489440 | Cyclic compounds The present invention relates to novel Aerothricins represented by the Formula (I), ##STR1## wherein R1, R2, R3, R4, R5, X, Y, Z, and m are as defined in Claim 1; and pharmaceutically acceptable salts... | 12/03/2002 |
| 6482958 | Methods for the preparation of 4-hydroxy benzothiophene The present invention is concerned with a novel process for the preparation of a hydroxybenzothiophene that is an intermediate for synthesizing pharmaceutically active substances, e.g. 5-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-7-benzothiophenylmethyl]... | 11/19/2002 |
| 6479666 | Phenyl-keto-imidazolidine thioamide derivatives It has been discovered that compounds of the formula: ##STR1## and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated wit... | 11/12/2002 |
| 6472404 | HIV protease inhibitors The present invention discloses novel isoquinoline carboxamide derivatives which are HIV protease inhibitors or prodrugs thereof, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the co... | 10/29/2002 |
| 6462226 | Process for the preparation of 4,5-diamino shikimic acid derivatives A new process for the preparation of 4,5-diamino shikimic acid derivatives starting from 4-amino-5-azido shikimic acid derivatives is provided. 4,5-diamino shikimic acid derivatives and its pharmaceutically acceptable addition salts are potent inhibitors of vi... | 10/08/2002 |
| 6455550 | N-alkanoylphenylalanine derivatives Compounds of the formula: ##STR1## are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 ... | 09/24/2002 |
| 6452010 | Process for the preparation of hydroxamic acid derivatives The present invention provides an improved process for preparing an hydroxycarbamoyl derivative of a carboxylic acid using a hydroxylammonium salt of a carboxylic acid as a reagent.... | 09/17/2002 |
| 6448399 | Fused heteroaromatic glucokinase activators Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.... | 09/10/2002 |
| 6441184 | Fused heteroaromatic glucokinase activators Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.... | 08/27/2002 |
| 6441180 | Tetrazolyl-phenyl actamide glucokinase activators Tetrazolyl-phenyl acetamides are active as glucokinase activators, and are able to increase insulin secretion, which makes them useful for treating type II diabetes.... | 08/27/2002 |
| 6437171 | Process for preparing 1,2-diamino compounds The invention provides a multistep process for preparing 1,2-diamino compounds of formula ##STR1## wherein R1, R1', R2, R2', R3 and R4 have the meaning given in the specification and pharma... | 08/20/2002 |
| 6437134 | Process for a phenylthiobutyl-isoquinoline and intermediates therefor A method for making phenylthiobutyl-isoquinoline compounds of formula ##STR1## and novel intermediates therefor.... | 08/20/2002 |
| 6437144 | Methods for the preparation of 4-hydroxy benzothiophene The present invention is concerned with a novel process for the preparation of the hydroxybenzothiophene of formula I ##STR1## comprising cyclocarbonylation of a compound of formula II ##STR2## wherein Y is as defined in the specification, followed by sap... | 08/20/2002 |
| 6429288 | Peptides containing an arginine mimetic for the treatment of bone metabolic disorders, their production, and drugs containing these compounds Arginine mimetic peptides according to Formula I of this application have a stimulating effect on bone formation and are useful for the treatment of bone metabolic disorders.... | 08/06/2002 |
| 6426348 | Diphenyl heterocyclic thioamide derivatives It has been discovered that compounds of the formula: ##STR1## and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated wit... | 07/30/2002 |
| 6423728 | Heterocyclic thioamide derivatives It has been discovered that compounds of the formula: ##STR1## and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are usefull in treating inflammation associated wi... | 07/23/2002 |
| 6420600 | Phenylalaninol derivatives It has been discovered that compounds of the formula: ##STR1## and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, are more readily absorbed and more bioavailable than the corresponding carboxylic acids from ... | 07/16/2002 |
| 6403824 | Process for the preparation for 4,5-diamino shikimic acid derivatives The invention provides a multistep synthesis for the preparation of 4,5-diamino shikimic acid derivatives of formula ##STR1## wherein R1, R2, R3 and R4 are defined in the specification, starting from furan. 4,5-... | 06/11/2002 |
| 6380387 | 4-Pyrimidinyl-n-acyl-l phenylalanines Compounds of Formula I are disclosed, ##STR1## having activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells ... | 04/30/2002 |
| 6376491 | Bicyclic compounds The present invention is directed to new bicyclic compounds of the formula [I], ##STR1## and pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R7, Q1... | 04/23/2002 |
| 6372883 | Antiviral medicaments The invention is concerned with amino acid derivatives of the formula ##STR1## and salts of acidic compounds of formula I with bases, which are viral proteinase inhibitors useful as antiviral agents, especially for the treatment or prophylaxis of infectio... | 04/16/2002 |
| 6372715 | Use of erythropoientin and iron preparations for producing pharmaceutical combination preparations for treating rheumatic diseases The present invention is concerned with the use of individual administration forms of an erythropoietin preparation and a physiologically compatible iron preparation corresponding to an equivalent amount of 1-40 mg of iron ions for the production of a pha... | 04/16/2002 |
| 6339093 | Isoquinoline derivatives The present invention relates to compounds of the formula ##STR1## wherein R1 is hydrogen, lower alkyl, lower alkoxy, hydroxy, amino, nitro, cyano, lower alkyl-amino, di-lower alkyl-amino or halogen; R2 is hydrogen, lower alkyl, amino, py... | 01/15/2002 |
| 6319933 | Azole derivatives The present invention is directed to new 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives of the formula (I), ##STR1## and pharmaceutically acceptable salts thereof wherein Q, R, X, Y and Z are the same as defined in the claims and the description. 1-... | 11/20/2001 |
| 6300353 | Azoles for treatment of fungal infections Azole derivatives of the formula I ##STR1## wherein R14, R15 are each independently hydrogen or fluorine, T is a group of the formula: ##STR2## wherein R9 is pyrrolidinyl or a group A--NH--B--, A is hydrogen or straight-chain o... | 10/09/2001 |
| 6235787 | Hydrazine derivatives Hydrazine derivatives of the formula ##STR1## wherein Y is CO or SO2 ; R1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R2 is lower alkyl, halo-lower alkyl, aryl-l... | 05/22/2001 |
| 6229011 | N-aroylphenylalanine derivative VCAM-1 inhibitors Compounds of the formula: ##STR1## are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 ... | 05/08/2001 |
| 6225316 | 3-phenyl-pyridine-derivatives The invention relates to compounds of the formula ##STR1## wherein R is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; R1 is hydrogen or halogen; or R and R1 may be together --CH.dbd.CH--CH.dbd.CH--; R2 is hydrogen... | 05/01/2001 |
| 6218385 | 1,2,4,5-Tetrahydro-benzo[D]azepin derivatives The present invention is concerned with 1,2,4,5-tetrahydro-benzo[d]azepin derivatives as well as with their pharmaceutically acceptable salts in their racemic and optically active form, which compounds are antagonists at metabotropic glutamate receptors a... | 04/17/2001 |
| 6153624 | Pyrrolidine and piperidine derivatives and treatment of neurodegenerative disorders The present invention relates to the use of pyrrolidine and piperidine derivatives of the general formula ##STR1## wherein R1 and R2 are, independently from each other, hydrogen, lower alkoxy, hydroxy, halogen, --CONH2 | 11/28/2000 |
| 6048516 | Light-screening agents The invention relates to a composition which comprises a dibenzoylmethane capable of absorbing UV-A radiation and a compound of formula I ##STR1## wherein R1 and R2 are independently hydrogen, alkyl or alkoxy containing 1 to 18 ... | 04/11/2000 |
| 5962450 | Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines and their use as medicaments The invention is concerned with basically-substituted imidazodiazepines of general formula I. These compounds can be used as anxiolytic and/or anticonvulsant and/or muscle relaxant and/or sedative-hypnotic active substances.... | 10/05/1999 |
| 5935895 | Heterogeneous catalysts A silica-titania mixed oxide catalyst and its method of manufacture is disclosed. Such catalysts can be used especially to catalyze the epoxidation of olefinically unsaturated compounds with organic hydroperoxides.... | 08/10/1999 |
| 5932748 | Process for permethylating non--tocopherols to produce -tocopherol A process for the conversion of non--tocopherols into (-tocopherol by the catalytic permethylation is disclosed. The methylating agent is methanol in the near-critical or super-critical pressure and temperature region or a mixture which is e... | 08/03/1999 |
| 5925381 | Encapsulation of oleophilic substances and compositions produced thereby Multiple micro-encapsulations of a high concentration oleophilic substance using heat to set the primary particle renders the composition suitable for the production of free-flowing powders or beadlets. Microencapsulation involves forming an emulsion out ... | 07/20/1999 |
