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| Number | Title | Issue Date |
| 8183380 | 2-aminoquinolines The present invention is concerned with 2-aminoquinoline derivatives of formula I where R1, R2, R3, R4, R5, R6, A, and n are as defined in the specification ... | 05/22/2012 |
| 8183262 | Pyridine derivatives as mGluR2 antagonists The present invention relates to compounds of formula (I), a process for the manufacture thereof, pharmaceutical compositions containing them, and their use for treating CNS disorders: wherein A, B, X, Y, R1, R | 05/22/2012 |
| 8183254 | Inhibitors of JNK The invention relates to prodrugs of JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses prodrugs of JNK inhibitors, as described below in formula I: | 05/22/2012 |
| 8178689 | Tricyclic compounds The present invention provides novel compounds of formula I, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the tre... | 05/15/2012 |
| 8178583 | Compounds The invention is concerned with compounds of formula I: wherein R, R2, and Q are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are useful as... | 05/15/2012 |
| 8178538 | Pyridazinones The present invention is concerned with novel pyridazinones of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologicall... | 05/15/2012 |
| 8173652 | Isoxazole-isoxazoles and isoxazole-isothiazoles The present invention is concerned with isoxazole-isoxazoles and isoxazole-isothiazoles of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as cognitive enhancers or for ... | 05/08/2012 |
| 8163906 | Dihydroquinone and dihydronaphthridine inhibitors of JNK Compounds of formula I are effective modulators of JNK: wherein X is CR11 or N; Y is —C(O)R3, 5-membered heteroaryl, or 5-membered heterocyclyl; | 04/24/2012 |
| 8163793 | Proline derivatives The invention relates to a compound of formula (I) wherein A, R1-R6 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament. ... | 04/24/2012 |
| 8163781 | Bi-aryl aminotetralines The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1-R5, A, B, Q, W, and X are defined in the detailed description and claims... | 04/24/2012 |
| 8163778 | Pyridines as FBPase inhibitors for treatment of diabetes Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof wherein the residues have the significance given in claim 1 and which can be used in the form of pharmaceutical compositions. | 04/24/2012 |
| 8163740 | 6-substituted benzoxazines The present invention is concerned with 6-substituted benzoxazine derivatives of formula (I) wherein X, Y, R1 and R2 are as described herein, their manufacture, and pharmaceutical compositions containi... | 04/24/2012 |
| 8163728 | Pyrazoles The present invention is concerned with isoxazole-pyrazoles of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutics. The active compounds of the present inven... | 04/24/2012 |
| 8158668 | Methods for treating CNS disorders with 4-imidazole derivatives The present invention relates to methods for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, n... | 04/17/2012 |
| 8158655 | Sulfonamide derivatives The invention is concerned with the novel sulfonamide derivatives of formula (I) wherein A, R1 to R2″, X and Y are as defined in the description and in the claims, as well as physiologically acceptab... | 04/17/2012 |
| 8153815 | Pseudoproline dipeptides Disclosed is a process for the manufacture of pseudo proline dipeptides of the formula wherein R1 is a side chain of an alpha amino acid, R2 is an amino protecting group and R3 and R4 | 04/10/2012 |
| 8153805 | Biaryl derivatives The invention is concerned with novel biaryl derivatives of formula (I), wherein m, R1, R2, R3, X1, X2 and X3 are... | 04/10/2012 |
| 8153679 | Radiolabelled inhibitors of the glycine 1 transporter The present invention relates to novel radiolabelled inhibitors of formula I for the Glycine 1 transporter (GlyT1), useful for the labelling and diagnostic imaging of the glycine 1 transporter functionality. wherein ... | 04/10/2012 |
| 8153663 | 3-amino-indazole or 3-amino-4,5,6,7-tetrahydro-indazole derivatives This invention relates to novel indazole derivatives of formula I: wherein R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compo... | 04/10/2012 |
| 8153653 | Amido-tropane derivatives The present invention relates to a compound of formula I wherein R1, R2 and R3 are each independently hydrogen, lower alkyl, lower alkoxy, cycloalkyl, lower alkyl substituted by... | 04/10/2012 |
| 8143442 | Preparation for a cyclohexanecarboxylic acid derivative and intermediates A process for the preparation of a compound of formula (Ia): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds. ... | 03/27/2012 |
| 8143422 | Benzimidazole derivatives The invention is concerned with novel benzimidazole derivatives of formula (I) wherein R1 to R6 are as defined in the description and in the claims, as well as physiologically acceptable salts and este... | 03/27/2012 |
| 8143281 | Indoles The present invention is concerned with novel indol-3-yl-carbonyl-piperidine-benzopyrrolone, -benzoxazolone and -benzotriazole derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of ... | 03/27/2012 |
| 8143280 | Glucocorticoid receptor antagonists The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts t... | 03/27/2012 |
| 8143273 | Quinolizidine and indolizidine derivatives The present invention relates to a compound of formula I-A or I-B wherein X, R1, R2 and R3 are defined herein; or to a pharmaceutically acceptable acid add... | 03/27/2012 |
| 8138208 | Aminotetrahydroindazoloacetic acids The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R1-R5 and n are defined in the detailed description and claims. In... | 03/20/2012 |
| 8138189 | Substituted benzene compounds as modulators of the glucocorticoid receptor The present invention relates to compounds of formula I wherein R.sup.1a to R.sup.1e and R.sup.2 to R.sup.5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are gluc... | 03/20/2012 |
| 8138175 | Heterocyclyl compounds The invention is concerned with novel heterocyclyl compounds of formula (I): wherein A, X, R3, R4, R5, R6, R7, R8, R9, R10, m, n and p ... | 03/20/2012 |
| 8134001 | Spiroindolinone derivatives There are provided compounds of the formula and pharmaceutically acceptable salts and esters thereof wherein W, V, X, Y, A, R and R′ are as described herein. The compounds are useful as ant... | 03/13/2012 |
| 8133979 | Antibodies against human angiopoietin 2 The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. ... | 03/13/2012 |
| 8133909 | Heteroaromatic monoamides as orexinin receptor antagonists The present invention is concerned with novel sulfonamides of formula wherein R1, R2, R3, R4, R5, Ar, Ar1, Ar2, n, o and p are as described in the... | 03/13/2012 |
| 8129423 | Imidazolone and imidazoloidinone derivatives as 11b-HSD1 inhibitors Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R6 have the significance given in claim 1 can be used in the form of pharmaceutical compositio... | 03/06/2012 |
| 8124641 | Aminotetrahydroindazoloacetic acids The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present inven... | 02/28/2012 |
| 8124636 | Imidazolidinone derivatives as 11B-HSD1 inhibitors Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein A and R1 to R4 have the significance given in claim 1 can be used in the form of pharmaceutical composition... | 02/28/2012 |
| 8124629 | Naphthylacetic acids The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addi... | 02/28/2012 |
| 8124604 | Inhibitors of bruton's tyrosine kinase This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives according to generic Formulae I-IV: wherein, variables R, X, Y1, Y2, Y2′, Y3, Y | 02/28/2012 |
| 8119636 | Pyrrolopyrazine kinase inhibitors The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-i... | 02/21/2012 |
| 8097637 | Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors The present invention relates to compounds of formula (I) wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their man... | 01/17/2012 |
| 8097634 | Azacyclic derivatives The invention provides novel compounds having the general formula (I) wherein R1, R2 and A are as described herein, compositions including the compounds and methods of using the compounds. The compound... | 01/17/2012 |
| 8093385 | Leukotriene Binhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 01/10/2012 |
