Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 8124763 | Process for the synthesis of 5-(methyl-1-imidazol-1-yl)-3-(trifluoromethyl)-benzeneamine The present invention provides a new method of making compounds of formula (I): wherein R1 is mono- or polysubstituted aryl; R2 is hydrogen, lower alkyl or aryl; and ... | 02/28/2012 |
| 8124611 | Inhibitors of the mutant form of kit The present invention relates to the treatment of KIT dependent diseases that are characterized by a mutant form of KIT whereby the mutant KIT is identified and an appropriate inhibitor of the mutant KIT is administered. ... | 02/28/2012 |
| 8115016 | Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP... | 02/14/2012 |
| 8106081 | Combination of organic compounds useful for treating diabetes The present invention relates to a combination, especially a pharmaceutical composition, comprising as active ingredients (i) an AT1-receptor antagonist or a pharmaceutically acceptable salt thereof; (ii) (a) an insulin secretion... | 01/31/2012 |
| 8101659 | Methods of treatment and pharmaceutical composition The invention relates a pharmaceutical composition comprising a combination of: (i) the AT 1-antagonist valsartan or a pharmaceutically acceptable salt thereof; and (ii) a NEP inhibitor or a pharmaceutically acceptable salt thereof and opti... | 01/24/2012 |
| 8058301 | Salt hydrates The invention relates to new forms of salts of valsartan or crystalline, also partly crystalline and amorphous salts of valsartan, the respective production and usage, and pharmaceutical preparations containing such a salt. ... | 11/15/2011 |
| 7943647 | Process for the preparation of tetrazole derivatives from organo aluminium azides The present invention relates to a method for preparing substituted tetrazoles of the formula or a tautomer or salt thereof, wherein R represents an organic residue. Also provided are compounds obtained according to this me... | 05/17/2011 |
| 7799342 | Fast dissolving tablet The present invention relates to processes for the preparation of tablets which dissolve rapidly in the mouth and provide an excellent mouthfeel. The tablets of the invention comprise a compound which melts at about 37° C. or lower, have a low hardness, high stabil... | 09/21/2010 |
| 7771744 | Bazedoxifene acetate formulations Bazedoxifene acetate formulations and compositions thereof having improved properties relating to reduction, elimination, or prevention of polymorphic conversion of bazedoxifene acetate, and processes for making such formulations and compositions. Components used in... | 08/10/2010 |
| 7759386 | Pharmaceutical compositions of estrogenic agents This invention relates to novel pharmaceutical carrier or excipient systems and oral pharmaceutical compositions comprising 1-[4-(2-Azepan-1yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol or 2-(4-Hydroxy-phenyl)-3-methyl-1-(4-(2-piperidin-1-yl-ethoxy)b... | 07/20/2010 |
| 7754753 | Analgesic and anti-inflammatory compositions containing Cox-2-inhibitors The present invention is directed to an analgesic composition which consists essentially of a cyclooxygenase-2 inhibitor and a compound selected from the group consisting of non-steroidal anti-inflammatory drugs, acetaminophen and mixtures thereof. The present inven... | 07/13/2010 |
| 7652062 | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof Progesterone receptor modulators of formula I, or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6 and R7 are as defined... | 01/26/2010 |
| 7652018 | Imidazolidin-2-one derivatives useful as PR modulators Compounds of the following structure are described: wherein R1-R6, R10, m, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug there... | 01/26/2010 |
| 7649007 | Oxazolidine derivatives as PR modulators Compounds of the following structure are described: wherein R1-R6, m, V, W, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These com... | 01/19/2010 |
| 7618990 | Oxazolidone derivatives as PR modulators Compounds of the following structure are described: wherein R1, R2, R5, R6, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or p... | 11/17/2009 |
| 7618989 | Tricyclic oxazolidone derivatives useful as PR modulators Compounds of the following structure are described: wherein R1-R6, R16, m, V, W, X, Y, and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug ther... | 11/17/2009 |
| 7576030 | Activated ignition promoters for metal catalyzed reactions The inventors have discovered catalyst ignition promoters comprising one or more activated metals. The catalyst ignition promoters are easily prepared from a number of metal sources, including spent catalysts, are activated quickly and provide effective catalyst ign... | 08/18/2009 |
| 7538107 | Oxazinan-2-one derivatives useful as PR modulators Compounds of the following structure are described: wherein R1-R6, m, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compou... | 05/26/2009 |
| 7524849 | 5-arylpyrimidines as anticancer agents This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for the treatme... | 04/28/2009 |
| 7521552 | Process for preparation of substituted amino alcohols There is provided a process for the preparation of substituted amino alcohols HO—(CH2)n—NR1R2 from haloalcohols HO—(CH2)n—X, where X is Cl, Br or I, by reaction with an amine HNR1R | 04/21/2009 |
| 7507739 | 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents This invention relates to certain 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents... | 03/24/2009 |
| 7501423 | Tubulin inhibitor and process for its preparation The invention provides 6-chloro-5-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]pyrimidin-4-amine hemifumarate which is a tubulin inhibitor useful in the treatment of cancer and processes of making said hemifuma... | 03/10/2009 |
| 7417148 | 4-anilino-3-quinolinecarbonitriles for the treatment of chronic myelogenous leukemia (CML) Compounds of the formula: wherein: n is an integer from 1-3; X is N, CH, provided that when X is N, n is 2 or 3; R is alkyl of 1 to 3 carbon atoms; R1 is 2,4... | 08/26/2008 |
| 7402703 | Stereoselective synthesis of (E)-vinylboronic esters via a Zr mediated hydroboration of alkynes There is herein provided a process for Zr-mediated hydroboration of alkynes which offers (E)-vinylboronic esters in high yield with stereoselectivity and regioselectivity. ... | 07/22/2008 |
| 7399865 | Protein tyrosine kinase enzyme inhibitors This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification. ... | 07/15/2008 |
| 7390910 | Compounds for treating tumors The invention provides compounds of formula (I): wherein E, A, B′, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful... | 06/24/2008 |
| 7365203 | Process for the synthesis of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application. ... | 04/29/2008 |
| 7361622 | Multi-staged catalyst systems and process for converting alkanes to alkenes and to their corresponding oxygenated products Alkenes, unsaturated saturated carboxylic acids, saturated carboxylic acids and their higher analogues are prepared cumulatively from corresponding alkanes utilizing using a multi-staged catalyst system and a multi-stage process which comprises steam cracking of alk... | 04/22/2008 |
| 7297795 | Process for preparation of 4-amino-3-quinolinecarbonitriles This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-su... | 11/20/2007 |
| 7294740 | Process for the synthesis of N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids The invention claimed herein provides a process to oxidize N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamides to N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids using potassium permanganate in the presence of magnesium sulfate in aqueous sulfolane or aqueous pyridine. ... | 11/13/2007 |
| 7285667 | Process for the synthesis of functionalized indolizidines The present invention provides a process for the preparation of functionalized indolizidines comprising the steps and products disclosed within this application. ... | 10/23/2007 |
| 6982307 | Matrix and process for polyolefin production Olefin-based materials react with a range of catalysts and catalytic systems to form catalytic matrices, which are employed in the production of a variety of polyolefin products. ... | 01/03/2006 |
| 6911491 | Hot melt adhesive A moisture reactive hot melt adhesive composition formed by admixing components including a polyisocyanate, an amorphous polyol, tri-C1-C6-alkyl citrate in the amount of 1.3 to 6% by weight based on the weight of said adhesive composition, and styrene/allyl alcohol ... | 06/28/2005 |
| 6855403 | Multi-layer coating composition and method of preparation A method for preparing multi-layer protective coatings having enhanced durability with easy removability under conventional stripping conditions is disclosed. The invention is based on applying to a substrate, a first-coating composition that is removable, followed ... | 02/15/2005 |
| 6770285 | Hydrophobic oil absorbing polymers and process Hydrophobic, oil-absorbing polymeric compositions, prepared from high levels of hydrophobic monomers, are provided for transferring oily substances and hydrophobic materials to and from various surfaces in a heterogeneous medium. A reversible process is described fo... | 08/03/2004 |
| 6750050 | Porous non-friable polymer film Porous films are provided which include a blend of a film forming polymer and a non-film forming material, the film having a network of pores or channels throughout the film. The porous polymer films are formed between 0° and 80° C. retain porosity at elevated tem... | 06/15/2004 |
| 6730816 | High productivity bisphenol-A catalyst A high productivity catalyst for bisphenol-A has been discovered which comprises strongly acidic cation-exchange resin spheres produced from a polystyrene/divinylbenzene (PS/DVB) copolymer sulfonated under conditions to introduce sulfone cross-linking. Surprisingly,... | 05/04/2004 |
| 6713557 | Redox system and process A process for preparing an aqueous emulsion polymer including providing at least one ethylenically unsaturated monomer and a free radical redox initiator system under emulsion polymerization conditions, the redox initiator system including an oxidant; a reductant an... | 03/30/2004 |
| 6646082 | Corrosion inhibiting compositions A new class of polymeric corrosion inhibiting compositions incorporating pendant heterocyclic groups which are surprisingly effective copper corrosion inhibitors are disclosed. The polymers form a protective barrier on metallic components to aqueous syste... | 11/11/2003 |
| 6610282 | Polymeric controlled release compositions Disclosed are compositions containing biologically active compounds that slowly release the biologically active compound. These compositions may be directly incorporated into the locus to be protected or may be applied to a structure in a coating.... | 08/26/2003 |
