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Attorney: Johnson; Maynard R.


Number of patents: 24
Last date: September 26, 1989

NumberTitleIssue Date
4870101Method of inhibiting interleukin-1 release
Methods useful for inhibiting the release of interleukin-1 and for alleviating interleukin-1 mediated conditions, such as IL-1-mediated inflammation, comprising administration of an effective amount of a pharmaceutically acceptable antioxidant compound su...
09/26/1989
4543221Method for making cellulose semipermeable hollow fibers
Improved cellulose semipermeable hollow fibers useful in detoxifying blood during hemodialysis or hemofiltration treatments. The cellulose fibers are fine, capillary fibers that are made by melt extrusion of certain cellulose ester polyol melt spin compos...
09/24/1985
45268903,6,7,8-Substituted-s-triazolo[4,3-b]pyridazines as bronchodilators
3,6,7,8-Substituted-s-triazolo-pyridazine compounds such as 7,8-dimethyl-6-morpholino-3-methyl-s-triazolo[4,3-b]pyridazine or 7,8-dimethyl-6-(1-pyrrolidinyl)-3-(isopropyl)-s-triazolo-[4,3-b]pyridazine are prepared by the reaction of a carboxylic acid with...
07/02/1985
4271155Water soluble hydrazones of 3-formylrifamycin SV, antibacterial compositions thereof and method of use thereof
The invention relates to new water soluble 3-formylrifamycin SV hydrazones wherein the hydrazone moiety contains a phosphonoxy lower alkyl radical which imparts water solubility. The compositions containing said rifamycin derivatives are also an object of...
06/02/1981
4072565Production of viruses in tissue culture without use of serum
Growth of cells in tissue culture and virus vaccine production in tissue culture in the absence of serum are disclosed. The cells in tissue culture are grown initially in a chemically defined medium containing protamine zinc insulin, and the protamine zin...
02/07/1978
4049814Substituted phenoxyalkyl quaternary ammonium compounds as antiarrhythemic agents
Quaternary ammonium compounds such as [2-(4-amino-2,6-dibromophenoxy)ethyl]dimethyl (allyl) ammonium bromide are prepared by the reaction of a tertiary amine such as 3,5-dibromo-ଲ-dimethylamino-p-phenetidine with a substituted organic compound ...
09/20/1977
4042692Substituted phenoxyalkyl quaternary ammonium compounds as antiarrhythemic agents
Quaternary ammonium compounds such as [2-(4-amino-2,6-dibromophenoxy)ethyl]dimethyl (allyl) ammonium bromide are prepared by the reaction of a tertiary amine such as 3,5-dibromo-ଲ-dimethylamino-p-phenetidine with a substituted organic compound ...
08/16/1977
4042709Substituted phenoxyalkyl quaternary ammonium compounds as antiarrhythmic agents
Quaternary ammonium compounds such as [2-(4-amino-2,6-dibromophenoxy)ethyl]dimethyl (allyl) ammonium bromide are prepared by the reaction of a tertiary amine such as 3,5-dibromo-ଲ-dimethylamino-p-phenetidine with a substituted organic compound ...
08/16/1977
4042712Substituted phenoxyalkyl quaternary ammonium compounds as antiarrhythemic agents
Quaternary ammonium compounds such as [2-(4-amino-2,6-dibromophenoxy)ethyl]dimethyl (allyl) ammonium bromide are prepared by the reaction of a tertiary amine such as 3,5-dibromo-8-dimethylamino-p-phenetidine with a substituted organic compound such a...
08/16/1977
4029703N,N'-disubstituted halophenylacetamidines
N,N'-Disubstituted halophenylacetamidine compounds such as N,N'-dimethyl-3,4-dichlorophenyl-acetamidine, and their pharmaceutically-acceptable salts are prepared by the reaction of a substituted phenylacetonitrile with an alkylamine and alkylammonium salt...
06/14/1977
4024021Determination of glutamate and glutamic transaminases
Glutamate and glutamic transaminases are determined by mixing a substrate-reagent composition that is essentially free of ammonia or ammonium ions with a specimen to be analyzed, incubating the resulting mixture for less than about 15 minutes, terminating...
05/17/1977
40161626-Morpholino-3-substituted phenyl-S-triazolo[4,3-b]pyridazines
6-Morpholino-3-substituted phenyl triazolopyridazine compounds such as 8-methyl-6-morpholino-3-phenyl-s-triazolo[4,3-b]pyridazine or 8-methyl-6-morpholino-3-(3,4,5-trimethoxyphenyl)-s-triazolo[4,3-b]pyridazi ne are prepared by the reaction of the correspon...
04/05/1977
4001089Method for determination of triglycerides and glycerol
A novel reagent and method for colorimetrically determining the concentration of triglycerides in biological fluids, and for rapid determination of glycerol are described. Triglycerides are hydrolyzed in methanolic base to glycerol, and glycerol content i...
01/04/1977
3991210Acetamidine urinary antiseptics
The disclosure relates to a method useful for combating microorganisms associated with infections of the urinary tract in mammals by means of administering to mammals an amount of a substituted acetamidine compound such as 2-(4-bromophenyl) acetamidine or...
11/09/1976
3989613Continuous balanced flow fixed boundary electrophoresis
A continuous balanced flow electrophoresis apparatus utilizes a fixed, colloid-permeable boundary membrane across which net liquid flow is minimized. The apparatus is employed in electrophoretic separation of colloids such as blood plasma proteins in whic...
11/02/1976
3988474N,N'-dialkyl-halobenzamidines as antidepressants
A method useful for alleviating central nervous system depression comprises administration to animals of an effective amount of an N,N'-dialkyl-halobenzamidine. Compositions useful in practicing the method are also disclosed....
10/26/1976
3983250Halophenyl acetamidines as anxiolytic antidepressants
A method useful for alleviating central nervous system depression and anxiety symptoms comprises administration to animals of an effective amount of an N,N'-dialkyl-2-halophenyl acetamidine. Compositions useful in practicing the method are also disclosed....
09/28/1976
3972931N,N'-Disubstituted benzamidines
N,N'-Disubstituted benzamidine compounds such as N,N'-dimethyl-3,4-dichlorobenzamidine, and their pharmaceutically-acceptable salts are prepared by the reaction of a substituted phenylacetonitrile with an alkylamine and alkylammonium salt or alternat...
08/03/1976
3951821Disintegrating agent for tablets
Disintegration of tablets is improved by the incorporation therein of a plurality of small tubules. The tubules can be prepared by subdivision of hollow fibers such as cellulose or cellulose acetate hollow fibers having inside diameters on the order of 50...
04/20/1976
3950538Anti-inflammatory methods utilizing certain thioureas
A method of alleviating symptoms of inflammation in a mammal suffering from an inflammatory condition which comprises the administration to such mammal of a pharmaceutically effective amount of a 1-aryl-3-(2-hydroxyethyl)thiourea derivative....
04/13/1976
3938954Determination of calcium
An improved reagent system for determining calcium by the orthocresolphthalein complexone color reaction. The reagent utilizes an alkaline buffer containing an aminoloweralkanol providing a pH of about 10.2 - 10.5. A method for using the reagent is also d...
02/17/1976
3934020Halophenyl acetamidines as anxiolytic antidepressants
A method useful for alleviating central nervous system depression and anxiety symptoms comprises administration to animals of an effective amount of an N,N'-dialkyl-2-halophenyl acetamidine. Compositions useful in practicing the method are also disclosed....
01/20/1976
3933912Substituted phenylthioamidines
Substituted phenylthioamidine compounds such as 2-(4-chlorophenylthio)acetamidine; 2-(4-chlorophenylthio)-acetamidoxime; and their pharmaceutically acceptable salts are prepared by the reaction of a substituted phenylthioacetonitrile with hydroxylamine hy...
01/20/1976
3932664Substituted phenoxyalkyl quaternary ammonium compounds as antiarrhythemic agents
Quaternary ammonium compounds such as [2-(4-amino-2,6-dibromophenoxy)ethyl[dimethyl (allyl) ammonium bromide are prepared by the reaction of a tertiary amine such as 3,5-dibromo-ଲ-dimethylamino-p-phenetidine with a substituted organic compound ...
01/13/1976
 
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