Johnson; Mark K. - US Patent Attorneys and Agents

Attorney: Johnson; Mark K.

Number of patents: 69
Last date: April 28, 2009

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Number	Title	Issue Date
7524680	Polyampholytes for delivering polyions to a cell An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrav...	04/28/2009
7507722	Intravascular delivery of nucleic acid Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian blood vessel. Prior to ...	03/24/2009
7501394	Compounds for targeting hepatocytes We describe compounds that bind to and are internalized by hepatocytes. Association of these compounds to other molecules or complexes can be used to target the molecules or complexes to hepatocytes in vivo or in vitro. ...	03/10/2009
7498017	Compositions for delivering nucleic acids to cells Cyclic amidinium containing compounds and their methods of preparation are described. Compositions containing these compounds facilitate delivery of biologically active polymers to cells in vitro and in vivo. ...	03/03/2009
7482160	Process of making a compound by forming a polymer from a template drug A method of forming polymers in the presence of nucleic acid using template polymerization. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes ...	01/27/2009
7473419	Intravascular delivery of nucleic acid Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the ...	01/06/2009
7470539	Formation of polyampholytes in the presence of a polyion Polyampholyte are able to condense nucleic acid to form small complexes which can be utilized in the delivery of nucleic acid to mammalian cells. The polyampholytes can be formed prior to interaction with nucleic acid or they can be formed in the presence of nucleic...	12/30/2008
7442764	Reversible modification of amine-containing compounds An process for the reversible modification of an amine-containing compound is described. Modification of the compound can be used to facilitate delivery of molecules to cells in vitro and in vivo or to alter interactions or activities the compounds. The described mo...	10/28/2008
7439051	Process for utilizing epitopes recognized by natural antibodies The present invention relates to compositions and methods for the selection and use of surface exposed epitopes. The present invention includes in vivo and in vitro phage peptide diplay methods for the identification and selection of peptides and peptide associated ...	10/21/2008
7435723	Process for delivery of polynucleotides to the prostate Disclosed is a system for providing in vivo delivery of polynucleotides to mammalian prostate cells using an intravascular administration route. The polynucleotides are inserted in an injection solution into a mammalian vasculature. Insertion of the injection soluti...	10/14/2008
7396919	Charge reversal of polyion complexes An ionic polymer is utilized in “recharging” (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or neg...	07/08/2008
7396821	Intravascular delivery of nucleic acid Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian blood vessel. Prior to ...	07/08/2008
7348453	Labile linkage for compound delivery to a cell Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The acetals can be used to reversibly link up to three different molecules and...	03/25/2008
7326780	Compounds and processes for single-pot attachment of a label to nucleic acid Compounds and methods are provided for a single-pot covalent attachment of a label to nucleic acids comprising forming a covalently attachable labeling reagent for alkylating the molecule. Then, combining the covalently attachable labeling reagent with a mixture con...	02/05/2008
7262056	Enhancing intermolecular integration of nucleic acids using integrator complexes We disclose compositions and processes for enhancing transposon mediated integration of a nucleic acid molecule into another target nucleic acid molecule. Integration by an integrator complex is enhanced by cationic reagents. ...	08/28/2007
7220400	Compositions for delivering nucleic acids to cells Cyclic amidinium containing compounds and their methods of preparation are described. Compositions containing these compounds facilitate delivery of biologically active polymers to cells in vitro and in vivo. ...	05/22/2007
7214369	Devices and processes for distribution of genetic material to mammalian limb A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from ischemia. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and distribution i...	05/08/2007
7208314	Compositions and methods for drug delivery using pH sensitive molecules A system relating to the delivery of desired compounds (e.g., drugs and nucleic acids) into cells using pH-sensitive delivery systems. The system provides compositions and methods for the delivery and release of a compound to a cell. ...	04/24/2007
7192605	Nucleic acid transfer complexes The present invention relates to compositions and methods for transferring nucleic acids into cells in vitro and in vivo. The compositions comprise a transfection reagent and one or more detergents. In preferred embodiments, the compositions comprise delivery system...	03/20/2007
7148205	Intravascular delivery of non-viral nucleic acid Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian vessel such as a tail v...	12/12/2006
7144869	Nucleic acid injected into hapatic vein lumen and delivered to primate liver Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in high level of gene expression with transient increases in liver enzymes....	12/05/2006
7138382	Compositions and methods for drug delivery using pH sensitive molecules A system relating to the delivery of desired compounds (e.g., drugs and nucleic acids) into cells using pH-sensitive delivery systems. The system provides compositions and methods for the delivery and release of a compound to a cell. ...	11/21/2006
7101995	Compositions and processes using siRNA, amphipathic compounds and polycations Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell. ...	09/05/2006
7098030	Polyampholytes for delivering polyions to a cell An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrav...	08/29/2006
7098032	Compositions and methods for drug delivery using pH sensitive molecules An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrav...	08/29/2006
7094605	Formation of polyampholytes in the presence of a polyion Polyampholyte are able to condense nucleic acid to form small complexes which can be utilized in the delivery of nucleic acid to mammalian cells. The polyampholytes can be formed prior to interaction with nucleic acid or they can be formed in the presence of nucleic...	08/22/2006
7091041	Micellar systems A complex is described that is deliverable to a cell comprising inserting a nucleic acid or other cargo into a reverse micelle. The reverse micelle has the property to compact the nucleic acid for easier delivery. ...	08/15/2006
7071163	Compounds for targeting hepatocytes in vivo We describe compounds that bind to and are internalized by hepatocytes. Association of these compounds to other molecules or complexes can be used to target the molecules or complexes to hepatocytes in vivo or in vitro. ...	07/04/2006
7049142	Gene expression with covalently modified polynucleotides A process and compound wherein nucleic acids can be modified with a host of molecules and maintain their ability to be expressed. A modifying chemical attachment of polyions to polynucleotides can be used to facilitate the change of tertiary structure of the nucleic...	05/23/2006
7049144	Process of making a compound by forming a polymer from a template drug A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for fo...	05/23/2006
7045356	Process for generating multilayered particles We describe a process for generating multilayer particles comprising condensing a polymer with an oppositely charged polymer to form a particle and sequentially adding oppositely charged polymers to the particle forming at least three layers of polymers. The process...	05/16/2006
7033607	pH-titratable polyampholytes for delivering polyions to a cell A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrava...	04/25/2006
7022525	Process of making a compound by forming a polymer from a template drug A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for fo...	04/04/2006
7019113	Reversible modification of membrane interaction An process for the reversible modification of membrane interaction of a compound is described. Modification of membrane interaction can be used to facilitate delivery of molecules to cells in vitro and in vivo. The described modifiers, which are used to reversibly i...	03/28/2006
7015040	Intravascular delivery of nucleic acid Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the ...	03/21/2006
6960690	Process of making a compound by forming a polymer from a template drug A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for fo...	11/01/2005
6936729	Compound containing a labile disulfide bond A labile disulfide-containing compound under physiological conditions, comprising: the disulfide-containing compound having a labile disulfide bond that is either a disulfide bond that is cleaved more rapidly than oxidized glutathione or a disulfide bond constructed...	08/30/2005
6919091	Compositions and methods for drug delivery using pH sensitive molecules An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrav...	07/19/2005
6897068	Polynucleotide complex delivery Disclosed is a complex for providing nucleic acid expression in a cell. A polynucleotide and a polymer are mixed together to form the complex wherein the zeta potential of the complex is not positive. Then the complex is delivered to the cell wherein the nucleic aci...	05/24/2005
6881576	Formation of polyampholytes in the presence of a polyion A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrava...	04/19/2005

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Attorney: Johnson; Mark K.