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| Number | Title | Issue Date |
| 8178550 | Hydrochloride salts of 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor Disclosed are hydrochloride and tosylate crystalline salt forms of (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one, represented by Formula I and methods of preparing the same. ... | 05/15/2012 |
| 8153414 | Microbial delivery system The present invention provides methods and compositions for treating or preventing allergic responses, particularly anaphylactic allergic responses, in subjects who are allergic to allergens or susceptible to allergies. Methods of the present invention utilize admin... | 04/10/2012 |
| 8137509 | Asymmetric synthesis of rocaglamides via enantioselective photocycloaddition mediated by chiral brønsted acids The present invention provides a new strategies for the synthesis of compounds of the rocaglamide family and related natural products. The synthetic approach generally involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative ... | 03/20/2012 |
| 8110590 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprisi... | 02/07/2012 |
| 8106098 | Protein conjugates with a water-soluble biocompatible, biodegradable polymer The present invention broadly relates to the field of protein modification, and, more specifically, to conjugates of proteins or analogs thereof to a water-soluble biocompatible polymer and methods of making and using the same. ... | 01/31/2012 |
| 8105652 | Methods of making decomposable thin films of polyelectrolytes and uses thereof A decomposable thin film comprising a plurality of polyelectrolyte layers of alternating charge, wherein decomposition of the thin film is characterized by degradation of at least a portion of the polyelectrolyte layers. ... | 01/31/2012 |
| 8101164 | Dual phase drug release system The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a modifier having a molecular weight ≦10 kDa; denotes direct of indirect at... | 01/24/2012 |
| 8101163 | Transdermal compositions The present invention is directed to transdermal compositions and the uses thereof. These compositions include at least one of the following components: a C1-C6 dialkyl, C12-C30 dialkyl quaternary ammonium salt, a C12... | 01/24/2012 |
| 8096540 | Tension ring lifting assembly A tension ring lifting assembly (101) for securing around a pipe, the assembly comprising a tension ring (112) and at least one lifting lug (130) by which the tension ring, and a pipe around which the tension ring has been secured, can be lifted... | 01/17/2012 |
| 8030459 | Oxime conjugates and methods for their formation and use The present invention relates to biodegradable biocompatible polyketals, methods for their preparation, and methods for creating animals by administration of biodegradable biocompatible polyketals. In one aspect, a method for forming the biodegradable biocompatible ... | 10/04/2011 |
| 8026364 | NKantagonists A compound having the general structure shown in Formula I: or pharmaceutically acceptable salt and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various... | 09/27/2011 |
| 8026317 | Isotactic specific catalyst for direct production of highly isotactic poly (propylene oxide) or highly isotactic poly (butylene oxide) (Salph or methoxy salph) Co (initiating ligand) catalyze homopolymerizing rac-PO to produce pure highly isotactic PPO and rac-1-butylene oxide to produce pure isotactic poly(butylene oxide). A product is unfractionated isotactic PPO of m-dyad content >81%, normally ... | 09/27/2011 |
| 8000904 | Methods and products related to the improved analysis of carbohydrates The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns ... | 08/16/2011 |
| 7981905 | Pharmaceutical formulations: salts of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-Ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and treatment methods using the same Pharmaceutical formulations containing salts of (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluoromethyl)phenyl]-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one, represented by Formula I, are disclosed. Disclosed also are methods of treatment utilizing such dosage forms... | 07/19/2011 |
| 7951898 | Biodegradable polyketal polymers and methods for their formation and use The present invention relates to biodegradable biocompatible polyketals, methods for their preparation, and methods for treating animals by administration of biodegradable biocompatible polyketals. In one aspect, a method for forming the biodegradable biocompatible ... | 05/31/2011 |
| 7947267 | Viral complement control proteins for eye disorders The present invention provides compositions and methods for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration or choroidal neovascularization. Certain of the compositions comprise a poxvirus complement co... | 05/24/2011 |
| 7923041 | Compositions and methods for enhancing cognitive function Disclosed are compositions for promoting general health and well-being, comprising an extract of a botanical raw material, wherein said extract inhibits the carboxyl demethylating activity of a protein phosphatase, and methods of making and using same. ... | 04/12/2011 |
| 7910623 | Synthesis of scabronines and analogues thereof A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, t... | 03/22/2011 |
| 7879977 | Methods and reagents for decreasing clinical reaction to allergy It has been determined that allergens, which are characterized by both humoral (IgE) and cellular (T cell) binding sites, can be modified to be less allergenic by modifying the IgE binding sites. The IgE binding sites can be converted to non-IgE binding sites by mas... | 02/01/2011 |
| RE41990 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention furth... | 12/07/2010 |
| 7879335 | Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof The present invention provides novel n-alkenyl glycosides and glycoconjugates, n-alkyl glycoamino acids, and methods for the synthesis thereof. In another aspect, the present invention provides novel clustered glycopeptides and methods for the synthesis thereof. In ... | 02/01/2011 |
| 7875734 | Low pressure carbonylation of heterocycles Heterocycles, e.g., epoxides, are carbonylated at low pressure with high percentage conversion to cyclic, ring expanded products using the catalyst where L is tetrahydrofuran (THF). ... | 01/25/2011 |
| 7875638 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprisi... | 01/25/2011 |
| 7854935 | Herbal therapy for the treatment of asthma The present invention provides herbal formulas, and compositions thereof, that can treat or reduce the severity, intensity, or duration of asthma and asthma-related symptoms. The compositions may optionally include one or more adjuvants, cytokines, encapsulating mat... | 12/21/2010 |
| 7854934 | Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof The present invention provides novel glycosides and glycoconjugates, glycoamino acids, and methods for the synthesis thereof. In another aspect, the present invention provides novel clustered glycopeptides and methods for the synthesis thereof. In still another aspe... | 12/21/2010 |
| 7851199 | Production of carotenoids in oleaginous yeast and fungi The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids. ... | 12/14/2010 |
| 7838619 | Biodegradable polyketal polymers and methods for their formation and use The present invention relates to biodegradable biocompatible polyketals, methods for their preparation, and methods for treating animals by administration of biodegradable biocompatible polyketals. In one aspect, a method for forming the biodegradable biocompatible ... | 11/23/2010 |
| 7829672 | Modulation of sodium channels in dorsal root ganglia A novel tetrodotoxin resistant sodium channel is described, along with isolated nucleotides that encode this receptor. Methods for identifying agents that modulate the Na+ current through the receptor are provided, as well as related therapeutic and diagn... | 11/09/2010 |
| 7820175 | Herbal therapy for the treatment of food allergy The present invention provides herbal formulas, and compositions thereof, that can treat or reduce the severity, intensity, or duration of food allergy and food allergy related symptoms. The compositions may optionally include one or more adjuvants, cytokines, encap... | 10/26/2010 |
| 7816544 | Synthesis of rocaglamide natural products via photochemical generation of oxidopyrylium species The present invention provides new strategies for the synthesis of compounds of the rocaglamide family and related natural products. In particular, the new biomimetic synthetic approach involves photochemical generation of an oxidopyrylium species from a 3-hydroxych... | 10/19/2010 |
| 7816518 | Porphyrin derivatives and their use in photon activation therapy The present invention relates to the use of a compound of formula (I) in the manufacture of a pharmaceuticals composition for cell death by photo activation therapy and the use of the compounds in the prevention and/or treatment of cancer. | 10/19/2010 |
| 7794965 | Method of identifying modulators of PP2A methylase The invention relates to methylated proteins that control protein phosphorylation, particularly phosphoesterases, such as PP2A. It relates to screening methods for determining agents that affect methylation of these proteins and thus also modulate the level of phosp... | 09/14/2010 |
| 7790150 | Dual phase drug release system The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a modifier having a molecular weight ≦10 kDa; denotes direct of indirect at... | 09/07/2010 |
| 7759374 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprisi... | 07/20/2010 |
| 7750164 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention furth... | 07/06/2010 |
| 7732659 | Injecting embryos The present invention provides systems that allow reliable multiplexed transformation of Drosophila embryos. The present invention provides methods and reagents that allow preparation of injection-quality nucleic acid samples and that allow simultaneous prepa... | 06/08/2010 |
| 7678759 | Diagnosis and treatment of neuroectodermal tumors The present invention provides fusion proteins for the detection and treatment of neuroectodermal tumors. Previous work demonstrated that chlorotoxin is specific for glial-derived or meningioma-derived tumor cells. The current invention has extended the use of chlor... | 03/16/2010 |
| 7645454 | Prostate specific antigens and uses thereof The present invention provides compounds having formula (I): wherein W1, W2, R1, R3, R4, R2A and R2B are as defined herei... | 01/12/2010 |
| 7635750 | Method for preparing polyfunctionalized peptides and/or proteins via native chemical ligation The present invention provides a method for preparing polyfunctionalized peptides and/or proteins at non-adjacent designated sites via native chemical ligation. In certain embodiments, the inventive method is a method for preparing a polyfunctionalized peptide compr... | 12/22/2009 |
| 7630908 | Wireless electronic prescription scanning and management system Methods and systems for rapidly and conveniently creating prescriptions through the use of portable digital assistants (PDAs) and bar code scanning technology are provided. Prescriptions are created using a form-based approach in which prescribing options are presen... | 12/08/2009 |
