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| Number | Title | Issue Date |
| 6284763 | Methods for remodeling neuronal and cardiovascular pathways The present invention provides a method of administration of an agent which acts to remodel neuronal or vascular pathways for the long term management of sexual dysfunction in both males and females. In a preferred embodiment, the invention provides a met... | 09/04/2001 |
| 6090756 | Ballistics conditioning with molybdenum disulfide The present invention provides compositions and methods for the coating and/or ballistics conditioning of firearm projectiles and firearm components including gun barrels, firearm chambers, fully assembled cartridges, shot gun shells, shotgun wads, shot c... | 07/18/2000 |
| 6074333 | Machine for cutting discrete components of a multi-component workpiece and depositing them with registration on a moving web of material The present invention provides a machine for cutting at least two components of a multi-component workpiece from webs of material which are moving at different speeds relative to one another, and depositing the two cut components on a third web of materia... | 06/13/2000 |
| 6059710 | Process for cutting of discrete components of a multi-component workpiece and depositing them with registration on a moving web of material The present invention provides a process for manufacturing a multi-component product comprising at least two components cut from moving webs of material, registering the components with respect to one another, and depositing the registered components on a... | 05/09/2000 |
| 6020380 | Method of treating chronic obstructive pulmonary disease A class of Ω-substituted-1,4-benzoquinon-2-yl]alkanoic acids are useful in the treatment of chronic obstructive pulmonary disease (COPD). The preferred compound for the method of treatment is 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic aci... | 02/01/2000 |
| 5559144 | Furyl and thienyl alkynyl-N-hydroxy urea derivatives Compounds of the structure ##STR1## where p and q are zero or one, but cannot both be the same, M is a pharmaceutically acceptable cation or a metabolically cleavable group, B is a valence bond or a straight or branched alkylene group, R is alkyl, ... | 09/24/1996 |
| 5559242 | Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2(S)-pyrrolidinyl) isoxazoles A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1 -C3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resultin... | 09/24/1996 |
| 5534548 | Method of treating preeclampsia Straight-chain alkanoic acids, substituted at the Ω-carbon atom by a substituted phenyl, naphthyl, furyl, or thienyl group and by a substituted 1,4-benzoquinon-2-yl group are effective in the therapy or prophylaxis of conditions associated with lipid per... | 07/09/1996 |
| 5523281 | Method of accelerating and prolonging flowering in plants Treatment of cotton plants or flowering ornamental plants with a formulation comprising an agent effective to inhibit 1-aminocyclopropane-1-carboxylic acid synthase activity accelerates the flowering of cotton plants and accelerates and extends flower lon... | 06/04/1996 |
| 5521181 | Bicyclic substituted hexahydrobenz[e]isoindole -1 adrenergic antagonists The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are -1 adrenergic antagonists and are useful in the treatment... | 05/28/1996 |
| 5516795 | Heteroatom substituted propanyl derivatives having 5-lipoxygenase inhibitory activity Compounds of the structure ##STR1## where R1 is alkyl of one to four carbon atoms and R2 is selected from (a) alkenyl of one to four carbon atoms, (b) ##STR2## (c) ##STR3## and (d) ##STR4## are potent in... | 05/14/1996 |
| 5516789 | Lipoxygenase and cyclooxygenase inhibiting compounds Compounds having the structure ##STR1## or a pharmaceutically acceptable salt thereof have activity as inhibitors of cylooxygenase and 5-lipoxygenase, reduce the biosynthesis of leukotrienes B4, C4, D4, and E4 | 05/14/1996 |
| 5516759 | LHRH antagonists having lactam groups at the N-terminus Peptides possessing LHRH antagonistic activity, and useful for the controlling the release of LHRH in mammals are decapeptide analogues of LHRH having a lactam group at the N-terminus of the formula ##STR1## where n is 1, 2, or 3 and R1 is... | 05/14/1996 |
| 5516912 | Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2(s)-pyrrolidinyl)isoxazoles A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1 -C3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resultin... | 05/14/1996 |
| 5514702 | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity The present invention provides certain (substituted carbocyclic aryl)amidoalkyl- and (substituted heterocyclic aryl)amidoalkyl-N-Hydroxy urea compounds which inhibit lipoxygenase enzyme activity and are thus useful in the treatment of allergic and inflamm... | 05/07/1996 |
| 5512581 | Iminoxycarboxylates and derivatives as inhibitors of leukotriene biosynthesis The present invention relates to a compound of formula W--X--Q--Y--CH(R1)--O--N.dbd.C(R2)--A--COM or a pharmaceutically acceptable salt thereof wherein W is optionally substituted aryl or heteroaryl; X is a valence bond, or methylene, div... | 04/30/1996 |
| 5508383 | Cyclic peptide LHRH antagonists A class of cyclic peptides are effective inhibitors of LHRH and are useful in the treatment of disease conditions which are mediated by sex hormones including prostate cancer, endometriosis, uterine fibroids, and precocious puberty.... | 04/16/1996 |
| 5505194 | Aerosol inhalation device having slideably and rotatably connected elliptical cylinder portions A collapsible, articulated actuator for the aerosol delivery of a medicament comprised comprises an elliptical expansion chamber hingedly and slideably attached to an aerosol cannister-receiving portion in a manner which permits the cannister-receiving po... | 04/09/1996 |
| 5506261 | Substituted aryl- and heteroarylalkenyl-N-hydroxyurea inhibitors of leukotriene biosynthesis Compounds of the structure ##STR1## wherein Z is selected from optionally substituted thienyl, thiazolyl, oxazolyl and furyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful i... | 04/09/1996 |
| 5504207 | Process and intermediate for the preparation of terazosin hydrochloride dihydrate A process for the preparation of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (terazosin hydrochloride dihydrate comprises the steps of reacting 4-amino-2-chloro-6,7-dimethoxy-quinazoline with N-(2-tetrahydr... | 04/02/1996 |
| 5502035 | N-terminus modified analogs of LHRH Decapaptide and undecapaptides substituted on the N-terminal nitrogen atom by acyl groups which include furo-2-yl, isonicotinyl, nicotinyl, 2-, 3-, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl, and tetrahydrofur-2-oyl are potent antagonists of LHRH ... | 03/26/1996 |
| 5500403 | Liquid formulations and process for extending the vase life of cut flowers Liquid formulations, suitable for use in extending the vase-life of cut flowers and which resist the development of unsightly discoloration and turbidity comprise from about 55 parts by weight to about 98 parts by weight of a sugar; from about 0.05 part b... | 03/19/1996 |
| 5491217 | LHRH antagonists having modified aminoacyl residues at positions 5 and 6 A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substimtedamino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or Ω-(substitutedamino)alkyl group, and additio... | 02/13/1996 |
| 5487898 | Compositions and method for the sublingual or buccal administration therapeutic agents Pharmaceutical compositions for the sublingual or buccal administration of therapeutic agents which are normally degraded upon oral administration comprise such a therapeutic agent, a solvent, optionally a cosolvent and/or hydrogel, and an oral mucosal me... | 01/30/1996 |
| 5486525 | Platelet activating factor antagonists: imidazopyridine indoles The present invention relates to compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distres... | 01/23/1996 |
| 5484786 | Pyran-4-ylmethyl substituted arylalkylaryl-, arylalkenylylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase Compounds of structure ##STR1## where W is selected from ##STR2## where Q is oxygen or sulfur, R5 and R6 are independently selected from hydrogen and alkyl, or R5 and R6, together with the nitroge... | 01/16/1996 |
| 5476873 | Acetylene derivatives having lipoxygenase inhibitory activity Compounds of the structure ##STR1## where p and q are zero or one, but cannot both be the same, M is a pharmaceutically acceptable cation or a metabolically cleavable group, B is a valence bond or a straight or branched alkylene group, R is alkyl, ... | 12/19/1995 |
| 5475009 | 1, 2-dialkoxyethanes as 5-lipoxygenase inhibitors Compounds of the structure ##STR1## where Ar1 is selected from optionally substituted carbocyclic aryl; optionally substituted 5- or 6-membered heterocyclic aryl; optionally substituted 10-membered bicyclic heterocyclic aryl containing one... | 12/12/1995 |
| 5459150 | Indole derivatives which inhibit leukotriene biosynthesis Substituted indolyl compounds of the formula ##STR1## are potent inhibitors of the lipoxygenase enzymes and are useful as agents for the treatment of allergies and inflammatory disease states.... | 10/17/1995 |
| 5459152 | Platelet activating factor antagonists Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in... | 10/17/1995 |
| 5446062 | ((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkenyl-, and arylalkynyl)urea inhibitors of 5-lipoxygenase Compounds of the structure ##STR1## where W is selected from ##STR2## where Q is oxygen or sulfur, R6 and R7 are hydrogen or alkyl, or R6 and R7, together with the nitrogen atoms to which they are ... | 08/29/1995 |
| 5446025 | Formulations and method of the percutaneous administration of leuprolide Compositions useful for the percutaneous administration of leuprolide comprise from about 1 to about 100 mg/ml of leuprolide in its free base form, a cutaneous membrane penetration enhancing component, and a pharmaceutically acceptable carrier. The cutane... | 08/29/1995 |
| 5446055 | Polyether naphthalenic lignan lactones as inhibitors of 5-lipoxygenase Compounds of formula ##STR1## Ar is optionally substituted phenyl, furyl, pyridyl, or thienyl; Y is selected from hydrogen, halogen, cyano, alkyl, haloalkyl, alkoxy, and alkoxycarbonyl; L is selected from ##STR2## and R1 and R | 08/29/1995 |
| 5432263 | Process for producing peptides with side chains containing imidazolinylamino, tetrahydropyrimidinylamino, or alkylguanidinyl groups The present invention provides a process for the preparation of peptides which have or side-chains containing an alkyl- or dialkyl-substituted guanidinyl group or a imidazinylamino or tetrahydropyrimidinylamino group. The process provides higher overall y... | 07/11/1995 |
| 5432194 | (4-alkoxypyran-4-yl) substituted arylalkylaryl-, aryalkenylaryl-, and aryalkynylarylurea inhibitors of 5-lipoxygenase Compounds of the structure ##STR1## wherein W is selected from ##STR2## where Q is oxygen or sulfur, R6 and R7 are hydrogen or alkyl, or R6 and R7, together with the nitrogen atoms to which they are ... | 07/11/1995 |
| 5426111 | [Alkoxy-, alkenyloxy-, alkynyloxy-, and phenylmethyloxyalkoxycycloalkyl or alkoxycycloheteroalkyl]naphtho[2,3-c]furan-1(3H)-one inhibitors of 5-lipoxygenase Compounds of formula ##STR1## Ar is selected from (a) phenyl, (b) phenyl substituted with one or more groups selected from halogen, cyano, alkyl, haloalkyl, alkoxy, and alkoxycarbonyl, (c) furyl, (d) furyl substituted with one or more groups sel... | 06/20/1995 |
| 5420282 | Thiopyrano(2,3,4-c,d) indolyloxime ether alkylcarboxylates Compounds of the structure ##STR1## wherein R1 is selected from the group consisting of ##STR2## are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatm... | 05/30/1995 |
| 5413990 | N-terminus modified analogs of LHRH Decapaptides substituted on the N-terminal nitrogen atom by acyl groups are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.... | 05/09/1995 |
| 5412095 | Terazosin monohydrochloride and processes and intermediate for its production The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation. Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as p... | 05/02/1995 |
| 5407959 | (Trans-1,4-dialkoxycyclohexyl) substituted arylalkylaryl-arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase Compounds of structure ##STR1## where W is selected from the group consisting of ##STR2## where Q is oxygen or sulfur, R7 and R8 are independently selected from hydrogen and alkyl, or R7 and R8, togeth... | 04/18/1995 |
